Pharmacological profile of mepolizumab.

Q4 Medicine
Norbert Pauk
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引用次数: 0

Abstract

An elevated number of eosinophils have been implicated in several type 2 inflammatory chronic diseases that occur at various sites in the body. Over the past 20 years, our knowledge of diseases associated with increased numbers of eosinophils has advanced thanks to the development of drugs that can reduce or even eliminate eosinophils. One such agent is mepolizumab, a humanized monoclonal antibody that binds to interleukin -5 (IL-5). This article briefly and clearly summarizes the pharmacological profile of mepolizumab and its current indications for a number of chronic eosinophilic diseases.

美波利珠单抗的药理学概况。
嗜酸性粒细胞数量的增加与发生在身体不同部位的几种2型炎症性慢性疾病有关。在过去的20年里,由于开发了可以减少甚至消除嗜酸性粒细胞的药物,我们对与嗜酸性粒增多相关的疾病的认识有所提高。其中一种药物是美波珠单抗,一种与白细胞介素-5(IL-5)结合的人源化单克隆抗体。本文简要而清晰地总结了美宝珠单抗的药理学特征及其目前对多种慢性嗜酸性粒细胞疾病的适应症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Vnitrni lekarstvi
Vnitrni lekarstvi Medicine-Internal Medicine
CiteScore
0.50
自引率
0.00%
发文量
104
期刊介绍: Vnitřní lékařství je tiskovým orgánem České internistické společnosti České lékařské společnosti Jana Evangelisty Purkyně a Slovenskej internistickej spoločnosti Slovenskej lekárskej spoločnosti. Je vydáván nepřetržitě od roku 1955. Časopis vychází jako měsíčník, tedy 12krát do roka a podle potřeby jsou v běžném ročníku vydávána jeho suplementa, která jsou obsahově zaměřena k určitému tématu. Tematicky je časopis zaměřen široce na oblast interní medicíny se zvláštní pozorností ke kardiologii, diabetologii a poruchám metabolizmu.
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