{"title":"[部分阿片类激动剂丁丙诺啡和丁托啡诺对失血性休克猫肝细胞质膜磷脂组成的影响比较]。","authors":"G F Leskova, Iu V Arkhipenko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Comparative effects of the partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of liver cell plasma membranes were investigated in cats under conditions of hemorrhagic shock. Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol. The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipid composition of liver cell plasma membranes by increasing the content of phosphatidylserine and by decreasing the contents of sphingomyelin and lysophosphatidylcholine. The protective effect of butorphanol on liver cells was more pronounced than that of buprenorphine.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"48 5","pages":"497-502"},"PeriodicalIF":0.0000,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats].\",\"authors\":\"G F Leskova, Iu V Arkhipenko\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Comparative effects of the partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of liver cell plasma membranes were investigated in cats under conditions of hemorrhagic shock. Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol. The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipid composition of liver cell plasma membranes by increasing the content of phosphatidylserine and by decreasing the contents of sphingomyelin and lysophosphatidylcholine. The protective effect of butorphanol on liver cells was more pronounced than that of buprenorphine.</p>\",\"PeriodicalId\":23535,\"journal\":{\"name\":\"Voprosy meditsinskoi khimii\",\"volume\":\"48 5\",\"pages\":\"497-502\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Voprosy meditsinskoi khimii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Voprosy meditsinskoi khimii","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats].
Comparative effects of the partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of liver cell plasma membranes were investigated in cats under conditions of hemorrhagic shock. Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol. The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipid composition of liver cell plasma membranes by increasing the content of phosphatidylserine and by decreasing the contents of sphingomyelin and lysophosphatidylcholine. The protective effect of butorphanol on liver cells was more pronounced than that of buprenorphine.
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