Urologia Journal最新文献

{"title":"Daily phosphodiesterase type 5 inhibitors plus acetylsalicylic acid improve curvature progression and pain intensity during the active phase of peyronie's disease.","authors":"Lucio Dell'Atti, Viktoria Slyusar","doi":"10.1177/03915603251344448","DOIUrl":"https://doi.org/10.1177/03915603251344448","url":null,"abstract":"<p><p>The purpose of this study is that the combination effects of Peyronie's disease (PD) therapy with Phosphodiesterase type 5 inhibitors (PDE5i) plus acetylsalicylic acid on improve curvature progression and pain in the active phase of disease. We performed a retrospective cohort study of 161 patients affected by PD in active stage and erectile dysfunction treated with tadalafil 5 mg once daily were divided in two groups. Group A(GA): 93 men treated with only PDE5i (tadalafil 5 mg) for 1 year or more and Group B(GB): 68 men that received tadalafil 5 mg plus aspirin 100 mg with the same protocol of GA. The patients of both groups were assessed at baseline and follow-up (6 months) for erectile function, painful erections, penile plaque size, and penile curvature. Six months after the treatment the patients in both groups had a non-significantly reduction of penile plaques. However, in GB patients had a clinically significant reduction of the curvature after 6 months by treatments 20.21° ± 7.20 versus 28.13° ± 8.11 (GA), (<i>p</i> < 0.001). In the analysis of our secondary endpoint, we demonstrated a significantly lower intensity of pain during erection in GB (1.43 ± 1.12) compared GA (1.89 ± 1.25; <i>p</i> < 0.001). We observed that the regular use of this therapeutic combination significantly provided more benefit in patients with active stage PD in terms of penile deformity, pain, and discomfort during penetrative intercourses.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251344448"},"PeriodicalIF":0.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the Allium stent for management of ureteral pathology: A real-world clinical practice study.","authors":"Jorge Panach-Navarrete, Lorena Valls-González, Marcos Antonio Lloret-Durà, Lucas Diéguez-Álvarez, José María Martínez-Jabaloyas","doi":"10.1177/03915603251341399","DOIUrl":"https://doi.org/10.1177/03915603251341399","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of the present study was to carry out a real-world clinical practice study, verifying through prospective analysis whether the Allium stent could resolve different types of ureteral pathologies, with strictures of different etiology and cases of urine leakage.</p><p><strong>Material and methods: </strong>Prospective observational study collecting all cases of Allium ureteral stent placement in our center between 2021 and 2022. Descriptive and comparative analyses were carried out to verify the success rate of Allium stents and pinpoint patient profiles in whom stent implantation would provide effective resolution of stricture or leakage.</p><p><strong>Results: </strong>A total of 30 Allium stent cases were collected in 30 patients, 10 of which were considered successful procedures (eight cases of stricture and two leakage) while 20 were classed as failures (15 stricture and five ureterointestinal urine leakage). The most frequent pathology was ureterointestinal stricture (33.3%) in patients with an ileal conduit, followed by retroperitoneal fibrosis (26.7%) and ureterointestinal urine leakage (16.7%). Furthermore, up to 40% of the sample had an infectious complication 1 month after stent implantation, while the most common cause of failure was persistent hydronephrosis (36.7%). Notably, only two of the 10 ureterointestinal stricture cases and one of the five cases of ureterointestinal urine leakage were resolved with the stent. Furthermore, a statistically significant relationship was found between the indication of the stent and its success: specifically, all cases of poor tolerance to DJ stents and ureteral urine leakage were resolved (OR: 12.66) with the Allium stent.</p><p><strong>Conclusions: </strong>The resolution rate of ureteral pathology with the Allium stent is relatively low. The patients who can benefit the most from this device are those with ureteral urine leakage or poor tolerance to the DJ stent. Among the possible complications, urinary infection in the first month after implantation is the most common.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251341399"},"PeriodicalIF":0.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"CLAMP Score\" to predict acute urinary retention in benign prostatic hyperplasia patients.","authors":"Saurav Karmakar, Asim Kumar Das, Tapan Kumar Mandal","doi":"10.1177/03915603251341397","DOIUrl":"https://doi.org/10.1177/03915603251341397","url":null,"abstract":"<p><strong>Introduction: </strong>In men older than 50 years, benign prostatic hyperplasia (BPH) is a common disease and progressive disease. Acute Urinary Retention (AUR) is one of the most common and painful long-term outcomes of BPH. Our study aimed at determining the risk factors which are responsible for developing AUR and formulating a novel scoring system known as \"Retention Score\" or \"CLAMP Score\" to predict the risk of developing AUR in BPH patients in future and manage them in advance.</p><p><strong>Materials and methods: </strong>The present study was a hospital-based comparative study which was conducted at the department of Urology, Nil Ratan Sircar Medical College and Hospital. Two groups were compared one \"with AUR\" and another \"without AUR.\" Various risk factors have been studied including age, international prostate symptom score (IPSS), comorbidities like diabetes mellitus, serum PSA etc. From the study we have formulated and validated a simple out-patient based risk scoring known as \"CLAMP Score\" by which we can stratify the BPH patients into various risk groups of developing AUR.</p><p><strong>Result: </strong>A total of 240 patients has been divided into two groups; 120 in each group. It was found that, majority number of patients with AUR are more than 60 years of age (92.5%) and has comorbidities (84.0%). 68% of these patients has a serum PSA over 1.4 ng/dL and a history of AUR (75%). The mean IPSS was 26.8 and intravesical prostatic projection is more than 12 mm. Our proposed scoring system has a significant association with the patients with AUR group.</p><p><strong>Conclusion: </strong>Our study provides valuable insights into the associations between various risk factors and AUR in BPH patients. Our proposed scoring system will be of great help in predicting AUR in BPH patients on out-patient basis and treat them accordingly in advance.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251341397"},"PeriodicalIF":0.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of lithotripsy with ureteroscopy for ureteral stones in octogenarians.","authors":"Ryo Sato, Asuka Uchiyama, Shungo Kakinuma, Rikiya Matsumoto","doi":"10.1177/03915603251343168","DOIUrl":"https://doi.org/10.1177/03915603251343168","url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy and safety of lithotripsy with ureteroscopy for managing ureteral stone in octogenarian patients.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed 314 patients who underwent retrograde lithotripsy with ureteroscopy for ureteral stones between January 2018 and August 2024. Patients were categorized into two groups based on age: the octogenarian group (⩾80 years) and the younger patient group (<80 years). Clinical parameters, including the stone-free rate, postoperative length of hospital stay, and postoperative complications, were compared. To minimize confounding variables, 1:1 propensity score matching was performed, resulting in 41 patients in each group.</p><p><strong>Results: </strong>After propensity score matching, no significant differences in baseline clinical characteristics between the groups. Additionally, no statistically significant differences were observed in the stone-free rate, postoperative length of hospital stay, or postoperative complication rates between the two cohorts.</p><p><strong>Conclusion: </strong>These findings suggest that lithotripsy with ureteroscopy is an effective and safe treatment option for ureteral stones in carefully selected octogenarian patients.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251343168"},"PeriodicalIF":0.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of CPB in surgery for extended tumor thrombosis of inferior vena cava and right atrium.","authors":"Mingchen Shao, Roman N Komarov, Leonid M Rapoport, Dmitry O Korolev, Ilya Vasalatii","doi":"10.1177/03915603251338717","DOIUrl":"https://doi.org/10.1177/03915603251338717","url":null,"abstract":"<p><strong>Objective: </strong>To research the best time to provide cardiopulmonary bypass (CPB) and the best way to do it when treating an extensive tumor thrombosis of the inferior vena cava vein (IVC).</p><p><strong>Results: </strong>The operating times in groups A and B were (376.7 ± 91.2) and (373.1 ± 80.7) minutes, respectively, with no statistically significant difference (<i>t</i> = 0.716, <i>p</i> > 0.05); intraoperative bleeding was (1916.7 ± 925.1) ml and (2600 ± 3756.3) ml, (<i>t</i> = -0.601, <i>p</i> < 0.05), and hospitalization was (32.3 ± 16.0) and (34.0 ± 8.0) days, with statistically significant differences (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The CPB approach has the advantages of less intraoperative blood loss, faster surgical procedures, and fewer hospitalizations.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251338717"},"PeriodicalIF":0.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of age, abstinence, and seasons with semen parameters in untreated male partners of infertile couples.","authors":"Natali Ilaria, Millanti Lorenzo, Siondino Sergio, Peluso Giuseppina, Errichiello Luigi","doi":"10.1177/03915603251334077","DOIUrl":"https://doi.org/10.1177/03915603251334077","url":null,"abstract":"<p><p>Many studies reveal the presence of an effect of age, abstinence and seasons on semen parameters, but the number of patients enrolled is small and the presence of therapies unknown. We aimed to evaluate the correlation between abstinence days, age, season, and semen parameters (volume, concentration, progressive motility, total number of sperms, morphology) among men referred to our laboratory. We proceeded with a cross-sectional, observational, exploratory study in an Andrology laboratory. A population of 348 male partners of infertile couples who did not receive any treatment in the 3 months preceding semen analysis was selected. Sperm volume, concentration, total number, progressive motility and morphology of sperms were conducted strictly following the guidelines indicated in the last edition of WHO manual for semen analysis. Pearson's correlation analysis and Kendall's correlation analysis were applied. Sperm concentration, semen volume and sperm total number moderately increased as well as the abstinence, while progressive motility and morphology moderately decreased. Regarding the age, in the 20-35 age group there was a weak inverse association with concentration, total number, motility and morphology and a weak positive association with volume; in the 42-63 age group there was a moderate positive association between age and concentration, motility and morphology, but an inverse association with volume. No correlation emerged between seasonal variations and semen parameters. These results suggested the importance of correct information to patients for proper semen analysis for diagnostic and therapeutic purposes.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251334077"},"PeriodicalIF":0.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical spectrum and management of Fournier's gangrene among diabetics and non-diabetics: A comparative study.","authors":"Ashish Ranjan, Samrat Biswas, Nidhi Bhatnagar, Debabrata Kundu","doi":"10.1177/03915603251338715","DOIUrl":"https://doi.org/10.1177/03915603251338715","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the clinical outcomes of Fournier's gangrene and its predisposing factors in male diabetic and non-diabetic patients. We also evaluated the disease severity using the Fournier's Gangrene Severity Index and examined management outcomes, including mode of wound closure and complications related to the disease and treatment.</p><p><strong>Methods: </strong>Patients with Fournier's gangrene underwent admission, with detailed history collection. Disease severity was clinically and laboratory assessed. Empirical antibiotics preceded surgical management and microbial evaluation. Wound closure involved primary suturing, skin grafting, or flaps. Patients were called for regular follow-up after discharge, and complications were identified.</p><p><strong>Results: </strong>Our study has shown that the overall FGSI was much higher among diabetics as compared to non-diabetics, and the same goes for the mortality rate, which was much higher in diabetics, owing to the higher rate of complications among them. It was also found that the prognosis of Fournier's gangrene is worse among diabetics. The mean number of debridement's in the diabetic group (3.00 ± 1.016) was higher than the non-diabetic group (2.22 ± 1.003). The association between number of debridement's in the two groups was statistically significant (<i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Early diagnosis and aggressive management are crucial to reduce Fournier's gangrene mortality. Effective diabetic control and repeated debridement are necessary to successfully manage these complex cases.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251338715"},"PeriodicalIF":0.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of operation time in percutaneous nephrolithotomy (PCNL) patients: A machine learning approach.","authors":"Owais Ghammaz, Rami Alazab, Nabil Ardah, Mohammed Jalal Akel, Bashar Tayyem, Nazih Alhirtani, Abdallah Bakeer, Bader Al-Deen Anabtawi, Eyas Amaierh, Azhar Al-Alwani","doi":"10.1177/03915603251338720","DOIUrl":"https://doi.org/10.1177/03915603251338720","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the factors influencing the length of percutaneous nephrolithotomy (PCNL) procedures and identify predictive variables for operation time using machine learning models.</p><p><strong>Materials and methods: </strong>A retrospective, observational cohort study was conducted at King Abdullah University Hospital, including 352 patients who underwent PCNL between January 2017 and September 2023. Data on preoperative and postoperative variables were collected from electronic health records. Four machine learning algorithms (Random Forest Classifier, AdaBoost Classifier, eXtreme Gradient Boosting Classifier, Logistic Regression) were employed to predict operation time, with features standardized using the StandardScaler module and Synthetic Minority Over-sampling Technique (SMOTE) used to address data imbalance. The dataset was split into training (80%) and testing (20%) sets. Model performance was evaluated using ROC curves, AUC scores, accuracy, precision, recall, and F1-score.</p><p><strong>Results: </strong>Stone burden, gender, and hydronephrosis were significantly associated with longer operation times. Machine learning analysis identified stone-free status, stone burden, and gender as key predictors, with the eXtreme Gradient Boosting Classifier achieving the highest AUC (0.789). Patients with non-stone-free status had longer operation times (<i>p</i> < 0.001). Stone burden and specific stone locations also significantly impacted procedure duration.</p><p><strong>Conclusion: </strong>Stone-free status followed by stone burden and gender are critical predictors of PCNL operation time. Achieving stone-free status significantly reduces procedure duration. Machine learning models, particularly eXtreme Gradient Boosting, provide valuable predictive insights, aiding in surgical planning and optimizing patient outcomes.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251338720"},"PeriodicalIF":0.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinner syndrome: Clinical insights from Western Norway.","authors":"Emanuel Bjurulf, Lars A R Reisæter, Hemamaalini Rajkumar, Adeel Asghar Chaudhury, Alfred Honoré, Florin Hopland-Nechita, Christian Arvei Moen, Julie Nøss Haugland, Ravi Rawal, Ingunn Roth, Anh Khoi Vo, Christian Beisland, Patrick Juliebø-Jones","doi":"10.1177/03915603251335609","DOIUrl":"https://doi.org/10.1177/03915603251335609","url":null,"abstract":"<p><strong>Introduction: </strong>Zinner syndrome (ZS) is characterised by unilateral renal agenesis, ipsilateral seminal vesicle cyst and obstruction of the ejaculatory duct. Although rare, urologists may encounter it at some point in their clinical practice. The literature is largely limited to case reports, and the condition is poorly understood. Our objective was to report on cases of ZS that have been managed at two centres in order to gain further clinical insights on this condition.</p><p><strong>Methods: </strong>A retrospective review was conducted on ZS cases presenting at two centres in Western Norway between January 2021 and June 2024. Data were collected on demographic details, symptomatology, imaging findings, management and fertility outcomes.</p><p><strong>Results: </strong>Six cases were identified that met the full triad for ZS, with ages ranging from 18 to 70 years. Five patients were symptomatic at presentation, reporting issues such as anejaculation and testicular pain during sexual activity. Two cases presented as emergencies, one with acute urinary retention and the other with severe pelvic pain. Half of the patients were successfully managed with a conservative approach. Two-thirds had children, either through natural conception or assisted reproductive methods, while the remaining patients underwent sperm cryopreservation.</p><p><strong>Conclusion: </strong>ZS presents with a wide range of symptoms and at varying ages. Not all symptomatic cases require surgical intervention, and management should be individualised. In select cases, a conservative approach can feasible.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251335609"},"PeriodicalIF":0.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between thyroid disorders and the Risk of developing prostate cancer: A systematic review and meta-analysis.","authors":"Daniel Andrés Nieva-Posso, Valeria Perea Ocampo, Daniel Alfonso Nieva Posso, Herney Andrés García-Perdomo","doi":"10.1177/03915603251336971","DOIUrl":"https://doi.org/10.1177/03915603251336971","url":null,"abstract":"<p><strong>Objective: </strong>To determine the association between thyroid disorders and the Risk of developing prostate cancer.</p><p><strong>Methods: </strong>We conducted this review following the recommendations of the Cochrane Collaboration and the PRISMA Statement. From the moment to the present, we have conducted a search strategy using MEDLINE, WEB OF SCIENCE, and GOOGLE SCHOLAR. We included cohort and case-control studies that examined the relationship between thyroid disorders and the Risk of developing prostate cancer. We assessed the Risk of bias using the Newcastle Ottawa Quality Assessment scale. Meta-analysis was conducted in Review Manager 5.4.1 (Revman^®).</p><p><strong>Results: </strong>We included nine studies in the analysis. The studies included were classified into two groups: those that studied hypothyroidism and those that studied hyperthyroidism. The results showed no association between thyroid abnormalities and prostate cancer risk, with an HR of 1.05 (95% CI: 0.90-1.22). Hyperthyroidism also showed no association with an HR 1.64 (95% CI: 1.00-2.69), characterized by increased serum T4 and decreased TSH. There was also no significant association with hypothyroidism, with an HR of 0.85 (95% CI: 0.67-1.10).</p><p><strong>Conclusion: </strong>Thyroid disorders were not associated with the Risk of developing prostate cancer.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251336971"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}