猪流行性腹泻病毒宿主限制因子综述

IF 3.7 1区农林科学 Q1 VETERINARY SCIENCES

Veterinary Research Pub Date : 2025-03-24 DOI:10.1186/s13567-025-01500-4

Hongqing Zheng, Cunyi Qiu, Haolun Tian, Xiaofu Zhu, Baoying Yin, Zhiding Zhou, Xuezhao Li, Jingjing Zhao

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引用次数: 0

摘要

猪流行性腹泻是由猪流行性腹泻病毒（PEDV）引起的一种急性传染性疾病，严重制约了全球养猪业的发展。宿主限制因子是抵御病毒感染的重要防御屏障，通常在病毒复制过程的特定阶段与病毒相互作用以破坏病毒。鉴于传统的PEDV疫苗往往难以有效激活母猪的粘膜免疫，从而无法通过乳汁为仔猪提供可靠的被动免疫，本文将重点介绍在限制PEDV感染和复制中起关键作用的宿主限制因素。目的是确定抗pedv药物开发的潜在靶点，并为探索新型疫苗佐剂提供见解。

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Host restriction factors against porcine epidemic diarrhea virus: a mini-review.

Porcine epidemic diarrhea is an acute contagious disease caused by porcine epidemic diarrhea virus (PEDV), which severely constrains the development of the global swine industry. Host restriction factors constitute a vital defensive barrier against viral infections, typically interacting with viruses at specific stages of their replication process to disrupt it. Considering that traditional PEDV vaccines often struggle to effectively activate mucosal immunity in sows and thereby fail to provide reliable passive immunity to piglets via milk, this review focuses on the host restriction factors that play crucial roles in restricting PEDV infection and replication. The aim is to identify potential targets for the development of anti-PEDV drugs and offer insights for the exploration of novel vaccine adjuvants.

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来源期刊

Veterinary Research 农林科学-兽医学

CiteScore

7.00

自引率

4.50%

发文量

审稿时长

3 months

期刊介绍： Veterinary Research is an open access journal that publishes high quality and novel research and review articles focusing on all aspects of infectious diseases and host-pathogen interaction in animals.