Value in health regional issues最新文献

{"title":"Latin American and Caribbean Trends and Health Priorities in Cost-Effectiveness Studies: A Bibliometric Analysis in Scopus in the 21st Century","authors":"Carlos Alva Dìaz MD ,&nbsp;Victor Velasquez-Rimachi MD ,&nbsp;Cristian Moràn-Mariños MD ,&nbsp;Wendy Nieto-Gutierrez MD ,&nbsp;Pedro Isaac Torres Balarezo MD ,&nbsp;Carlos Quispe-Vicuña MD ,&nbsp;Mariela Huerta-Rosario MD ,&nbsp;Edward Mezones-Holguin MD","doi":"10.1016/j.vhri.2025.101496","DOIUrl":"10.1016/j.vhri.2025.101496","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyze the trends and priorities in the scientific production on cost-effectiveness analysis (CEA) in Latin America and the Caribbean during the first 2 decades of the 21st century.</div></div><div><h3>Methods</h3><div>We conducted a bibliometric analysis of published studies on CEA in Latin America reported from 2000 to 2021 in journals indexed in Scopus. We extracted annual research, countries, journals, authors, institutions, citation frequency, and journal metrics. In addition, the results of an author and country cooccurrence analysis were presented as network visualization maps using VOSviewer.</div></div><div><h3>Results</h3><div>A total of 3017 CEA-related publications were identified, and the majority were original articles (65.6%). We found an increasing trend with a significant correlation (R2: 0.981; <em>P</em> &lt; .001) between the number and date of publication. Brazil was the country with the highest number of publications followed by Mexico and Argentina, in which the greatest production was concentrated in countries with medium and high resources. The largest number of research studies with CEA corresponded to the topics of diabetes mellitus and hypertension. The majority of the most productive journals were extraregional with a Q1 quartile.</div></div><div><h3>Conclusions</h3><div>The trend of publications on CEA is increasing in Latin America and the Caribbean, particularly in countries with higher economic income and collaboration networks. It was observed that the trend in the subject of CEA is related to the epidemiology of the region, with emphasis on chronic and infectious diseases.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101496"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Team Learning in Head and Neck Surgery: An Economic and Quality Management Perspective","authors":"Carsten Bauer PhD ,&nbsp;Oliver Unger PhD ,&nbsp;Martin Holderried MD Habil, PhD","doi":"10.1016/j.vhri.2025.101503","DOIUrl":"10.1016/j.vhri.2025.101503","url":null,"abstract":"<div><h3>Objectives</h3><div>Healthcare systems around the world face significant cost pressure and need to find ways to deal with this challenge without compromising treatment quality. Investigating and using learning effects might be an approach to achieve this goal. This study investigates surgeons’ learning effects of a standard surgical procedure in otorhinolaryngology, the tonsillectomy. It focuses on short-, medium-, and long-term effects using incision-suture times and complications as cost indicators. Surgeons’ experience, measured by qualification level, was also assessed.</div></div><div><h3>Methods</h3><div>Using process, quality, and economic data from a German tertiary care hospital, the economic effects of team learning processes and medical experience were compared using statistical methods to assess teamwork’s impact on outcomes.</div></div><div><h3>Results</h3><div>Team learning and increased surgeon experience yielded cost savings and quality improvements across short-, medium-, and long-term periods. Teamwork accelerated learning, reducing operation times compared with individual settings. Resident physicians benefitted from engaging in team surgeries for accelerated knowledge acquisition.</div></div><div><h3>Conclusions</h3><div>Team learning in tonsillectomies as a very common surgical procedure in the field of otorhinolaryngology offers insights into improving surgical outcomes from an economic and quality management perspective. The importance of teamwork in enhancing learning curves and reducing costs in head and neck surgery is underscored. Recommendations advocate for integrating quality management principles into surgical practices to optimize outcomes and resource utilization.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"52 ","pages":"Article 101503"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valuation of EQ-5D Health States for Adults in Low-, Lower-Middle, and Upper-Middle-Income Countries: A Systematic Review","authors":"Marufa Sultana PhD ,&nbsp;Thomas Chiu MSS ,&nbsp;Mostafa Kamal PhD ,&nbsp;Mohammod A. Kabir MSc, MEcon ,&nbsp;Sayem Ahmed PhD ,&nbsp;Rumana Huque PhD ,&nbsp;Jahangir Khan PhD","doi":"10.1016/j.vhri.2025.101505","DOIUrl":"10.1016/j.vhri.2025.101505","url":null,"abstract":"<div><h3>Objectives</h3><div>Preference-based measurement of health-related quality of life is crucial for informing resource allocation decisions, with the EQ-5D instrument widely used as a measure of health-related quality of life. Although country-specific value sets are well established in many high-income countries, current summarized evidence from valuation studies in low- and middle-income countries (LMICs) remains limited. This review systematically identified EQ-5D valuation studies in LMICs, summarized methodologies and scoring algorithms by country type, and highlighted key challenges.</div></div><div><h3>Methods</h3><div>A systematic search was undertaken across 7 academic databases and the EuroQol website. Two independent reviewers screened titles and abstracts and performed full-text reviews and data extraction. Reporting followed Checklist Reporting Valuation Studies of Multi-Attribute Utility-Based Instruments for quality assessment. The synthesis included study characteristics, methodologies, and summarized scoring algorithms from the best-performing models, highlighting variations across countries.</div></div><div><h3>Results</h3><div>Through screening 9378 studies, 35 studies from 22 LMICs were included. Of these, 20 (58%) were from upper-middle-income countries, whereas low-middle and low-income countries accounted for 13 (37%) and 2 (6%) studies, respectively. Eighteen (51%) studies reported EQ-5D-5L valuations. Sample sizes ranged from 148 to 5503, with the time trade-off method being predominant. Scoring algorithms showed no significant variation between upper-middle- and low-middle-income countries, except for the pain/discomfort dimension in EQ-5D-5L. Mobility was the most reported utility decrement among studies.</div></div><div><h3>Conclusions</h3><div>There is a growing trend in developing country-specific value sets in LMICs. Contextually relevant designs and adequate pilot studies could enhance the accuracy of value sets in culturally diverse settings, particularly where severe health states are commonly reported.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101505"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Heart Failure With Icosapent Ethyl Results in Cost-Savings in the Spanish Population With Established Cardiovascular Disease","authors":"Laurence Tilley MPharmacol ,&nbsp;Rory McAtamney BSc ,&nbsp;Charlotte Heeks MSc ,&nbsp;Kenneth Agyei-Kyeremateng MSc ,&nbsp;Sabine Gaugris MSc ,&nbsp;Gustavo Vitale MD, MSc, MBA ,&nbsp;David Jakouloff MD ,&nbsp;María Basalo MD, PhD ,&nbsp;Josep Comin-Colet MD, PhD","doi":"10.1016/j.vhri.2025.101500","DOIUrl":"10.1016/j.vhri.2025.101500","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the budget impact resulting from reducing heart failure incidence through the introduction of icosapent ethyl to the Spanish healthcare system.</div></div><div><h3>Methods</h3><div>A cost-offset model was developed to estimate the budget impact resulting from introducing icosapent ethyl in Spanish hospitals in patients at high risk for cardiovascular diseases with established cardiovascular disease. Population and cost inputs were sourced from Spanish databases and clinically validated published literature. Clinical inputs were sourced from clinical trials or clinically validated published literature. The comparator was best supportive care, consisting of background statin with or without ezetimibe therapy, which reflects current treatments used in Spanish centers for the target population.</div></div><div><h3>Results</h3><div>Over 5 years, icosapent ethyl prevented 383 heart failures, corresponding to 1722 total days spent in hospital. This resulted in cost savings of €2 469 888 (1.8%).</div></div><div><h3>Conclusions</h3><div>This study demonstrated that the use of icosapent ethyl in patients at high risk for cardiovascular diseases with established cardiovascular disease will result in cost savings in Spanish hospitals, as the benefits of preventing heart failure outweigh the acquisition costs of icosapent ethyl.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101500"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Burden of Ischemic Heart Disease in Morocco: Evidence From a Teaching Hospital, a Cost-of-Illness Study","authors":"Moncef Maiouak MD ,&nbsp;Mohammed Cherti MD, PhD ,&nbsp;Mohamed Youbi MD ,&nbsp;Latifa Belakhel MD ,&nbsp;Loubna Abouselham MD ,&nbsp;Samira El Fakir MD, PhD ,&nbsp;Mohamed Berraho MD, PhD ,&nbsp;Imane El Menchawy MD ,&nbsp;Fatima Zahra Benmessaoud MD ,&nbsp;Nabil Tachfouti MD, MPH, PhD","doi":"10.1016/j.vhri.2025.101504","DOIUrl":"10.1016/j.vhri.2025.101504","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the direct and indirect costs of ischemic heart disease (IHD) in Morocco and identify its main determinants.</div></div><div><h3>Methods</h3><div>A retrospective prevalence-based cost-of-illness study was carried out in patients with IHD admitted to a university hospital in 2019. Collected data included sociodemographic data, clinical profiles, and healthcare utilization. Direct medical costs were estimated using national insurance rates. Indirect costs, due to productivity loss, were calculated using the human capital approach and limited to working-age individuals based on Morocco’s retirement age. A bottom-up approach from a societal perspective was used over a 12-month period. The mean total cost was compared according to sociodemographic and clinical characteristics.</div></div><div><h3>Results</h3><div>The study included 180 patients; 58.3% were male, mean age was 62.1 years, and 46.1% were current or former smokers. Mean direct medical cost per patient was $3519.9 (95% CI $3141.8-$3898.0), with revascularization and medications as the main cost components. The mean indirect cost was $336.4 (95% CI $313.7-$359.0), with a mean productivity loss of 41.8 days. The mean total cost was $3856.3 (95% CI $3349.1-$4129.2), significantly higher for males (<em>P</em> = .015) and smokers (<em>P</em> &lt; .001). The national economic burden of IHD was approximately $1.23 billion annually.</div></div><div><h3>Conclusions</h3><div>IHD imposes a substantial economic burden in Morocco, particularly among high-risk populations. Beyond tobacco control, integrated prevention strategies, including early detection and risk factor management, are urgently needed. In addition, healthcare resource planning and equitable access to medications are essential to reduce the burden of IHD.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"52 ","pages":"Article 101504"},"PeriodicalIF":1.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Factor Structure of the Preliminary Version of EuroQol Health and Well-Being Instrument in China: A Replication of the Confirmatory Factor Analysis","authors":"Guangjie Zhang MSc ,&nbsp;Zhihao Yang PhD ,&nbsp;Nan Luo PhD ,&nbsp;Tessa Peasgood PhD ,&nbsp;Jan Busschbach PhD","doi":"10.1016/j.vhri.2025.101501","DOIUrl":"10.1016/j.vhri.2025.101501","url":null,"abstract":"<div><h3>Objectives</h3><div>During the development of EuroQol Health and Well-Being instrument (EQ-HWB), the Chinese online sample showed a weaker model fit for the confirmatory factor model based on the UK sample, even after adjustments. This may be because of cultural differences affecting item interpretation or demographic disparities, particularly in age and education. To address this, the study aimed to replicate the Chinese-adjusted model, a version of the UK model modified based on the Chinese online sample, using a more diverse Chinese face-to-face sample to assess potential improvements in model fit.</div></div><div><h3>Methods</h3><div>We conducted face-to-face interviews to recruit respondents with diverse age and education backgrounds. The Chinese-adjusted model, a bifactor confirmatory model with 9 factors and 2 measurement factors, was replicated in 2 stages. First, the Chinese online sample validated the model. Then, the face-to-face sample assessed improvements in model fit. The confirmatory factor analysis model fit criteria were as follows: comparative fit index and Tucker-Lewis index greater than 0.95 and root mean square error of approximation less than 0.06.</div></div><div><h3>Results</h3><div>We recruited 553 respondents, including 96 with lung cancer, 125 with diabetes, 102 with depression, 113 with schizophrenia, 16 with other diseases, and 101 healthy individuals. In the face-to-face sample, the goodness-of-fit indices for the Chinese-adjusted model were a comparative fit index of 0.943, Tucker-Lewis index of 0.939, and root mean square error of approximation of 0.052 (90% CI 0.050-0.054), indicating a significantly better fit than in the original study.</div></div><div><h3>Conclusions</h3><div>The misfit of the UK EQ-HWB model to Chinese data in a previous study had seemed to be because of limited variance. Using a more diverse data set, our study supported the EQ-HWB factor structure's comparability at an international level.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101501"},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Framework for Patient Prioritization in Bariatric Surgery Using a Predictive Success Score Versus a First-In First-Out Approach: A Cost-Effectiveness Analysis","authors":"Fellipe S. Mocellin MD ,&nbsp;Jeruza L. Neyeloff PhD ,&nbsp;Flávio S. Fogliatto PhD ,&nbsp;Carina Blume PhD ,&nbsp;Luciana Bahia PhD ,&nbsp;Beatriz D. Schaan PhD","doi":"10.1016/j.vhri.2025.101497","DOIUrl":"10.1016/j.vhri.2025.101497","url":null,"abstract":"<div><h3>Objectives</h3><div>Bariatric surgery is an important therapy for managing obesity; however, most low- and middle-income countries have more eligible patients than the healthcare system can accommodate. Despite ample literature about its effectiveness, as well as many economic studies comparing it with other interventions, decision-analytic studies on which patients should be prioritized for the procedure are lacking. A predictive scoring system to anticipate success after surgery grounded in clinical parameters observed before the procedure was previously proposed; here, we aim to assess its cost-effectiveness when compared with the current paradigm of directing the patients to a reference center based on a simple queue, the “first in, first out” approach.</div></div><div><h3>Methods</h3><div>We developed a Monte Carlo microsimulation branching model in RStudio, to assess costs and quality-adjusted life-years, across 6 different supply constraints, comparing a simulated cohort undergoing surgery based on their predictive success scores with another group undergoing surgery according to their position within a straightforward queue. The analysis adopted the perspective of the Brazilian National Health System, with a monthly cycle duration, with a 5% annual discount rate.</div></div><div><h3>Results</h3><div>Across all analyzed scenarios, the incremental cost-effectiveness ratio of using the success score over performing surgery via queue ranged from R$227 to R$2883 ($45 to $579 in the current exchange rate), falling well below commonly used willingness-to-pay thresholds. The cohorts prioritized by the score had longer total life-years, less cardiovascular mortality, and slightly higher costs associated with surgical procedures and management of chronic illnesses.</div></div><div><h3>Conclusions</h3><div>Prioritizing patients based on predicted success is a promising strategy to improve health outcomes at an affordable cost, across different levels of supply constraints.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101497"},"PeriodicalIF":1.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Testing Psychometric Properties of the Thai Version of Vision Bolt-On EQ-5D in Patients With Visual Impairment","authors":"Nuntachai Surawatsatien MD, MSc ,&nbsp;Pear Ferreira Pongsachareonnont MD, MPH, PhD ,&nbsp;Sarinyaporn Waoraweewon PharmD ,&nbsp;Gorawit Homkong PharmD ,&nbsp;Anchisa Keereekeaw PharmD ,&nbsp;Phantipa Sakthong PhD","doi":"10.1016/j.vhri.2025.101498","DOIUrl":"10.1016/j.vhri.2025.101498","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Thai versions of the vision bolt-on EQ-5D-3L and EQ-5D-5L, comparing them with the standard EQ-5D-3L, EQ-5D-5L, and EQ-VAS in individuals with varying degrees of visual impairment.</div></div><div><h3>Methods</h3><div>Following EuroQol Translation Guidelines, the vision bolt-on items were translated through forward-backward processes and underwent cognitive debriefing. A total of 301 participants were interviewed at baseline, with 275 completing a 2-week follow-up. Known-groups validity was assessed based on visual acuity classifications and comorbidity status; convergent validity was tested by using Spearman’s correlations. Test-retest reliability was evaluated with intraclass correlation coefficients (ICCs) and weighted kappa. Responsiveness was analyzed using a standardized effect size in participants who reported better or worse vision.</div></div><div><h3>Results</h3><div>Both versions of the vision bolt-on had no missing data and demonstrated moderate to good test-retest reliability (ICC range 0.62-0.64). They effectively differentiated quality-of-life scores across varying degrees of vision impairment, showing reduced ceiling effects (5%-9%) compared with the standard EQ-5D. Correlations with EQ-VAS were moderate (rho 0.40-0.45). When participants reported improved vision, the vision bolt-on EQ-5D-5L exhibited the highest responsiveness, whereas all instruments were generally less responsive for worsening vision.</div></div><div><h3>Conclusions</h3><div>The Thai versions of the vision bolt-on EQ-5D-3L and EQ-5D-5L demonstrated acceptable reliability, validity, and moderate responsiveness for capturing vision-related health changes, with the 5L version showing slightly greater sensitivity. These findings support the usefulness of adding a vision dimension to EQ-5D for Thai-speaking populations, facilitating more precise evaluations of interventions targeting visual health.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"51 ","pages":"Article 101498"},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Real-World Treatment, and Economic Burden of Waldenström Macroglobulinemia: A Comprehensive Analysis Based on Anonymized Claims Data Between 2010 and 2022","authors":"Christian Buske MD ,&nbsp;Michael Herold MD ,&nbsp;Nasim Bahar MPH ,&nbsp;Keri Yang PhD ,&nbsp;Boxiong Tang MD ,&nbsp;Sabrina Müller MSc ,&nbsp;Georg Hess MD","doi":"10.1016/j.vhri.2025.101162","DOIUrl":"10.1016/j.vhri.2025.101162","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to provide evidence on the epidemiology, real-world treatment patterns, overall survival, and economic burden of Waldenström macroglobulinemia (WM).</div></div><div><h3>Methods</h3><div>A retrospective analysis of an anonymized large German claims database from January 1, 2010, to June 30, 2022, identified incident WM cases based on a 12-month diagnosis-free period before the first confirmed WM diagnosis (ICD-10-GM code C88.0). WM diagnosis was validated through at least 2 confirmed outpatient diagnoses in different quarters within 12 months or 1 inpatient diagnosis (further sensitivity scenarios were tested). Treatment patterns were analyzed based on the follow-up period after diagnosis, with line of treatment derived by an algorithm using outpatient prescription/inpatient procedure information. Incremental costs were derived by comparing patients with WM with a propensity-score-matched control group.</div></div><div><h3>Results</h3><div>A total of 593 incident WM cases were identified (mean age: 72.7 years; 46.5% female). In 2021, standardized cumulative incidence ranged from 1.39 to 1.90 per 100 000 persons (males: 1.98 to 2.60; females: 0.73 to 1.25). Median overall survival was 7.9 years. Nearly 70% of patients initially followed a watch-and-wait approach, with less than one-third starting therapy after 2 years. Rituximab, often combined with bendamustine or unspecified inpatient chemotherapy, was the most common treatment. Recently, ibrutinib has been used more frequently in later lines. Incremental cost analysis showed substantial care costs, mainly driven by medications and inpatient care.</div></div><div><h3>Conclusions</h3><div>The study indicates an increasing incidence of WM in Germany, associated with significant economic burden, despite the majority of newly diagnosed patients initially adopting a watch-and-wait approach.</div></div>","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"50 ","pages":"Article 101162"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing the Groundwork for Future Research Into Adherence Measurement for Patients With HIV/AIDS","authors":"Hinpetch Daungsupawong PhD ,&nbsp;Viroj Wiwanitkit MD","doi":"10.1016/j.vhri.2025.101168","DOIUrl":"10.1016/j.vhri.2025.101168","url":null,"abstract":"","PeriodicalId":23497,"journal":{"name":"Value in health regional issues","volume":"49 ","pages":"Article 101168"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}