Urologia Journal最新文献

{"title":"Neutrophils to lymphocytes ratio as a predictor of BCG response in non-muscle invasive bladder cancer.","authors":"Ahmed Higazy, Amr Elsawy, Ahmed Lofty, Hany M Abdallah, Ahmed Radwan","doi":"10.1177/03915603241308974","DOIUrl":"10.1177/03915603241308974","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the role of preoperative neutrophils to lymphocytes ratio (NLR) as a predictor for the response to BCG in patients with non-muscle invasive bladder cancer (NMIBC).</p><p><strong>Materials: </strong>Nighty six patients with NMIBC were prospectively included in our study. Our study population was classified into two groups, based on pre-operative (NLR) either ⩽ or > 3. After receiving BCG, patients were followed up for 3 years to evaluate the correlation between BCG failure and (NLR).</p><p><strong>Results: </strong>Nighty two patients were evaluated at the end of our study. The NLR > 3 group of patients showed a higher age and T stage compared to the NLR ⩽ 3 group with a significant difference. BCG failure was reported to be higher in the NLR > 3 group with a failure rate of 66.7% compared to 28.3% in the other group (<i>p</i>-value < 0.001). Time to failure in NLR > 3 group compared to NLR ⩽ 3 group was 10.44 ± 4.3 and 15 ± 3.9 months respectively with a (<i>p</i>-value = 0.002). Univariate and multivariate logistic regression revealed that the most significant predictors of BCG failure were NLR > 3, Initial T stage, and age respectively.</p><p><strong>Conclusion: </strong>BCG response is highly affected by the NLR, with a higher failure rate with NLR > 3.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"237-242"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active surveillance in low risk prostate cancer: Role of multiparametric MRI and cancer progression predictors.","authors":"Nasser Simforoosh, Mehdi Dadpour, Behzad Narouie, Mohammad Hamidi Madani","doi":"10.1177/03915603251322577","DOIUrl":"10.1177/03915603251322577","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the outcomes of active surveillance (AS) strategy for patients with favorable risk prostate cancer (PCa) and identify multiparametric MRI role and PCa progression predictors.</p><p><strong>Method: </strong>This was a 5-year follow-up cohort study which enrolled 153 favorable-risk PCa patients in an AS program from April 2017 to February 2023. Patients were included in this study based on AS protocol inclusion criteria. MpMRI was also a part of this protocol. Active surveillance outcomes such as adherence to AS treatment strategy and the oncologic outcomes were assessed.</p><p><strong>Results: </strong>During the 4.23 ± 0.5 years follow-up, 39 of 153 patients left the AS protocol by their own decision (14) or other physicians' advice, due to the concern of cancer progression; 5 of 153 died from another cause other than PCa; 9 of 153 revealed cancer progression during this time and underwent radical prostatectomy; The remaining 100 patients stayed on the AS protocol during the follow up. Adherence to AS strategy protocol was 60.55% in our study. Older age, positive family history for PCa, initial clinical stage, higher total PSA, greater PSA density, more positive cores, and greater core involvement were the most common predictors for progression. The sensitivity, specificity, positive predictive value, and negative predictive value of mpMRI for cancer progression detection were 55.55%, 97%, 62.25%, and 96%, respectively.</p><p><strong>Conclusion: </strong>AS can be a suitable alternative treatment for low-risk and very low risk prostate cancer to avoid the probable complications of radical prostatectomy. MpMRI is valid and reliable for identifying PCa progression and provides useful information when combined with biopsy.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"282-287"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential value of Prostate Cancer Antigen 3 score in prediction of final cancer pathology parameters in radical prostatectomy patients.","authors":"Mohammad Soleimani, Navid Masoumi, Ali Jouzi, Mohammad Mehdi Darzi","doi":"10.1177/03915603241303637","DOIUrl":"10.1177/03915603241303637","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the potential capability of preoperative urinary Prostate Cancer Antigen 3 (PCA3) in predicting adverse pathologic features in patients with any- risk prostate cancer undergoing open retro-pubic radical prostatectomy.</p><p><strong>Methods: </strong>Sixty-one biopsy-proven, clinically localized prostate cancer patients who underwent open radical prostatectomy were included in a prospectively designed cohort to evaluate the association of PCA3 score with various Adverse Pathologic Features (APF). The Area Under the Curve (AUC) of the Receiver Operating Characteristics (ROC) curve was used to quantify the predictive accuracy of PCA3 and a cut-off point was calculated to determine the predictability potential of PCA3 in foretelling the study parameters.</p><p><strong>Results: </strong>Patients with APFs (e.g. extra-capsular extension, higher tumor volume, etc.) had a higher mean level of PCA3 compared to patients without these features, with statistically significant differences. PCA3 was a significant predictor of any APFs except perineural invasion in our study cohort.</p><p><strong>Conclusion: </strong>Increasing PCA3 level was associated with any APFs except perineural invasion in our study, which comprised mostly of intermediate and high-risk prostate cancer patients. Therefore, PCA3 could be used as an adjunctive measure in selecting patients for definitive treatments.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"259-266"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hemoglobin, albumin, lymphocyte and platelet (HALP) score with testicular tumor aggressiveness and prognosis.","authors":"Ozgur Ekici, Ugur Akgun, Erkan Buyukdemirci, Sinan Avci, Volkan Caglayan, Abdullah Erdogan, Efe Onen, Ridvan Ozcan, Sedat Oner","doi":"10.1177/03915603241292199","DOIUrl":"10.1177/03915603241292199","url":null,"abstract":"<p><strong>Background: </strong>The hemoglobin, albumin, lymphocyte and platelet (HALP) score integrates readily available blood markers that reflect systemic inflammation, nutritional status, and immune response, all of which can influence cancer progression. This study investigated the association between the HALP score and clinicopathological characteristics in patients with testicular tumor.</p><p><strong>Methods: </strong>Data of patients who underwent radical orchiectomy for testicular tumors between January 2020 and January 2024 were reviewed. Preoperative serum tumor markers, hemogram parameters and albumin levels were recorded. Tumor stages were recorded from postoperative radiological imaging and serum tumor markers. The association between postoperative results and HALP score was analyzed.</p><p><strong>Results: </strong>A total of 74 male patients were included in the study. The mean age of the patients was 30.27 ± 6.42 years. The mean HALP score in the patient group with metastasis and retroperitoneal lypmh node invasion (RPLNI) was statistically significantly lower than the patients without metastasis and RPLNI. HALP score decreased statistically significantly with increasing tumor T stage, N stage and M stage. In addition, the mean HALP score values of patients who received chemotherapy, developed progression and mortality were statistically significantly lower than those of patients who did not.</p><p><strong>Conclusions: </strong>Lower HALP scores are significantly associated with advanced disease and poorer prognosis in patients with testicular tumor. The HALP score, composed of routinely measured blood markers, may serve as a convenient and cost-effective prognostic tool to identify patients at higher risk and guide personalized management strategies.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"317-323"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pyelonephritis in adults. Should we adopt the pediatric guidelines?","authors":"Binyamin B Neeman, Ilan Kafka, Ariel Mamber, Ala Eldin Natsheh, Dmitry Koulikov, Jawdat Jaber, Boris Chertin","doi":"10.1177/03915603241309426","DOIUrl":"10.1177/03915603241309426","url":null,"abstract":"<p><strong>Purpose: </strong>There are no guidelines, what recommend pro or against cystography for identification of VUR for adults who suffer from first episode of pyelonephritis. The aim of this study was to look at incidence of VUR in adults with first episode of pyelonephritis, and to highlight recommendations for possible reflux investigation in these patients.</p><p><strong>Methods: </strong>We have performed retrospective review of all patients who admitted at our department over the last decade with the working diagnosis of acute pyelonephritis. Following discharge from the department, individuals with no pre-existing urological history were advised to undergo a VCUG or CEVUS.</p><p><strong>Results: </strong>We have identified 76 patients (62 females and 14 males) with an average age of 31.73 years who were hospitalized in our departments between 2006 and 2022. Forty-eight (63%) presented with right pyelonephritis, 26(34%) with left, and 2(3%) had bilateral disease. Of those, 23(30%) patients returned for clinical follow-up after completion of VCUG/CEVUS. Reflux was demonstrated in 14(60%) patients comprising 18 renal refluxing units (RRU). Six had grade IV reflux, 4 grade III, 4 grade II, and 4 grade I respectively. DMSA demonstrated 27.2 ± 11.9% relative function of the reflux kidney. Of those VUR patients, 9(64%) underwent endoscopic correction, 1(7%) refused surgery, and 4(29%) are under clinical follow-up.</p><p><strong>Conclusions: </strong>Our data demonstrate high incidence of VUR in adult patients with acute pyelonephritis patients, therefore VUR investigation at least should be considered in adult patients even after first episode of pyelonephritis, especially in cases where there is evidence of nephronia, abscess, kidney scars, atrophic kidney, or hydronephrosis.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"312-316"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging strategies in tackling antimicrobial resistance in urology: Narrative review and expert opinion.","authors":"Tommaso Ceccato, Simone Botti, Carlo Tascini, Massimiliano Lanzafame, Anna Brugnolli, Lorenzo Ruggera, Orietta Massidda, Vito Racanelli, Truls E Bjerklund Johansen, Tommaso Cai","doi":"10.1177/03915603241310389","DOIUrl":"10.1177/03915603241310389","url":null,"abstract":"<p><p>Urinary tract infections (UTIs) are highly prevalent and frequently treated with antibiotics, making antimicrobial stewardship (AMS) crucial in this field to benefit both individual patients and society. This narrative review examines recent advancements in managing urinary tract infections, focusing on AMS and antimicrobial resistance (AMR). AMS is essential in urology, where antibiotics are frequently prescribed for UTI. AMS promotes optimal antibiotic use to improve patient outcomes, control AMR, and safeguard public health. Key AMS practices in urology include selecting antibiotics at the appropriate dose and duration, especially for uncomplicated UTIs, asymptomatic bacteriuria, and catheter-associated infections. Following evidence-based guidelines, such as those from EAU and the IDSA, helps prioritize narrow-spectrum antibiotics and discourage empirical broad-spectrum use. Regular audits and feedback on antibiotic use help align practices with AMS goals, reducing inappropriate prescriptions. Multidisciplinary AMS teams, including urologists, microbiologists, and pharmacists, enhance treatment precision and antibiotic optimization in complex cases. Reassessing antibiotic therapy based on culture results after 48-72 h enables clinicians to refine treatment, minimizing unnecessary broad-spectrum use and strengthening AMS efforts in urology. In conclusion, addressing AMR in urology requires a careful approach that combines evidence-based antibiotic use, attention to local resistance patterns, and patient-specific factors. Non-antibiotic strategies for recurrent UTI prevention, judicious catheter management, and tailored treatment for complex infections are key AMS components. Emerging technologies in diagnostics and precision medicine offer tools for targeted, personalized therapy, enhancing AMS efforts, and helping to reduce reliance on broad-spectrum antibiotics.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":"92 2","pages":"185-193"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective comparative study of open versus laparoscopic stage II Fowler-Stephens orchidopexy in pediatric patients.","authors":"Raashid Hamid, Akshit Sudanshu, Mir Fahiem-Ul-Hassan, Ubayer Nabi, Waseem Jan Shah, Nisar A Bhat, Ajaz A Baba, Gowhar Nazir Mufti, Idrees Bashir, Fayaz Ahmad","doi":"10.1177/03915603241313025","DOIUrl":"10.1177/03915603241313025","url":null,"abstract":"<p><strong>Introduction: </strong>Laparoscopic Fowler Stephens orchidopexy, single stage or two-stage, is now routinely performed in non-palpable testis. We performed second stage orchidopexy as open inguinal approach and compared the outcome of this approach to two-staged laparoscopic orchidopexy.</p><p><strong>Methods: </strong>We performed a prospective randomized interventional study of two different approaches for intra-abdominal testis. In group A, Laparoscopic stage I (SFO) followed by open inguinal orchidopexy was compared for final outcome in group B cases, who underwent laparoscopic staged SF orchidopexy. The average duration between stage I SF and stage II SF was 6 months. All the procedures were done under GA and caudal analgesia. The pre-operative and post-operative USG dimensions were compared in cm and cm³/ml. The procedure outcome was considered successful if testis remained inside scrotum below mid-scrotal point. Any testis above the mid-scrotal point was considered as unacceptable or failure of procedure.</p><p><strong>Results: </strong>This study was performed on 74 children with 84 testis (group 'A' 38 patients (48 testis) and group 'B' 36 patients (46 testes)), with average age was 3.3 ± 0.46 and 3.9 ± 0.58 years, respectively. In group 'A', 38 patients (48 testes) underwent lap SFO I followed by inguinal orchidopexy and in group 'B', 36 patients (46 testes) underwent laparoscopic staged SF O. The mean testicular volume pre-operative in group 'A' & 'B' was 0.28 ± 0.04 and 0.23 ± 0.06 cm², respectively. The mean post-operative testicular volume was 0.34 ± 0.07 and 0.28 ± 0.05 cm², respectively. The average follow-up of the patients in group 'A' & 'B' was 24 ± 3.67 and 20 ± 2.90 months, respectively. Testis was having good volume in 87.5% and 76.60% of these successful cases, respectively. There were (3/48) 6.25% (4/46) 8.69% testicular atrophy cases in group 'A' & 'B', respectively. The differences were not statistically significant (<i>p</i> < 0.05). The mean operative time in group A was 20 ± 8.07 min and group B 30 ± 7.19 min in stage II procedure.</p><p><strong>Conclusion: </strong>The success rate in group A was more than the group B which was statistically significant (<i>p</i> > 0.05). Our study connotes that open stage II orchidopexy is still feasible and practicable with better final outcome of management of non-palpable cases.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"361-365"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanks to reviewers.","authors":"","doi":"10.1177/03915603251317784","DOIUrl":"https://doi.org/10.1177/03915603251317784","url":null,"abstract":"","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251317784"},"PeriodicalIF":0.8,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of sibling couple infertility history with semen parameters of infertile men, a cohort study.","authors":"Iman Menbari Oskouie, Hamed Akhavizadegan, Amir Kasaeian, Shima Esmaeilpanah, Mohammad Lotfi","doi":"10.1177/03915603241278112","DOIUrl":"10.1177/03915603241278112","url":null,"abstract":"<p><strong>Introduction: </strong>Infertility is a growing issue globally, particularly in industrialized cultures, affecting 13%-18% of couples of reproductive ages. In recent years, numerous studies have aimed to identify prognostic factors for infertility and abnormal semen analysis. To date, no study has examined the relationship between the number of infertile siblings and abnormal sperm parameters. This study aims to investigate whether the number of infertile siblings can be considered a prognostic factor for abnormal sperm parameters.</p><p><strong>Method: </strong>Semen samples were collected from the male partners of couples experiencing infertility issues. Study participants completed a questionnaire detailing demographic information including age and family history of infertility. Each participant provided two semen samples, with a minimum 15-day interval between collections. Sperm concentration, motility, and morphology were assessed for each sample. Clinical investigators conducted physical examinations, using an orchidometer to measure testicular size.</p><p><strong>Results: </strong>The number of infertile brothers and testis volume were prognostic factors for abnormal sperm count (OR = 1.374, <i>p</i>-value = 0.03; OR = 0.786, <i>p</i>-value < 0.001; respectively) and abnormal motility (OR = 1.514, <i>p</i>-value = 0.018; OR = 26.74, <i>p</i>-value < 0.001, respectively). There was no significant association between the percentage of abnormal morphology of sperm cells and the mentioned prognostic factors. The optimal cut-off point of the number of infertile brothers for both abnormal sperm count and abnormal sperm motility was one.</p><p><strong>Conclusion: </strong>It is recommended that males with at least one infertile brother, undergo sperm analysis to identify individuals at risk of infertility.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"112-119"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective study investigating the influence of nutritional intervention on biochemical profiles in patients with recurrent urolithiasis.","authors":"Rym Ben Othman, Kahena Bouzid, Amira Ben Sassi, Ouns Naija, Wafa Ferjani, Ramla Mizouri, Ahlem Bartkiz, Khouloud Ammari, Amel Gamoudi, Olfa Berriche, Henda Jamoussi","doi":"10.1177/03915603241283874","DOIUrl":"10.1177/03915603241283874","url":null,"abstract":"<p><strong>Background and objectives: </strong>Urolithiasis, commonly known as kidney stones, is a condition significantly impacted by dietary habits. The objective of this study is to evaluate the impact of a tailored dietary plan on the crystalluria and biological parameters of patients with different types of kidney stones over a 3-month period.</p><p><strong>Methods and study design: </strong>We conducted a prospective study of 3 months. The study involved patients with recurrent nephrolithiasis. Alongside the medical consultation, a comprehensive dietary survey was performed to assess the patients' nutritional habits. Urinary parameters, including volume, calcium, oxalate, uric acid, and power of hydrogen (pH), were evaluated both before and after the dietary intervention.</p><p><strong>Results: </strong>69 patients were involved. There were 17 patients diagnosed with cystine lithiasis, 33 with oxalocalcic lithiasis and 19 with uric lithiasis. After 3 months, only 32 patients revisited for follow-up. There were significant changes (<i>p</i> = 0.002 and 0.04) in urine crystalluria for cystinic and uric lithiasis. For the urinary oxalate variation, there was a significant decrease from T1 (before dietary intervention) to T2 (after dietary intervention), with levels dropping from 0.289 ± 0.10 umol/l to 0.215 ± 0.079 umol/l (<i>p</i> = 0.02).Regarding urinary calcium (calciuria), there was a trend toward a decrease from T1 to T2, although the change was not statistically significant, with levels decreasing from 2.42 ± 1.68 umol/l to 2.14 ± 1.62 umol/l (<i>p</i> = 0.1).</p><p><strong>Conclusions: </strong>Our research underscores the favorable effects of a tailored and well-balanced diet on both the crystalluria and biological parameters of individuals with recurrent lithiasis.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"96-103"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}