Veterinary journal最新文献_第7页

Risk factors for antimicrobial usage and diseases in Dutch veal calf farms: A cross-sectional study 荷兰小牛养殖场使用抗菌剂和疾病的风险因素：横断面研究。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-11-08 DOI: 10.1016/j.tvjl.2024.106263

Panagiotis Mallioris , Effrosyni Kritsi , Peter Theeuwes , Jaap A. Wagenaar , Arjan Stegeman , Lapo Mughini-Gras

{"title":"Risk factors for antimicrobial usage and diseases in Dutch veal calf farms: A cross-sectional study","authors":"Panagiotis Mallioris , Effrosyni Kritsi , Peter Theeuwes , Jaap A. Wagenaar , Arjan Stegeman , Lapo Mughini-Gras","doi":"10.1016/j.tvjl.2024.106263","DOIUrl":"10.1016/j.tvjl.2024.106263","url":null,"abstract":"<div><div>Antimicrobial use <strong>(AMU)</strong> is the main driver of antimicrobial resistance <strong>(AMR)</strong>. In the Netherlands, the veal calf sector was among the largest consumers of antimicrobials in Defined Daily Doses Animal <strong>(DDDA)</strong> for the year of 2022. As preventive use in Dutch livestock farms is forbidden since 2011, most AMU is due to the herd health status which is affected by the farm environment in which the conditions for diseases to spread are created. The aim of this study was to determine which disease etiologies for group treatments are associated with AMU in rosé starter veal calves, and which modifiable technical risk factors on farm are associated with those diseases and with total AMU. Cross-sectional data were collected from 36 Dutch rosé starter veal calf farms in the Netherlands in 2021 using a digital survey. Linear regression analysis showed that the main indications for AMU were respiratory infections, for which mainly tetracyclines and macrolides were used. Partial least squares regression analysis <strong>(PLS)</strong> revealed 13 on-farm practices associated with the number of group treatments for respiratory diseases and 19 with total AMU. Overlapping variables in both PLS models were related to regrouping of calves, micro-climate conditions, water access and weaning strategies. Overall, these features focused on improving animal welfare and nutrition during production and enhancing a farm’s internal and external biosecurity. This study identified opportunities for reducing AMU in rosé starter veal calf farms, which thereby could contribute to limiting AMR emergence and spread.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106263"},"PeriodicalIF":2.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of a mouse polyclonal antibody against the truncated ORFV113 recombinant protein of Orf virus 针对截短的 Orf 病毒 ORFV113 重组蛋白的小鼠多克隆抗体的制备与表征。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-11-07 DOI: 10.1016/j.tvjl.2024.106265

Shaobo Liang, Qinqin Long, Feng Pang

{"title":"Preparation and characterization of a mouse polyclonal antibody against the truncated ORFV113 recombinant protein of Orf virus","authors":"Shaobo Liang, Qinqin Long, Feng Pang","doi":"10.1016/j.tvjl.2024.106265","DOIUrl":"10.1016/j.tvjl.2024.106265","url":null,"abstract":"<div><div>Orf is a contagious zoonotic disease caused by Orf virus (ORFV), posing a threat to both animal and human health. The ORFV113 gene, located in the terminal variable region of the ORFV genome, has been demonstrated as a significant virulence gene, but its function remains largely unknown. In the study, we first amplified the truncated version of the ORFV113 gene (ORFV113t) by removing its transmembrane domain at the 5′ end. We then constructed the pET-32a-ORFV113t recombinant plasmid and expressed the truncated ORFV113 recombinant protein in <em>Escherichia coli</em> (<em>E.coli</em>). The purified ORFV113t fusion protein was used to immunize mice and generate a polyclonal antibody. This polyclonal antibody was subsequently used to detect the expression and subcellular localization of the ORFV113 protein. Additionally, virus neutralization test was utilized to determine the neutralizing titer of the polyclonal antibody. The results demonstrated that we successfully expressed the ORFV113t recombinant protein in a prokaryotic expression system and generated a mouse-derived polyclonal antibody targeting the ORFV113t recombinant protein with a titer of 1:204,800. This antibody exhibited specificity for detecting the ORFV113 protein expressed in both prokaryotic and eukaryotic cells. The ORFV113 protein was found to be localized in the cytoplasm of infected Lamb testis (LT) cells. Notably, the polyclonal antibody demonstrated neutralizing activity against ORFV in vitro, with a neutralizing titer of 1:32. The prepared mouse anti-ORFV113t protein polyclonal antibody can be utilized for further study on potential functions of the ORFV113 protein in viral pathogenesis.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106265"},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines ERK和Akt通路抑制剂在犬组织细胞肉瘤细胞系中的抗肿瘤作用。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-11-04 DOI: 10.1016/j.tvjl.2024.106264

H. Sakuma , H. Tomiyasu , A. Tani , Y. Goto-Koshino , H. Tani , K. Ohno , H. Tsujimoto , M. Bonkobara , M. Okuda

{"title":"Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines","authors":"H. Sakuma , H. Tomiyasu , A. Tani , Y. Goto-Koshino , H. Tani , K. Ohno , H. Tsujimoto , M. Bonkobara , M. Okuda","doi":"10.1016/j.tvjl.2024.106264","DOIUrl":"10.1016/j.tvjl.2024.106264","url":null,"abstract":"<div><div>Canine histiocytic sarcoma (CHS) is characterized by aggressive biological behavior. In our previous study, ERK and Akt pathways were found to be activated in CHS tissues. Thus, the objective of this study was set to investigate the relationships between the activation status of these pathways and the proliferation of CHS cell lines by examining the effects of single and co-administrations of drugs targeting these pathways. First, we evaluated the changes in cell proliferations and the activations of ERK and Akt pathways after treatments with ERK and Akt-specific inhibitors in CHS cells. Then, these changes after treatments with dasatinib and trametinib were also examined in CHS cells. Inhibitors specific to ERK and Akt pathways successfully inhibited the respective pathways in CHS cell lines. It was also indicated that these pathways were associated with the regulations of proliferations of CHS cells, although the anti-proliferative effect was not necessarily observed by inhibition of Akt pathway alone. Dasatinib and trametinib also showed the inhibitions of Akt and ERK pathway activations, respectively, in CHS cells. However, the anti-proliferative effects of these drugs varied among CHS cell lines, and co-administration showed enhanced anti-proliferative effects in only a part of CHS cell lines. Further studies are needed to investigate the molecular mechanisms associated with the sensitivities to these molecular-targeted drugs in CHS cells.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106264"},"PeriodicalIF":2.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary Cystatin B as a marker of acute kidney injury in cats 作为猫急性肾损伤标志物的尿胱抑素 B。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-30 DOI: 10.1016/j.tvjl.2024.106262

Hilla Chen , Yochai Avital , Sarah Peterson , Zenhwa Ouyang , Murthy Yerramilli , Itamar Aroch , Gilad Segev

{"title":"Urinary Cystatin B as a marker of acute kidney injury in cats","authors":"Hilla Chen , Yochai Avital , Sarah Peterson , Zenhwa Ouyang , Murthy Yerramilli , Itamar Aroch , Gilad Segev","doi":"10.1016/j.tvjl.2024.106262","DOIUrl":"10.1016/j.tvjl.2024.106262","url":null,"abstract":"<div><div>Diagnosing acute kidney injury (AKI) might be challenging due to lack of sensitive early markers. The objective of this study was to evaluate the diagnostic and prognostic utility of the urinary biomarker Cystatin B (uCysB) in cats with AKI. Seventy-six client-owned cats were included. Urine samples of healthy cats and cats with various urinary tract disease including urethral obstruction (UO), chronic kidney disease (CKD) and AKI, were collected. uCysB concentration was measured using a research sandwich format ELISA at IDEXX Laboratories, Inc. uCysB was different among groups (<em>P</em> <0.001). uCysB was higher in the AKI (<em>P</em> <0.001) and CKD (<em>P</em> =0.006) groups compared with controls [1052 ng/mL (range, 7–3858) and 112 ng/mL (range, 14–1370) vs. 22 ng/mL (range, 11–154), respectively]. Cats with AKI had higher uCysB compared with cats with CKD (<em>P</em> =0.001) or UO (<em>P</em> =0.004). Receiver operator characteristic curve (ROC) analysis of uCysB as an AKI predictor vs. controls had an area under the curve (AUC) of 0.92 (95 % CI, 0.84–1.0). An 84 ng/mL cutoff point corresponded to sensitivity and specificity of 90 % and 92 %, respectively. uCysB concentration was higher in AKI non-survivors compared with survivors (1572 ng/mL, range, 140–3858 vs. 584 ng/mL, range, 7–2803 respectively; <em>P</em> =0.004). ROC analysis of uCysB as an AKI outcome predictor had an AUC of 0.84 (95 % CI, 0.56–1.0), with an optimal cut-off point of 469 ng/mL, corresponding to sensitivity and specificity of 100 % and 75 % respectively. In conclusion, uCysB is a useful diagnostic and prognostic marker of AKI in cats.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106262"},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibody development and antigenic epitope identification of infectious bursal disease virus VP5 传染性法氏囊病病毒 VP5 的单克隆抗体开发和抗原表位鉴定。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-29 DOI: 10.1016/j.tvjl.2024.106254

Jinze Han , Xinxin Niu , Chengfei Ge , Ziwen Wu , Guodong Wang , Mengmeng Huang , Yulong Zhang , Runhang Liu , Mengmeng Xu , Hangbo Yu , Jingzhe Han , Suyan Wang , Yongzhen Liu , Yuntong Chen , Hongyu Cui , Yanping Zhang , Yulu Duan , Xiaomei Wang , Liuan Li , Yulong Gao , Xiaole Qi

{"title":"Monoclonal antibody development and antigenic epitope identification of infectious bursal disease virus VP5","authors":"Jinze Han , Xinxin Niu , Chengfei Ge , Ziwen Wu , Guodong Wang , Mengmeng Huang , Yulong Zhang , Runhang Liu , Mengmeng Xu , Hangbo Yu , Jingzhe Han , Suyan Wang , Yongzhen Liu , Yuntong Chen , Hongyu Cui , Yanping Zhang , Yulu Duan , Xiaomei Wang , Liuan Li , Yulong Gao , Xiaole Qi","doi":"10.1016/j.tvjl.2024.106254","DOIUrl":"10.1016/j.tvjl.2024.106254","url":null,"abstract":"<div><div>Infectious bursal disease (IBD) is an important immunosuppressive disease affecting chickens and is caused by infectious bursal disease virus (IBDV) infection. VP5 is a non-essential protein for IBDV replication but plays a critical role in IBDV pathogenesis. A deeper understanding of the biological functions of VP5 is lacking. This study utilized a prokaryotic system to express and purify soluble VP5 from the dominant epidemic strain of IBDV and developed a hybridoma cell line capable of secreting IBDV VP5 monoclonal antibody (MAb). The VP5 MAb demonstrated strong specificity for IBDV VP5 and could effectively discriminate between IBDV and its VP5-deleted strain. Furthermore, the antigen epitope of 137RRDLPKPE145 from IBDV VP5 was identified, which is the first detailed report of an IBDV VP5 antigen epitope. This antigen epitope, which is located at the C-terminus of VP5, is conserved across various IBDV serotype 1 strains. The findings of this study offer valuable insights for further exploration of gene function and differential detection of VP5.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106254"},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of respiratory signal analysis to assess severity of Brachycephalic Obstructive Airway Syndrome (BOAS) in dogs 利用呼吸信号分析评估犬类 "脑性气道阻塞综合征"（BOAS）的严重程度。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-28 DOI: 10.1016/j.tvjl.2024.106261

M. Dimopoulou , H. Peterson , O. Stensöta , M. Karlsteen , I. Ljungvall , J. Rydén , E. Skiöldebrand

{"title":"Use of respiratory signal analysis to assess severity of Brachycephalic Obstructive Airway Syndrome (BOAS) in dogs","authors":"M. Dimopoulou , H. Peterson , O. Stensöta , M. Karlsteen , I. Ljungvall , J. Rydén , E. Skiöldebrand","doi":"10.1016/j.tvjl.2024.106261","DOIUrl":"10.1016/j.tvjl.2024.106261","url":null,"abstract":"<div><div>Brachycephalic Obstructive Airway Syndrome (BOAS) is a potentially life-threatening condition that can be challenging to diagnose and grade objectively. The aim of this study was to investigate the use of respiratory signal analysis to assess severity of BOAS in dogs. Hundred and seventeen client-owned dogs of brachycephalic and non-brachycephalic breeds were enrolled. Respiratory sounds were recorded using an electronic stethoscope before and after a 3-minute exercise test (ET). Dogs were assigned a BOAS severity grade (BOAS 0–3) using a validated respiratory functional grading scheme. Signal analysis techniques were used to identify seven sound variables. Analysis of variance (ANOVA) was used to investigate associations between variables and BOAS severity and receiver operating characteristic (ROC) curves to assess the diagnostic efficacy of each sound variable. For each sound variable, there was a significant association with BOAS grade. An increase in BOAS grade resulted in greater sound magnitude in the frequency spectrum (0–1000 Hz), and in a greater contribution of lower frequencies (170–260 Hz). The variable “Peak 1” had the best performance in predicting BOAS negative (BOAS 0 +1) versus BOAS positive dogs (BOAS 2 + 3) before the ET; area under the curve (AUC) = 76.6 % (95 % confidence interval 67.4–85.8 %), whereas the variable “Valley 1” had the highest predictive value after the ET; AUC = 87.8 % (95 % confidence interval 81.4–94.3 %). Respiratory signal analysis has good potential for assessing BOAS severity and could be valuable for clinicians in clinical decision processes and for breeders when selecting suitable breeding dogs.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106261"},"PeriodicalIF":2.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic profile of prepartum dairy cows and its influence on the immediate postpartum period, colostrum quality and passive immunity transference 产前奶牛的代谢特征及其对产后初期、初乳质量和被动免疫转移的影响

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-26 DOI: 10.1016/j.tvjl.2024.106260

D.A.C. Hoffmann , M. Furtado , L.F. Bragança , G. de M. Araujo , F. Moreira , V.R. Rabassa , J.O. Feijó , M.N. Corrêa , V. Peripolli , E. Schwegler

{"title":"Metabolic profile of prepartum dairy cows and its influence on the immediate postpartum period, colostrum quality and passive immunity transference","authors":"D.A.C. Hoffmann , M. Furtado , L.F. Bragança , G. de M. Araujo , F. Moreira , V.R. Rabassa , J.O. Feijó , M.N. Corrêa , V. Peripolli , E. Schwegler","doi":"10.1016/j.tvjl.2024.106260","DOIUrl":"10.1016/j.tvjl.2024.106260","url":null,"abstract":"<div><div>The objective of this study was to evaluate which biochemical markers in the prepartum period of dairy cows influence the immediate postpartum period, the quality of colostrum, and the passive immunity transference in the calves. The experiment was performed on a commercial dairy farm with 52 pregnant multiparous Holstein cows. Animals that gave birth to twins or males were discarded from the experiment. On days −20 of the expected calving date and 24 hours after calving, blood collections, body condition score assessments, and animals weighing were performed. Blood samples from calves were performed 24 hours after colostrum intake. Calf plasma was used to estimate the passive immunity transfer by % brix and total plasma proteins (TPP). In the principal component analysis, it was shown that postpartum NEFA and BHBA was higher in cows with higher prepartum urinary pH and Ca lower prepartum. The cows with the highest NEFA and BHBA in pre and postpartum were the ones that had the lowest % brix in the colostrum. The % brix of the cow’s colostrum directly influenced the % brix and TPP of the calves. The NEFA in the cows prepartum negatively influenced the markers of immunity, the higher the NEFA, the lower the % brix of the cows’ colostrum, % brix of the calves, and TPP. In multivariate regression analyses it was shown that pre-calving NEFA was the marker that most influenced post-calving cow markers and calf % brix, along with colostrum time and % brix of the colostrum (P= 0.0092; r<sup>2</sup>= 0.83). Cows with higher values NEFA in the prepartum had lower calcemic in the immediate postpartum period. Prepartum NEFA was the marker that most influenced the cows’ immediate postpartum period, being directly related to Ca serum, and also to the passive immunity transference.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106260"},"PeriodicalIF":2.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A first step towards objective grading of equine laryngeal function 马喉功能客观分级的第一步。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-26 DOI: 10.1016/j.tvjl.2024.106259

Josephine Hardwick , Benjamin Ahern , Samantha Franklin

{"title":"A first step towards objective grading of equine laryngeal function","authors":"Josephine Hardwick , Benjamin Ahern , Samantha Franklin","doi":"10.1016/j.tvjl.2024.106259","DOIUrl":"10.1016/j.tvjl.2024.106259","url":null,"abstract":"<div><div>Due to concerns about disagreement between veterinarians when grading resting laryngeal function (LF), a diagnostic decision tree (DDT) has been developed by codifying the Havemeyer grading system and objectively defining certain terms to remove ambiguity. Videoendoscopic examinations of the equine larynx that had previously been assigned a unanimous LF grade by 3 experienced observers were used to develop the DDT and determine the cut-off values.</div><div>The DDT is a flow chart consisting of a series of dichotomous (yes/no) decisions, to dictate the order of decision making and direct the observer down a pathway towards the most appropriate LF grade. To use the DDT, the observer must know the frame rate of the video and use frame-by-frame video playback when reviewing the videos. The first decision involves determining if full left arytenoid cartilage (LAC) abduction is achieved (≤ grade III.1), or not achieved (> grade III.1). Maintained full LAC abduction (≤ grade II.2) is defined as maintenance of full abduction for ≥ 0.2 seconds. Full LAC abduction that is achieved but not maintained (grade III.1) is defined as maintenance of full abduction for < 0.2 seconds. Arytenoid abductor deficit is categorized into left arytenoid abduction ≥45° from vertical midline (grade III.2) and <45° abduction (grade III.3). The DDT could be used as a first step towards computer assisted laryngeal function grading.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106259"},"PeriodicalIF":2.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic factors of equine osteochondrosis and fetlock osteochondral fragments: A scoping review - Part 2 马骨软骨病和蹄骨软骨碎片的遗传因素：范围综述 - 第二部分。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-22 DOI: 10.1016/j.tvjl.2024.106258

B. Van Mol , S. Janssens , M. Oosterlinck , F. Pille , N. Buys

{"title":"Genetic factors of equine osteochondrosis and fetlock osteochondral fragments: A scoping review - Part 2","authors":"B. Van Mol , S. Janssens , M. Oosterlinck , F. Pille , N. Buys","doi":"10.1016/j.tvjl.2024.106258","DOIUrl":"10.1016/j.tvjl.2024.106258","url":null,"abstract":"<div><div>Equine osteochondrosis and osteochondral fragments in the fetlock joint are linked to various environmental and genetic risk factors. To assess the scope of the literature linking these risk factors to the development of these osteochondral disorders, while identifying knowledge gaps and challenges to guide future research, a scoping review was performed. This article constitutes the second part of this scoping review and focuses on genetic factors, with the first part addressing environmental factors. To identify potentially relevant papers, online bibliographical databases PubMed and Web of Science were utilised, supplemented with articles listed on the OMIA website (OMIA:000750–9796). After collecting entries, removing duplicates, screening titles, abstracts, and full-text documents for eligibility, and manually searching reference lists of the remaining articles, a total of 212 studies were identified for this scoping review. First, a brief overview of the etiopathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint is provided. Subsequently, this article delves into the genetic aspects by presenting an overview of significantly associated quantitative trait loci and potential candidate genes. Next, the challenges in both phenotypic and genomic selection against these osteochondral disorders are discussed, with a focus on the difficulties in phenotyping, the establishment of large and representative reference populations, publication bias, lesion-specific heritabilities, and studbook policies. In conclusion, while there is considerable potential to implement preventive measures that can alleviate the economic burden and enhance animal welfare, further research is necessary. This research should utilize precise and standardized phenotype definitions applied across studies with preferably larger populations.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106258"},"PeriodicalIF":2.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does cranial cruciate ligament repair by tibial plateau leveling osteotomy surgery restore dog’s natural kinematics? – A case series 通过胫骨平台平整截骨手术修复颅交叉韧带是否能恢复狗的自然运动学？- 病例系列。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-10-18 DOI: 10.1016/j.tvjl.2024.106257

Paul G. Arauz , Patricio Chiriboga , Verónica Garcés , Gabriela Garcia , Imin Kao

{"title":"Does cranial cruciate ligament repair by tibial plateau leveling osteotomy surgery restore dog’s natural kinematics? – A case series","authors":"Paul G. Arauz , Patricio Chiriboga , Verónica Garcés , Gabriela Garcia , Imin Kao","doi":"10.1016/j.tvjl.2024.106257","DOIUrl":"10.1016/j.tvjl.2024.106257","url":null,"abstract":"<div><div>Tibial plateau leveling osteotomy (TPLO) serves as an effective method of functional stabilization for treating cranial cruciate ligament (CrCL) deficiency. It is not clear if TPLO could restore the natural kinematics of the stifle, hip, and tarsal joints of the affected limb during walking. The hind limb motion between TPLO cases and control groups in eight adult dogs (4 French Bulldogs and 4 Pit Bull Terrier) was recorded by a motion capture system. Three-dimensional (3D) angular motions of the hip, stifle, and tarsal joints—including flexion-extension, abduction-adduction, and rotations—were computed and compared. Significant differences in joint kinematics were observed between TPLO cases and controls. In Case 1, the TPLO case in the French Bulldog showed differences in hip, stifle, and tarsal flexion-extension, abduction-adduction, and internal-external rotation. Asymmetries between affected and unaffected limbs were also detected in hip and stifle motions (up to 43° in some cases). Similar patterns of differences were found in Pit Bull Terriers Case 2 and Case 3, with significant variations in hip, stifle, and tarsal movements. Case 3 did not show hip asymmetries, but notable stifle and tarsal asymmetries were observed. The general daily activity performance for French Bulldogs and Pit Bull Terriers that underwent TPLO procedures was positive. The general daily restricted activity performance for the French Bulldog and Pit Bull Terriers that underwent TPLO procedures was positive. Our findings suggested that natural hind limb kinematics during gait was not restored in TPLO hind limb cases in both breeds.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106257"},"PeriodicalIF":2.3,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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