Urologia Journal最新文献

{"title":"I-Tind for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Mid-term outcomes from a multicenter cohort.","authors":"Mauro Dimitri, Alessandro Calarco, Beatrice Filippi, Pietro Viscuso, Vincenzo Asero, Guglielmo Mantica, Francesca Ambrosini, Gianluca Spena, Bruno Bucca, Riccardo Schiavina, Pietro Piazza, Gabriele Iacono, Antonio Tufano, Rosario Leonardi","doi":"10.1177/03915603251360530","DOIUrl":"https://doi.org/10.1177/03915603251360530","url":null,"abstract":"<p><p>Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in aging men, significantly impacting quality of life. Although pharmacological therapies, especially alpha-blockers, are the standard first-line treatment, their long-term adherence is limited by side effects and insufficient symptom control. Transurethral resection of the prostate (TURP) remains the surgical gold standard but is associated with notable morbidity, prompting interest in minimally invasive alternatives. The temporary implantable nitinol device (I-Tind) offers a tissue-sparing approach designed to remodel the prostatic urethra and relieve LUTS without compromising sexual function. This multicenter prospective study evaluated the safety, efficacy, and functional outcomes of I-Tind in 120 patients with symptomatic BPH unresponsive to alpha-blockers, treated between 2019 and 2023. Follow-up assessments were done at 3, 6, and 12 months. The study showed significant improvements in urinary flow and symptom scores. Mean Qmax improved from 7.6 to 15.7 mL/s, and mean IPSS decreased from 21.5 to 9.7 at 12 month-follow-up (<i>p</i> < 0.001). Quality of life measures also improved, and sexual and ejaculatory functions were fully preserved. The procedure was well-tolerated, with all implants successfully retrieved after a mean of 6 days and a low complication rate. I-Tind appears to be a safe and effective minimally invasive option for selected BPH patients, combining symptom relief with preservation of quality of life. Further randomized trials are needed to confirm these findings and better define its role in the BPH treatment algorithm.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"3915603251360530"},"PeriodicalIF":0.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Z\" Anatomical Needle Cut Leads Ejaculation (ZANCLE): Unilateral incision for bladder neck obstruction with ejaculation-sparing intent: A single-surgeon experience.","authors":"Alessandro Calarco, Pietro Viscuso, Beatrice Filippi, Rosario Leonardi, Guglielmo Mantica, Cosimo Magazzino, Antonio Tufano","doi":"10.1177/03915603251334084","DOIUrl":"10.1177/03915603251334084","url":null,"abstract":"<p><p>This study aimed to evaluate functional outcomes and anterograde ejaculation rates in patients undergoing monopolar, unilateral transurethral incision of the prostate (TUIP) with \"Z\" shaped incision with ejaculatory sphincter sparing for primary bladder neck obstruction (PBNO) in a case series performed by a single surgeon. Between December 2018 and July 2023, data from patients who underwent monopolar, unilateral TUIP were prospectively collected. Patients with a prostate volume of less than 30 mL were included. Functional outcomes, including maximum flow rate (Qmax, mL/s), post-void residual volume (PVR, mL), International Prostate Symptom Score (IPSS), and IPSS Quality of Life (IPSS QoL) score, were assessed preoperatively and at 1, 6, and 12 months postoperatively. A total of 106 patients met the inclusion criteria, with a median age of 42 years (range: 37-57) and a median prostate volume of 27 mL (range: 20-29). The median hospital stay was 1 day, and the median catheterization time was 3 days. At 1-month follow-up, the mean Qmax increased from 10.2 ± 2.5 mL/s to 22.8 ± 3.9 mL/s, while the mean IPSS score and IPSS QoL score decreased from 16 ± 2.7 to 6.9 ± 1.5 and from 4.3 ± 0.9 to 1.9 ± 1.6, respectively (<i>p</i> < 0.001). The mean PVR volume decreased from 125.5 ± 16.1 mL to 27.7 ± 7.3 mL (<i>p</i> < 0.001). Uroflowmetry results remained statistically significant at 12 months of follow-up (each <i>p</i> < 0.001). Anterograde ejaculation was preserved in all cases. Unilateral monopolar TUIP confirms to be a feasible and safe procedure for the treatment of BNO in young and sexually active patients.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"466-469"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of percutaneous nephrolithotripsy versus retrograde intrarenal surgery for obese patients with pelvic 1.5:3 cm renal stones.","authors":"Mohamed Soliman, Tarek Abd El-Mageed Salem, Bassem Adel Husein Metwally, Mohamed Mahmoud Abdelfatah Zaza","doi":"10.1177/03915603251317647","DOIUrl":"10.1177/03915603251317647","url":null,"abstract":"<p><strong>Background: </strong>Retrograde intrarenal surgery (RIRS) has recently made significant breakthroughs, drawing some attention to it as a secondary or alternative method of treating kidney stones.</p><p><strong>Objectives: </strong>To compare the safety and efficacy of the percutaneous nephrolithotripsy (PCNL) in the prone position vs retrograde intrarenal surgery (RIRS) in surgical treatment of unilateral pelvic renal stones from 1.5 to 3 cm is size in adult obese patients with body mass index ⩾30.</p><p><strong>Methods: </strong>This prospective randomized comparative study was done at Helwan University Hospital. It was conducted on 120 patients with unilateral pelvic renal stones from 1.5 to 3 cm in largest diameter who was admitted through duration to compare the two procedures' differences in terms of complications, analgesic use, hospital stay, operational time, and stone-free rates.</p><p><strong>Results: </strong>There was no significant difference between the two groups as regard stone free rate and complications. Stone free rate was 91.1% in PCNL group while it was 84.5% in RIRS group (<i>p</i>-value = 0.314). The mean operative time for PCNL & RIRS groups was 96 ± 28.23 min and 119 ± 14.4 min, respectively (<i>p</i>-value = 0.026). Mean hospital stay was 3.16 ± 0.77 days in PCNL group while it was 1.19 ± 0.69 days in RIRS group (<i>p</i>-value < 0.001).</p><p><strong>Conclusion: </strong>RIRS can be used as the first option in obese individuals with 1.5 to 3 cm renal stones is based on the satisfactory results attained in the RIRS groups.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"446-451"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for pelvic organ prolapse, a case-control study in a tertiary hospital in Iran.","authors":"Farzaneh Sharifiaghdas, Behzad Narouie, Hamideh Hanafi Bojd, Mehdi Dadpour, Niloofar Rostaminejad, Seyed Kasra Motevalli Amini, Parham Torabinavid, Hamidreza Rouientan, Hamidreza Momeni, Negar Radpour, Mohammad Hassan Matin, Sara Saygin","doi":"10.1177/03915603251316701","DOIUrl":"10.1177/03915603251316701","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ descent is a common gynecological disorder called pelvic organ prolapse (POP). Conservative care and surgical repair are women's primary treatments for pelvic organ prolapse. Modifying risk factors is a crucial keystone to reducing its prevalence.</p><p><strong>Methods: </strong>This unmatched case-control study was conducted at a Tehran referral hospital (June 15 to September 10, 2020) and involved 287 participants (139 cases, 148 controls). Structured questionnaires gathered socio-demographic, obstetric, health, and lifestyle data. Analyses encompassed univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Among cases, 69 (49.6%) had anterior prolapse, 46 (33.1%) had posterior prolapse, and 24 (17.3%) experienced complete prolapse. The mean age of participants with POP was 62.7 ± 10.7 years compared to 44.5 ± 12.7 years for controls. Risk factors significantly associated with POP included higher BMI (28.01 ± 4.7 vs 26.18 ± 4.6; <i>p</i> = 0.002), gravidity (4.49 ± 2.89 vs 2.18 ± 1.63; <i>p</i> < 0.001), vaginal deliveries (3.60 ± 2.07 vs 1.03 ± 1.57; <i>p</i> < 0.001), prolonged labor (12.2% vs 2.7%; OR: 4.91, 95% CI: 1.61-14.99), and comorbidities such as diabetes mellitus (30.2% vs 8.8%; OR: 4.49, 95% CI: 2.29-8.83) and hypertension (34.5% vs 6.8%; OR: 7.28, 95% CI: 3.50-15.12). Protective factors included higher education levels and a history of cesarean delivery (mean cesarean count: 0.31 ± 0.72 vs 0.78 ± 0.88; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>This study highlights key risk factors for POP among Iranian women, emphasizing the need for targeted preventive strategies. Public health interventions addressing these factors may reduce the burden of POP in developing regions.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"517-524"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of concomitant treatment for Chronic Pelvic Pain Syndrome.","authors":"Reza Valipour, Behzad Narouie, Arash Rastgou, Mehdi Dadpour, Negar Radpour, Hamidreza Momeni, Amirreza Momeni, Mohadese Ahmadzade, Hamidreza Rouientan, Sajedeh Jadidi, Sara Saygin","doi":"10.1177/03915603251316706","DOIUrl":"10.1177/03915603251316706","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common and challenging condition with no consensus on the best treatment. Also, based on a search in reputable scientific databases, it was found that so far, no study has been conducted to evaluate the response to treatment with concomitant use of tamsulosin, levofloxacin, and celecoxib in chronic pelvic pain syndrome in men.</p><p><strong>Methods: </strong>Ninety six male patients under 40 years of age with chronic pelvic pain syndrome who met the inclusion criteria and exclusion criteria were included in the study. Patients (there was only one group of patients in this study) were treated simultaneously with 3 drugs tamsulosin (0.4 mg), levofloxacin (500 mg), and celecoxib (200 mg) for 1 month and after 1 month of treatment response to treatment (pain relief) according to age factors. Weight, underlying disease, smoking, BMI, prostatitis family history, and education were recorded by the researcher in preprepared data collection forms. The results and information obtained were entered into statistical software and analyzed.</p><p><strong>Results: </strong>About 42.7% of patients experienced pain relief after treatment. Age, smoking, and family history of prostatitis showed significant relationships with pain reduction. Weight gain decreased the chances of pain reduction (OR = 0.303), while increased BMI (OR = 0.476) and smoking (OR = 0.801) also negatively influenced pain relief.</p><p><strong>Conclusions: </strong>The results of this study showed that the concomitant use of tamsulosin, levofloxacin and celecoxib in patients with chronic pelvic pain syndrome had acceptable results in reducing the symptoms of patients.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"525-528"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of age, abstinence, and seasons with semen parameters in untreated male partners of infertile couples.","authors":"Natali Ilaria, Millanti Lorenzo, Siondino Sergio, Peluso Giuseppina, Errichiello Luigi","doi":"10.1177/03915603251334077","DOIUrl":"10.1177/03915603251334077","url":null,"abstract":"<p><p>Many studies reveal the presence of an effect of age, abstinence and seasons on semen parameters, but the number of patients enrolled is small and the presence of therapies unknown. We aimed to evaluate the correlation between abstinence days, age, season, and semen parameters (volume, concentration, progressive motility, total number of sperms, morphology) among men referred to our laboratory. We proceeded with a cross-sectional, observational, exploratory study in an Andrology laboratory. A population of 348 male partners of infertile couples who did not receive any treatment in the 3 months preceding semen analysis was selected. Sperm volume, concentration, total number, progressive motility and morphology of sperms were conducted strictly following the guidelines indicated in the last edition of WHO manual for semen analysis. Pearson's correlation analysis and Kendall's correlation analysis were applied. Sperm concentration, semen volume and sperm total number moderately increased as well as the abstinence, while progressive motility and morphology moderately decreased. Regarding the age, in the 20-35 age group there was a weak inverse association with concentration, total number, motility and morphology and a weak positive association with volume; in the 42-63 age group there was a moderate positive association between age and concentration, motility and morphology, but an inverse association with volume. No correlation emerged between seasonal variations and semen parameters. These results suggested the importance of correct information to patients for proper semen analysis for diagnostic and therapeutic purposes.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"509-516"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of surgical trends in upper urinary tract stone management in Ontario, Canada, and Israel.","authors":"Dor Golomb, Orit Raz, Amir Cooper, J Andrew McClure, Blayne Welk, Sumit Dave, Fernanda Gabrigna Berto, Jennifer Bjazevic, Hassan Razvi","doi":"10.1177/03915603251325096","DOIUrl":"10.1177/03915603251325096","url":null,"abstract":"<p><strong>Objective: </strong>To compare trends and incidence of surgical intervention among adults with urolithiasis in Ontario, Canada, and Israel.</p><p><strong>Patients and methods: </strong>A retrospective analysis was conducted using administrative databases from Clalit Health Service in Israel and IC/ES in Canada. The study included adults who underwent their initial surgical treatment for urolithiasis. Descriptive statistics summarized baseline patient demographics, while comparisons were analyzed with a <i>t</i>-test.</p><p><strong>Results: </strong>Between 2003 and 2018, 31,034 and 105,013 patients who underwent surgical intervention for upper urinary tract stones for the first time in their clinical history, excluding those with prior surgical treatments for the same condition, in Israel and Ontario, respectively. The number of insured at Clalit Health Services increased by 21.3%, while the population in Ontario grew by 18.5%. The total number of treated cases rose by 82% and 64.4% in Israel and Ontario, respectively. The procedures per 100,000 people increased by 51% in Israel and 34.6% in Ontario. In Israel, the proportion of females undergoing surgery decreased from 33.5% to 32%, while in Ontario, it increased from 36.3% to 49.8%. Ureteroscopy (URS) was more commonly used in Ontario, while shock wave lithotripsy (SWL) was more common in Israel. URS utilization surged by 281% in Israel and 145.5% in Ontario. Percutaneous nephrolithotripsy (PCNL) increased by 52% in Israel and 8.6% in Ontario, while SWL procedures declined by 57% in Israel and 32.5% in Ontario.</p><p><strong>Conclusions: </strong>A significant rise in the number of patients undergoing their first stone-related procedure in both regions, particularly in Israel. There was a difference in the proportion of female patients requiring surgical intervention, with an increase in Ontario and a decrease in Israel.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"452-457"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors for benign prostatic hyperplasia in patients with bladder calculi.","authors":"Junjie Lu, Wanting Gao, Chunyang Fei, Wenqiang Liao, Gaoming Hou, Yuxue Lin, Wenwang Rao, Qingtao Yang, Xuxia Sui","doi":"10.1177/03915603251318869","DOIUrl":"10.1177/03915603251318869","url":null,"abstract":"<p><strong>Purpose: </strong>A retrospective study was performed to identify potential metabolic abnormalities and inflammatory abnormalities associated with benign prostatic hyperplasia (BPH) secondary to bladder calculi.</p><p><strong>Materials and methods: </strong>This study enrolled 646 patients with bladder calculi between 2008 and 2022, including 314 patients with benign prostatic hyperplasia (BPH) and 332 without BPH. Demographic characteristics, serum biochemical parameters, prostate volume, maximum bladder calculus diameter, and randomized urinary metabolic profiles were compared between the two groups.</p><p><strong>Results: </strong>BPH was associated with increased aspartate aminotransferase/alanine aminotransferase (mean 1.2 vs 1.1, <i>P</i> < 0.05), lower cholinesterase (mean 7240.5 vs 7778.4, <i>P</i> < 0.01), increased systolic pressure (mean 137.2 vs 133.4, <i>P</i> < 0.01). Patients with BPH were significantly older and had higher systolic blood pressure compared to non-BPH patients. BPH group exhibited significantly lower levels of albumin/globulin ratio, cholinesterase, phosphorus, triglycerides, platelet count, neutrophil count, and white blood cell count, while demonstrating higher aspartate aminotransferase/alanine aminotransferase ratio, mean corpuscular volume, monocyte ratio, and urinary red blood cell count. Prostate volume was proportional to body weight and crystal count. Lower phosphorus (OR = 0.207; 95%CI = 0.068, 0.635; <i>P</i> < 0.01) and higher age (OR = 1.065; 95%CI = 1.041, 1.090; <i>P</i> < 0.001) were associated with BPH.</p><p><strong>Conclusions: </strong>Advanced age was identified as a significant risk factor for prostate hyperplasia in patients with bladder calculi, whereas elevated phosphorus levels emerged as a protective factor. The pathogenesis of BPH secondary to bladder calculi appears to be multifactorial, primarily influenced by metabolic abnormalities and inflammatory processes. These findings provide valuable insights for the clinical assessment and management of BPH secondary to bladder calculi.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"406-414"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does salvage endoscopically guided tract dilatation increase complications during sonography-guided percutaneous nephrolithotomy?","authors":"Hamid Pakmanesh, MohammadAli Kohansal, Aida Barfzadeh","doi":"10.1177/03915603251325422","DOIUrl":"10.1177/03915603251325422","url":null,"abstract":"<p><strong>Background: </strong>In percutaneous nephrolithotomy, when tract dilatation fails due to short advancement, endoscopic tract dilatation can be used as a salvage technique for renal access. We aimed to report complications of this technique and compare it with uneventful dilatation cases.</p><p><strong>Methods and materials: </strong>The study enrolled patients who underwent sonography-guided PCNL for six consecutive months in 2023. After renal puncture under the sonography guide, an Amplatz dilator was used for one-shot tract dilation. In the case of short-advancement, a bi-prong forceps was used under direct endoscopic vision for tract dilatation. The study compared the operation time, postoperative complications, and stone-free rate between successful one-shot Amplatz dilatation (SA) and those with salvage endoscopic tract dilatation (SE).</p><p><strong>Results: </strong>The study included 108 patients with a mean age of 47.9 ± 11.6 (50.9% male). Short-advancement occurred in 63 patients (58.3%). The salvage technique was successful in 95.2% of occasions of short advancement. Pre-operative demographic and clinical data were not different in this group compared to the (SA) group. The operative time was 21.1 ± 14.5 min in the (SE) group, which was not longer than the (SA) group with 22.7 ± 12.6 min (<i>p</i> = 0.2). The stone-free rate was 81.0% in the (SE) group, which was not inferior to 73% in the (SA) group (<i>p</i> = 0.3). The transfusion rate and complications were not different as well.</p><p><strong>Conclusion: </strong>Salvage bi-prong forceps tract dilation in the event of short advancement after one-shot Amplatz tract dilation during percutaneous nephrolithotomy is not linked to a higher complication rate or inferior clinical outcomes compared to successful one-shot dilation.</p>","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"458-465"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and susceptibility patterns of uropathogens in a private teaching hospital: A six years retrospective study at GAMBY teaching hospital, Bahir Dar, Ethiopia.","authors":"Adugna Tasew Tebabal, Ashagrachew Tewabe Yayehrad, Ebrahim Abdela Siraj, Dagninet Derebe Abie, Haylemariam Adera Bayleyegn, Abyot Terefe Teshome, Beselam Gizachew Astatekie, Sefiw Abere Zeleke, Samrawit Temesgen Setargew, Solomon Kassahun Tessega, Litgebew Yitayih Gelaw","doi":"10.1177/03915603251316700","DOIUrl":"10.1177/03915603251316700","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Urinary tract infection (UTI) is humans' second most common bacterial infection. Indiscriminate use of antibiotics is a common practice in underdeveloped and many developing countries that often leads to the emergence of resistant microorganisms to one or several of these agents with gradual narrowing of scope for effective molecules to combat bacterial infections including UTIs. As a common practice, empirical antimicrobial treatment is initiated before the laboratory results of urine culture are available which may lead to the emergence and spread of antimicrobial-resistant strains. Therefore, this study was conducted to identify the common bacterial uropathogens associated with urinary tract infection and their susceptibility to antibiotics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aims to analyze the prevalence of culture-positive isolates and determine the susceptibility patterns of bacterial uropathogens to antibiotics at GAMBY Teaching General Hospital, Bahir Dar, Ethiopia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An institution-based retrospective study was conducted at GAMBY Teaching General Hospital (GTGH) for patients who had UTIs, from November 1, 2015, to December 30, 2021 G.C. Antimicrobial sensitivity tests were done using the disc diffusion technique as per the standard of the Kirby-Bauer method.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 1,714 urine samples were processed. Of the total urine samples collected, 974 (56.8%) were from women and 456 (26.6%) revealed a positive culture. Among the positive isolates, the gram-negative was 340 (74.6 %), which makes it the most prevalent type. E. coli, 276 (60.5%) and S. saprophyticus, 78 (17.1%) were the two most prevalent uropathogens isolated. The highest percentage of susceptibility to antimicrobial agents was seen with nitrofurantoin 338 (91.4%), Clindamycin 72 (83.7%), Norfloxacin 244 (79.2%), and Cefoxitin 22 (78.6%). Ampicillin 48 (100%), Piperacillin 6(100%), Cefixime 6 (100%), Clarithromycin 6 (100%), Amoxicillin 96 (96%), Amoxicillin/clavulanic acid 242 (89.6%), and Penicillin 12 (85.7%) had the highest percentage of resistance among all isolates to the antimicrobial agents.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and recommendations: &lt;/strong&gt;Urinary tract infections are mostly caused by Gram-negative bacteria predominantly in females and Escherichia coli is the most common isolated bacteria. Nitrofurantoin, Norfloxacin, cefoxitin, and clindamycin are considered appropriate antimicrobials for the empirical treatment of urinary tract infections. The majority of uropathogens were resistant to antibiotics commonly used in clinical practice. The resistance pattern to all of the microorganisms incriminated showed there was a progressive increment of resistance to the common antibiotics over the study period. Empirical treatment of UTIs should be guided on the newer culture and sensitivity pattern and more importantly, prescriptions should be revised following the cult","PeriodicalId":23574,"journal":{"name":"Urologia Journal","volume":" ","pages":"493-502"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}