Veterinary microbiology最新文献

{"title":"Corrigendum to “A G219A hemagglutinin substitution increases pathogenicity and viral replication of Eurasian avian-like H1N1 swine influenza viruses” [Vet. Microbiol. 306 (2025) 110565]","authors":"Cong He , Xiaokun Hu , Junmei Huang , Congjun Jia , Mengling Zhang , Weilin Xu , Meidi Li , Mengkai Cai","doi":"10.1016/j.vetmic.2025.110611","DOIUrl":"10.1016/j.vetmic.2025.110611","url":null,"abstract":"","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110611"},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEF1D signaling contributes to Bovine alpha herpesvirus 1 productive infection, potentially through regulation of viral replication compartments","authors":"Bin Hou,&nbsp;Xiaotian Fu,&nbsp;Yuanshan Luo,&nbsp;Xiuyan Ding,&nbsp;Liqian Zhu","doi":"10.1016/j.vetmic.2025.110613","DOIUrl":"10.1016/j.vetmic.2025.110613","url":null,"abstract":"<div><div>Bovine alpha herpesvirus 1 (BoAHV1) is one of the most significant viruses affecting cattle, causing substantial economic losses to the cattle industry worldwide. Eukaryotic translation elongation factor 1δ (EEF1D), a component of the elongation factor 1 complex, plays a crucial role in the elongation phase of protein synthesis. However, the interplay between viral infection and EEF1D signaling remains poorly understood within the virus community. Here, we report that BoAHV1 productive infection leads to increased steady-state protein expression of EEF1D in cell cultures. Immunofluorescence assays demonstrated that productive viral infection in MDBK cells induces the enhanced translocation of EEF1D into the nucleus, where it forms specific puncta and co-localizes with the puncta of viral protein ICP8, a marker of the viral replication compartment. Additionally, viral infection in MDBK cells re-localizes a portion of EEF1D in the cytoplasm, where it co-localizes with the virion-associated proteins, such as viral protein gD. While, co-localization of EEF1D with virion-associated proteins is primarily observed in the nuclei of virus-infected Neuro-2A cells. Moreover, siRNA-mediated knockdown of EEF1D expression significantly decreases BoAHV1 productive infection in MDBK cells. Thus, the association of EEF1D with multiple viral proteins, particularly ICP8, a component of the viral replication compartment, may represent a potential mechanism by which EEF1D regulates viral replication.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110613"},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honokiol rescues progranulin deficiency in pathogen-induced and genetically driven neurodegeneration: Bridging veterinary models with therapeutic development","authors":"Zezhao Cao ,&nbsp;Wenqi He ,&nbsp;Ruijie Hu ,&nbsp;Yuzhu Chen,&nbsp;Jun Xue,&nbsp;Feng Gao,&nbsp;Yungang Lan","doi":"10.1016/j.vetmic.2025.110616","DOIUrl":"10.1016/j.vetmic.2025.110616","url":null,"abstract":"<div><div>Progranulin (PGRN), a crucial regulator of lysosomal function, is deficient in several neurodegenerative disorders. Restoring PGRN levels with small molecules presents a promising therapeutic strategy for these conditions. Honokiol (HNK), a polyphenolic compound known for its neuroprotective effects, has demonstrated potential in various neurodegenerative diseases (ND), though its precise mechanisms remain unclear. This study explores HNK’s ability to upregulate PGRN expression in nerve cells and central nervous system tissues. Our results show that HNK enhances PGRN expression and lysosomal targeting in nerve cells, rescues PGRN deficiency in PHEV-infected models both <em>in vitro</em> and <em>in vivo</em>, and significantly increases brain PGRN levels in <em>GRN</em> haploinsufficient mice following oral administration. Collectively, these findings establish HNK's multimodal action as a promising therapeutic intervention for neurodegenerative conditions spanning both infectious (PHEV-mediated) and genetic (<em>GRN</em>-linked) etiologies of PGRN deficiency.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110616"},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core genome multilocus sequence typing (cgMLST) indicates herd specificity of Fusobacterium necrophorum ssp. necrophorum isolated from dairy cattle interdigital phlegmon outbreaks in Finland","authors":"Miia Kontturi ,&nbsp;Heli Simojoki ,&nbsp;Sinikka Pelkonen ,&nbsp;Minna Kujala-Wirth ,&nbsp;Taru Lienemann","doi":"10.1016/j.vetmic.2025.110618","DOIUrl":"10.1016/j.vetmic.2025.110618","url":null,"abstract":"<div><div>Numerous outbreaks of interdigital phlegmon (IP) occurred in Finnish dairy herds country-wide in the 2010s, resulting in significant but varying morbidity and severe clinical signs. These outbreaks increased antibiotic use and caused financial losses on the affected farms. During 2012–2015, we performed a study on the epidemiology, clinical presentation and bacteriology of IP outbreaks on 19 IP-affected farms. In addition, we collected <em>Fusobacterium necrophorum</em> isolates from IP cows for further studies. Here, we present an analysis of 25 isolates from early-stage IP from seven herds representing both moderate and high morbidity using whole genome sequencing (WGS). Our aim was to determine whether a novel contagious <em>F. necrophorum</em> strain had spread between the herds, causing the outbreaks, and whether the isolates possessed antibiotic resistance or known major virulence genes <em>in silico</em>. The Finnish <em>F. necrophorum</em> ssp. <em>necrophorum</em> isolates clustered into seven different groups, each corresponding to the herd of origin. Therefore, the isolates from high and moderate morbidity herds did not cluster together either. Our analysis revealed no known antibiotic resistance genes in the isolates, despite the clinical response to treatment being inconsistent. All isolates harboured virulence genes for leukotoxin and haemolysin but were devoid of adhesin. Instead of only one novel contagious strain, we identified herd-specific strains of <em>F. necrophorum</em> ssp. <em>necrophorum</em> in IP cows from Finnish dairy cattle herds. Therefore, the cause of IP outbreaks in Finland remains unknown and merits further research.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110618"},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic epidemiology of avian pathogenic Escherichia coli in two broiler colibacillosis outbreaks in Finland","authors":"Mia Biström ,&nbsp;Pia Vennerström ,&nbsp;Taru Lienemann ,&nbsp;Paula Kurittu ,&nbsp;Annamari Heikinheimo ,&nbsp;Tarja Pohjanvirta","doi":"10.1016/j.vetmic.2025.110617","DOIUrl":"10.1016/j.vetmic.2025.110617","url":null,"abstract":"<div><div>In Finland, notable colibacillosis outbreaks occurred in 2015 and 2021, impacting numerous flocks across the country. Diagnostic examinations of broiler carcasses revealed classical colibacillosis indicators such as polyserositis, cellulitis, and femoral head necrosis. Avian pathogenic <em>Escherichia coli</em> (APEC) isolates were mainly collected from the bone marrow of diseased birds for molecular typing by PCR. Typing was conducted for 375 and 217 APEC isolates from 64 and 91 flocks from the years 2015 and 2021, respectively. Typing consisted of determination of the <em>E. coli</em> phylogeny group, O-serogroup, and eight virulence-associated genes. Two predominant APEC types were detected in the 2015 outbreak and one in the 2021 outbreak. These predominant types were present in the majority of investigated flocks (47 out of 64 flocks (73 %) in 2015 and 75 out of 91 flocks (81 %) in 2021). Subsequent whole-genome sequencing (WGS) analysis of a subset of APEC isolates of these predominant types revealed them to be ST117 O78:H4 and ST117 O53:H4 in 2015 and ST23 O78:H4 in 2021. The isolates represented three distinct clonal lineages with small genetic differences. In addition, APEC isolates belonging to the same clonal lineages were detected in other Nordic countries at the same time. The affected flocks were epidemiologically linked by common ancestral parent and grandparent flocks. This study underscores that certain APEC strains with a high virulence potential can trigger severe colibacillosis outbreaks affecting multiple farms in several countries by vertical transmission from ancestral flocks to offspring. PCR typing emerged as a cost-effective and reliable method for promptly detecting the APEC clonal lineages responsible for colibacillosis outbreaks, and subsequent WGS analysis provided more detailed epidemiological and genetic information. The results of this study could also be used in assessing sampling methods and determining genetic differences between APEC isolates in the diagnosis of potential colibacillosis outbreaks.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"308 ","pages":"Article 110617"},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and diversity of porcine rotavirus groups A, B, C and H in Danish pigs","authors":"Nicole B. Goecke ,&nbsp;Marianne V. Agerlin ,&nbsp;Karina Skadborg ,&nbsp;Elisabeth O. Nielsen ,&nbsp;Svend Haugegaard ,&nbsp;Nicolai R. Weber ,&nbsp;Lars E. Larsen","doi":"10.1016/j.vetmic.2025.110615","DOIUrl":"10.1016/j.vetmic.2025.110615","url":null,"abstract":"<div><div>Rotaviruses (RVs) are one of the main infectious causes of acute gastroenteritis and are widespread among pigs with enteric disease. RVs are classified into nine groups or species (RVA-RVD and RVF-RVJ) and, to date, four of these (RVA, RVB, RVC, RVD and RVH) have been identified in pigs, with RVA being the most frequent and characterized species. In the present study, reverse transcription quantitative real-time PCR (RT-qPCR) assays specific for RVB, RVC and RVH were designed and validated and used together with a published RVA RT-qPCR assay to evaluate the occurrence of these RV species in rectal swab samples from 90 pigs from 22 Danish sow herds (2–8 pigs per herd). The pigs were 1–35 days of age, and the majority had experienced diarrhea and macroscopic signs of enteritis. Overall, RVs were detected in 81.1 % of the pigs with RVA (37.8 %) and RVB (38.9 %) being predominant, followed by RVC (28.9 %) and RVH (1.1 %). Co-infections with two or three different RV species were observed in 10.0 % and 7.8 % of the pigs, respectively. On herd level, RVs were detected in 95.5 % of the investigated herds with the following distribution: RVA (59.1 %), RVB (54.5 %), RVC (45.5 %) and RVH (4.5 %). In 40.9 % of the herds, more than one RV species was present. While it is known that RVA is frequently found in Danish pigs, this study shows that there is a rich RV diversity in Danish pigs and sow herds.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110615"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the epidemiology and genetic complexity of Escherichia coli in vertically integrated pig production systems using whole genome sequencing","authors":"Anna Vilaró ,&nbsp;Laia Serra ,&nbsp;Emma Solé ,&nbsp;Ingrid Seró ,&nbsp;Elena Novell ,&nbsp;Vicens Enrique-Tarancón ,&nbsp;Lorenzo Fraile ,&nbsp;Lourdes Migura-Garcia","doi":"10.1016/j.vetmic.2025.110610","DOIUrl":"10.1016/j.vetmic.2025.110610","url":null,"abstract":"<div><div><em>Escherichia coli</em> is a major pathogen responsible for enteric diseases in swine. This study aims to assess the genetic diversity, virulence factors, and antimicrobial resistance genes of <em>E. coli</em> isolated from diarrheic pigs within Spanish integrated production systems. Metadata, including epidemiological data and minimum inhibitory concentration (MIC), was collected for 350 clinical isolates reported to the laboratory between 2018 and 2022. MIC analysis using Ward’s hierarchical clustering identified 17 phenotypic resistance clusters. A subset of 206 isolates, representing different production pyramids and phenotypic clusters, was selected for whole genome sequencing (WGS). <em>In silico</em> serotyping and multilocus sequence typing revealed high genetic diversity, with predominant serotypes O138:H14, O147:H14, O141:H4, and O108:H39, and sequence types ST10 and ST42. Only three ST131 isolates were found in a single production pyramid suggesting that swine associated ST131 is not contributing significantly to the epidemiology of human infections associated to this ST. Isolates were classified into six phylogroups, with phylogroup A being the most represented. AMR profiling identified a high percentage of resistance (&gt; 50 %) to tetracyclines, aminoglycosides, quinolones, trimethoprim and sulphonamides, while resistance to third-generation cephalosporins and colistin remained low (&lt; 25 %). Comparative genomic analysis demonstrated high genetic diversity within production pyramids, although, some clones persisted over time, suggesting transmission within batches. Statistical analyses found no association between genetic traits and farm origins, although outbreaks often involved clones with minimal SNP differences. This study underscores the complexity of <em>E. coli</em> transmission in swine and highlights the need for genomic surveillance to monitor AMR.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110610"},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BVDV antagonizes the antiviral activity of MDA5 by promoting its degradation via CCDC50-dependent selective autophagy","authors":"Zhen Wang,&nbsp;Shizhe Liu,&nbsp;Liang Xu,&nbsp;Jingyu Wang,&nbsp;Shaotang Ye,&nbsp;Siqi Cai,&nbsp;Kun Jia,&nbsp;Shoujun Li","doi":"10.1016/j.vetmic.2025.110601","DOIUrl":"10.1016/j.vetmic.2025.110601","url":null,"abstract":"<div><div>Bovine viral diarrhea-mucosal disease (BVD-MD), caused by bovine viral diarrhea virus (BVDV), is a major infectious disease affecting the cattle industry. The nonstructural protein NS4B of BVDV has been shown to induce autophagy and antagonize the expression of the host innate immune sensor MDA5. However, the precise mechanism underlying NS4B-mediated suppression of MDA5 remains unclear. In this study, we demonstrate that NS4B interacts with the host protein CCDC50, as confirmed by co-immunoprecipitation and indirect immunofluorescence assays. Stable overexpression of CCDC50 significantly promoted MDA5 degradation and enhanced BVDV replication, whereas CCDC50 knockdown markedly impaired NS4B-mediated degradation of MDA5 in HEK293T cells. Interestingly, CCDC50 also suppressed the production of type I interferons (IFN-I) and interferon-stimulated genes (ISGs) during BVDV infection. Furthermore, the translocation of CCDC50 reduced MDA5 protein levels through the autophagy pathway. Mechanistically, we found that CCDC50 interacts with MDA5 and facilitates NS4B-mediated autophagic degradation of MDA5. These findings uncover a novel mechanism by which BVDV NS4B hijacks the host protein CCDC50 to subvert antiviral innate immunity by promoting MDA5 autophagic degradation and suppressing IFN-I signaling.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110601"},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross pathology and epidemiological features of mule deerpox virus infections in farmed white-tailed deer (Odocoileus virginianus) in Florida","authors":"An-Chi Cheng ,&nbsp;Pedro H.O. Viadanna ,&nbsp;Tracey L. Moquin ,&nbsp;Laura Roldan ,&nbsp;John A. Lednicky ,&nbsp;Samantha M. Wisely ,&nbsp;Kuttichantran Subramaniam ,&nbsp;Juan M. Campos Krauer","doi":"10.1016/j.vetmic.2025.110608","DOIUrl":"10.1016/j.vetmic.2025.110608","url":null,"abstract":"<div><div>Mule deerpox virus (DPV) is a member of the <em>Poxviridae</em> family that affects various deer species, causing crustaceous skin lesions and potentially lethal infections. In this study, we aimed to investigate the spatial and temporal distribution of DPV in farmed white-tailed deer (WTD; <em>Odocoileus virginianus</em>) in Florida, USA, from 2017 to 2023. Necropsies were performed, and specimens were collected from 776 deer. Focusing on 145 animals with DPV-like lesions, polymerase chain reaction (PCR) testing and whole genome sequencing confirmed the presence of DPV in multiple specimen types. The results indicated that 49 out of 145 deer (33.8 %, 95 % CI: 25.7 %-40.9 %) tested positive for DPV. Mule deerpox virus was identified in 20 of the 37 counties and 8 of the 10 deer management units (DMUs) where we collected specimens. All DPV infection cases occurred in summer and fall. Lesion swabs (4/4, 100 %) and lesion tissues (16/18, 89 %) exhibited the highest PCR-positivity rates among the specimens collected from DPV-infected animals, while no whole blood samples (0/13, 0 %) tested positive. Additionally, DPV nucleic acid was also detected in fecal swabs (4/9, 44 %), suggesting that DPV may be transmitted through the oral-fecal route. Fawns aged 1–3 months (37/70, 52.9 %, 95 % CI: 41.3 %-64.1 %) exhibited statistically higher positivity rates than other age groups. This is the first study investigating the spatial and temporal patterns of DPV in farmed WTD in Florida. The findings emphasize the need for enhanced disease surveillance, non-invasive testing methods, and preventive measures to mitigate the impact of DPV on the deer farming industry and wildlife conservation.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110608"},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of autophagic and Wnt/β-catenin signaling occurrence during Schmallenberg virus (SBV) infection on BHK-21 cells","authors":"Consiglia Longobardi ,&nbsp;Davide Lelli ,&nbsp;Manuel Corsa ,&nbsp;Ugo Pagnini ,&nbsp;Francesco Origgi ,&nbsp;Hyun-Jin Shin ,&nbsp;Gianmarco Ferrara","doi":"10.1016/j.vetmic.2025.110609","DOIUrl":"10.1016/j.vetmic.2025.110609","url":null,"abstract":"<div><div>Schmallenberg virus (SBV) is a ruminant pathogen that is widely distributed around the world, but little is known about its interactions with permissive cells or about its pathogenetic mechanisms. This study highlighted, through a phenotypic approach, the changes in the expression of some autophagy and Wnt/β-catenin pathway markers that SBV causes on baby hamster kidney (BHK-21) cells. Western blot analysis revealed that SBV caused autophagy induction at 48 h post infection. Several markers, such as PI3K, Akt, and Wnt/β-catenin, were downregulated at the same time point. Furthermore, downregulation in the expression of PI3K, p-mTOR and Beclin-1 showed differences between multiplicity of infection (MOI) 0.05 and 0.5, but not between MOI 0.5 and 1.5. Exceptions for this trend were Akt and LC3-II, which progressively decreased depending on time, and β-catenin, whose expression almost disappeared regardless of MOI. The use of several chemical inducers and inhibitors has demonstrated the efficacy of late autophagy inhibitors (bafilomycin and chloroquine) in significantly lowering SBV infection and also preventing the changes caused by viral replication. Early autophagy inhibitors and inducers showed no effect on cellular viability or viral titers. Silencing the expression of Akt and β-catenin revealed a slight increase in the expression of viral glycoprotein Gc. These findings revealed the relationship that SBV has in important cellular regulatory pathways, expanding the knowledge about the cellular interactions of this virus and suggesting a central role for late stages of autophagy in the replication of this bunyavirus.</div></div>","PeriodicalId":23551,"journal":{"name":"Veterinary microbiology","volume":"307 ","pages":"Article 110609"},"PeriodicalIF":2.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}