VNU Journal of Science: Medical and Pharmaceutical Sciences最新文献_第2页

Phenolic Acids, Steroids, and Triterpenoids Isolated from Platycodon grandiflorus (Jacq.) A. DC. 从桔梗（Jacq.）

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-03-22 DOI: 10.25073/2588-1132/vnumps.4558

Tran Huu Giap, Nguyen Thi Tu Oanh, Nguyen Xuan Nhiem, Nguyen Van Hung, Vu Mai Thao, Ha Thi Thoa, Bui Phuoc Hoa, Nguyen Thi Minh Hang

引用次数: 0

In Vivo Bioequivalence Study of Drug: An Analysis of Bidding in Vietnam Period 2018 - 2022 药物体内生物等效性研究：2018-2022年越南招标分析

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-03-22 DOI: 10.25073/2588-1132/vnumps.4580

Tang Quoc Hung, Nguyen Thi Thanh Hai, Tran Bich Ngoc, Tran Thi Thu Thu

{"title":"In Vivo Bioequivalence Study of Drug: An Analysis of Bidding in Vietnam Period 2018 - 2022","authors":"Tang Quoc Hung, Nguyen Thi Thanh Hai, Tran Bich Ngoc, Tran Thi Thu Thu","doi":"10.25073/2588-1132/vnumps.4580","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4580","url":null,"abstract":"To promote the development of bioequivalent drugs, the Ministry of Health of Vietnam has classified a separate bidding group for bioequivalent drugs. According to the results of bidding for bioequivalent drugs in the period 2018 - 2022 has achieved very encouraging results, the ratio of domestic bioequivalent drugs compared to foreign bioequivalent drugs winning bids is from 2.13 to 3.63 times higher. Regarding active pharmaceutical ingredients of bioequivalent drugs, bioequivalent drugs with the highest total winning value (including all dosage forms, concentrations,...) focus mainly on antibiotics (cefuroxime, cefixime,…), anti-diabetic drugs (gliclazide, metformin,...), high blood pressure drugs (amlodipine), antipyretic and pain relievers (paracetamol). The winning drug dosage forms are still mainly conventional dosage forms (tablets, film-coated tablets, capsules) and their active ingredients are almost single. In particular, several multi-component bioequivalence drugs have a large total winning value but do not belong to the pharmaceutical group on the list of mandatory bioequivalence test reports when registering the drug, such as the combination of Gliclazide + Metformin; Glibenclamide + Metformin; Glimepiride + Metformin. The trend of selecting pharmaceutical substances/groups of pharmaceutical substances that manufacturers focus on researching/registering bioequivalent drugs in Vietnam is focused on drugs on the list of drugs covered by health insurance. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140219922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Clinical Decision Support System on Dose Adjustments in Inpatients with Renal Failure at Thai Binh Medical University Hospital 临床决策支持系统对泰平医科大学医院肾衰竭住院患者剂量调整的影响

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-03-22 DOI: 10.25073/2588-1132/vnumps.4579

Nguyen Thi Thanh Hai, Dang Nguyet Ha, Le Trong Hieu, Tran Thi Cat Khanh, Nguyen Viet Khanh, Vu Than Binh, Tran Thi Thu Thuy, Nguyen Xuan Bach

{"title":"Effect of Clinical Decision Support System on Dose Adjustments in Inpatients with Renal Failure at Thai Binh Medical University Hospital","authors":"Nguyen Thi Thanh Hai, Dang Nguyet Ha, Le Trong Hieu, Tran Thi Cat Khanh, Nguyen Viet Khanh, Vu Than Binh, Tran Thi Thu Thuy, Nguyen Xuan Bach","doi":"10.25073/2588-1132/vnumps.4579","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4579","url":null,"abstract":"Objective: The study aimed to evaluate the effectiveness of the Clinical Decision Support System (CDSS) in dosage adjustment for inpatients with renal impairment at Thai Binh University Hospital. Subjects and methods: Medical records of inpatients treated at Thai Binh University Hospital were reviewed during the periods from 01/01/2022 to 30/11/2022 and from 01/12/2022 to 15/03/2023. Study design: a cross-sectional descriptive study. Results: Before the integration of CDSS, among 300 medical records, dose adjustment was required in 81.7% of medical records, which included 64.5% inappropriate dosage modification. There were 406 prescriptions requiring dose adjustment, accounting for 31.5% of the total prescriptions, and 52.7% of the total prescriptions had inappropriate dose adjustment. After the integration of CDSS, 320 alerts were recorded for 55 patients between December 1st, 2022, and March 15th, 2023. The alert cancellation proportion was 2.8%. Among the alerts that were overridden, 55.6% involved clinical pharmacist consultations. The combination of CDSS and clinical pharmacist consultations reduced the proportion of prescriptions and medical records having inappropriate dosage adjustments to 10.6% and 16.4%, respectively. Conclusion: CDSS had positive impacts on dosage adjustments in inpatients with renal insufficiency at Thai Binh Medical University Hospital. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140212025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening In Silico Alpha-amylase and Alpha-glucosidase Inhibitory Activity of Flavonoid Compounds for the Treatment of Type 2 Diabetes 用于治疗 2 型糖尿病的黄酮类化合物的α-淀粉酶和α-葡萄糖苷酶抑制活性的硅学筛选

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-03-22 DOI: 10.25073/2588-1132/vnumps.4581

Bui Thanh Tung, Le Thi Huong, Trinh Thi Duong, Nguyen Thi Huyen, Nguyễn Thi Thuy

{"title":"Screening In Silico Alpha-amylase and Alpha-glucosidase Inhibitory Activity of Flavonoid Compounds for the Treatment of Type 2 Diabetes","authors":"Bui Thanh Tung, Le Thi Huong, Trinh Thi Duong, Nguyen Thi Huyen, Nguyễn Thi Thuy","doi":"10.25073/2588-1132/vnumps.4581","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4581","url":null,"abstract":"Diabetes mellitus (diabetes) is a chronic disease associated with metabolic disorders and hyperglycemia. α-glucosidase and α-amylase, which play an important role in the hydrolysis of starch and carbohydrates, are enzymes. They are related to the increase and decrease in blood glucose levels. Flavonoids are a common group of natural compounds that have been shown to have many beneficial health effects. This study used molecular docking methods and drug-like criteria, predicting pharmacokinetics-toxicity (ADMET) to screen and evaluate potential flavonoid compounds in the treatment of type 2 diabetes. After screening the compounds, we obtained 46 compounds with lower binding energies than the positive controls, which are acarbose. Using Lipinski's rule of five, we evaluated the drug-likeness of the compounds and identified 12 compounds that met the criteria. Then, continuing to analyze according to pharmacokinetic and toxicological parameters (ADMET), we obtained 3 compounds including Galangin, Maackiain, and Corylin, that have the potential to be developed into drugs when showing the ability to simultaneously inhibit both enzymes α-glucosidase and α-amylase have positive properties: binding energy is lower than the control, creates many interactions with target proteins in the active site, has drug-like properties, relatively good pharmacokinetic properties and low toxicity. Therefore, further in vitro and in vivo studies are needed to develop these potential compounds into drugs for the treatment of type 2 diabetes. \u0000 \u0000 \u0000 \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Protective Effect of Ethyl Acetate Fraction and Bioactive Compounds of Mimosa pudica L. Leaves in Methylglyoxal-induced Glucotoxicity 含羞草叶乙酸乙酯馏分和生物活性化合物对甲基乙二醛诱导的葡萄糖毒性的保护作用

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-01-20 DOI: 10.25073/2588-1132/vnumps.4576

Pham Thi Lan, Pham Thi Nguyet Hang, Bui Thanh Tung

{"title":"The Protective Effect of Ethyl Acetate Fraction and Bioactive Compounds of Mimosa pudica L. Leaves in Methylglyoxal-induced Glucotoxicity","authors":"Pham Thi Lan, Pham Thi Nguyet Hang, Bui Thanh Tung","doi":"10.25073/2588-1132/vnumps.4576","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4576","url":null,"abstract":"Mimosa pudica L. has been used as a traditional medicine to treat leprosy, dysentery, burning sensation, asthma, inflammation, fatigue, and blood diseases. The purpose of this study was to evaluate the ethyl acetate (EtOAc) fraction and two compounds protocatechuic acid and syringic acid of Mimosa pudica L. against methylglyoxal (MGO)- induced glucotoxicity. The inhibitory effects of EtOAc fraction and two compounds of Mimosa pudica L. on glucotoxicity in Human umbilical vein endothelial cells (HUVECs) and inhibit Advanced glycation end products (AGEs) formation and also breaking effects on MGO-AGEs were measured. Our results demonstrated that EtOAc fraction and two bioactive compounds protocatechuic acid and syringic acid of Mimosa pudica L. leaves inhibit MGO-induced AGEs formation, and break down MGO-AGEs, resulting in the reduction of glucotoxicity. EtOAc fraction and two bioactive compounds protocatechuic acid and syringic acid are promised in effective in preventing or treating MGO-induced endothelial dysfunction. \u0000Keywords: Advanced glycation end products (AGEs); Methylglyoxal (MGO); Human umbilical vein endothelial cells (HUVECs); Mimosa pudica L.; ethyl acetate fraction; protocatechuic acid; syringic acid. \u0000 \u0000*","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"10 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo Evaluation of Berberine-loaded Liposomes in the Exogenous Hyperlipidemia Animal Model 小檗碱脂质体在外源性高脂血症动物模型中的体内评估

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-12-24 DOI: 10.25073/2588-1132/vnumps.4573

Duong Thi Thuan, Nguyen Thi Quynh Trang, Nguyen Thuy Duong, Nguyen Thi Thanh Hai, Pham Thi Minh Hue

引用次数: 0

Evaluation of Antioxidant Activity, Total Phenolic Content, and Total Flavonoid Content of the Aerial Part of Canna edulis Ker Gawl. Canna edulis Ker Gawl草本植物抗氧化活性、总酚含量和总黄酮类化合物含量的评估。

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-12-24 DOI: 10.25073/2588-1132/vnumps.4553

Nguyen Thi Van Anh, Bui Thanh Tung, Le Hong Luyen

{"title":"Evaluation of Antioxidant Activity, Total Phenolic Content, and Total Flavonoid Content of the Aerial Part of Canna edulis Ker Gawl.","authors":"Nguyen Thi Van Anh, Bui Thanh Tung, Le Hong Luyen","doi":"10.25073/2588-1132/vnumps.4553","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4553","url":null,"abstract":"Canna edulis Ker Gawl. (CE) is an important agricultural plant in Vietnam. The whole plant is traditionally used to treat many different diseases. However, scientific evidence on the pharmacological effects and chemical composition of this plant is limited and focuses mainly on the roots. This study aimed to evaluate the antioxidant activity and quantify the total phenolic and flavonoid content of extracts from the aerial part of CE. The in vitro antioxidant effect was evaluated by DPPH and ABTS free radical scavenging methods. Total phenolic content was evaluated with the Folin-Ciocalteu reagent, and total flavonoid content was evaluated by the aluminum chloride colorimetric method. The results showed that the ethyl acetate fraction had the most antioxidant activity with the IC50 values for DPPH and ABTS of 103.73 ± 9.80 and 76.52 ± 3.57 µg/mL, respectively. In addition, the ethyl acetate fraction contained the highest total phenolic and total flavonoid content with values of 70.93 ± 7.18 mg GAE/g extract and 64.93 ± 5.75 mg QE/g extract, respectively. Therefore, the aerial part of CE, especially the ethyl acetate fraction, is a potential plant source for the investigation of antioxidant compounds. Keywords: Canna edulis, antioxidant, flavonoids, phenolic, DPPH, ABTS.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"1975 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of the Research System Cost-effectiveness of Emicizumab in Preventing Bleeding for People with Hemophilia A 埃米珠单抗预防 A 型血友病患者出血的研究系统成本效益概述

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-12-24 DOI: 10.25073/2588-1132/vnumps.4557

Ha Van Thuy, Tran Thi Thu Thu, Nguyen Ngoc Nghia, Bui Thi Xuan

{"title":"Overview of the Research System Cost-effectiveness of Emicizumab in Preventing Bleeding for People with Hemophilia A","authors":"Ha Van Thuy, Tran Thi Thu Thu, Nguyen Ngoc Nghia, Bui Thi Xuan","doi":"10.25073/2588-1132/vnumps.4557","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4557","url":null,"abstract":"Systematic review research helps provide more scientific evidence for doctors in drug use as well as policymakers for safe, rational, and effective drug use. Emicizumab was first approved by the FDA in 2017 for patients with congenital hemophilia A and was later approved for prophylaxis. However, the high cost of Emicizumab treatment makes it difficult for patients to access the drug as well as pay for this by the insurance fund. A systematic review of studies on Emicizumab in the world that meets the conditions inclusion and exclusion criteria shows that 7 out of 8 studies (accounting for 87.5%) showed results that helped reduce total costs and increase treatment effectiveness compared to the placebo or alternatives. One study (accounting for 12.5%) resulted in increased total costs and reduced effectiveness compared to the intervention substance. Of these seven studies, one study achieved cost-effectiveness, three studies did not achieve cost-effectiveness (because ICER was lower than the willingness-to-pay threshold), and three studies could not be concluded as to whether they achieved cost-effectiveness. Keywords: Systematic review, cost, effectiveness, Emicizumab, Hemophilia A.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"250 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stigma, Help-seeking and Factors Associated with Mental Health Literacy in Adults: A Literature Review 成见、求助以及与成人心理健康素养相关的因素：文献综述

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-12-24 DOI: 10.25073/2588-1132/vnumps.4561

Nguyen Xuan Bach, Nguyen Ngoc Bich, Dang Hoang Anh

{"title":"Stigma, Help-seeking and Factors Associated with Mental Health Literacy in Adults: A Literature Review","authors":"Nguyen Xuan Bach, Nguyen Ngoc Bich, Dang Hoang Anh","doi":"10.25073/2588-1132/vnumps.4561","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4561","url":null,"abstract":"The article aims to review domestic and foreign research to provide information about the current condition of two of the three aspects of mental health literacy, namely stigma, and help-seeking, and the related factors to understand impact measures to help improve the adults' mental health literacy. This study uses a literature review method with English and Vietnamese keyword searching on PubMed and Vietnamese journals. Results show that stigma happens to be higher in Asian regions than in Australia, Europe, and America. Reducing stigma will improve treatment effectiveness and enhance the mental health literacy of individuals and communities. Regarding help-seeking, it shows that the rate of seeking help ranges from 28.2% to 76.9%. People with low mental health literacy are often less likely to seek help. Age, gender, education level, income, employment position, marital status, medical history, and alcohol use history are factors related to mental health literacy. Previous studies have shown that people with higher knowledge tend to seek help, while those with less stigma have a higher ability to seek help. Keywords: Related factors, mental health literacy, adults, stigma, help-seeking.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"360 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selection of Primer Location for qMSP Analysis of Alu Methylation Level in Vietnamese Patients with Breast Cancer 越南乳腺癌患者 Alu 甲基化水平 qMSP 分析引物位置的选择

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-12-24 DOI: 10.25073/2588-1132/vnumps.4536

Tran Thi Quynh Trang, Pham The Tung, Nguyen Thi Than, Vo Thi Thuong Lan

{"title":"Selection of Primer Location for qMSP Analysis of Alu Methylation Level in Vietnamese Patients with Breast Cancer","authors":"Tran Thi Quynh Trang, Pham The Tung, Nguyen Thi Than, Vo Thi Thuong Lan","doi":"10.25073/2588-1132/vnumps.4536","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4536","url":null,"abstract":"In the mammalian genome, DNA methylation occurs at the cytosine in CpG complexes. Changes in genomic DNA methylation status, reflected by the CpG methylation status of the retrotransposon Alu elements, are closely related to the initiation and development of cancer. Abnormalities in Alu methylation have been documented in many early-stage tumors where the Alu methylation level correlates with cellular malignancy. Therefore, the assessment of Alu methylation level as a biomarker for early diagnosis and prognosis has been of interest in many types of cancer. Our study aims to investigate the nucleotide positions on the CpG-rich sequence of Alu for the design of primers used for quantitative methylation-specific PCR reaction (qMSP). Using two primer pairs designed from the 5' Alu region for analysis of the Alu methylation level in 25 pairs of cancer/adjacent tissue samples of Vietnamese patients with breast cancer, we find out the primer pair that significantly distinguished the Alu methylation status between cancer and adjacent tissue samples. Selecting the right qMSP primer pair will facilitate the profiling of Alu methylation levels in breast cancer samples when compared with non-cancerous samples, thereby determining its potential in becoming an epigenetic marker for early diagnosis, prognosis as well as in supporting breast cancer treatment to be more effective in Vietnam. Keywords: Alu methylation, breast cancer, primers of qMSP.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"2011 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0