Tissue Barriers最新文献_第2页

Antagonists of the N-cadherin/Fibroblast growth factor receptor tyrosine kinase complex. n -钙粘蛋白/成纤维细胞生长因子受体酪氨酸激酶复合物的拮抗剂。

IF 3.6

Tissue Barriers Pub Date : 2025-07-11 DOI: 10.1080/21688370.2025.2532160

Orest W Blaschuk

引用次数: 0

Involvement of claudins 6 and 9 in epithelial-mesenchymal transition and the metastatic process. claudin 6和9参与上皮-间质转化和转移过程。

IF 3.6

Tissue Barriers Pub Date : 2025-07-04 DOI: 10.1080/21688370.2025.2529091

Naresh E Diego, Luis F Montaño, Erika P Rendón-Huerta

{"title":"Involvement of claudins 6 and 9 in epithelial-mesenchymal transition and the metastatic process.","authors":"Naresh E Diego, Luis F Montaño, Erika P Rendón-Huerta","doi":"10.1080/21688370.2025.2529091","DOIUrl":"10.1080/21688370.2025.2529091","url":null,"abstract":"Claudins are essential components of tight junctions, and their abnormal expression is linked to cancer development. Claudin-6 (CLDN6) and Claudin-9 (CLDN9) are claudins whose expression is suppressed post-development but reinduced in various malignancies. This review highlights the distinct yet complementary roles of CLDN6 and CLDN9 during epithelial-mesenchymal transition (EMT) and their contributions to cell migration and invasion in cancer. CLDN9 primarily enhances cell migration by inducing cytoskeletal rearrangement and activating pathways, including MAPK and Tyk2/STAT3. Moreover, CLDN9 overexpression is associated with pseudopodia formation, glycolytic remodeling, and immune evasion. Conversely, CLDN6 is more strongly linked to cell invasiveness and matrix degradation, primarily through the induction of MMPs via the EGFR/mTOR and PI3K/AKT pathways. CLDN6 also plays a role in stemness and therapy resistance in specific cancers. While CLDN6 and CLDN9 can function independently, their co-expression is connected with aggressive tumor behavior and poor prognosis, suggesting a synergistic process that promotes migration and invasion.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2529091"},"PeriodicalIF":3.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced glycation endproducts induce cytokine dysregulation and weaken lung epithelial and endothelial barrier integrity. 晚期糖基化终产物诱导细胞因子失调，削弱肺上皮和内皮屏障的完整性。

IF 3.6

Tissue Barriers Pub Date : 2025-06-20 DOI: 10.1080/21688370.2025.2521136

Abdulaziz H Alanazi, Mohamed S Selim, Yin Zhu, Duo Zhang, S Priya Narayanan, Payaningal R Somanath

{"title":"Advanced glycation endproducts induce cytokine dysregulation and weaken lung epithelial and endothelial barrier integrity.","authors":"Abdulaziz H Alanazi, Mohamed S Selim, Yin Zhu, Duo Zhang, S Priya Narayanan, Payaningal R Somanath","doi":"10.1080/21688370.2025.2521136","DOIUrl":"10.1080/21688370.2025.2521136","url":null,"abstract":"Diabetes mellitus is a systemic disease characterized by chronic hyperglycemia, persistent inflammation, and oxidative stress. While the vascular complications of diabetes are well-documented, their impact on lung barrier integrity remains underexplored. In this study, we investigated the molecular mechanisms by which advanced glycation end-products (AGE) compromise the integrity of lung endothelial and epithelial barriers. Using human lung microvascular endothelial cells and epithelial (A549) cells, we assessed the impact of AGE on the tight junction protein claudin-5, adherens junction protein VE-cadherin, and key signaling molecules including the receptor for AGE (RAGE), phosphorylated Akt, and p38 MAPK as well as a panel of pro-inflammatory cytokines. Our findings demonstrated that AGE exposure (50 μg/mL) significantly activated Akt and p38 MAPK, upregulated Claudin-5 and RAGE, and downregulated VE-cadherin, correlating with reduced transendothelial electrical resistance in vitro. Notably, we observed similar effects on lung epithelial cells. Moreover, AGE-treated conditioned media from THP-1 macrophages induced a pronounced increase in inflammatory cytokines, amplifying the disruption of lung barrier integrity. These findings reveal a potential mechanism linking diabetes-induced vascular dysfunction and immune activation to compromised lung barrier function, emphasizing the need for further research into diabetes-associated lung complications.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2521136"},"PeriodicalIF":3.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal epithelial cells in health and disease. 肠上皮细胞在健康和疾病中的作用。

IF 3.6

Tissue Barriers Pub Date : 2025-05-22 DOI: 10.1080/21688370.2025.2504744

Chenchen An, Chonggui Jiang, Wangxiang Pei, Ao Li, Minghui Wang, Yufei Wang, Hua Wang, Li Zuo

{"title":"Intestinal epithelial cells in health and disease.","authors":"Chenchen An, Chonggui Jiang, Wangxiang Pei, Ao Li, Minghui Wang, Yufei Wang, Hua Wang, Li Zuo","doi":"10.1080/21688370.2025.2504744","DOIUrl":"https://doi.org/10.1080/21688370.2025.2504744","url":null,"abstract":"This comprehensive review delves into the pivotal role of intestinal epithelial cells in the context of various diseases. It provides an in-depth analysis of the diverse types and functions of these cells, explores the influence of multiple signaling pathways on their differentiation, and elucidates their critical roles in a spectrum of diseases. The significance of the gastrointestinal tract in maintaining overall health is extremely important and cannot be exaggerated. This complex and elongated organ acts as a crucial link between the internal and external environments, making it vulnerable to various harmful influences. Preserving the normal structure and function of the gut is essential for well-being. Intestinal epithelial cells serve as the primary defense mechanism within the gastrointestinal tract and play a crucial role in preventing harmful substances from infiltrating the body. As the main components of the digestive system, they not only participate in the absorption and secretion of nutrients and the maintenance of barrier function but also play a pivotal role in immune defense. Therefore, the health of intestinal epithelial cells is of vital importance for overall health.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2504744"},"PeriodicalIF":3.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paracrine signaling mediators of vascular endothelial barrier dysfunction in sepsis: implications for therapeutic targeting. 脓毒症中血管内皮屏障功能障碍的旁分泌信号介质：治疗靶向的意义。

IF 3.6

Tissue Barriers Pub Date : 2025-05-16 DOI: 10.1080/21688370.2025.2503523

Shahid Puthiyottil, Tom Skaria

{"title":"Paracrine signaling mediators of vascular endothelial barrier dysfunction in sepsis: implications for therapeutic targeting.","authors":"Shahid Puthiyottil, Tom Skaria","doi":"10.1080/21688370.2025.2503523","DOIUrl":"https://doi.org/10.1080/21688370.2025.2503523","url":null,"abstract":"Vascular endothelial barrier disruption is a critical determinant of morbidity and mortality in sepsis. Whole blood represents a key source of paracrine signaling molecules inducing vascular endothelial barrier disruption in sepsis. This study analyzes whole-genome transcriptome data from sepsis patients' whole blood available in the NCBI GEO database to identify paracrine mediators of vascular endothelial barrier dysfunction, uncovering novel insights that may guide drug repositioning strategies. This study identifies the regulated expression of paracrine signaling molecules TFPI, MMP9, PROS1, JAG1, S1PR1, and S1PR5 which either disrupt or protect vascular endothelial barrier function in sepsis and could serve as potential targets for repositioning existing drugs. Specifically, TFPI (barrier protective), MMP9 (barrier destructive), PROS1 (barrier protective), and JAG1 (barrier destructive) are upregulated, while S1PR1 (barrier protective) and S1PR5 (barrier protective) are downregulated. Our observations highlight the importance of considering both protective and disruptive mediators in the development of therapeutic strategies to restore endothelial barrier integrity in septic patients. Identifying TFPI, MMP9, PROS1, JAG1, S1PR1, and S1PR5 as druggable paracrine regulators of vascular endothelial barrier function in sepsis could pave the way for precision medicine approaches, enabling personalized treatments that target specific mediators of endothelial barrier disruption to improve patient outcomes in sepsis.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2503523"},"PeriodicalIF":3.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions. 血脑屏障完整性和神经变性十字路口的去泛素化酶：机制见解，治疗靶向和未来方向。

IF 3.6

Tissue Barriers Pub Date : 2025-05-13 DOI: 10.1080/21688370.2025.2504738

Fahima Munavar-K, Nibedita Lenka

{"title":"Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions.","authors":"Fahima Munavar-K, Nibedita Lenka","doi":"10.1080/21688370.2025.2504738","DOIUrl":"https://doi.org/10.1080/21688370.2025.2504738","url":null,"abstract":"The ubiquitin-proteasome system (UPS) carries immense significance concerning cellular homeostasis that encompasses both ubiquitination and deubiquitination as key facets for maintaining protein stability. The deubiquitinating enzymes (DUBs) have emerged as critical regulators of proteostasis, neuroinflammation and blood-brain barrier (BBB) integrity by controlling the fate of crucial proteins associated with barrier architectures in CNS and neurodegenerative disorders (NDs) alike. However, a concrete understanding of their specific neurodevelopmental and neuroprotective functions is yet to be discerned. This article discusses the multifaceted roles of DUBs in the maintenance of BBB integrity, neuroprotection and various NDs and also underscores the therapeutic prospects targeting the same. While DUBs like USP7, USP9X, USP27X, UCHL1, etc. participate in neural stem cell maintenance and neurogenesis, including BBB function, USP13, USP14, USP25, BRCC3 and CYLD, among others, are associated with BBB dysfunction and NDs. The mechanistic underpinning concerning their hitherto unexplored mode of action, DUB-substrate interactions and specificity would facilitate developing the therapeutic agonists and small-molecule inhibitors to prevent or reverse neuroinflammation, BBB impairment and developmental disorders. Recent innovations concerning DUB-targeting chimaeras (DUBTACs) and proteolysis-targeting chimaeras (PROTACs) can be explored further for their plausible administration via nanoparticle-based delivery approaches to alleviate the progressive neurodegeneration.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2504738"},"PeriodicalIF":3.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue microRNA dynamics in sinonasal inverted papilloma: implications for pathology and therapy. 鼻腔内翻性乳头状瘤的组织microRNA动力学：病理和治疗意义。

IF 3.6

Tissue Barriers Pub Date : 2025-05-09 DOI: 10.1080/21688370.2025.2502709

Giovanna Lucia Piazzetta, Nadia Lobello, Corrado Pelaia, Mariaimmacolata Preianò, Nicola Lombardo, Emanuela Chiarella

{"title":"Tissue microRNA dynamics in sinonasal inverted papilloma: implications for pathology and therapy.","authors":"Giovanna Lucia Piazzetta, Nadia Lobello, Corrado Pelaia, Mariaimmacolata Preianò, Nicola Lombardo, Emanuela Chiarella","doi":"10.1080/21688370.2025.2502709","DOIUrl":"https://doi.org/10.1080/21688370.2025.2502709","url":null,"abstract":"Sinonasal inverted papilloma (SNIP) is a benign epithelial neoplasm of the Schneiderian membrane, known for its locally aggressive behavior, high recurrence rates, and potential for malignant transformation into sinonasal squamous cell carcinoma (SNSCC). Emerging evidence emphasizes the role of microRNAs (miRNAs) in the pathogenesis, progression, and clinical management of SNIP. These small non-coding RNAs regulate key cellular pathways, particularly the PTEN/PI3K/AKT axis, which governs tumor growth, apoptosis resistance, and chemoresistance. Among the miRNAs studied, miR-296-3p, miR-214-3p, and the miR-449 cluster show significant dysregulation. miR-296-3p is upregulated in SNSCC, promoting oncogenesis by inhibiting PTEN and activating the PI3K/Akt pathway. Conversely, miR-214-3p is downregulated in SNIP and correlates with advanced disease and increased recurrence, identifying it as a potential diagnostic and prognostic biomarker. The miR-449 cluster, with known tumor-suppressive properties, is progressively downregulated during malignant transformation, highlighting its role in maintaining epithelial structure. Despite their promise, clinical application of miRNA-based diagnostics and therapies faces challenges such as delivery optimization, specificity, and off-target effects. Nonetheless, the noninvasive detection of circulating miRNAs in bodily fluids offers a compelling approach for future diagnostic tools and patient monitoring. This review highlights the transformative potential of miRNA research in advancing SNIP diagnosis and treatment. By integrating molecular insights into clinical practice, miRNA-based strategies could pave the way for more personalized interventions, ultimately reducing recurrence rates and preventing malignant transformation.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2502709"},"PeriodicalIF":3.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucus and mucin: changes in the mucus barrier in disease states. 黏液和粘蛋白：疾病状态下黏液屏障的变化。

IF 3.6

Tissue Barriers Pub Date : 2025-05-08 DOI: 10.1080/21688370.2025.2499752

Fangfang Fan, Ruihan Guo, Kun Pan, Hongye Xu, Xiaoqin Chu

{"title":"Mucus and mucin: changes in the mucus barrier in disease states.","authors":"Fangfang Fan, Ruihan Guo, Kun Pan, Hongye Xu, Xiaoqin Chu","doi":"10.1080/21688370.2025.2499752","DOIUrl":"https://doi.org/10.1080/21688370.2025.2499752","url":null,"abstract":"In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing cells that covers and protects all non-keratinized wet epithelial surfaces. In addition to the surface of organs directly contacting with the external environment such as the eyes, this layer provides protection to the underlying gastrointestinal, respiratory and female reproductive tracts by trapping pathogens, irritants, environmental fine particles and potentially harmful foreign substances. Mucins, the primary structural components of mucus, form structurally different mucus layers at different sites in a process regulated by a variety of factors. Currently, more and more studies have shown that the mucus barrier is not only closely related to various intestinal mucus diseases, but also involved in the occurrence and development of various airway diseases and mucus-related diseases, thus it may become a new target for the treatment of various related diseases in the future. Since the dysfunction of the mucous layer is closely related to various pathological processes, in-depth understanding of its molecular mechanism and physiological role is of great theoretical and practical significance for disease prevention and treatment. Here, we discuss different aspects of the mucus layer by focusing on its chemical composition, synthetic pathways, and some of the characteristics of the mucus layer in physiological and pathological situations.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2499752"},"PeriodicalIF":3.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of decellularized amniotic membrane and Wharton's jelly on the healing of experimental skin wounds in rats. 脱细胞羊膜及华氏胶对实验性皮肤创面愈合的影响。

IF 3.6

Tissue Barriers Pub Date : 2025-04-24 DOI: 10.1080/21688370.2025.2497101

Aline L Takejima, Rossana B Simeoni, Milka L Takejima, Angela G Lemke, Seigo Nagashima, Anna C F Silva, Julio C Francisco, Ricardo A Pinho, Lúcia de Noronha, Luiz C Guarita-Souza

{"title":"The effects of decellularized amniotic membrane and Wharton's jelly on the healing of experimental skin wounds in rats.","authors":"Aline L Takejima, Rossana B Simeoni, Milka L Takejima, Angela G Lemke, Seigo Nagashima, Anna C F Silva, Julio C Francisco, Ricardo A Pinho, Lúcia de Noronha, Luiz C Guarita-Souza","doi":"10.1080/21688370.2025.2497101","DOIUrl":"https://doi.org/10.1080/21688370.2025.2497101","url":null,"abstract":"Several studies have focused on novel therapeutic strategies for extensive skin lesions aiming to improve healing quality and reduce treatment duration. In this context, the use of amniotic membrane (AM) and Wharton's jelly (WJ) emerges as promising alternatives. Full-thickness dorsal skin wounds were created in 21 Wistar rats, randomly divided into three groups: control (C), AM - covered by AM and WJ - covered by WJ. Wound contraction rate was measured weekly. On day 28, histochemical (Picrosirius red) and immunohistochemical analyses matrix metalloproteinase-9 (MMP-9), transforming growth factor beta (TGF-β), and alpha-smooth muscle actin (α-SMA) were performed. On day seven, wound contraction rate was higher in the AM group (38.8%), followed by the WJ (27.4%) and control (26.5%) with statistically significance. During the first 14 days, the AM group maintained the highest contraction rate, followed by the control and WJ groups. However, by day 21, wound contraction rates increased in the order of WJ to AM to control groups (85.6%, 87.0%, and 91.1%) with statistically significance. Type I collagen predominated across all groups, without statistically significant differences among them. TGF-β expression significantly increased from WJ to AM to control groups (19.75%, 26.00%, and 36.56%) with statistically significance. MMP-9 and α-SMA expressions decreased from control to WJ to AM groups, but no significant differences were observed. Both AM and WJ enhanced early wound contraction and may support skin repair by attenuating fibrotic signaling. These findings highlight the potential of AM and WJ as biomaterials for promoting tissue regeneration at epithelial barriers.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2497101"},"PeriodicalIF":3.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of selenium nanoparticles versus selenium on experimentally induced diabetic retinopathy via modulation of TLR4 / NF-_kB P65 / VEGF / connexin 43 signaling. 纳米硒与硒通过调节TLR4 / NF-kB P65 / VEGF / connexin 43信号通路对实验性糖尿病视网膜病变的治疗作用

IF 3.6

Tissue Barriers Pub Date : 2025-04-17 DOI: 10.1080/21688370.2025.2491911

Nafesa Ashraf Mahmoud Khashaba, Sara Mohamed Naguib Abdel Hafez, Walaa Yehia Abdelzaher, Rehab Ahmed Rifaai, Nada Amgad Mohamed Abdel Majeed

{"title":"Therapeutic effects of selenium nanoparticles versus selenium on experimentally induced diabetic retinopathy via modulation of TLR4 / NF-kB P65 / VEGF / connexin 43 signaling.","authors":"Nafesa Ashraf Mahmoud Khashaba, Sara Mohamed Naguib Abdel Hafez, Walaa Yehia Abdelzaher, Rehab Ahmed Rifaai, Nada Amgad Mohamed Abdel Majeed","doi":"10.1080/21688370.2025.2491911","DOIUrl":"https://doi.org/10.1080/21688370.2025.2491911","url":null,"abstract":"Diabetic retinopathy is the most prevalent microvascular consequences of diabetes mellitus that can result in vision loss. Nanotechnology has been widely used in the treatment of ophthalmic diseases. Selenium is a naturally occurring compound that has antioxidant and anti-inflammatory effects. This study aimed at comparing the possible ameliorating effect of selenium versus Nano-selenium on streptozotocin-induced diabetic retinopathy in rats. Sixty adult male albino-Wister rats were divided randomly into six groups; control, Selenium+ve, Nanoselenium+ve, diabetic, DR-Se treated group, and DR-NS treated group. Animals were anesthetized and sacrificed at the end of study. Eyes were removed and prepared for biochemical, histological, and immunohistochemical studies. The results showed that the diabetic group had an apparent decrease in retinal thickness, loss of photoreceptors, dilated congested blood vessels in retinal layers. Additionally, a significant increase in malondialdehyde and significant decrease in Total Antioxidant Capacity were detected. Significant increase in surface area fraction of vascular endothelial growth factor, nuclear factor kappa B, Glial fibrillary acidic protein immune stained cells were noticed, and significant decrease in connexin 43 expression was also detected. Improvement in all mentioned parameters in DR-Se and DR-NS groups was noticed. Our study suggested that Selenium, whether in its regular or nano form, holds promise for alleviating diabetic retinopathy in rats on biochemical, histological, and immunohistochemical basis.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2491911"},"PeriodicalIF":3.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0