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[Effect of treatment with perftoran on the course of experimental uveitis, lipid peroxidation and activity of antioxidant defense enzymes]. [pertoran对实验性葡萄膜炎病程、脂质过氧化及抗氧化防御酶活性的影响]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
M Kh Karimova, F Kh Inoiatova
{"title":"[Effect of treatment with perftoran on the course of experimental uveitis, lipid peroxidation and activity of antioxidant defense enzymes].","authors":"M Kh Karimova,&nbsp;F Kh Inoiatova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental uveitis is characterized by a pronounced lipid peroxidation (LPO) in damaged tissues of eye, which is complicated by reduced activity of the antioxidant enzymes, SOD and catalase. The intensification of LPO was also found in blood serum and hepatic tissue. However, hepatic lipid peroxidation was accompanied by compensatory increase of catalase activity. The activity of antioxidant defence enzymes decreased in blood, whereas catalase was activated in hepatic tissue. The therapeutic effect was accompanied by a decrease of LPO products and increase of activity of the antioxidant enzymes in all tissues. Treatment of uveitis with gentamycin and, especially, perftoran reduced inflammatory events.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"450-4"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of UV-radiation on the level of ascorbic acid, SH-groups, and activity of glutathione reductase in the eye lens]. [紫外线辐射对眼球晶状体中抗坏血酸、sh -基团水平和谷胱甘肽还原酶活性的影响]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
L N Byshneva, V V Senchuk
{"title":"[Effect of UV-radiation on the level of ascorbic acid, SH-groups, and activity of glutathione reductase in the eye lens].","authors":"L N Byshneva,&nbsp;V V Senchuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of UV radiation in vitro on the level of ascorbate, SH-groups and glutathione reductase activity in the soluble fraction of bovine eye lens was studied. UV-Irradiation increased NADPH-oxidoreductase activity, the level of ascorbate oxidation and decreased the content of SH-groups and activity of glutathione reductase. Significant activation of the NADPH-oxidoreductase activity in the presence of ascorbate and Cu2+ was observed after UV-irradiation. It is suggested that ascorbate may play an important role in the UV-induced lens pathology.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"455-60"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Monoclonal anti-NSE-antibodies: purification, characterization, and immunoenzyme analysis]. [单克隆抗nse抗体:纯化、表征和免疫酶分析]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
V P Chekhonin, O I Gurina, T S Portnaia, I A Riabukhin, I I Shepeleva
{"title":"[Monoclonal anti-NSE-antibodies: purification, characterization, and immunoenzyme analysis].","authors":"V P Chekhonin,&nbsp;O I Gurina,&nbsp;T S Portnaia,&nbsp;I A Riabukhin,&nbsp;I I Shepeleva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of NSE purification procedure, as well as hybridoma technology of anti NSE monoclonal antibodies synthesis are presented. The employment of this procedure yielded highly purified NSE preparation. The immunization of BALB/C mice with NSE preparation led to sensitization of the immunocompetent cells, which could form hybridomes, producing the anti-NSE monoclonal antibodies, after the confluence with myeloma cells Sp 2/0-Ag 14. The ELISA test-system for NSE analysis was developed on the basis of highly purified NSE preparation and monoclonal anti-NSE antibodies. This system was characterized by high specificity, accuracy and reliability. This system may be recommended for analysis of blood-brain barrier functions in the neurological and psychiatric diseases.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"477-84"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The activity of NAD(P)-dependent dehydrogenases in blood lymphocytes in children and adolescents with different duration of insulin-dependent diabetes mellitus]. [胰岛素依赖型糖尿病不同病程儿童和青少年血淋巴细胞NAD(P)依赖性脱氢酶活性的研究]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
A A Savchenko, E V Kriukova, V T Manchuk
{"title":"[The activity of NAD(P)-dependent dehydrogenases in blood lymphocytes in children and adolescents with different duration of insulin-dependent diabetes mellitus].","authors":"A A Savchenko,&nbsp;E V Kriukova,&nbsp;V T Manchuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The levels of blood lymphocyte NAD(P)-dependent dehydrogenases were investigated in children and teenagers with different duration of insulin-dependent diabetes mellitus (IDDM). The level of some NAD(P)-dependent dehydrogenases changed proportionally in dependence of IDDM duration and insulin therapy did not restore their activities to the normal level. It is suggested that these changes may reflect decrease of energy metabolism and plastic processes in blood lymphocytes from diabetic children and teenagers reflecting. These changes correspond to altered functional reactivity of immunocompetent cells and represent metabolic basis of immunopathogenic complications of IDDM.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"519-25"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22167826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glutamine metabolism in the liver after partial hepatectomy in chronic hepatitis]. [慢性肝炎部分肝切除术后肝脏谷氨酰胺代谢]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
P N Savilov
{"title":"[Glutamine metabolism in the liver after partial hepatectomy in chronic hepatitis].","authors":"P N Savilov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A long-term treatment of female rats with CCl4 caused a decrease of glutamine content in the liver. This decrease may be attributed to stable reduction of glutamine synthetase activity and slightly elevated (or unchanged) phosphate-dependent glutaminase. Partial hepatectony (15-20% of the liver) did not normalise glutamine metabolism.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"461-8"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats]. [部分阿片类激动剂丁丙诺啡和丁托啡诺对失血性休克猫肝细胞质膜磷脂组成的影响比较]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
G F Leskova, Iu V Arkhipenko
{"title":"[Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats].","authors":"G F Leskova,&nbsp;Iu V Arkhipenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Comparative effects of the partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of liver cell plasma membranes were investigated in cats under conditions of hemorrhagic shock. Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol. The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipid composition of liver cell plasma membranes by increasing the content of phosphatidylserine and by decreasing the contents of sphingomyelin and lysophosphatidylcholine. The protective effect of butorphanol on liver cells was more pronounced than that of buprenorphine.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"497-502"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in the system of antioxidant blood defence in newborns with different pathology]. 不同病理新生儿抗氧化血液防御系统的变化
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
L A Litvinenko, L A Danilova, N P Shabalov
{"title":"[Changes in the system of antioxidant blood defence in newborns with different pathology].","authors":"L A Litvinenko,&nbsp;L A Danilova,&nbsp;N P Shabalov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Blood antioxidant enzymes (superoxide dismutase, catalase, ceruloplasmin) were investigated in gestational ages and diseases. Low activity of blood superoxide dismutase and catalase were observed in premature babies and in newborns after acute and chronic hypoxia. In hemolytic disease the activity of antioxidant enzymes of newborns was significantly higher than in healthy infants. This work demonstrates advantages of haemosorbtion compared to exchange blood transfusion. So the antioxidant activity in blood, decreased after blood transfusion, remained at a high level after haemosorbtion. Any deficiency of antioxidant enzymes in newborns may lead to toxyc oxygen effects. Antioxidants are potential therapeutic agents in the above mentioned conditions.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"513-8"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of opioid receptors by thyroliberin analogues]. [甲状腺素类似物对阿片受体的调节]。
Voprosy meditsinskoi khimii Pub Date : 2002-09-01
A M Balashov, T N Aliab'eva, L F Panchenko
{"title":"[Regulation of opioid receptors by thyroliberin analogues].","authors":"A M Balashov,&nbsp;T N Aliab'eva,&nbsp;L F Panchenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ability of thyroliberin (TRH) to interact with opioid receptors (OR) was studied using radioligand analysis. TRH did not influence specific binding of [3H]-naloxone, but increased affinity of high affinity binding sites for the ligand in a dose-dependent manner. TRH also decreased affinity of low- affinity binding sites. Kinetic analysis of low-affinity binding sites suggests the existence of at least two subpopulations of OR, which differed in their affinity to naloxone and mode of interaction with TRH. TRH acted as non-competitive and competitive inhibitor of receptor binding sites with the lowest and moderate affinity, respectively. The allosteric pattern of TRH influence on OR with high and the lowest affinity to naloxone was suggested. TRH analogues were estimated for their ability to change in OR binding characteristics. The level of [3H]-DADL specific binding was not influenced by the peptides tested but the affinity was changed. Blind control experiment showed the ability of the TRH relative substances to increase in affinity of d-receptors could be ranked in the row: dihydroorotyl-hystidyl-prolinamide > TRH > methionyl-asparagyl-phenylalaninamide. This is consistent with ability of these compounds to influence the dopaminergic events.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"436-42"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22168491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern approaches to pharmacotherapy of diabetes mellitus type II]. 2型糖尿病药物治疗的现代途径
Voprosy meditsinskoi khimii Pub Date : 2002-07-01
I R Kovel'man, A I Tochilkin, N F Beliaeva, V K Gorodetskiĭ, V A Kniazhev, S B Tkachenko, L L Semenov, N V Semenova
{"title":"[Modern approaches to pharmacotherapy of diabetes mellitus type II].","authors":"I R Kovel'man,&nbsp;A I Tochilkin,&nbsp;N F Beliaeva,&nbsp;V K Gorodetskiĭ,&nbsp;V A Kniazhev,&nbsp;S B Tkachenko,&nbsp;L L Semenov,&nbsp;N V Semenova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pharmacological approaches to the treatment of type 2 diabetes mellitus were reviewed. Special attention was paid to the new therapeutic agents that are able to decrease plasma glucose levels. The possible mechanisms of the hypoglycemic effects are discussed. Briefly, repaginide, nateglinede and alpha-glucosidase inhibitors prevent postprandial hypoclycemia while thiazaolidinediones improve the sensitivity to insulin and vanadium compounds act as an insulin action enhancer.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 4","pages":"337-52"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22177143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Numerical euristic approach to the proteome map analysis]. [蛋白质组图谱分析的数值神经学方法]
Voprosy meditsinskoi khimii Pub Date : 2002-07-01
P G Lokhov
{"title":"[Numerical euristic approach to the proteome map analysis].","authors":"P G Lokhov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The possibility of numerical-heuristic approach has been examined for proteome map analysis that realized by neural network processing of 2D protein electrophoregramms. The fetal alcohol syndrome was used to illustrate that this approach islatively effective for diagnostics of diseases.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 4","pages":"353-6"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22177144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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