Urologia Journal最新文献

{"title":"Comment on: Evaluation of the analgesic effect of a combination of oral acetaminophen and oxycodone after extracorporeal shock wave lithotripsy (SWL).","authors":"Hüsnü Tokgöz, Özlem Tokgöz","doi":"10.1177/03915603251377595","DOIUrl":"https://doi.org/10.1177/03915603251377595","url":null,"abstract":"","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251377595"},"PeriodicalIF":0.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using epigenetics as an alternative treatment for bladder cancer: A literature review.","authors":"Maria Juliana Chaves Medina, Daniela Villada Florez, David Andrés Castañeda Millán, Herney Andrés García-Perdomo","doi":"10.1177/03915603251372377","DOIUrl":"https://doi.org/10.1177/03915603251372377","url":null,"abstract":"<p><strong>Background and objective: </strong>Bladder cancer (BC) is the sixth most common cancer in the U.S., with risk factors such as smoking, older age, and male sex. The primary symptom is painless hematuria. Diagnosis is made through cystoscopy, though this method is invasive and expensive. The study investigates the potential of epigenetic modifications, such as DNA methylation, histone modification, and microRNAs (miRNAs), in diagnosing and treating BC.</p><p><strong>Methods: </strong>A literature review was conducted on epigenetic changes, specifically DNA methylation in genes such as CDH1 and RASSF1A, and their impact on bladder cancer development. Gene mutations (e.g. FGFR3, TP53) and their influence on cancer progression were also investigated. In addition, epigenetic therapies, such as DNA methylation inhibitors, were discussed as potential treatments for advanced BC.Key findings and limitations:Epigenetic changes, such as DNA methylation, contribute to the development of BC, and histone modifications affect gene expression. MiRNAs regulate cancer cell proliferation. Additionally, mutations in genes such as FGFR3 and TP53 are crucial for specific BC subtypes. Despite promising results, challenges such as treatment resistance and difficulties in patient selection for epigenetic therapies remain.</p><p><strong>Conclusions and clinical implications: </strong>Epigenetic changes could serve as biomarkers for BC and as therapeutic targets. Epigenetic therapies offer an alternative to traditional treatments, especially for advanced BC. Clinical trials are underway to address challenges such as treatment resistance and to refine patient selection for these therapies.</p><p><strong>Patient summary: </strong>Bladder cancer is common and is related to lifestyle and genetic factors. Advances in epigenetics could lead to more personalized and less invasive treatments, improving outcomes for patients with advanced BC.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251372377"},"PeriodicalIF":0.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus vaccination and its effect on genital men's health. Considerations for a public health strategy.","authors":"Juan Camilo Barrera Cardenas, Philippe E Spiess, Herney Andrés García-Perdomo","doi":"10.1177/03915603251370915","DOIUrl":"https://doi.org/10.1177/03915603251370915","url":null,"abstract":"<p><p>Human papillomavirus (HPV) is a prevalent sexually transmitted disease worldwide. Very little is known about the effect of HPV on men's health. It is estimated that it is one of the most critical causes of penile cancer worldwide, representing a considerable percentage of the cases. We aimed to review the information on HPV vaccination strategy plans worldwide and the effect on male genital health. Studies on the outcomes of countries that include males in HPV vaccination programs and what the result will be in those that do not indicate favorable data in terms of preventing disease and thus the cost-effectiveness of gender-neutral HPV vaccination in most high-income countries (HIC) as well as in low-to-middle income countries (LMIC), considering HPV universal vaccination as a public health strategy. Vaccination of men against HPV is an effective strategy to prevent the development of genital cancers in this population.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251370915"},"PeriodicalIF":0.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrolithometry scoring systems in predicting acute kidney injury following percutaneous nephrolithotomy - A prospective observational study.","authors":"Anupam Choudhary, A V B Krishnakanth, K R Surag, Ankit Agarwal, Abhijit Shah, Kasi Viswanath Gali, Padmaraj Hegde","doi":"10.1177/03915603251355819","DOIUrl":"https://doi.org/10.1177/03915603251355819","url":null,"abstract":"<p><strong>Introduction: </strong>Various nephrolithometry scoring systems have been introduced to assess the outcomes of percutaneous nephrolithotomy (PCNL) and postoperative complications. Previous studies have incorporated various variables to determine factors influencing postoperative acute kidney injury (AKI). Using separate scoring systems or nomograms to predict postoperative outcomes and AKI is cumbersome. Our study aims to find if stone scoring systems can be used to predict AKI following a PCNL procedure.</p><p><strong>Materials and methods: </strong>A prospective observational study was conducted at Kasturba Hospital and Medical College from December 2023 to June 2024. All patients undergoing PCNL were included in the study. Scores were calculated for all patients pre-operatively using various nephrolithometry scoring systems. Patients were divided into two groups based on the presence or absence of AKI following PCNL. The various stone scoring systems were assessed for their ability to predict AKI following PCNL.</p><p><strong>Results: </strong>Out of the 90 patients in the study, 15 (16.66%) developed AKI, and 75 (83.33%) had no AKI following PCNL. Statistical significance was found in stone size (<i>p</i> < 0.001), stone location (<i>p</i> = 0.011), Staghorn (<i>p</i> < 0.001), Guy's Score (<i>p</i> = 0.001), STONE score (0.002), CROES Score (<i>p</i> = 0.001), Amplatz size (<i>p</i> = 0.012) and energy source (<i>p</i> = 0.01). No statistical significance was found when comparing sex, comorbidities, number of stones, the severity of HN, puncture location and number, intraoperative hypotension, operative time, and duration of hospital stay.</p><p><strong>Conclusion: </strong>Nephrolithometry scoring systems, in addition to assessing postoperative outcomes such as stone-free rate and complications, can also be used to predict the occurrence of AKI. The use of a limited number of scoring systems to assess all the postoperative outcomes will help simplify and facilitate their use in routine clinical practice.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251355819"},"PeriodicalIF":0.7,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bugs and babies: How gut microbiota affect infertility? A narrative Review.","authors":"Omnia Azmy Nabeh, Rahma Menshawey, Esraa Menshawey, Elsayed S Moubarak","doi":"10.1177/03915603251358953","DOIUrl":"https://doi.org/10.1177/03915603251358953","url":null,"abstract":"<p><p>Infertility is a disease of the reproductive system which is defined as the inability to conceive after more than 12 months of unprotected intercourse. It affects millions of people and has far-reaching impacts on quality of life, sexual dysfunction, marital impact, and societal implications. Despite advancements in understanding infertility, the cause of infertility in around 28% of cases remains unclear. This review addresses the pivotal relation between Gut microbiota (GM) and infertility. GM is now believed to interplay with the human body at different levels and is essential for our well-being. The abnormal translocation of GM to the systemic circulation, known as dysbiosis triggers an over-stimulated immune response associated with a marked increase in pro-inflammatory cytokines. This inflammatory situation may disrupt the hypothalamic-pituitary-gonadal axis and lead to disseminated inflammation ending in adhesions and obstructive lesions of the reproductive tract. Dysbiosis can also predispose individuals to obesity and insulin resistance, where both are risk factors for diabetes, hypertension, polycystic ovary syndrome (PCOS), impaired spermatogenesis, erectile dysfunction, and infertility. GM has an inevitable role in the pharmacokinetics of many drugs and can regulate the expression of many cytochrome P450 enzymes and several transporters. Further research is needed to validate the possible implication of GM in the pathophysiology of infertility, the efficacy of infertility medications, and the potential of GM-based therapies to treat infertile couples.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251358953"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and oncological outcome of transperitoneal laparoscopic partial nephrectomy for renal tumors with RENAL nephrometry score ⩽9 in absence of intraoperative ultrasound.","authors":"Rahul Gupta, Chetan Sharma, Yasir Mehmood, Arti Mahajan, Sunana Gupta, Kshitij Gupta, Yaser Rahman","doi":"10.1177/03915603251357641","DOIUrl":"https://doi.org/10.1177/03915603251357641","url":null,"abstract":"<p><strong>Introduction: </strong>Partial nephrectomy is the gold standard treatment for incidentally detected small renal tumors. To optimize the outcomes, use of intra operative imaging techniques like ultrasound (IOUS), OCT (optical coherence technique) and fluorescence along with augmented reality is indicated. However, these are not available in all the centers and may also not be needed for predominantly exophytic tumors with low RENAL nephrometry scores.</p><p><strong>Aim and objective: </strong>To evaluate the oncological outcomes and efficacy of transperitoneal laparoscopic partial nephrectomy (LPN) in patients with RENAL nephrometry score of ⩽9 without the use of IOUS.</p><p><strong>Material and methods: </strong>This was a single centered, single surgeon, retrospective, descriptive, record-based study carried out from January 2013 till December 2018 at postgraduate department of Urology GMC Jammu with a follow up 5 years. After initial evaluation by CECT abdomen with CT renal angio the patients were subjected to transperitoneal LPN and outcomes were recorded in the patient data sheet. Demographic, intra and post op data including RENAL nephrometry score and follow up was retrieved from the patient chart after taking the due clearance from Institutional Ethics Committee.</p><p><strong>Results: </strong>Sixty-five patients were included in the study and the average age was 52.6 ± 8 years of 40 were males and 25 were females with average BMI of 23.84 ± 5. Right sided tumors accounted for 62% of cases with upper polar 38%. Total operative time was 100 ± 20 with an average warm ischemia time of 21.55 ± 2. Average size of the tumor in our series was 4.1 ± 2 cms. One patient required blood transfusion. Surgical margins were negative in all. Average follow up in our series was 5.5 ± 1 years.</p><p><strong>Conclusion: </strong>Transperitoneal laparoscopic partial nephrectomy for low to intermediate RENAL nephrometry score (score ⩽9) without the use of IOUS is feasible and safe with acceptable surgical and oncological outcomes on long term follow up.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251357641"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive CT-based parameters for successful medical expulsive therapy in unilateral ureteral calculi: A prospective observational study.","authors":"Viswas Raghavendra Marathi, Devashish Kaushal, Kumar Madhavan, Rajesh Malik, Abhineeth Kp","doi":"10.1177/03915603251360160","DOIUrl":"https://doi.org/10.1177/03915603251360160","url":null,"abstract":"<p><strong>Introduction: </strong>Medical expulsive therapy (MET) has been shown to be a safe and effective option for the spontaneous passage of uncomplicated ureteric stones sizing ⩽10 mm in selected cases. However, there is lack of evidence on the predictors of successful MET. Our objective was to identify parameters that can accurately predict the spontaneous passage of ureteral stones during MET.</p><p><strong>Methods: </strong>Patients receiving MET (Tamsulosin 0.4 mg once daily (OD)) for a single unilateral ureteral calculi sizing ⩽10 mm were followed after 1 month using Non contrast Computed tomography (NCCT). Various parameters such as stone-related parameters (location, density, volume and transverse, longitudinal, and sagittal diameters), ureter-related parameters (diameter, density, and wall thickness at the stone site) and grade of hydronephrosis were evaluated on CT images and analyzed by using univariate, multivariate and receiver operating characteristic (ROC) curve analyses.</p><p><strong>Results: </strong>Of 55 patients, 31 (56.4%) passed the stone successfully within 4 weeks of MET. Univariate analysis revealed these patients tended to have lower ureteric stones (<i>p</i>-value- 0.048), lower longitudinal (<i>p</i>-value- 0.024) and transverse stone diameters (<i>p</i>-value- 0.006), lower stone volume (<i>p</i>-value- 0.015) and ureteral wall thickness (UWT; <i>p</i>-value- 0.001). In multivariate analysis, only UWT at the stone site (<i>p</i> 0.036) was a significant predictor of the successful passage of calculus. The UWT cut-off was 2.1 mm with sensitivity and specificity of 83.8% and 62.5%, respectively, with an Area Under Curve (AUC) of 0.7856.</p><p><strong>Conclusion: </strong>The most significant predictor of successful stone passage in MET of unilateral ureteral stones was maximal UWT, with an optimal cut-off point of 2.1 mm.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251360160"},"PeriodicalIF":0.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of neoadjuvant chemotherapy on short-term complications following robotic radical cystectomy.","authors":"Ameer Nsair, Kamil Malshy, Hussein Hijazi, Etan Eigner, Nicola Feza, Melissa Atallah, Azik Hoffman, Gilad E Amiel","doi":"10.1177/03915603251360580","DOIUrl":"https://doi.org/10.1177/03915603251360580","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of neoadjuvant chemotherapy (NAC) on short-term complications following robotic radical cystectomy (RRC).</p><p><strong>Methods: </strong>A retrospective review of 134 bladder cancer patients who underwent RRC. Perioperative outcomes were compared between patients who received NAC (nRRC) and those who underwent upfront RRC (uRRC).</p><p><strong>Primary outcome: </strong>30-day Clavien-Dindo classification score of ⩾2 (CDC ⩾ 2).</p><p><strong>Secondary outcomes: </strong>30-day infectious complications, readmission rates, postoperative ileus, blood transfusion, and mortality.</p><p><strong>Results: </strong>Of the 134 patients, 90 (67%) were in the nRRC group and 44 (33%) in the uRRC group. The total 30-day CDC ⩾ 2 complication rates and high-grade complications were comparable between the groups. Among the various outcomes assessed, only postoperative ileus showed a statistically significant difference, with lower rates in the nRRC (20% vs 38.4%, OR = 0.39, <i>p</i> = 0.021). Other outcomes, including 30-day readmission, infectious complications and blood transfusions, were similar. All four cases of 30-day mortality occurred in the nRRC group.</p><p><strong>Conclusion: </strong>NAC in the era of RRC was not associated with a statistically significant increase in overall perioperative complication rates in our cohort. NAC can likely be administered without a significant increase in perioperative complications, although confirmation in larger studies is warranted.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251360580"},"PeriodicalIF":0.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation and survival for urachal cancer: Findings from a nationwide multicenter cohort study in Norway.","authors":"Saima Naz Akhtar, Gigja Gudbrandsdottir, Erling Aarsæther, Birgitte Carlsen, Magne Dimmen, Ingrid Hannestad, Erik Skaaheim Haug, Olav Andreas Hopland, Ann-Karoline Karlsvik, Eirik Kjøbli, Stig Müller, Christian Arvei Moen, Patrick Juliebø-Jones, Christian Beisland","doi":"10.1177/03915603251358961","DOIUrl":"https://doi.org/10.1177/03915603251358961","url":null,"abstract":"<p><strong>Background and objective: </strong>This study aims to map the prevalence and treatment of urachal cancer (UrC) in Norway, establish survival rates, identify prognostic factors, and evaluate whether any of the three commonly used staging systems for UrC provide superior prognostic value.</p><p><strong>Methods: </strong>In this retrospective cohort study, data from the National Cancer Register was collected to identify patients diagnosed with UrC between1997 and2022. Eligible cases (<i>n</i> = 43) underwent retrospective review of their individual hospital records. All patients were staged using the Sheldon, Mayo, and Limonnik-revised TNM systems. This was performed locally and then checked by the coordinating center.Key findings and limitations:The median age at surgery was 59.5 years (IQR 49-73), with 57% of patients being male. The median follow-up time for survivors was 98 months (IQR 81-153). Macroscopic hematuria was the most common presentation (67%, <i>n</i> = 28). Recurrence-free survival (RFS) rates at 1, 3, and 5 years were 71%, 57%, and 53%, respectively. Cancer specific survival (CSS) was 95%, 62%, 55%, and overall survival (OS) rates were 93%, 61%, 46% at the same time points. Smaller tumor size was an independent predictor of improved CSS (HR 1.3, CI: 1.01-1.6, <i>p</i> = 0.045). Of the three staging systems, only the Mayo system showed statistically significant differences between stages for OS, while none of the systems, including Mayo, showed significant differences for CSS. Study limitations include a small sample size and a prolonged study period of 25 years, which may affect the generalizability of the findings and introduce bias due to changes in clinical practice over time, such as advancements in surgical techniques, and oncological therapies.</p><p><strong>Conclusions and clinical implications: </strong>Urachal cancer is frequently diagnosed at an advanced stage. Our findings suggest that the Mayo system more effectively distinguishes between localized, locally advanced, and advanced disease compared to the Sheldon and Limonnik-revised TNM systems.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251358961"},"PeriodicalIF":0.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in targeted therapies by PARP inhibitors for the treatment of prostate cancer: A scientometric approach.","authors":"Iman Menbari Oskouie, Naghmeh Khavandgar, Hediyeh Alemi, Heydar Ali Mardani-Fard, Amir-Hossein Mousavian, Maryam Noori, Azadeh AleTaha, Akbar Soltani, Fateme Guitynavard, Seyed Reza Yahyazadeh, Amir Kasaeian","doi":"10.1177/03915603251360527","DOIUrl":"https://doi.org/10.1177/03915603251360527","url":null,"abstract":"<p><strong>Introduction: </strong>The most prevalent cancer in men is prostate cancer (PCa). One significant discovery involves attacking tumors with mutations in DNA damage repair genes via the blockage of poly(ADP-ribose) polymerase (PARP) enzymes. In this study, we provide a summary of the present research status of PARP inhibitors in PCa, highlighting areas of interest and emerging trends.</p><p><strong>Method: </strong>Our search covered the Scopus database for literature on PARP inhibitors in PCa up to the year 2023. We conducted a scientometric review using VOSviewer to evaluate the output across countries, institutions, authors, journals, references, and keywords.</p><p><strong>Results: </strong>The study included 1850 articles on PARP inhibitors in prostate cancer (PCa) published until 2023, with medicine, biochemistry, and pharmacology being the most represented subject areas. The United States led in publication volume (<i>n</i> = 800, 43.2%), followed by the United Kingdom (<i>n</i> = 281, 15.2%) and China (<i>n</i> = 198, 10.7%), and also achieved the highest total citations and H-index. A positive correlation was identified between publication volume and gross domestic product (GDP; <i>r</i> = 0.843, <i>p</i> < 0.001). <i>Antonarakis, E.S.</i>, from the United States, ranked as the most prolific author (49 publications) and achieved the highest H-index, while Mateo, J. was the most cited. The <i>Institute of Cancer Research</i> emerged as the most active institution, publishing 91 articles, and the journal <i>Cancers</i> contributed the highest number with 99 articles. In keyword analysis, \"prostate cancer\" and \"PARP inhibitors\" were the most used terms, forming six thematic clusters. Citation and co-citation analysis highlighted the influential role of high-impact journals like <i>New England Journal of Medicine</i> and <i>Journal of Clinical Oncology</i>.</p><p><strong>Conclusion: </strong>The United States has taken the lead in this sector by making the largest contribution in terms of overall publications. Although international partnerships are occurring globally, there is a need for more assistance and expansion of research on PAPR inhibitors in PCa, particularly in underdeveloped nations. This study offers assistance to medical professionals, scientists, and surgery assistants on the worldwide results of PAPR inhibitors in PCa research.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251360527"},"PeriodicalIF":0.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}