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[The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450]. [γ - l -谷氨酰组胺对实验性过敏反应严重程度、激素状态及肝细胞色素p-450的影响]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
V E Nebol'sin, V V Krzhechkovskaia, G A Zheltukhina, R P Evstigneeva, V L Kovaleva
{"title":"[The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450].","authors":"V E Nebol'sin,&nbsp;V V Krzhechkovskaia,&nbsp;G A Zheltukhina,&nbsp;R P Evstigneeva,&nbsp;V L Kovaleva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>gamma-L-Glutamyl-histamine (gamma-GluHA) was synthesized at Department of the chemistry and technology of fine organic compounds M. V. Lomonosov Moscow state academy of fine chemical technology. It was investigated the influence of gamma-L-glutamyl-histamine on the severity of experimental anaphylactic reaction, hormonal content in blood plasma and liver cytochrome P-450. The induction of liver cytochrome P-450, the elevation of hormonal content (thyroxine and glucocorticoids) in blood plasma and decrease of the severity of experimental anaphylactic reaction are observed.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"482-8"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lipid peroxidation, peroxyl radical-scavenging system of plasma and liver and heart pathology in adolescence heroin users]. [青少年海洛因使用者血浆、肝脏和心脏的脂质过氧化、过氧自由基清除系统病理]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
L F Panchenko, S V Pirozhkov, A V Nadezhdin, V Iu Baronets, N N Usmanova
{"title":"[Lipid peroxidation, peroxyl radical-scavenging system of plasma and liver and heart pathology in adolescence heroin users].","authors":"L F Panchenko,&nbsp;S V Pirozhkov,&nbsp;A V Nadezhdin,&nbsp;V Iu Baronets,&nbsp;N N Usmanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic opiate intoxication has been shown to cause various pathologic changes in the liver almost in 100% of cases. Earlier it has been demonstrated that acute or chronic morphine intoxication evokes activation of lipid peroxidation in the liver, heart, and brain cells. The aim of the present work was to assess parameters reflecting cytolysis in the liver and heart, and the plasma content of factors contributing to the peroxyl radical-scavenging system of the blood of teenagers using heroin. Blood samples were obtained from 20 male patients from 14 to 16 years old, with a mean duration of regular heroin use of 1.7 years. The control group included 13 healthy teenagers which denied the previous drug use. Mean plasma ALT and myocardial isoform of LDH activities were significantly higher (1.7- and 1.4-times respectively) in the heroin users than in the control group. The mean plasma level of lipid peroxides in the heroin users is increased by 20% compared to the control individuals. In teenagers using heroin a high level of correlation was observed between the plasma content of lipid peroxides and myocardial LDH activity (r = 0.76; P < 0.01). The effect of heroin use on the content of the plasma peroxyl radical-scavenging factors--vitamin E, ascorbic acid, and protein SH-groups--was not found. It has been concluded that heart injury during heroin use in teenagers may be associated with activation of lipid peroxidation reactions in the myocardium.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"501-6"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Common properties of pharmacological agonists and antagonists of surface membrane receptors]. [表面膜受体的药物激动剂和拮抗剂的共同特性]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
A I Luĭk, V V Prokopenko, V Iu Tanchuk, V V Kholodovich, I V Semeniuta
{"title":"[Common properties of pharmacological agonists and antagonists of surface membrane receptors].","authors":"A I Luĭk,&nbsp;V V Prokopenko,&nbsp;V Iu Tanchuk,&nbsp;V V Kholodovich,&nbsp;I V Semeniuta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using experimental transcription model in vitro, and method of electron-topological calculations the elements of pharmacological and structural community have been found in the groups of physiologically active compounds (PAC), blocking and activating external cellular receptors. This finding confirms the necessity of subdivision special groups of bio-substrates blockators and activators for hierarchical classification, of PAC.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"514-24"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Functional role of vitamin K]. [维生素K的功能作用]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
A A Sokol'nikov, V M Kodentsova
{"title":"[Functional role of vitamin K].","authors":"A A Sokol'nikov,&nbsp;V M Kodentsova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three basic functions of vitamin K in organism are considered. Besides (vitamin K-dependent) posttranslational modification of Ca-binding proteins, this vitamin can operate via vitamin D hormonal system, and can directly influence membranes.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"453-61"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators]. 氨基甲酸酯类胆碱酯酶抑制剂对armin中毒小鼠的保护作用及其对某些理化指标的依赖性。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
V B Prozorovskiĭ, L V Pavlova, I M Suslova, A V Sazonova, A V Kokushkina
{"title":"[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators].","authors":"V B Prozorovskiĭ,&nbsp;L V Pavlova,&nbsp;I M Suslova,&nbsp;A V Sazonova,&nbsp;A V Kokushkina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the \"leaving portion\" of the molecule of carbamates.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"525-9"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in the activity of neutral and acidic isoforms of sphingomyelinase in hepatoma-22, regenerating and ischemic liver]. [肝癌-22、再生肝和缺血肝鞘磷脂酶中性和酸性同工型活性的变化]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
A V Alesenko, E S Zubova, L B Dudnik, E I Gal'perin, L V Platonova, N Shono, A Iu Chevokin, E V Diatlovitskaia
{"title":"[Changes in the activity of neutral and acidic isoforms of sphingomyelinase in hepatoma-22, regenerating and ischemic liver].","authors":"A V Alesenko,&nbsp;E S Zubova,&nbsp;L B Dudnik,&nbsp;E I Gal'perin,&nbsp;L V Platonova,&nbsp;N Shono,&nbsp;A Iu Chevokin,&nbsp;E V Diatlovitskaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Activity of neutral and acidic sphingomyelinases (N- and A-SMases) were studied in regenerating liver after partial hepatectomy (during 48 hrs after operation), in ischemic liver during 15, 30 min and 1 and 2 hrs ischemia and during following reperfusion (from 5 min up to 2 hrs), in hepatoma- 22 after 15 days of transplantation and in liver of tumor bearing animals. It was shown that activity of N-SMase is increased in hepatoma-22 and in regenerating liver and it is decreased in ischemic liver. Following reperfusion of ischemic liver area activity of enzyme was found to have returned to baseline in dependence on time of ischemia and reperfusion. Activity of A-SMase is decreased in tumor, is not changed in regenerating liver and increased after long time of ischemia. It was supposed that N-SMase is involved in cell proliferation, but A-SMase is connected with cell damage.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"472-81"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The use of ion-selective field transistors (ISFT) with photopolymerizable polyurethane membranes in nephrology for determination of potassium concentration (activity)]. [离子选择场晶体管(ISFT)和光聚合聚氨酯膜在肾脏病学中用于钾浓度(活性)的测定]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
N Iu Abramova, Iu A Borisov, A V Bratov, P V Gavrilenkov, K Dominguez, V N Spiridonov, E D Suglobova
{"title":"[The use of ion-selective field transistors (ISFT) with photopolymerizable polyurethane membranes in nephrology for determination of potassium concentration (activity)].","authors":"N Iu Abramova,&nbsp;Iu A Borisov,&nbsp;A V Bratov,&nbsp;P V Gavrilenkov,&nbsp;K Dominguez,&nbsp;V N Spiridonov,&nbsp;E D Suglobova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The applicability is examined of ion selective field transistors with photocurable polyurethane membranes to control of the electrolytic composition of dialyzing solutions used in artificial kidney apparatus, and also of plasma in patient treated by chronic hemodialysis. The short- and long-time characteristics of the efficiency of K(+)-selective field transistors in continuous contact with solutions. Comparative testing of such transistors and other sensing systems is made. It is demonstrated that a sufficient reliability of measurements in the range of physiological concentrations in combination with low cost provide the possibility of using K(+)-selective field transistors for monitoring of the potassium concentration both in dialyzing solutions and plasma in patients on chronic hemodialysis treatment.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"530-8"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The dynamic of biochemical stress reaction inductors in various tactics for surgical treatment of patients with a combined trauma of cranium and lower limbs ]. [生化应激反应诱导因子在颅下肢联合创伤手术治疗中的动态变化]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
V V Lebedev, P P Golikov, B V Davydov, K I Rakhimi, A G Suvalian, N Iu Nikolaeva, N V Fedorova, V V Marchenko
{"title":"[The dynamic of biochemical stress reaction inductors in various tactics for surgical treatment of patients with a combined trauma of cranium and lower limbs ].","authors":"V V Lebedev,&nbsp;P P Golikov,&nbsp;B V Davydov,&nbsp;K I Rakhimi,&nbsp;A G Suvalian,&nbsp;N Iu Nikolaeva,&nbsp;N V Fedorova,&nbsp;V V Marchenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 31 patients after a craniocerebral trauma combined with a trauma of locomotor system (CCCT), and in 28 patients with only a limb fractures a time course (1, 3, 7, and 14 days) of biochemical stress reaction inductors (cortisol, serotonin, histamine, lipid peroxidation products) in various tactics of surgical treatment was studied. It was established that CCCT in a significantly stronger degree increases cortisol and lipid peroxidation products' levels than an isolated locomotor system trauma. An early postponed surgical intervention in lower extremities in CCCT results in the same increase in the biochemical stress reaction inductors as a late postpone surgical intervention in the lower extremities. In an early postponed osteosynthesis in CCCT patients, a mean term of hospital stay was 67 days, and in a late postponed one 117 days. The disability period was correspondingly 200 vs 315 days.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"494-500"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intensity of free radical process and antioxidant enzymes activity in human saliva and plasma under emotional stress]. [情绪应激下唾液和血浆中自由基过程强度及抗氧化酶活性]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
A I Lukash, V G Zaika, N P Miliutina, A O Kucherenko
{"title":"[Intensity of free radical process and antioxidant enzymes activity in human saliva and plasma under emotional stress].","authors":"A I Lukash,&nbsp;V G Zaika,&nbsp;N P Miliutina,&nbsp;A O Kucherenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intensity of free radical processes (FRP) and the activity of antioxidant (AO) systems in human blood plasma and saliva were studied under physiological emotional strain and depressive pathologies (before and after treatment). The significant alterations in the dynamics of investigative indexes under different emotional strain were revealed. These alterations in saliva were more intensive than in blood plasma. The treatment led to the stabilization of FRP intensity and the activity of AO protection. The correlation between saliva and blood plasma parametres allows to use saliva for the estimation of emotional strain and of the efficiency of therapeutics under depressive pathologies.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"507-13"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism]. [乙醇抑制酗酒患者血小板单胺氧化酶 B 型活性]。
Voprosy meditsinskoi khimii Pub Date : 1999-11-01
E M Krupitskiĭ, G F Karandashova, V V Vostrikov, N M Lavrova, N I Grinenko, T Iu Slavina, A Ia Grinenko
{"title":"[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism].","authors":"E M Krupitskiĭ,&nbsp;G F Karandashova,&nbsp;V V Vostrikov,&nbsp;N M Lavrova,&nbsp;N I Grinenko,&nbsp;T Iu Slavina,&nbsp;A Ia Grinenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.</p>","PeriodicalId":23535,"journal":{"name":"Voprosy meditsinskoi khimii","volume":"45 6","pages":"489-93"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21611108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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