Value in health regional issues最新文献

{"title":"Validation of the Bangla Version of the HeartQoL Health-Related Quality-of-Life Questionnaire for Patients With Coronary Heart Disease in Bangladesh","authors":"Jamal Uddin MPH ,&nbsp;Sayed I. Alam MSc ,&nbsp;Graziella Zangger MSc ,&nbsp;Lau C. Thygesen PhD ,&nbsp;Md. Rezaul Karim MBBS ,&nbsp;Mohammad A. Rashid MPH ,&nbsp;Fazila-Tun-Nesa Malik MRCP ,&nbsp;Mir Ishraquzzaman MBBS ,&nbsp;Sheikh Mohammad M. Sobhan MPH ,&nbsp;Sohel R. Choudhury PhD ,&nbsp;Ann-Dorthe O. Zwisler MD, PhD ,&nbsp;Neil B. Oldridge PhD ,&nbsp;Rod S. Taylor PhD","doi":"10.1016/j.vhri.2025.101126","DOIUrl":"10.1016/j.vhri.2025.101126","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the psychometric properties of the Bangla version of the HeartQoL questionnaire, a core heart disease health-related quality-of-life (HRQoL) instrument, specifically in coronary heart disease (CHD) patients.</div></div><div><h3>Methods</h3><div>The English HeartQoL was translated into Bangla and then a cross-sectional and a test-retest study was undertaken in 2 specialized cardiac hospitals in Bangladesh. All patients admitted for percutaneous coronary intervention or coronary artery bypass graft between April and October 2019 and diagnosed with CHD were eligible for recruitment. The Bangla HeartQoL, EQ-5D-3L, PHQ-9, and GAD-7 questionnaires were administered before and after discharge. Factor structure, internal consistency, and construct validity of Bangla HeartQoL were assessed.</div></div><div><h3>Results</h3><div>A total of 945 patients with CHD were enrolled with a subgroup of 198 patients providing test-retest data. Mokken scale analysis supported the 2-factor structure (physical/mental subscales) of the HeartQoL Bangla questionnaire. Although no floor effects were observed, there was some evidence of a ceiling effect on the HeartQoL emotional subscale in 16.1% of patients. The Bangla HeartQoL questionnaire demonstrated satisfactory internal consistency (Cronbach’s alpha &gt; 0.75), discriminative validity (lower scores in patients with poorer health), and responsiveness to change (effect sizes of 0.23 to 0.68).</div></div><div><h3>Conclusions</h3><div>The Bangla HeartQoL questionnaire was found to be a valid, reliable, and responsive measure of HRQoL in CHD patients. However, future research is needed around its use, particularly in terms of its potential cultural sensitivity.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"49 ","pages":"Article 101126"},"PeriodicalIF":1.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical and Statistical Issues in the Randomized Controlled Trial Assessing Cost-Effectiveness of Olanzapine Versus Aprepitant","authors":"Manraj Singh Sra MBBS","doi":"10.1016/j.vhri.2025.101133","DOIUrl":"10.1016/j.vhri.2025.101133","url":null,"abstract":"","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101133"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply: Investment Case for Mental Health","authors":"Cyprian M. Mostert MSc, MM, MSP, PhD","doi":"10.1016/j.vhri.2025.101131","DOIUrl":"10.1016/j.vhri.2025.101131","url":null,"abstract":"","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101131"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Cross-Cultural Adaptation of Treatment Satisfaction Questionnaire for Medication Version 2 Among Older Adult Patients in Malaysia: A Psychometric Testing Study","authors":"Mohammad Adam Al Haqimy Mohammad Yunus MPharm ,&nbsp;Muhammad Eid Akkawi PhD","doi":"10.1016/j.vhri.2025.101128","DOIUrl":"10.1016/j.vhri.2025.101128","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the full psychometric testing of the translated Malay version of Treatment Satisfaction Questionnaire for Medication version 2 (TSQM v.2).</div></div><div><h3>Methods</h3><div>This is a cross-sectional study involving a convenience sample of 429 older adult patients at outpatient settings of a teaching hospital in Malaysia. All patients answered the Malay version (M-TSQM v.2). The instrument reliability was tested using Cronbach’s alpha and composite reliability. Content validity was assessed by a panel of experts, whereas convergent validity was tested using the average variance extracted values. Confirmatory factor analysis was used to determine factorial validity and subsequently construct validity.</div></div><div><h3>Results</h3><div>Cronbach’s α for all the domains in the M-TSQM v.2 yielded a value above 0.7, and all domains exhibit a composite reliability value above 0.6, which indicate a good internal consistency. The confirmatory factor analysis of the 11 items in the 4 domains demonstrated acceptable factor loading (≥0.6), confirming the 4-factor dimensionality. The applied hierarchical confirmatory factor analysis proved that the model was good fit based on the absolute, incremental, and parsimonious fitness indices.</div></div><div><h3>Conclusions</h3><div>The M-TSQM v.2 is a valid, reliable, and psychometrically sound instrument for assessing treatment satisfaction among Malay-speaking populations. Therefore, it could be utilized crucially to capture the trueness level of treatment satisfaction in Malaysian patients regardless of their morbidity status, given that it is a generic measurement tool.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"49 ","pages":"Article 101128"},"PeriodicalIF":1.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of the Experimental Version of EQ-5D-Y-5L Into Bahasa Indonesia","authors":"Titi S. Fitriana PhD ,&nbsp;Fredrick D. Purba PhD ,&nbsp;Elly Stolk PhD ,&nbsp;Jan J.V. Busschbach PhD","doi":"10.1016/j.vhri.2025.101121","DOIUrl":"10.1016/j.vhri.2025.101121","url":null,"abstract":"<div><h3>Objectives</h3><div>The EQ-5D-Y-5L has been developed to provide an appropriate version of EQ-5D for children. This article reports the EQ-5D-Y-5L adaptation process into Bahasa Indonesia.</div></div><div><h3>Methods</h3><div>Forward and backward translations were performed to produce equal qualifiers between EQ-5D-Y-5L English and Bahasa versions. Unresolved issues were addressed in a cognitive debriefing, conducted with 10 children aged 8 to 15. A linguist proofread the final stage of the translation.</div></div><div><h3>Results</h3><div>Differences were found in wordings, headings, font styles, and qualifiers in EQ-5D English versions that require consideration when translating the English version into other languages. Two issues arose: first, levels 1, 2, and 4 in EQ-5D-Y-5L Bahasa matched the levels 1, 2, and 3 of EQ-5D-Y-3L, rather than levels 1, 3, and 4, as is the case in the English versions. Second, the translated words for “pain” and “worried,” used in the other EQ-5D Bahasa, were difficult to comprehend. Hence, we replaced these words with alternative Bahasa words at the cost of breaking consistency between the EQ-5D-Y-3L and EQ-5D-Y-5L Bahasa. There was an indication that the extensive cognitive debriefing caused response fatigue in children.</div></div><div><h3>Conclusions</h3><div>The adaptation process resulted in a comprehensible EQ-5D-Y-5L Bahasa Indonesia for children aged 8 to 16. Our findings suggest a need to review the existing EQ-5D-Y-3L and EQ-5D-3L in Bahasa Indonesia. While awaiting this review, research related to these 2 measures should be interpreted with caution in the context of international comparisons. Furthermore, we propose consideration of a more user-friendly approach to cognitive debriefing tailored for children.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"49 ","pages":"Article 101121"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Costs of Myocardial Infarction in Denmark: A Nation-Wide Registry-Based Cohort Study","authors":"Kristoffer Jarlov Jensen PhD ,&nbsp;Jedidiah I. Morton PhD ,&nbsp;Marius Mølsted Flege MD ,&nbsp;Janne Petersen PhD ,&nbsp;Zanfina Ademi PhD","doi":"10.1016/j.vhri.2025.101125","DOIUrl":"10.1016/j.vhri.2025.101125","url":null,"abstract":"<div><h3>Objectives</h3><div>Myocardial infarction (MI) is highly detrimental and healthcare intensive with a high incidence globally. This study aimed to estimate the individual healthcare costs of MI in Denmark from a public health provider perspective.</div></div><div><h3>Methods</h3><div>In this nation-wide registry-based cohort study, individuals with incident MI between 2012 and 2016 were propensity score-matched 1:3 with non-MI controls. Excess costs were calculated as costs of patients with MI minus average costs of matched controls, accounting for all individual-level hospital contacts and treatment, primary care, and reimbursed prescription medicine, analyzed as acute or long-term costs in 6-month intervals during 4 years before and 4 years after the MI event. For acute costs and the first 6 months, data were available to extend the cohort period to include index year 2019.</div></div><div><h3>Results</h3><div>In total, 34 310 individuals with a first-time MI were matched to non-MI controls. The mean total acute healthcare cost of first-time MI was €11 462 (95% confidence interval: 11 313-11 612), and cost was €5966 (5788-6145) during the first 6 months, decreasing to €1696 (1565-1827) during the next 6 months. Females with MI incurred 26% lower acute costs and 20% lower excess costs during the first 6 months than males did but higher excess costs than males past 1 year. Costs were highest in people aged 60 to 79 and gradually decreased over the later study years.</div></div><div><h3>Conclusions</h3><div>We found that MI is associated with significant acute and long-term health care costs. With constant or slightly decreasing healthcare expenses on a background of a general decline in MI incidence rates, the total healthcare spendings on MI may decline in the years ahead.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101125"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admissions and Deaths Due to Heart Failure and Acute Myocardial Infarction in the State of Minas Gerais: Analysis of Time Series","authors":"Priscila R. Cintra ,&nbsp;Ryan R.O. de Paula ,&nbsp;Luiz O.O. Pala PhD ,&nbsp;Thelma Sáfadi PhD ,&nbsp;Luciano J. Pereira PhD","doi":"10.1016/j.vhri.2025.101123","DOIUrl":"10.1016/j.vhri.2025.101123","url":null,"abstract":"<div><h3>Objectives</h3><div>Cardiovascular diseases (CVDs) are responsible for nearly one-third of the deaths in Brazil. Time-series studies help evaluate the effectiveness of prevention strategies and assist in health planning. Therefore, the aim of this study was to conduct a retrospective temporal analysis, considering sex and comorbidities, of hospitalizations and deaths due to acute myocardial infarction (AMI) and heart failure (HF) among adults over 20 years of age in Minas Gerais from 2016 to 2022.</div></div><div><h3>Methods</h3><div>The data were obtained from the Hospital Information System of the Unified Health System. Seasonal Autoregressive Integrated Moving Average with Exogenous variables models were created to evaluate seasonal components and/or interventions in the time series of deaths.</div></div><div><h3>Results</h3><div>We recorded a total of 90 670 hospitalizations due to AMI, with a case fatality rate of 0.085, and 178 477 hospitalizations due to HF, with a case fatality rate of 0.100. Men predominantly experienced AMI, whereas women predominantly experienced HF. We found that winter periods correlated with an increase in hospitalizations due to AMI and HF. We observed that hospitalizations due to respiratory diseases were associated with a higher risk of CVD. During the pandemic, we observed a reduction in hospitalizations due to CVDs. In September 2020, we observed a significant increase in male deaths due to AMI. Among women, we found an inverse relationship between hospitalizations for AIDS and deaths from HF. Hospitalizations due to HF decreased over time, whereas those for AMI increased.</div></div><div><h3>Conclusions</h3><div>Respiratory diseases were associated with an increased risk of CVD. Winter periods showed an increase in hospitalizations for AMI and HF.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"49 ","pages":"Article 101123"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life in Children With Sickle Cell Anemia in Malaria-Endemic Regions: The Impact of Disease States and Malaria Prevention Strategies","authors":"Carol Kamya MPH ,&nbsp;Richard Idro MD, PhD ,&nbsp;Perez Ochanda MA ,&nbsp;Dennis Kalibbala MSc ,&nbsp;Thandile Nkosi-Gondwe PhD ,&nbsp;Pamela R. Akun MA ,&nbsp;Kamija S. Phiri PhD ,&nbsp;Feiko O ter Kuile PhD ,&nbsp;Oddvar Kaarboe PhD ,&nbsp;Bjarne Robberstad PhD","doi":"10.1016/j.vhri.2025.101120","DOIUrl":"10.1016/j.vhri.2025.101120","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the health-related quality of life (HRQoL) of children with sickle cell anemia (SCA) in Uganda and Malawi during steady disease states and sick attacks and to examine the impact of malaria chemoprevention with weekly dihydroartemisinin-piperaquine compared to monthly sulfadoxine-pyrimethamine.</div></div><div><h3>Methods</h3><div>This cohort study was nested within a clinical trial comparing weekly dihydroartemisinin-piperaquine with the standard of care (monthly sulfadoxine-pyrimethamine) among children with SCA. HRQoL was assessed using EQ-5D tools during steady states and sick attacks. Ordinary least squares regression identified factors associated with HRQoL.</div></div><div><h3>Results</h3><div>A total of 633 children with SCA were enrolled (mean age 8.1 years, standard deviation [SD] 3.7). HRQoL was higher during steady states but deteriorated during sick attacks, with the most problems reported in pain and discomfort. Older children (ages 12-16: mean difference [MD] = 0.09, <em>P</em> &lt; .0001) experienced higher HRQoL during steady states but lower HRQoL during sick attacks. Hospitalization negatively affected HRQoL; children hospitalized 1 to 3 times (MD = −0.27, <em>P</em> = .01) or ≥4 times (MD = −0.24, <em>P</em> = .02) had substantially lower HRQoL. There were no HRQoL differences between treatment arms.</div></div><div><h3>Conclusions</h3><div>The HRQoL of children with SCA was relatively high during steady states but declined substantially during sick attacks, especially because of severe pain and discomfort. HRQoL is influenced by a child’s age and frequency of hospitalization. Results provide information for calculation of quality-adjusted life years for future economic evaluation.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101120"},"PeriodicalIF":1.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness Analysis of Angiotensin Receptor Neprilysin Inhibitor Compared With Angiotensin-Converting Enzyme Inhibitor Among Patients With Heart Failure With Reduced Ejection Fraction in Malaysia","authors":"Wai Chee Kuan BPharm ,&nbsp;Zanfina Ademi PhD ,&nbsp;Sit Wai Lee MMedSc ,&nbsp;Siew Chin Ong PhD ,&nbsp;Kok Han Chee MBBS ,&nbsp;Sazzli Kasim MBChB ,&nbsp;Raja Ezman Raja Shariff MBChB ,&nbsp;Azmee Mohd Ghazi MBChB ,&nbsp;Muhamad Ali S.K. Abdul Kader MD ,&nbsp;Ka Keat Lim PhD ,&nbsp;Siddesh Shetty MD ,&nbsp;Julia Fox-Rushby PhD ,&nbsp;Juman Dujaili PhD ,&nbsp;Kenneth Kwing-Chin Lee PhD ,&nbsp;Siew Li Teoh PhD","doi":"10.1016/j.vhri.2025.101118","DOIUrl":"10.1016/j.vhri.2025.101118","url":null,"abstract":"<div><h3>Objectives</h3><div>This study compared the costs and effectiveness of angiotensin receptor neprilysin inhibitor (ARNI) with angiotensin-converting enzyme inhibitor (ACEI) for the heart failure with reduced ejection fraction population from the Malaysian Ministry of Health’s perspective.</div></div><div><h3>Methods</h3><div>A 3-state Markov model, with a monthly cycle, was constructed to estimate the lifetime healthcare costs, quality-adjusted life year (QALY), and incremental cost-effectiveness ratio (ICER) of ARNI and ACEI. The monthly baseline risks for all-cause mortality and heart failure (HF) hospitalization were estimated from the PARADIGM-HF trial and age-adjusted to the Malaysian population. The treatment effects were obtained from the PARADIGM-HF trial. All-cause mortality risks from hospitalization, utility values, and costs were derived from local studies. All costs were adjusted to 2023. The ICER was compared with Malaysian Ringgit (RM) 55 426 per QALY (one gross domestic product per capita).</div></div><div><h3>Results</h3><div>Despite ARNI being more expensive compared with ACEI, it gained more QALYs, resulting in an ICER of RM46 498 per QALY. One-way sensitivity analyses found that the key model drivers were the relative treatment effects on cardiovascular mortality, duration of treatment effects, and time horizon. Probabilistic sensitivity analysis estimated that ARNI is 66% cost-effective at the cost-effectiveness threshold of RM55 426 per QALY. Subgroup analysis showed that ICER increased with age. Scenario analysis demonstrated that initiation of ARNI alongside sodium-glucose cotransporter-2 inhibitor (SGLT-2i) produces more favorable ICER and ARNI without SGLT-2i.</div></div><div><h3>Conclusions</h3><div>At the cost-effectiveness threshold of RM55 426 per QALY, ARNI is cost-effective compared with ACEI for the heart failure with reduced ejection fraction population. Expanding patient access to ARNI is likely to improve health outcomes cost-effectively.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101118"},"PeriodicalIF":1.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Utility and Budget Impact Analyses of Herpes Zoster Vaccines in Patients With Human Immunodeficiency Virus in Thailand","authors":"Nattanichcha Kulthanachairojana PhD ,&nbsp;Jatapat Hemapanpairoa PharmD ,&nbsp;Chanyanoot Santhaveesook PharmD ,&nbsp;Papassara Piboonsatsanasakul PharmD ,&nbsp;Arisa Fueymee PharmD","doi":"10.1016/j.vhri.2025.101119","DOIUrl":"10.1016/j.vhri.2025.101119","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to perform cost-utility and budget impact analyses of zoster vaccine live (ZVL) and recombinant zoster vaccine (RZV) compared with no vaccination in patients infected with human immunodeficiency virus (HIV) in Thailand.</div></div><div><h3>Methods</h3><div>A Markov model was used to estimate costs and outcomes as a quality-adjusted life year from a societal perspective. Costs and outcomes were discounted at 3% per year. Parameters for herpes zoster prevalence and complications were estimated from previous studies. The target population included patients with HIV infection aged ≥18 years with a CD4 count ≥ 200 cells/mm³. Direct medical and nonmedical costs were included in the analysis. Deterministic and probabilistic sensitivity analyses were performed to assess the robustness of the results. A 5-year budget impact analysis of the vaccination program was performed.</div></div><div><h3>Results</h3><div>The incremental cost-effectiveness ratios of ZVL and RZV compared with no vaccination for patients with HIV infection were $2908.70 and $4391.36 per quality-adjusted life year gain, respectively. ZVL was more likely to be cost-effective. Threshold analysis revealed that RZV could be cost-effective if the cost per dose of RZV was reduced by 0.86%. An additional budget of $15 276 033 for ZVL and $43 338 761 for RZV was estimated to be needed over 5 years.</div></div><div><h3>Conclusions</h3><div>ZVL is cost-effective at the Thai willingness-to-pay threshold for patients with HIV infection aged ≥18 years with a CD4 count ≥ 200 cells/mm³. RZV needs a 0.86% price reduction to be cost-effective. These findings may be useful in evidence-based policymaking.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"48 ","pages":"Article 101119"},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}