E2, Brute? Unveiling an unexpected role of estrogen signaling in nephrogenesis during embryonic zebrafish kidney development.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Tissue Barriers Pub Date : 2025-04-07 DOI:10.1080/21688370.2025.2487716

Landon B Gibbins, Dorrian G Cohen, Rebecca A Wingert

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Abstract

Recent years have heralded many exciting advancements in our knowledge about kidney development. In particular, there has been tremendous progress in identifying genes and signaling pathways that pattern renal functional units - a process known as nephron segmentation. An intriguing potential regulator of this process, 17β-estradiol (E2), was implicated previously by a high-throughput screen that examined the effects of known bioactive molecules on nephrogenesis. Now, a detailed study has shown that exogenous E2 or exposure to several xenoestrogens has significant effects on nephron distal tubule establishment during development of the zebrafish pronephros, or embryonic kidney. Attenuation of estrogen receptor 2b (Esr2b) activity by pharmacological antagonism or genetic knockdown revealed that E2/Esr2b signaling is necessary for normal distal segment pattern by regulating the expression of Iroquois transcription factors. These findings demonstrate that estrogen signaling influences renal stem cell development during the process of vertebrate nephron segmentation and may have important ramifications for understanding congenital birth defects and kidney diseases.

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.