Urologia Journal最新文献

{"title":"Redefining clinical success in minimally invasive surgery for BPH: A composite endpoint integrating ejaculatory function, urinary improvement, and safety metrics.","authors":"Umberto Anceschi, Daniele Amparore, Antonio Minore, Antonio Tufano, Luca Ferrando, Michele Ortenzi, Enrico Checcucci, Giampaolo Siena, Andrea Cocci, Rocco Simone Flammia, Francesco Prata, Salvatore Basile, Sabrina De Cillis, Riccardo Mastroianni, Aldo Brassetti, Maria Consiglia Ferriero, Alfredo Maria Bove, Gabriele Tuderti, Giovanni Ferrari, Francesco Varvello, Vito Pansadoro, Andrea Minervini, Cristian Fiori, Francesco Porpiglia, Luca Cindolo, Giuseppe Simone","doi":"10.1177/03915603261457524","DOIUrl":"10.1177/03915603261457524","url":null,"abstract":"<p><strong>Objectives: </strong>Achieving both relief of urinary obstruction and preservation of ejaculatory function is a key goal of modern surgical management for benign prostatic hyperplasia (BPH). However, standardized definitions of success that integrate multiple clinical domains remain limited. This study introduces a composite definition of clinical success and explores its predictors using a multicenter dataset of minimally invasive, ejaculation-preserving procedures.</p><p><strong>Methods: </strong>Multi-institutional data were combined, including patients who underwent urethral-sparing robot-assisted simple prostatectomy (usRASP; <i>n</i> = 94), Aquablation (<i>n</i> = 95), or Rezum (<i>n</i> = 308). Complete clinical success (CSS) was defined as: (1) ⩾30% International Prostatic Symptoms Score (IPSS) reduction at 12-months; (2) preserved ejaculation, based on a positive response to the Male Sexual Health Questionnaire Ejaculatory Dysfunction (MSHQ-EjD Q3); and (3) absence of ⩾Grade III Clavien-Dindo complications. Partial clinical success (PCS) was defined as the achievement of any two of the three criteria. A multivariable logistic regression analysis identified independent predictors of CCS.</p><p><strong>Results: </strong>The final cohort included 497 patients. CCS rates were 66.0% (usRASP), 73.6% (Aquablation), and 68.8% (Rezum); PCS rates were 28.7%, 14.7%, and 20.1%, respectively. No significant differences were observed among groups for IPSS (<i>p</i> = 0.455), ejaculation rates (<i>p</i> = 0.07), or complication rates (<i>p</i> = 0.445). On multivariable analysis, prostate volume < 110 mL (OR 0.52; <i>p</i> = 0.034), higher MSHQ-EjD Q3 (OR 1.07; <i>p</i> < 0.001), and shorter catheterization time (OR 0.91; <i>p</i> = 0.02) independently predicted CCS at 1 year.</p><p><strong>Conclusions: </strong>This composite endpoint offers a pragmatic and clinically relevant framework for evaluating success in minimally invasive BPH surgery. Its adoption may enhance cross-technique comparisons and inform individualized treatment strategies.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"705-712"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of BMI on stone clearance and surgical outcomes in retrograde intrarenal surgery: A comparative analysis across four BMI categories.","authors":"Assad Ur Rehman, Nadeem Bin Nusrat, Nauman Zafar, Shujah Muhammad, Sarmad Imtiaz, Hafiz Abdul Hanan, Ammar Asghar, Sharafat Ali, Mustafa Khaleel Gondal, Saira Imtiaz, Moin Arshad","doi":"10.1177/03915603261433492","DOIUrl":"10.1177/03915603261433492","url":null,"abstract":"<p><strong>Objective: </strong>Retrograde Intrarenal Surgery (RIRS) is prevalent in the treatment of renal calculi. The effect of Body Mass Index (BMI) on stone clearance and surgical results has not yet been investigated extensively. This study sought to analyze the effect of BMI on clinical, procedural, and postoperative outcomes of patients undergoing RIRS.</p><p><strong>Methods: </strong>This retrospective observational study was performed at the Pakistan Kidney and Liver Institute and Research Center (PKLI & RC), Lahore, between September 2018 and August 2024. Two hundred and sixty adult patients who underwent RIRS for renal stones were classified into four groups based on BMI: normal weight (<25 kg/m²), overweight (25-29.9 kg/m²), obese (30-39.9 kg/m²), and morbidly obese (⩾40 kg/m²). The clinical and operative information was recorded from electronic data. Outcomes assessed included stone clearance, rates of complications, hospital stay, pain scores, and secondary intervention requirement. Statistics used were Chi-square tests, ANOVA/Kruskal-Wallis tests, and binary logistic regression.</p><p><strong>Results: </strong>Stone clearance rates varied across BMI groups (<i>p</i> = 0.027), though multivariate analysis showed that BMI was not an independent predictor. Increased BMI was also found to be linked with more residual fragments (<i>p</i> = 0.029), longer hospital stays (<i>p</i> = 0.004), increased pain scores (<i>p</i> = 0.002). These differences, notwithstanding intraoperative safety, were uniform across the groups. Binary logistic regression found that stone burden ⩾20 mm was the only independent predictor of incomplete clearance (OR = 0.165, <i>p</i> < 0.001), whereas BMI was not an independent predictor.</p><p><strong>Conclusion: </strong>RIRS is a safe and successful procedure in all BMI groups. Obese and overweight patients can have suboptimal results, especially regarding clearance of stones and postoperative recovery. Burden of stone continues to be the most important predictor of surgical success. The results indicate the necessity of personalized planning and follow-up, particularly in those with high stone burden or higher BMI.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"736-743"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-derived short-chain fatty acids are associated with symptoms in chronic prostatitis/chronic pelvic pain syndrome through the production of proinflammatory cytokines: Results from a comparative study.","authors":"Tommaso Cai, Irene Tamanini, Katia Odorizzi, Tommaso Ceccato, Simone Botti, Luca Gallelli, Sandra Mazzoli, Alessandro Palmieri, Truls E Bjerklund Johansen","doi":"10.1177/03915603261476871","DOIUrl":"10.1177/03915603261476871","url":null,"abstract":"<p><p>In recent years we have witnessed increasing interest for the role of microbiota in the pathophysiology and management of prostatic diseases. However, there are several aspects to comprehend. Here, we aim to assess the gut microbiota composition and faecal microbiota-derived short-chain fatty acids production (SCFAs) in the pathogenesis of CP/CPPS. All patients with CP/CPPS attending our urology centre, were enrolled in this study, and underwent urological examination, microbiological evaluation, intestinal microbiota analysis and measurement of interleukins in semen. A cohort of subjects who had undergone intestinal microbiota investigation for various reasons but did not exhibit any symptoms of urological disease, was used as control group. Laboratory data from the two groups were analysed in terms of gut microbiota composition and levels of SCFAs. We enrolled 37 patients and 45 controls. In the CP/CPPS patient group, the mean levels of interleukins were: IL-8 934 pg/ml, IL-10 64 pg/ml, IL-6 871 pg/ml. In this patient group, we found higher levels of Bifidobacteriaceae and Bacteroidaceae and lower levels of Prevotella and Lactobacillus with a Firmicutes/Bacteroides mean ratio at 0.27. The control group had a normal Firmicutes/Bacteroides mean ratio (1.6). The two groups showed a significant difference in total SCFAs levels (<i>p</i> = 0.001) and in particular regarding indole-3-propionic acid (<i>p</i> = 0.003) and butyric acid (<i>p</i> < 0.001). A statistically significant correlation was found between the levels of IL-8 and a decreasing SCFAs production (<i>p</i> < 0.001). A difference in gut microbiota between patients with CP/CPPS and controls, together with a reduction in faecal levels of microbiota-derived short-chain fatty acids and decreased IL-8 levels in semen, might be part of the pathophysiological mechanism in CP/CPPS.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"777-784"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult male circumcision with a circular stapler: Is this the new standard?","authors":"Luciano Ola, Federica Pini, Giovanni Busacca, Ettore Dalmasso, Juliette Meziere, Filippo Poletti, Paola Irene Ornaghi, Roberta Aimar, Daniele Dutto, Ivano Morra","doi":"10.1177/03915603261447737","DOIUrl":"10.1177/03915603261447737","url":null,"abstract":"<p><strong>Introduction: </strong>Circumcision is a simple procedure, but it is not free from complications. New methods have recently been developed, including the circular stapler CircumCYS^®.</p><p><strong>Material and methods: </strong>This a retrospective analysis of our institutional series of 80 consecutive procedures. The stapler consists of a inner bell (in six different sizes), that it is designed to protect the gland, a pistol with a trigger, a circular scalpel and a stapler for the suture. The circumference of the penile shaft is measured at the level of the balano-preputial fold with the provided device. No antibiotic prophylaxis was necessary. A Dorsal Penile Nerve Block (DPNB) were performed by the urologist. Data were collected from medical records 14 days and 1 month after the surgery. Complication rate and Visual Analog Scale were investigated.</p><p><strong>Results: </strong>Eighty patients were treated between August 2023 and January 2024. The average operating time was 10 min (ds 6). Postoperatively we observed three scar edemas and two minor bleedings. The most common complication was the incarceration of the metal stitches within the scar (five cases). The average time for the stitches to fall out was 24.9 days (ds 3.9). Pain was consistently well-controlled (Visual Analog Scale 2/10 one hour post-surgery - ds 0.8).</p><p><strong>Conclusion: </strong>CircumCYS^® is a reliable, safe and easy-to-use tool. The technique is very fast and this allows the execution of many circumcisions in a single session. The learning curve appears minimal.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"785-789"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of failed pyeloplasty patients with recurrent pelvi-ureteric junction obstruction.","authors":"Kuriapillil Venugopal Vishnu Sankar, Krishnendu Maiti, Debansu Sarkar","doi":"10.1177/03915603261441147","DOIUrl":"10.1177/03915603261441147","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent pelvi-ureteric junction obstruction (PUJO) poses significant management challenges, and the optimal salvage procedure remains debated. This study evaluated outcomes of various salvage interventions using a structured selection algorithm and standardized objective endpoints.</p><p><strong>Methods: </strong>This prospective study included 40 patients with recurrent PUJO following previous pyeloplasty. Treatment allocation-redo pyeloplasty, endopyelotomy, ureterocalycostomy, or DJ stenting-was based on renal function, hydronephrosis grade, and intraoperative retrograde pyelogram findings including stricture length and distensibility. The primary endpoint was radiological success at ⩾3 months, defined as improvement or stabilization of drainage (T½ < 20 min) without further intervention. Secondary endpoints included symptomatic improvement, renal functional stability (change ⩾ 5 ml/min/1.73 m²), and complications.</p><p><strong>Results: </strong>Redo pyeloplasty achieved the highest success rate (91.7%), followed by endopyelotomy (76.9%), DJ stenting (100% in one patient), and ureterocalycostomy (50%). Overall success was 85% (34/40). However, the differences in success among the procedures were not statistically significant (<i>p</i> = 0.284). Six patients (15%) met criteria for failure. No major perioperative complications were observed.</p><p><strong>Conclusions: </strong>Salvage management of recurrent PUJO using a structured algorithm provides favorable overall success. Redo pyeloplasty demonstrated the highest success rate, although superiority over endopyelotomy did not reach statistical significance in this cohort. Larger prospective studies are needed to validate procedure selection criteria and refine individualized salvage strategies.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"761-766"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of combined pelvic floor and abdominal muscle training for urinary incontinence: Home-based program.","authors":"Havva Sumeyye Eroglu, Emine Ipek Halatci, Ilker Sen, Ilke Keser","doi":"10.1177/03915603261452344","DOIUrl":"10.1177/03915603261452344","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the impact of incontinence severity on the outcomes of pelvic floor and abdominal muscle strengthening training in women with stress urinary incontinence (UI).</p><p><strong>Methods: </strong>Sixteen women with stress and mixed UI were divided into two groups based on 24-h pad test results: mild (4-20 g, <i>n</i> = 9) and moderate-severe (⩾ 21 g, <i>n</i> = 7). Both groups underwent a 6-week home-based program including Pelvic Floor Muscle Training (PFMT) and Abdominal Muscle Training. Outcomes assessed before and after intervention included UI severity (24 h pad test), pelvic floor muscle strength (EMG biofeedback), quality of life (King's Health Questionnaire), symptom distress (UDI-6), and pelvic floor dysfunction (GPFBQ).</p><p><strong>Results: </strong>Both groups showed significant reductions in UI severity and improvements in pelvic floor muscle strength, quality of life, and symptom scores after the intervention. The decrease in UI severity was more pronounced in the moderate-to-severe group (<i>p</i> < 0.05). No significant differences were found between groups regarding muscle strength or quality of life.</p><p><strong>Conclusion: </strong>These preliminary results suggest that home-based combined PFMT and abdominal muscle training can effectively reduce UI severity and improve pelvic floor function and quality of life in women with UI, regardless of initial severity. These findings support integrating abdominal muscle exercises into the conservative management of UI. Further large-scale studies are required to confirm these findings. NCT05549193, 22/09/2022, retrospectively registered.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"805-814"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary management of vesicovaginal and rectovesical fistulas developing after laparoscopic hysterectomy: A Qualitative Case Study.","authors":"Arife Büşra Karaosmanoğlu, Sevcan Sarıkaya, Yasemin Erkal Aksoy","doi":"10.1177/03915603261445174","DOIUrl":"10.1177/03915603261445174","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the clinical course of a patient who developed vesicovaginal and rectovesical fistulas following LAH, with a focus on multidisciplinary management and the role of midwifery care in the patient's experience.</p><p><strong>Methods: </strong>This study was conducted using a qualitative case study design. The case comprised a 48-year-old female patient who required secondary surgical intervention due to bladder perforation and the development of a rectovesical fistula following laparoscopic hysterectomy. Data were collected from multiple sources, including the patient's medical records, clinical observations, multidisciplinary team documentation, and a semi-structured, in-depth interview with the patient. Qualitative data were analyzed using the six-phase thematic analysis approach described by Braun and Clarke.</p><p><strong>Results: </strong>Findings showed that surgical complications caused significant psychological distress, while multidisciplinary management and midwifery interventions improved clinical stabilization, psychological wellbeing, and adherence to care.</p><p><strong>Conclusion: </strong>A multidisciplinary and holistic care approach in the management of complex surgical complications has positive effects on patient safety, psychological wellbeing, and overall care outcomes.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"838-845"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of complications in our extraperitoneal radical cystoprostatectomy with orthotopic urinary diversion cases and the intraperitoneal approach reported in the literature.","authors":"Mesut Cilli, Sinasi Yavuz Onol","doi":"10.1177/03915603261445165","DOIUrl":"10.1177/03915603261445165","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the postoperative complications of extraperitoneal radical cystoprostatectomy (EPRC) with orthotopic urinary diversion performed in our clinic. Because no contemporaneous intraperitoneal control group was included, outcomes were compared indirectly with those reported in previously published series of intraperitoneal radical cystoprostatectomy (IPRC). Although IPRC remains the standard approach, the extraperitoneal technique has attracted increasing interest due to its potential to reduce bowel manipulation and thereby lower gastrointestinal complication rates.</p><p><strong>Methods: </strong>Over a 4-year period, 24 male patients with muscle-invasive bladder cancer underwent EPRC with orthotopic urinary diversion. Clinical records and digital data were retrospectively reviewed to assess early (⩽1 month) and late (>1 month) postoperative complications. No contemporaneous intraperitoneal control group was included; therefore, comparisons were made against previously published intraperitoneal series.</p><p><strong>Results: </strong>The mean operative time was 260 ± 25 min, and the length of hospital stay was 7 ± 2 days. Overall early and late complication rates were 44.2% and 38.3%, respectively. Gastrointestinal complications were the most frequent early events; importantly, <i>no mechanical ileus was observed</i>, and all instances of bowel distension resolved with conservative management. No urine leak, intra-abdominal abscess, or pelvic lymphocele developed. One patient developed distant metastasis during follow-up, and no local recurrence occurred. Daytime continence was largely maintained, whereas nocturnal incontinence was detected in 41.6% of patients.</p><p><strong>Conclusions: </strong>EPRC with orthotopic urinary diversion appears to be a safe and feasible alternative to the intraperitoneal technique. In indirect comparison with previously published intraperitoneal series, it may offer an advantage in reducing gastrointestinal and intra-abdominal complications. The absence of mechanical ileus in our cohort may suggest a potential perioperative advantage associated with preservation of peritoneal integrity, although this observation should be interpreted cautiously given the indirect nature of the comparison. Larger prospective studies are required to validate these findings across broader patient populations.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"674-681"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current standing of standard PCNL in the era of miniaturization.","authors":"Deepak Prakash Bhirud, Jaideep Singh Soni, Shiv Charan Navriya, Vikram Singh, Gautam Ram Choudhary, Mahendra Singh, Arjun Singh Sandhu","doi":"10.1177/03915603261457526","DOIUrl":"10.1177/03915603261457526","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate how standard operating procedures (SOPs), modification in puncture techniques, advancements in preoperative imaging to better understand calyceal anatomy have revitalized standard percutaneous nephrolithotomy (PCNL) for large kidney stones (>2.5 cm).</p><p><strong>Methods: </strong>At our center, renal stones are managed with extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PCNL), and retrograde intrarenal surgery (RIRS) according to stone characteristics and patient profile. Renal stones larger than 2.5 cm are managed with standard PCNL. In this retrospective study patients undergoing standard PCNL at a tertiary healthcare center from January 2018 to December 2023 having complete records were included. Data on demographics, stone characteristics, operative details, and outcomes were assessed using SPSS v26, with ethical approval ensuring confidentiality.</p><p><strong>Results: </strong>A total of 766 patients were included. Mean age was 43.75 ± 16.0 years; 69.7% were male. Mean stone size was 3.8 ± 1.2 cm, with 46.7% complex (Guy's Stone Score [GSS] ⩾ 2). Using a 24 ± 3 Fr sheath and 1.3 tracts per procedure, operative time averaged 92.5 ± 20.3 min. Stone clearance was 91.3%, with significant intraoperative bleeding (requiring transfusion) in 1.7%. Overall complication rate was 16.4%, and hospital stay averaged 3.6 ± 1.2 days; 8.7% required additional interventions, including RIRS in 44.3% of those cases.</p><p><strong>Conclusion: </strong>Modern standard PCNL achieves high clearance (91.3%) with minimal morbidity, reaffirming its role for large stones despite mini-PCNL's rise.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"551-559"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular damage from electromagnetic radiation in rats and evaluation of protective agents.","authors":"Ali Gözüküçük, Basri Çakıroğlu, Bekir Sami Uyanik, Hasan Hüseyin Kılıç, İbrahim Seyfettin Çelik","doi":"10.1177/03915603261448981","DOIUrl":"10.1177/03915603261448981","url":null,"abstract":"<p><strong>Background: </strong>Male infertility has been associated with various environmental, physiological, and genetic factors. In recent years, the widespread use of mobile phones has raised concerns regarding exposure to electromagnetic radiation (EMR). EMR emitted from mobile devices may adversely affect male reproductive function by inducing oxidative stress and impairing spermatogenesis.</p><p><strong>Objective: </strong>This study aimed to evaluate the potential protective effects of vitamin E and N-acetylcysteine (NAC) against EMR-induced testicular damage in rats.</p><p><strong>Methods: </strong>A total of 35 adult male Wistar rats were randomly divided into five groups (<i>n</i> = 7 per group): control, EMR exposure, EMR + NAC, EMR + vitamin E, and EMR + NAC + vitamin E. Rats were exposed to EMR generated by a mobile phone operating in the GSM frequency band (900/1800 MHz) in active call mode, positioned at a fixed distance of 15 cm from the cages, for 3 h daily over 28 days. The specific absorption rate (SAR) was based on manufacturer-reported values. Biochemical analyses were performed to assess total antioxidant capacity (TAC), glutathione peroxidase (GPX), superoxide dismutase (SOD), and malondialdehyde (MDA) levels. Data distribution was evaluated using the Shapiro-Wilk test, and group comparisons were conducted using the Kruskal-Wallis test with appropriate post-hoc analyses.</p><p><strong>Results: </strong>Significant differences were observed among groups in terms of total antioxidant capacity (TAC) (<i>p</i> < 0.001). TAC levels were reduced in the EMR-only group compared to controls, whereas antioxidant supplementation (NAC and/or vitamin <b>E) resulted in increased</b> TAC levels. Post-hoc analyses demonstrated significant improvements in TAC in treatment groups compared to both control and EMR-only groups. However, no statistically significant differences were observed among groups for GPX, SOD, and MDA levels (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>N-acetylcysteine (NAC) and vitamin E may exert partial protective effects against EMR-induced oxidative alterations in rat testes, particularly as reflected by improvements in total antioxidant capacity. However, given that other oxidative stress markers did not demonstrate statistically significant differences, these findings should be interpreted with caution. Further experimental and clinical studies with larger sample sizes and detailed histopathological evaluation are required to better elucidate the potential therapeutic role and clinical relevance of these antioxidant agents.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"790-795"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}