Urologia Journal最新文献_第3页

Intralesional injection of mitomycin C following visual internal urethrotomy for recurrent urethral stricture: a randomized controlled study. 针对复发性尿道狭窄的可视内尿道切开术后丝裂霉素 C 的区域内注射：随机对照研究。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-10-10 DOI: 10.1177/03915603241283109

Diaaeldin Mostafa, Ahmed Higazy, Mostafa L Raslan, Mohamed S Salim

{"title":"Intralesional injection of mitomycin C following visual internal urethrotomy for recurrent urethral stricture: a randomized controlled study.","authors":"Diaaeldin Mostafa, Ahmed Higazy, Mostafa L Raslan, Mohamed S Salim","doi":"10.1177/03915603241283109","DOIUrl":"10.1177/03915603241283109","url":null,"abstract":"Aim: To assess the efficacy of Intralesional injection of mitomycin C (MMC) following visual internal urethrotomy (VIU) in the management of recurrent urethral stricture.Materials: Fifty male patients diagnosed with recurrent single bulbar urethral stricture measuring less than 1.5 cm previously treated with VIU were randomly allocated into two equal groups, (Group A) planned for VIU only and (Group B) planned for VIU with intralesional MMC injection using Botox injection needle. All patients were objectively evaluated pre- and post-operatively at 3, 6, and 12 months using uroflowmetry, post-void residual urine volume, and retrograde urethrography.Results: Forty-five patients completed their follow-up in our study. Patients who underwent intralesional MMC injection showed significant improvement in uroflowmetry, post-voiding residual, and with a success rate (82.6% in Group B, compared to 50% in Group A with a highly statistically significant difference, p-value: <0.001). VIU with MMC was the only factor associated with a marked decrease in stricture recurrence (p = 0.02) as shown in the Multivariate Cox regression analysis.Conclusion: Intralesional injection of mitomycin C seems to be a safe and effective modality in reducing the recurrent stricture rate after VIU.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"288-293"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness of multiparametric MRI for local staging of bladder cancer. 多参数MRI对膀胱癌局部分期的价值。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-12-29 DOI: 10.1177/03915603241310390

Prajwal Paudyal, Uttam Mete, Ujjwal Gorsi, Santosh Kumar, Nandita Kakkar

{"title":"Usefulness of multiparametric MRI for local staging of bladder cancer.","authors":"Prajwal Paudyal, Uttam Mete, Ujjwal Gorsi, Santosh Kumar, Nandita Kakkar","doi":"10.1177/03915603241310390","DOIUrl":"10.1177/03915603241310390","url":null,"abstract":"Introduction: Under staging and over staging are not uncommon with traditional MRI while staging bladder cancer. Current improvements in MRI technology due to addition of functional MR sequences that is, dynamic contrast-enhanced (DCE) imaging and diffusion-weighted imaging (DWI) have enhanced its clinical utility. The current study was designed to look for staging accuracy of multiparametric MRI (mp-MRI) that is, T2W + DCE + DWI, over conventional MRI.Material and methods: Forty patients with bladder cancer were included were subjected to mp-MRI on a 3T scanner with a phased array body coil. Four MR image sets that is, T2W, T2W + DCE, T2W + DWI, and T2W + DCE + DWI were interpreted. Accuracy of each image set was determined separately and was compared with the gold standard histopathological staging.Result: Staging accuracy of different image set increased from T2W (55%) to DCE (72.5%) to DWI (80%). Maximum accuracy was seen in mp-MRI (T2W + DWI + DCE) (87.5%). While differentiating non muscle invasive from muscle invasive disease (⩽T1 vs ⩾T2 stage) staging accuracy increased from T2W (65%) to DCE (80%) to DWI (85%) with maximum in mp-MRI (90%).Conclusion: mp-MRI offers high staging accuracy for bladder cancer.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":"92 2","pages":"231-236"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urolithiasis management: An umbrella review on the efficacy and safety of extracorporeal shock wave lithotripsy (ESWL) versus the ureteroscopic approach. 尿石症的治疗：体外冲击波碎石术（ESWL）与输尿管镜方法的有效性和安全性综述。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2025-01-22 DOI: 10.1177/03915603241313162

Anis Sani, Rasa Beheshti, Rozhin Khalichi, Maryam Taraghikhah, Elaheh Nourollahi, Ashkan Shafigh, Fariba Pashazadeh, Morteza Ghojazadeh, Hadi Mostafaei, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi

{"title":"Urolithiasis management: An umbrella review on the efficacy and safety of extracorporeal shock wave lithotripsy (ESWL) versus the ureteroscopic approach.","authors":"Anis Sani, Rasa Beheshti, Rozhin Khalichi, Maryam Taraghikhah, Elaheh Nourollahi, Ashkan Shafigh, Fariba Pashazadeh, Morteza Ghojazadeh, Hadi Mostafaei, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi","doi":"10.1177/03915603241313162","DOIUrl":"10.1177/03915603241313162","url":null,"abstract":"This Umbrella Review aims to gather high-quality evidence on urolithiasis outcomes and complications, comparing extracorporeal shockwave lithotripsy (ESWL), ureteroscopic lithotripsy (URSL), and retrograde intrarenal surgery (RIRS). We incorporated systematic reviews, some containing meta-analyses, into two separate reports, focusing on quantitative and qualitative results. Additionally, when data permitted, a secondary meta-analysis was conducted using final effect estimates from multiple meta-analyses. Stone-free rate (SFR) served as the primary outcome, with complications, retreatment, and hospital stay as secondary outcomes. Adhering to Joanna Briggs Institute (JBI) guidelines, we initially screened 282 titles, narrowed down to 166 titles and abstracts, ultimately selecting 55 full-text articles for review. Of these, 22 met our inclusion criteria for the umbrella review. We evaluated study quality using JBI criteria, excluding five low-quality studies. Analysis showed ESWL had lower SFR compared to RIRS (RR: 0.577, 95% CI: 0.482-0.692) and URSL (RR: 0.570, 95% CI: 0.450-0.722); lower overall risk compared to ureteroscopy (RR: 0.58, 95% CI: 0.51-0.66). ESWL had fewer complications than RIRS (p < 0.001), but lower SFR than ureteroscopy. However, the need for retreatment and auxiliary procedures in RIRS and URSL were lower than that in ESWL. In contrast, individuals undergoing ureteroscopy experienced a greater frequency of complications and longer duration of operation compared to those undergoing ESWL.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"294-311"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of age specific serum Prostate Specific Antigen (PSA) levels for Indian population: A retrospective analysis at a tertiary healthcare facility. 印度人口特定年龄血清前列腺特异抗原（PSA）水平评估：一家三级医疗机构的回顾性分析。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-10-13 DOI: 10.1177/03915603241283295

Kudunthail Jeena R, Choudhary Gautam Ram, Navriya Shiv Charan, Singh Mahendra, Sandhu Arjun S, Bhirud Deepak, Sharma Kartik, Shukla Kamla Kant, Nandagopal Srividhya

{"title":"Assessment of age specific serum Prostate Specific Antigen (PSA) levels for Indian population: A retrospective analysis at a tertiary healthcare facility.","authors":"Kudunthail Jeena R, Choudhary Gautam Ram, Navriya Shiv Charan, Singh Mahendra, Sandhu Arjun S, Bhirud Deepak, Sharma Kartik, Shukla Kamla Kant, Nandagopal Srividhya","doi":"10.1177/03915603241283295","DOIUrl":"10.1177/03915603241283295","url":null,"abstract":"Introduction: Prostate-specific antigen (PSA) is a key marker for prostate cancer screening, but its utility is debated, prompting exploration of PSA derivatives for improved accuracy. While racial variations in serum PSA levels are documented, limited data exists for the Indian population. Given increasing life expectancy and heightened awareness of prostate cancer, this study aims to establish age-specific PSA ranges in an Indian cohort, contributing vital insights for population-specific screening and diagnosis.Methods: A cross-sectional study was conducted on 4860 men with lower urinary tract symptoms (LUTS). Data, collected from April 2016 to March 2023, included age, PSA levels, digital rectal examination (DRE), and biopsy results. Statistical analysis involved Spearman's correlation, descriptive statistics, and confidence intervals.Results: Of the studied participants, 809 underwent prostatic biopsy, revealing malignancy in 500 cases. Age-specific PSA values were studied in 4170 subjects and showed positive correlation with increasing age and prostate size. Most cancers were metastatic (66%), emphasizing the need for early detection. Age-specific PSA ranges were lower in the Indian population compared to the West. This study's Indian cohort exhibited higher PSA values than some previous Indian studies but lower than Western populations, aligning with global trends. The rising incidence of prostate cancer in India underscores the importance of understanding the disease burden.Conclusion: PSA levels exhibit race-specific variations, cautioning against direct extrapolation of Western data to the Indian population. This study contributes age-specific PSA ranges for an Indian cohort, facilitating nuanced prostate cancer screening strategies.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"252-258"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of health-related quality of life in patients undergoing medical expulsion therapy for acute renal colic. 急性肾绞痛患者接受药物驱逐治疗的健康相关生活质量的决定因素

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI: 10.1177/03915603251316740

Katsuhiro Ito, Toshifumi Takahashi, Shigeki Koterazawa, Shinya Somiya, Takao Haitani, Toru Kanno, Yoshihito Higashi, Hitoshi Yamada

{"title":"Determinants of health-related quality of life in patients undergoing medical expulsion therapy for acute renal colic.","authors":"Katsuhiro Ito, Toshifumi Takahashi, Shigeki Koterazawa, Shinya Somiya, Takao Haitani, Toru Kanno, Yoshihito Higashi, Hitoshi Yamada","doi":"10.1177/03915603251316740","DOIUrl":"10.1177/03915603251316740","url":null,"abstract":"Purpose: Patients with ureteral stones and acute renal colic significantly impaired their quality of life (QOL). However, the factors that affect quality of life during conservative management, particularly medical expulsive therapy (MET), are not well understood. This study aimed to assess the determinant of QOL.Materials and methods: We conducted a prospective study to longitudinally assess QOL using the EuroQol-5 Dimension (EQ-5D) in patients undergoing medical expulsive therapy.Results: Ninety-three patients were enrolled between April 2020 and December 2022, and 187 questionnaires were completed at each visit before spontaneous passage or intervention. The study found that a higher pain intensity was significantly associated with worse QOL during the primary visit (p = 0.03). At the second visit, younger age (p < 0.01), increased frequency of renal colic attacks (p < 0.01), maximum pain intensity since the last visit (p < 0.01), and shorter time from disease onset (p = 0.03) were associated with a worse QOL. Multivariate analysis showed that only the total number of renal colic attacks was associated with EQ-5D score (p = 0.047). The stone location significantly affected the cumulative incidence of renal colic attacks (p = 0.02). The mean total number of renal colic until stone passage was 3.58 in individuals with proximal stones versus 0.86 in with distal stones (p < 0.01).Conclusions: This study identified pain intensity and colic frequency as key factors contributing to the decline in QOL in patients with ureteral stones. Patients with proximal stones may be good candidates for early intervention to reduce colic events.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"209-215"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On integrative analysis of multi-level gene expression data in Kidney cancer subgrouping. 肾癌分组中多级基因表达数据的综合分析

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-12-13 DOI: 10.1177/03915603241304604

Pratheeba Jeyananthan, Maduranga W P N, Rodrigo S M

{"title":"On integrative analysis of multi-level gene expression data in Kidney cancer subgrouping.","authors":"Pratheeba Jeyananthan, Maduranga W P N, Rodrigo S M","doi":"10.1177/03915603241304604","DOIUrl":"10.1177/03915603241304604","url":null,"abstract":"Kidney cancer is one of the most dangerous cancer mainly targeting men. In 2020, around 430, 000 people were diagnosed with this disease worldwide. It can be divided into three prime subgroups such as kidney renal cell carcinoma (KIRC), kidney renal papilliary cell carcinoma (KIRP) and kidney chromophobe (KICH). Correct identification of these subgroups on time is crucial for the initiation and determination of proper treatment. On-time identification of this disease and its subgroup can help both the clinicians and patients to improve the situation. Hence, this study checks the possibility of using multi-omics data in the kidney cancer subgrouping, whether integrating multiple omics data will increase the subgrouping accuracy or not. Four different molecular data such as genomics, proteomics, epigenomics and miRNA from The Cancer Genome Atlas (TCGA) are used in this study. As the data is in a very high dimension world, this study starts with selecting the relevant features of the study using Pearson's correlation coefficient. Those selected features are used with three different classification algorithms such as k-nearest neighbor (KNN), supporting vector machines (SVMs) and random forest. Performances are compared to see whether the integration of multi-omics data can improve the accuracy of kidney cancer subgrouping. This study shows that integration of multi-omics data can improve the performance of the kidney cancer subgrouping. The highest performance (accuracy value of 0.98±0.03) is gained by top 400 features selected from integrated multi-omics data, with support vector machines.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"194-200"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrograde urethrography (RUG) combined with voiding cystourethrography (VCUG) versus surgical findings in assessment of urethral strictures length. 在评估尿道狭窄长度时，逆行尿道造影术（RUG）与排尿膀胱尿道造影术（VCUG）对比手术结果。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-11-18 DOI: 10.1177/03915603241292840

Hojat Salimi, Iman Menbari Oskouie, Rayeheh Mohammadi, Mohammad Javad Nazarpour, Nasim Niknam, Mohammad Reza Nikoubakht, Seyed Hamid Mousavi

{"title":"Retrograde urethrography (RUG) combined with voiding cystourethrography (VCUG) versus surgical findings in assessment of urethral strictures length.","authors":"Hojat Salimi, Iman Menbari Oskouie, Rayeheh Mohammadi, Mohammad Javad Nazarpour, Nasim Niknam, Mohammad Reza Nikoubakht, Seyed Hamid Mousavi","doi":"10.1177/03915603241292840","DOIUrl":"10.1177/03915603241292840","url":null,"abstract":"Background and objective: Retrograde urethrography (RUG) combined with voiding cystourethrography (VCUG) is the most common and preferred imaging modality for evaluating urethral strictures, despite its well-known limitations and disadvantages. In this study, we assessed the clinical relevance of RUG + VCUG, along with intraoperative assessment in measuring male urethral strictures.Method: This study was a single-center retrospective study involving 134 male patients diagnosed with urethral stricture disease. All participants underwent RUG + VCUG before the intervention, and the results were interpreted by a single radiologist. The location and length of urethral strictures were assessed. The accuracy of urethral stricture measurements obtained from combined VCUG and RUG imaging was compared to intraoperative measurements, which served as the reference standard. Urethral strictures were classified into three types: membranous and bulbomembranous, bulbar, and penile.Results: A total of 130 patients were included (38.14 ± 12.05 years) in the study. For patients with membranous and bulbar strictures, there were statistically significant differences in stricture length measurements between VCUG + RUG and surgical evaluation (p < 0.05). However, for patients with penile strictures, the differences in stricture length measurements between VCUG + RUG and surgical evaluation were not statistically significant (p = 0.448).Conclusion: This study suggests that RUG + VCUG may underestimate urethral stricture, particularly in the membranous and bulbar regions.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"342-347"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of BOLA3-DT as a diagnostic biomarker in prostate cancer. 探讨BOLA3-DT作为前列腺癌诊断生物标志物的潜力。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1177/03915603251314995

Debansu Sarkar, Badre Alam Khan, Abhishek Bardhan, Amlan Ghosh, Dilip Kumar Pal

{"title":"Exploring the potential of BOLA3-DT as a diagnostic biomarker in prostate cancer.","authors":"Debansu Sarkar, Badre Alam Khan, Abhishek Bardhan, Amlan Ghosh, Dilip Kumar Pal","doi":"10.1177/03915603251314995","DOIUrl":"10.1177/03915603251314995","url":null,"abstract":"Background: Exploring the potential of BOLA3-DT as a diagnostic biomarker in prostate cancer.Methods: Expression of the lncRNA BOLA3-DT was analyzed between normal and tumor samples in the GDC TCGA PRAD (Genomic Data Commons: The Cancer Genome Atlas Prostate Adenocarcinoma Collection) dataset. Disease progression-related clinicopathological parameters such as serum PSA level (ng/ml) and Gleason score were associated with the expression of BOLA3-DT using the same GDC TCGA PRAD dataset. To validate these findings, the expression of BOLA3-DT was checked in our sample set of 15 PCa (prostate cancer) and 15 BPH (benign hypertrophy of the prostate) patients.Results: In the GDC TCGA PRAD dataset, the expression of the lncRNA BOLA3-DT was significantly downregulated in prostate cancer tissue samples (n = 492) compared to adjacent normal (n = 52; p < 0.0001), and, there was a significant negative correlation between the expression of the lncRNA BOLA3-DT and the serum PSA level (p < 0.01). However, no significant association was found between the lncRNA BOLA3-DT expression and the Gleason score (p > 0.05). In this study, it was found that BOLA3-DT was downregulated in PCa tissue samples compared to BPH samples (p > 0.05). In the GDC TCGA PRAD dataset, it was revealed that BOLA3-DT could serve as an excellent diagnostic marker with a sensitivity of 86.9% and a specificity of 84.6% (AUC-0.916).Conclusion: LncRNA BOLA3-DT, a novel long non-coding RNA, was found to be downregulated in prostate cancer. The expression of the lncRNA BOLA3-DT can serve as a diagnostic marker in prostate cancer.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"267-272"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAR-200: Investigational intravesical drug delivery system for bladder cancer. TAR-200：膀胱内给药系统用于膀胱癌的研究。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.1177/03915603251319133

Muhammed Munavvir, Mujeeburahiman M, Altaf Khan, Gaurav Das Debashish

{"title":"TAR-200: Investigational intravesical drug delivery system for bladder cancer.","authors":"Muhammed Munavvir, Mujeeburahiman M, Altaf Khan, Gaurav Das Debashish","doi":"10.1177/03915603251319133","DOIUrl":"10.1177/03915603251319133","url":null,"abstract":"Bladder cancer is second among the most common urothelial malignancy and one of the most expensive in terms of treatment. Localized bladder cancer is classified into non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). First line approach for treatment of NMIBC is transurethral resection of bladder tumor (TURBT) followed by intravesical instillation of immuno/chemotherapeutic agents to prevent or delay recurrence or progression. Historically intravesical Bacillus Calmette Geurin (BCG) instillation has been a mainstay of therapy for NMIBC post-TURBT. Commonly followed drug delivery is intravesical instillation that maximizes exposure of the drug to the lesion and minimizes systemic side effects. Gemcitabine used in bladder cancer due to its pharmacological properties making it appropriate for intravesical instillation. Limitations of intravesical instillation is low bladder permeability leading to decreased drug concentration in bladder tissues and frequent urination causing drug wash out or dilution reducing the effect of treatment. Effective intravesical therapy depends on the penetration of the drug into the tumor. TAR200 is a novel drug delivery system that facilitates sustained release of continuous low dose gemcitabine over an indwelling period providing a uniform concentration of drug after each voiding cycle and exposure of drug to the bladder tumor. There are completed and ongoing clinical trials to evaluate the efficacy of TAR200 alone or in combination with other chemotherapeutic agents in NMIBC and MIBC. FDA has granted breakthrough therapy designation (BTD) for TAR-200 in December 2023. This review highlights the potential of TAR-200 and clinical trials that improve bladder cancer treatment outcome.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"243-251"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New masculinities in uro-oncology: A social theory that contributes to the mental health of patients with penile cancer. 泌尿肿瘤学中的新男子气概：有助于阴茎癌患者心理健康的社会理论。

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Urologia Journal Pub Date : 2025-05-01 Epub Date: 2024-11-07 DOI: 10.1177/03915603241293840

Natalia Barbosa Daza, Daniel Andrés Nieva-Posso, Herney Andrés García-Perdomo

{"title":"New masculinities in uro-oncology: A social theory that contributes to the mental health of patients with penile cancer.","authors":"Natalia Barbosa Daza, Daniel Andrés Nieva-Posso, Herney Andrés García-Perdomo","doi":"10.1177/03915603241293840","DOIUrl":"10.1177/03915603241293840","url":null,"abstract":"Sociocultural, the penis has represented an essential element in the identity and masculinity of Western men. Therefore, its injury, damage, or loss leads to psychosocial problems affecting these people's health and well-being. Penile cancer is a rare malignancy (it represents 1.44% of the cases of genitourinary cancers) that has direct effects on the genitals, and its treatment consists of penectomy (removal of the penis). The loss of the penis due to this disease has a profound impact on the survivors. It is associated with higher rates of depression, anxiety, and loss of male identity, some even feeling like \"castrated animals\" or fewer men, having not only biological but also social and psychological problems, leading to the loss or decrease of sexual activity, self-esteem, and ability to relate to others. The new masculinities (a social theory much discussed these days) is offered as an alternative to understanding the behavior of men concerning what represents the penis, and the construction of their identity, focusing on the need to reconstruct the idea of masculinity and unlink the identity of men outside their genitals, the discussion of such social elements can be offered alternatives to help improve the psychological condition of patients who have survived the penectomy and contribute significantly to their health and quality of life, especially in improving your mental health.","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"324-328"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0