Vnitrni lekarstvi最新文献_第5页

News in gastroenterology, hepatology and digestive endoscopy. 胃肠病学、肝病学和消化内窥镜新闻。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.034

Přemysl Falt, Dana Uricová, Tomáš Fejfar, Štěpán Šembera, Ilja Tachecí

引用次数: 0

Successful treatment of SAPHO syndrome (chronic nonbacterial osteomyelitis and acne) with anakinra and denosumab. Case report and review of therapy. anakinra和denosumab成功治疗SAPHO综合征（慢性非细菌性骨髓炎和痤疮）。病例报告和治疗回顾。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.065

Zdeněk Adam, Anna Šedivá, David Zeman, Zdeněk Fojtík, Hana Petrášová, Jana Diatková, Miroslav Tomíška, Zdeněk Král, Jana Treglerová, Vojtěch Peřina, Kateřina Kamaradová, Zdenka Adamová, Luděk Pour

{"title":"Successful treatment of SAPHO syndrome (chronic nonbacterial osteomyelitis and acne) with anakinra and denosumab. Case report and review of therapy.","authors":"Zdeněk Adam, Anna Šedivá, David Zeman, Zdeněk Fojtík, Hana Petrášová, Jana Diatková, Miroslav Tomíška, Zdeněk Král, Jana Treglerová, Vojtěch Peřina, Kateřina Kamaradová, Zdenka Adamová, Luděk Pour","doi":"10.36290/vnl.2023.065","DOIUrl":"10.36290/vnl.2023.065","url":null,"abstract":"SAPHO is an acronym derived from capital letters of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO). SAPHO syndrome is an umbrella term covering a constellation of bone lesions and skin manifestations. A 40-year-old male complained about his jaw and back pain, swelling of multiple joints and weight loss accompanied by physical deterioration and acne type skin lesions. Laboratory tests revealed abnormal elevation of inflammatory markers. Imaging studies illustrated multiple osteolytic bone lesions and paraosseal infiltrates. According to the set of criteria diagnosis of SAPHO syndrome was stated. The patient was treated with glucocorticoids and non-steroidal anti-inflammatory drugs (NSAIDs), but only high dose dexamethasone and prednisone were effective. Daily subcutaneous administration of anakinra at the dose of 100 mg was initiated due to limited response to more classical therapies. Because of planned mandibular osteosynthesis initiation of denosumab was preferred before bisphosphonates. Therapeutic response was confirmed by FDG-PET/MR after 5 months of anakinra and denosumab therapy, showing decreased accumulation of FDG in periosteal and paraosseal infiltrates. Inflammatory markers significantly decreased, bone pain deferred but skin manifestation receded only partially. Therefore the response was evaluated as partial remission.","PeriodicalId":23501,"journal":{"name":"Vnitrni lekarstvi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41214155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological profile of mepolizumab. 美波利珠单抗的药理学概况。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.063

Norbert Pauk

引用次数: 0

Severe autoimune thyreotoxicosis complicated by febrile neutropenia as a result of thyreostatic therapy. 严重的自身免疫性甲状腺毒症并发发热性中性粒细胞减少症，这是甲状腺激素治疗的结果。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.024

Marie Jarolímová, Michal Kazmíř

引用次数: 0

New perspectives in the treatment of chronic heart failure. 治疗慢性心力衰竭的新视角。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.015

Barbora Nussbaumerová

引用次数: 0

News in diagnostics and treament of cardiomyopathies. 心肌病诊断和治疗方面的新闻。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.016

Hana Poloczková, Tomáš Honek, Anna Chaloupka, Lukáš Opatřil, Mária Bakošová, Jan Krejčí

{"title":"News in diagnostics and treament of cardiomyopathies.","authors":"Hana Poloczková, Tomáš Honek, Anna Chaloupka, Lukáš Opatřil, Mária Bakošová, Jan Krejčí","doi":"10.36290/vnl.2023.016","DOIUrl":"10.36290/vnl.2023.016","url":null,"abstract":"Cardiomyopathies are defined as myocardial disorders in which the heart muscle is structurally and functionaly abnormal in the absence of a disease sufficient to cause this abnormality such as coronary artery disease, hypertension, valvular or congenital heart disease. According to the phenotype expresion cardiomyopathies are divided into dilated, hypertrophic, restrictive, arrhytmogenic and unclassified cardiomyopathies (noncompaction and tako-tsubo cardiomyopathy). The same phenotypic expression may include etiologically different forms of the disease, and at the same time phenotypic expression may change in many cardiomyopathies in the course of illness. For each type of cardiomyopathy, we further distinguish the familial (genetic) form and the acquired form. The clinical manifestation of the disease includes symptoms of heart failure, with reduced, mildly reduced or preserved ejection fraction, symptoms resulting from a number of arrhythmias and extracardiac symptoms, but in some cases symptoms may not be presented for a relatively long time. The disease can lead to significant morbidity and mortality if not detected and treated early, especially in young people who are frequently affected. Significant developments in diagnostic and treatment methods have led to an improvement in the prognosis of patients with cardiomyopathies in recent years.","PeriodicalId":23501,"journal":{"name":"Vnitrni lekarstvi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive cardiology: Quo vadis? 预防心脏病学：库瓦迪斯？

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.014

Hana Rosolová

引用次数: 0

Comparison of polypharmacy and pharmacotherapy among seniors in social institutions in 2001 and 2019. 2001 年和 2019 年社会养老机构中老年人的多药治疗和药物治疗情况比较。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.022

Ivan Bartošovič, Ivana Ivánková Bartošovičová, Katarína Zrubáková, Peter Mikus, Róbert Ochaba, Irina Goljerová

{"title":"Comparison of polypharmacy and pharmacotherapy among seniors in social institutions in 2001 and 2019.","authors":"Ivan Bartošovič, Ivana Ivánková Bartošovičová, Katarína Zrubáková, Peter Mikus, Róbert Ochaba, Irina Goljerová","doi":"10.36290/vnl.2023.022","DOIUrl":"10.36290/vnl.2023.022","url":null,"abstract":"Introduction: Polypharmacy (polypharmacotherapy) is a serious problem among seniors. The aim of the work was to compare pharmacotherapy and polypharmacy among seniors in social facilities in 2001 and 2019.Methodology: As of December 31, 2001, we collected data on the pharmacotherapy of 151 residents of two retirement homes (average age 75.1 years, 68.9% women). We compared the results with the pharmacotherapy of residents of two facilities for seniors as of October 31, 2019 (237 seniors, average age 80.5 years, 73.4% women). According to the medical records, we determined and compared the regularly used medicines of all residents, the use of medicines by age and sex, the use of 0-4 medicines, 5-9 medicines, 5 or more medicines, 10 or more medicines and the groups of medicines according to the ATC classification. For statistical processing, we used the t-test and chi-square test.Results: In 2001, residents regularly used a total of 891 medicines, 18 years later, they used a total of 2099 medicines. We observed a significant increase in the average number of regularly used medications per resident by more than a half (from 5.90 medications to 8.86 medications), in women from 6.11 drugs to 9.24 drugs and in men from 5.45 drugs to 7.81 drugs. The number of residents with polypharmacy (regular use of ≥ 5 drugs) increased by almost a quarter (from 70.2% to 87.3%), and the number of seniors with excessive polypharmacy (regular use of ≥ 10 drugs) increased 4.6 times (from 9, 3% to 43.5%).Conclusion: Our work confirmed that over the course of 18 years, the number of medications used by seniors in social-type institutions has increased. It also points to the trend of increasing polypharmacy and excessive polypharmacy among seniors, especially at the age of 75+ and among women.","PeriodicalId":23501,"journal":{"name":"Vnitrni lekarstvi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9772177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histamine intolerance. 组胺不耐症

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.005

Roman Hakl, Jiří Litzman

引用次数: 0

Deep vein thrombosis - the role of ultrasound in the diagnosis and follow-up of patients. 深静脉血栓--超声波在诊断和随访患者中的作用。

Vnitrni lekarstvi Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.046

Tomáš Hauer

引用次数: 0