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HSP70 positively regulates translation by interacting with the IRES and stabilizes the viral structural proteins VP1 and VP3 to facilitate duck hepatitis A virus type 1 replication. HSP70 通过与 IRES 相互作用来积极调节翻译,并稳定病毒结构蛋白 VP1 和 VP3,从而促进甲型肝炎病毒 1 型鸭的复制。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-17 DOI: 10.1186/s13567-024-01315-9
Yurui Jiang, Chenxia Xu, Anchun Cheng, Mingshu Wang, Wei Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Di Sun, Yu He, Zhen Wu, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu
{"title":"HSP70 positively regulates translation by interacting with the IRES and stabilizes the viral structural proteins VP1 and VP3 to facilitate duck hepatitis A virus type 1 replication.","authors":"Yurui Jiang, Chenxia Xu, Anchun Cheng, Mingshu Wang, Wei Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Di Sun, Yu He, Zhen Wu, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu","doi":"10.1186/s13567-024-01315-9","DOIUrl":"10.1186/s13567-024-01315-9","url":null,"abstract":"<p><p>The maintenance of viral protein homeostasis depends on the interaction between host cell proteins and viral proteins. As a molecular chaperone, heat shock protein 70 (HSP70) has been shown to play an important role in viral infection. Our results showed that HSP70 can affect translation, replication, assembly, and release during the life cycle of duck hepatitis A virus type 1 (DHAV-1). We demonstrated that HSP70 can regulate viral translation by interacting with the DHAV-1 internal ribosome entry site (IRES). In addition, HSP70 interacts with the viral capsid proteins VP1 and VP3 and promotes their stability by inhibiting proteasomal degradation, thereby facilitating the assembly of DHAV-1 virions. This study demonstrates the specific role of HSP70 in regulating DHAV-1 replication, which are helpful for understanding the pathogenesis of DHAV-1 infection and provide additional information about the role of HSP70 in infection by different kinds of picornaviruses, as well as the interaction between picornaviruses and host cells.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents. 尽管两种朊病毒病原体之间存在菌株相似性,但传统 BSE 仍被认为是导致挪威赤鹿患上 CWD 的原因。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-15 DOI: 10.1186/s13567-024-01320-y
Alba Marín-Moreno, Sylvie L Benestad, Tomas Barrio, Laura Pirisinu, Juan Carlos Espinosa, Linh Tran, Alvina Huor, Michele Angelo Di Bari, Hasier Eraña, Ben C Maddison, Claudia D'Agostino, Natalia Fernández-Borges, Sara Canoyra, Nuria Jerez-Garrido, Joaquín Castilla, John Spiropoulos, Keith Bishop, Kevin C Gough, Romolo Nonno, Jorn Våge, Olivier Andréoletti, Juan María Torres
{"title":"Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents.","authors":"Alba Marín-Moreno, Sylvie L Benestad, Tomas Barrio, Laura Pirisinu, Juan Carlos Espinosa, Linh Tran, Alvina Huor, Michele Angelo Di Bari, Hasier Eraña, Ben C Maddison, Claudia D'Agostino, Natalia Fernández-Borges, Sara Canoyra, Nuria Jerez-Garrido, Joaquín Castilla, John Spiropoulos, Keith Bishop, Kevin C Gough, Romolo Nonno, Jorn Våge, Olivier Andréoletti, Juan María Torres","doi":"10.1186/s13567-024-01320-y","DOIUrl":"10.1186/s13567-024-01320-y","url":null,"abstract":"<p><p>The first case of CWD in a Norwegian red deer was detected by a routine ELISA test and confirmed by western blotting and immunohistochemistry in the brain stem of the animal. Two different western blotting tests were conducted independently in two different laboratories, showing that the red deer glycoprofile was different from the Norwegian CWD reindeer and CWD moose and from North American CWD. The isolate showed nevertheless features similar to the classical BSE (BSE-C) strain. Furthermore, BSE-C could not be excluded based on the PrP<sup>Sc</sup> immunohistochemistry staining in the brainstem and the absence of detectable PrP<sup>Sc</sup> in the lymphoid tissues. Because of the known ability of BSE-C to cross species barriers as well as its zoonotic potential, the CWD red deer isolate was submitted to the EURL Strain Typing Expert Group (STEG) as a BSE-C suspect for further investigation. In addition, different strain typing in vivo and in vitro strategies aiming at identifying the BSE-C strain in the red deer isolate were performed independently in three research groups and BSE-C was not found in it. These results suggest that the Norwegian CWD red deer case was infected with a previously unknown CWD type and further investigation is needed to determine the characteristics of this potential new CWD strain.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-320 inhibits PRRSV replication by targeting PRRSV ORF6 and porcine CEBPB. MiR-320 通过靶向 PRRSV ORF6 和猪 CEBPB 抑制 PRRSV 复制。
IF 3.7 1区 农林科学
Veterinary Research Pub Date : 2024-05-15 DOI: 10.1186/s13567-024-01309-7
Xiaoxiao Gao, Xiangbin You, Guowei Wang, Mengtian Liu, Longlong Ye, Yufeng Meng, Gan Luo, Dequan Xu, Min Liu
{"title":"MiR-320 inhibits PRRSV replication by targeting PRRSV ORF6 and porcine CEBPB.","authors":"Xiaoxiao Gao, Xiangbin You, Guowei Wang, Mengtian Liu, Longlong Ye, Yufeng Meng, Gan Luo, Dequan Xu, Min Liu","doi":"10.1186/s13567-024-01309-7","DOIUrl":"10.1186/s13567-024-01309-7","url":null,"abstract":"<p><p>Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV), results in huge economic losses to the world pig industry. MiRNAs have been reported to be involved in regulation of viral infection. In our study, miR-320 was one of 21 common differentially expressed miRNAs of Meishan, Pietrain, and Landrace pig breeds at 9-h post-infection (hpi). Bioinformatics and experiments found that PRRSV replication was inhibited by miR-320 through directly targeting PRRSV ORF6. In addition, the expression of CCAAT enhancer binding protein beta (CEBPB) was also inhibited by miR-320 by targeting the 3' UTR of CEBPB, which significantly promotes PRRSV replication. Intramuscular injection of pEGFP-N1-miR-320 verified that miR-320 significantly inhibited the replication of PRRSV and alleviated the symptoms caused by PRRSV in piglets. Taken together, miR-320 have significant roles in the infection and may be promising therapeutic target for PRRS.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of ClpB, a molecular chaperone involved in the stress tolerance and virulence of Streptococcus agalactiae. 鉴定参与无乳链球菌应激耐受性和毒力的分子伴侣 ClpB。
IF 3.7 1区 农林科学
Veterinary Research Pub Date : 2024-05-15 DOI: 10.1186/s13567-024-01318-6
Lan Yang, Zhihao Wu, Tian-Yu Ma, Hui Zeng, Ming Chen, Yong-An Zhang, Yang Zhou
{"title":"Identification of ClpB, a molecular chaperone involved in the stress tolerance and virulence of Streptococcus agalactiae.","authors":"Lan Yang, Zhihao Wu, Tian-Yu Ma, Hui Zeng, Ming Chen, Yong-An Zhang, Yang Zhou","doi":"10.1186/s13567-024-01318-6","DOIUrl":"10.1186/s13567-024-01318-6","url":null,"abstract":"<p><p>Bacterial ClpB is an ATP-dependent disaggregate that belongs to the Hsp100/Clp family and facilitates bacterial survival under hostile environmental conditions. Streptococcus agalactiae, which is regarded as the major bacterial pathogen of farmed Nile tilapia (Oreochromis niloticus), is known to cause high mortality and large economic losses. Here, we report a ClpB homologue of S. agalactiae and explore its functionality. S. agalactiae with a clpB deletion mutant (∆clpB) exhibited defective tolerance against heat and acidic stress, without affecting growth or morphology under optimal conditions. Moreover, the ΔclpB mutant exhibited reduced intracellular survival in RAW264.7 cells, diminished adherence to the brain cells of tilapia, increased sensitivity to leukocytes from the head kidney of tilapia and whole blood killing, and reduced mortality and bacterial loads in a tilapia infection assay. Furthermore, the reduced virulence of the ∆clpB mutant was investigated by transcriptome analysis, which revealed that deletion of clpB altered the expression levels of multiple genes that contribute to the stress response as well as certain metabolic pathways. Collectively, our findings demonstrated that ClpB, a molecular chaperone, plays critical roles in heat and acid stress resistance and virulence in S. agalactiae. This finding provides an enhanced understanding of the functionality of this ClpB homologue in gram-positive bacteria and the survival strategy of S. agalactiae against immune clearance during infection.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Porcine cis-acting lnc-CAST positively regulates CXCL8 expression through histone H3K27ac. 猪顺式作用lnc-CAST通过组蛋白H3K27ac正向调节CXCL8的表达。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-07 DOI: 10.1186/s13567-024-01296-9
Junxin Gao, Haidong Yu, Yu Pan, Xinrong Wang, He Zhang, Yunfei Xu, Wenjie Ma, Wenli Zhang, Lizhi Fu, Yue Wang
{"title":"Porcine cis-acting lnc-CAST positively regulates CXCL8 expression through histone H3K27ac.","authors":"Junxin Gao, Haidong Yu, Yu Pan, Xinrong Wang, He Zhang, Yunfei Xu, Wenjie Ma, Wenli Zhang, Lizhi Fu, Yue Wang","doi":"10.1186/s13567-024-01296-9","DOIUrl":"10.1186/s13567-024-01296-9","url":null,"abstract":"<p><p>The chemokine CXCL8, also known as the neutrophil chemotactic factor, plays a crucial role in mediating inflammatory responses and managing cellular immune reactions during viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) primarily infects pulmonary alveolar macrophages (PAMs), leading to acute pulmonary infections. In this study, we explored a novel long non-coding RNA (lncRNA), termed lnc-CAST, situated within the Cxcl8 gene locus. This lncRNA was found to be highly expressed in porcine macrophages. We observed that both lnc-CAST and CXCL8 were significantly upregulated in PAMs following PRRSV infection, and after treatments with lipopolysaccharide (LPS) or lipoteichoic acid (LTA). Furthermore, we noticed a concurrent upregulation of lnc-CAST and CXCL8 expression in lungs of PRRSV-infected pigs. We then determined that lnc-CAST positively influenced CXCL8 expression in PAMs. Overexpression of lnc-CAST led to an increase in CXCL8 production, which in turn enhanced the migration of epithelial cells and the recruitment of neutrophils. Conversely, inhibiting lnc-CAST expression resulted in reduced CXCL8 production in PAMs, leading to decreased migration levels of epithelial cells and neutrophils. From a mechanistic perspective, we found that lnc-CAST, localized in the nucleus, facilitated the enrichment of histone H3K27ac in CXCL8 promoter region, thereby stimulating CXCL8 transcription in a cis-regulatory manner. In conclusion, our study underscores the pivotal critical role of lnc-CAST in regulating CXCL8 production, offering valuable insights into chemokine regulation and lung damage during PRRSV infection.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The haemagglutinin-neuraminidase protein of velogenic Newcastle disease virus enhances viral infection through NF-κB-mediated programmed cell death. 绒源新城疫病毒的血凝素-神经氨酸酶蛋白通过 NF-κB 介导的程序性细胞死亡增强病毒感染。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-07 DOI: 10.1186/s13567-024-01312-y
Xiaolong Lu, Tiansong Zhan, Qiwen Zhou, Wenhao Yang, Kaituo Liu, Yu Chen, Ruyi Gao, Jiao Hu, Min Gu, Shunlin Hu, Xin-An Jiao, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu
{"title":"The haemagglutinin-neuraminidase protein of velogenic Newcastle disease virus enhances viral infection through NF-κB-mediated programmed cell death.","authors":"Xiaolong Lu, Tiansong Zhan, Qiwen Zhou, Wenhao Yang, Kaituo Liu, Yu Chen, Ruyi Gao, Jiao Hu, Min Gu, Shunlin Hu, Xin-An Jiao, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu","doi":"10.1186/s13567-024-01312-y","DOIUrl":"10.1186/s13567-024-01312-y","url":null,"abstract":"<p><p>The haemagglutinin-neuraminidase (HN) protein, a vital membrane glycoprotein, plays a pivotal role in the pathogenesis of Newcastle disease virus (NDV). Previously, we demonstrated that a mutation in the HN protein is essential for the enhanced virulence of JS/7/05/Ch, a velogenic variant NDV strain originating from the mesogenic vaccine strain Mukteswar. Here, we explored the effects of the HN protein during viral infection in vitro using three viruses: JS/7/05/Ch, Mukteswar, and an HN-replacement chimeric NDV, JS/MukHN. Through microscopic observation, CCK-8, and LDH release assays, we demonstrated that compared with Mukteswar and JS/MukHN, JS/7/05/Ch intensified the cellular damage and mortality attributed to the mutant HN protein. Furthermore, JS/7/05/Ch induced greater levels of apoptosis, as evidenced by the activation of caspase-3/8/9. Moreover, JS/7/05/Ch promoted autophagy, leading to increased autophagosome formation and autophagic flux. Subsequent pharmacological experiments revealed that inhibition of apoptosis and autophagy significantly impacted virus replication and cell viability in the JS/7/05/Ch-infected group, whereas less significant effects were observed in the other two infected groups. Notably, the mutant HN protein enhanced JS/7/05/Ch-induced apoptosis and autophagy by suppressing NF-κB activation, while it mitigated the effects of NF-κB on NDV infection. Overall, our study offers novel insights into the mechanisms underlying the increased virulence of NDV and serves as a reference for the development of vaccines.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune response induced by a Streptococcus suis multi-serotype autogenous vaccine used in sows to protect post-weaned piglets. 用于母猪的猪链球菌多血清型自体疫苗诱导的免疫反应,以保护断奶后的仔猪。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-07 DOI: 10.1186/s13567-024-01313-x
Alison Jeffery, Mélina Gilbert, Lorelei Corsaut, Annie Gaudreau, Milan R Obradovic, Simon Cloutier, Marie-Christine Frenette, Charles Surprenant, Sonia Lacouture, Jose Luis Arnal, Marcelo Gottschalk, Mariela Segura
{"title":"Immune response induced by a Streptococcus suis multi-serotype autogenous vaccine used in sows to protect post-weaned piglets.","authors":"Alison Jeffery, Mélina Gilbert, Lorelei Corsaut, Annie Gaudreau, Milan R Obradovic, Simon Cloutier, Marie-Christine Frenette, Charles Surprenant, Sonia Lacouture, Jose Luis Arnal, Marcelo Gottschalk, Mariela Segura","doi":"10.1186/s13567-024-01313-x","DOIUrl":"10.1186/s13567-024-01313-x","url":null,"abstract":"<p><p>Streptococcus suis is a bacterial pathogen that causes important economic losses to the swine industry worldwide. Since there are no current commercial vaccines, the use of autogenous vaccines applied to gilts/sows to enhance transfer of passive immunity is an attractive alternative to protect weaned piglets. However, there is no universal standardization in the production of autogenous vaccines and the vaccine formulation may be highly different among licenced manufacturing laboratories. In the present study, an autogenous vaccine that included S. suis serotypes 2, 1/2, 5, 7 and 14 was prepared by a licensed laboratory and administrated to gilts using a three-dose program prior to farrowing. The antibody response in gilts as well as the passive transfer of antibodies to piglets was then evaluated. In divergence with previously published data with an autogenous vaccine produced by a different company, the increased response seen in gilts was sufficient to improve maternal antibody transfer to piglets up to 5 weeks of age. However, piglets would still remain susceptible to S. suis disease which often appears during the second part of the nursery period. Vaccination did not affect the shedding of S. suis (as well as that of the specific S. suis serotypes included in the vaccine) by either gilts or piglets. Although all antibiotic treatments were absent during the trial, the clinical protective effect of the vaccination program with the autogenous vaccine could not be evaluated, since limited S. suis cases were present during the trial, confirming the need for a complete evaluation of the clinical protection that must include laboratory confirmation of the aetiological agent involved in the presence of S. suis-associated clinical signs. Further studies to evaluate the usefulness of gilt/sow vaccination with autogenous vaccines to protect nursery piglets should be done.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic efficacy of a K5-specific phage and depolymerase against Klebsiella pneumoniae in a mouse model of infection. 在小鼠感染模型中,K5 特异性噬菌体和解聚酶对肺炎克雷伯氏菌的治疗效果。
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-05-07 DOI: 10.1186/s13567-024-01311-z
Pei Li, Genglin Guo, Xiangkuan Zheng, Sixiang Xu, Yu Zhou, Xiayan Qin, Zimeng Hu, Yanfei Yu, Zhongming Tan, Jiale Ma, Long Chen, Wei Zhang
{"title":"Therapeutic efficacy of a K5-specific phage and depolymerase against Klebsiella pneumoniae in a mouse model of infection.","authors":"Pei Li, Genglin Guo, Xiangkuan Zheng, Sixiang Xu, Yu Zhou, Xiayan Qin, Zimeng Hu, Yanfei Yu, Zhongming Tan, Jiale Ma, Long Chen, Wei Zhang","doi":"10.1186/s13567-024-01311-z","DOIUrl":"10.1186/s13567-024-01311-z","url":null,"abstract":"<p><p>Klebsiella pneumoniae has become one of the most intractable gram-negative pathogens infecting humans and animals due to its severe antibiotic resistance. Bacteriophages and protein products derived from them are receiving increasing amounts of attention as potential alternatives to antibiotics. In this study, we isolated and investigated the characteristics of a new lytic phage, P1011, which lyses K5 K. pneumoniae specifically among 26 serotypes. The K5-specific capsular polysaccharide-degrading depolymerase dep1011 was identified and expressed. By establishing murine infection models using bovine strain B16 (capable of supporting phage proliferation) and human strain KP181 (incapable of sustaining phage expansion), we explored the safety and efficacy of phage and dep1011 treatments against K5 K. pneumoniae. Phage P1011 resulted in a 60% survival rate of the mice challenged with K. pneumoniae supporting phage multiplication, concurrently lowering the bacterial burden in their blood, liver, and lungs. Unexpectedly, even when confronted with bacteria impervious to phage multiplication, phage therapy markedly decreased the number of viable organisms. The protective efficacy of the depolymerase was significantly better than that of the phage. The depolymerase achieved 100% survival in both treatment groups regardless of phage propagation compatibility. These findings indicated that P1011 and dep1011 might be used as potential antibacterial agents to control K5 K. pneumoniae infection.</p>","PeriodicalId":23658,"journal":{"name":"Veterinary Research","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Emergence and genomic characterization of Proteus mirabilis harboring blaNDM-1 in Korean companion dogs 更正:韩国伴侣犬中携带 blaNDM-1 的 mirabilis 变形杆菌的出现和基因组特征描述
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-04-29 DOI: 10.1186/s13567-024-01317-7
Su Min Kyung, Jun Ho Lee, Eun‑Seo Lee, Xi‑Rui Xiang, Han Sang Yoo
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引用次数: 0
Interactions between avian viruses and skin in farm birds 禽流感病毒与农场鸟类皮肤之间的相互作用
IF 4.4 1区 农林科学
Veterinary Research Pub Date : 2024-04-26 DOI: 10.1186/s13567-024-01310-0
Laurent Souci, C. Denesvre
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引用次数: 0
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