The Protective Effect of Ethyl Acetate Fraction and Bioactive Compounds of Mimosa pudica L. Leaves in Methylglyoxal-induced Glucotoxicity

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2024-01-20 DOI:10.25073/2588-1132/vnumps.4576

Pham Thi Lan, Pham Thi Nguyet Hang, Bui Thanh Tung

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Abstract

Mimosa pudica L. has been used as a traditional medicine to treat leprosy, dysentery, burning sensation, asthma, inflammation, fatigue, and blood diseases. The purpose of this study was to evaluate the ethyl acetate (EtOAc) fraction and two compounds protocatechuic acid and syringic acid of Mimosa pudica L. against methylglyoxal (MGO)- induced glucotoxicity. The inhibitory effects of EtOAc fraction and two compounds of Mimosa pudica L. on glucotoxicity in Human umbilical vein endothelial cells (HUVECs) and inhibit Advanced glycation end products (AGEs) formation and also breaking effects on MGO-AGEs were measured. Our results demonstrated that EtOAc fraction and two bioactive compounds protocatechuic acid and syringic acid of Mimosa pudica L. leaves inhibit MGO-induced AGEs formation, and break down MGO-AGEs, resulting in the reduction of glucotoxicity. EtOAc fraction and two bioactive compounds protocatechuic acid and syringic acid are promised in effective in preventing or treating MGO-induced endothelial dysfunction. Keywords: Advanced glycation end products (AGEs); Methylglyoxal (MGO); Human umbilical vein endothelial cells (HUVECs); Mimosa pudica L.; ethyl acetate fraction; protocatechuic acid; syringic acid. *

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含羞草叶乙酸乙酯馏分和生物活性化合物对甲基乙二醛诱导的葡萄糖毒性的保护作用

含羞草一直被用作治疗麻风病、痢疾、烧灼感、哮喘、炎症、疲劳和血液病的传统药物。本研究的目的是评估含羞草乙酸乙酯（EtOAc）馏分和两种化合物原儿茶酸和丁香酸对甲基乙二醛（MGO）诱导的葡萄糖毒性的抑制作用。测定了含羞草萃取物和两种化合物对人脐静脉内皮细胞（HUVECs）葡萄糖毒性的抑制作用、对高级糖化终产物（AGEs）形成的抑制作用以及对 MGO-AGEs 的破壁作用。结果表明，含羞草叶中的 EtOAc 部分和两种生物活性化合物原儿茶酸和丁香酸能抑制 MGO 诱导的 AGEs 形成，并能分解 MGO-AGEs，从而降低葡萄糖毒性。EtOAc组分和两种生物活性化合物原儿茶酸和丁香酸有望有效预防或治疗MGO诱导的内皮功能障碍。关键词高级糖化终产物（AGEs）；甲基乙二醛（MGO）；人脐静脉内皮细胞（HUVECs）；含羞草；乙酸乙酯部分；原儿茶酸；丁香酸。 *

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VNU Journal of Science: Medical and Pharmaceutical Sciences

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