{"title":"小檗碱脂质体在外源性高脂血症动物模型中的体内评估","authors":"Duong Thi Thuan, Nguyen Thi Quynh Trang, Nguyen Thuy Duong, Nguyen Thi Thanh Hai, Pham Thi Minh Hue","doi":"10.25073/2588-1132/vnumps.4573","DOIUrl":null,"url":null,"abstract":"Berberine (BBR) is an alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects in the literature. In this study, the exogenous lipid-lowering effects of oral BBR-loaded liposomes were investigated in rats compared with free BBR within four weeks. The BBR-loaded liposomes at the daily oral dose of 25 mg BBR/kg of body weight in rats reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) by 22.34% (p>0.05), 43.93% (p<0.05), respectively. These values (TC and LDL-C) when rats were given BBR-loaded liposomes at the daily oral dose of 50 mg BBR/kg were 30.72% (p<0.05) and 42.77% (p<0.05) compared with those values of the untreated control group, respectively. Both doses of BBR-loaded liposomes have no signals in decreasing triglycerides. Keywords: Berberine, berberine-loaded liposomes, anti-hyperlipidemia, animal model.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"358 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vivo Evaluation of Berberine-loaded Liposomes in the Exogenous Hyperlipidemia Animal Model\",\"authors\":\"Duong Thi Thuan, Nguyen Thi Quynh Trang, Nguyen Thuy Duong, Nguyen Thi Thanh Hai, Pham Thi Minh Hue\",\"doi\":\"10.25073/2588-1132/vnumps.4573\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Berberine (BBR) is an alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects in the literature. In this study, the exogenous lipid-lowering effects of oral BBR-loaded liposomes were investigated in rats compared with free BBR within four weeks. The BBR-loaded liposomes at the daily oral dose of 25 mg BBR/kg of body weight in rats reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) by 22.34% (p>0.05), 43.93% (p<0.05), respectively. These values (TC and LDL-C) when rats were given BBR-loaded liposomes at the daily oral dose of 50 mg BBR/kg were 30.72% (p<0.05) and 42.77% (p<0.05) compared with those values of the untreated control group, respectively. Both doses of BBR-loaded liposomes have no signals in decreasing triglycerides. Keywords: Berberine, berberine-loaded liposomes, anti-hyperlipidemia, animal model.\",\"PeriodicalId\":23520,\"journal\":{\"name\":\"VNU Journal of Science: Medical and Pharmaceutical Sciences\",\"volume\":\"358 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"VNU Journal of Science: Medical and Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25073/2588-1132/vnumps.4573\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"VNU Journal of Science: Medical and Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25073/2588-1132/vnumps.4573","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vivo Evaluation of Berberine-loaded Liposomes in the Exogenous Hyperlipidemia Animal Model
Berberine (BBR) is an alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects in the literature. In this study, the exogenous lipid-lowering effects of oral BBR-loaded liposomes were investigated in rats compared with free BBR within four weeks. The BBR-loaded liposomes at the daily oral dose of 25 mg BBR/kg of body weight in rats reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) by 22.34% (p>0.05), 43.93% (p<0.05), respectively. These values (TC and LDL-C) when rats were given BBR-loaded liposomes at the daily oral dose of 50 mg BBR/kg were 30.72% (p<0.05) and 42.77% (p<0.05) compared with those values of the untreated control group, respectively. Both doses of BBR-loaded liposomes have no signals in decreasing triglycerides. Keywords: Berberine, berberine-loaded liposomes, anti-hyperlipidemia, animal model.
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