Twin Research and Human Genetics最新文献_第6页

The Co-Twin Control Design: Implementation and Methodological Considerations. 双生控制设计:实施和方法学考虑。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-09-01 DOI: 10.1017/thg.2023.35

Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Jenny van Dongen, Dorret I Boomsma

引用次数: 0

Maternal and Neonatal Outcomes of Twin Pregnant Women With Anemia. 双胎孕妇贫血的孕产妇和新生儿结局。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-08-31 DOI: 10.1017/thg.2023.33

Nacheng Lin, Ping Shen, Huilian Hu, Wenying Song, Yali Hu, Yimin Dai, Yi-Hua Zhou

{"title":"Maternal and Neonatal Outcomes of Twin Pregnant Women With Anemia.","authors":"Nacheng Lin, Ping Shen, Huilian Hu, Wenying Song, Yali Hu, Yimin Dai, Yi-Hua Zhou","doi":"10.1017/thg.2023.33","DOIUrl":"https://doi.org/10.1017/thg.2023.33","url":null,"abstract":"The aim of this study was to investigate the prevalence of anemia in twin pregnancies and the influence of anemia on maternal and neonatal outcomes. This retrospective study included twin pregnant women who delivered in a tertiary hospital in China from January 2018 to December 2018. Patients were divided by WHO criteria (hemoglobin <11.0 g/dL): the anemic and nonanemic groups. Patients with anemia were further classified as recovered or unrecovered subgroup after oral iron therapy. Maternal and neonatal outcomes in women carrying twins were compared using Student's t test and the chi-squared test or the Fisher exact test. Univariable and multivariable logistic regression models were used to determine the association of maternal and neonatal characteristics with anemia. Linear regression analysis was used to estimate mean birth weight and gestational week. The prevalence of anemia was 42.6% (182/427) in twin pregnancies. The anemic group had higher rates of low 1-minute Apgar score (4.4% vs. 1.8%, p = .028), perinatal death (1.9% vs. 0.2%, p = .012) and neonatal intensive care unit (NICU) admission (27.2% vs. 20.2%, p = .017; adjusted OR, 1.478; 95% CI [1.07, 2.044]). The recovered subgroup had lower NICU admission rate (13.5% vs. 30.3%, p = .006; OR, 0.388; 95% CI [0.186, 0.809]), higher gestational week and birth weight (β, 0.954 week; 95% CI [0.114, 1.794] and β, 171.01 g; 95% CI [9.894, 332.126] respectively). The prevalence of anemia in twin gestation is high. Anemia is associated with adverse neonatal outcomes, and correction of anemia significantly improved the pregnancy outcomes.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 18th International Twin Congress, and a Look at Twin Research in Wales/Twin Research Reviews: Temperamental Similarities and Twin Relations; Maximizing Twin Designs; Rare Tubal Ectopic Pregnancy; Twins' Academic Self-Concept Formation/In the Media: Identical Infant Twins Reunited; Birth of Identical-Fraternal Quadruplets; Identical Twin Comedians; 'Twice in a Lifetime': Meeting an Unrelated Look-Alike; Twins in the Tour de France. 第18届国际双胞胎大会，以及对威尔士双胞胎研究的展望/双胞胎研究评论:气质相似性和双胞胎关系;最大化孪生设计;罕见输卵管异位妊娠;双胞胎学术自我概念的形成/媒体:同卵婴儿双胞胎的团聚同卵异卵四胞胎的诞生;同卵双胞胎喜剧演员;“一生两次”:遇到一个毫无关系的相似者;双胞胎参加环法自行车赛。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-08-29 DOI: 10.1017/thg.2023.31

Nancy L Segal

{"title":"The 18th International Twin Congress, and a Look at Twin Research in Wales/Twin Research Reviews: Temperamental Similarities and Twin Relations; Maximizing Twin Designs; Rare Tubal Ectopic Pregnancy; Twins' Academic Self-Concept Formation/In the Media: Identical Infant Twins Reunited; Birth of Identical-Fraternal Quadruplets; Identical Twin Comedians; 'Twice in a Lifetime': Meeting an Unrelated Look-Alike; Twins in the Tour de France.","authors":"Nancy L Segal","doi":"10.1017/thg.2023.31","DOIUrl":"https://doi.org/10.1017/thg.2023.31","url":null,"abstract":"The 18th International Society for Twin Studies convention took place between June 15-17, 2023, in Budapest, Hungary. A selective sampling of highlights from the meeting are presented. This is followed by a brief overview of ongoing twin research at the University of Aberystwyth in Wales and some twin treasures in the National Library. Next, reviews of timely research that examine temperamental similarities and twin relations, the maximization of twin research designs, a rare ectopic twin pregnancy, and twins' academic self-concept formation are presented. The final section covers stories appearing in various media sources that are informative, enlightening, and interesting, namely a reunion of identical infant twins, the birth of identical-fraternal quadruplets, identical twin comedians, meeting an unrelated look-alike, and twins in the Tour de France.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10466741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Genetics Society of Australasia Position Statement: Genetic Testing and Personal Insurance Products in Australia - CORRIGENDUM. 澳大利亚人类遗传学会立场声明:基因检测和个人保险产品在澳大利亚-勘误表。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-08-29 DOI: 10.1017/thg.2023.36

Aideen M McInerney-Leo, Samantha Ayres, Jackie Boyle, Chris Jacobs, Ainsley J Newson

引用次数: 0

THG volume 26 issue 4-5 Cover THG 第 26 卷第 4-5 期封面

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-08-01 DOI: 10.1017/thg.2023.50

引用次数: 0

THG volume 26 issue 6 Cover THG 第 26 卷第 6 期封面

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-08-01 DOI: 10.1017/thg.2023.52

引用次数: 0

Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population. 预测他汀类药物治疗在哈萨克人群中的有效性和安全性的候选基因。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-07-25 DOI: 10.1017/thg.2023.28

Raikhan Y Tuleutayeva, Assem R Makhatova, Saule O Rakhyzhanova, Lashyn K Zhazykbayeva, Dana K Kozhakhmetova

{"title":"Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population.","authors":"Raikhan Y Tuleutayeva, Assem R Makhatova, Saule O Rakhyzhanova, Lashyn K Zhazykbayeva, Dana K Kozhakhmetova","doi":"10.1017/thg.2023.28","DOIUrl":"https://doi.org/10.1017/thg.2023.28","url":null,"abstract":"The purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of genetic variants that determine the increased risk of complications of statin use was revealed. There was a tendency toward an increase in the activity of creatine phosphokinase (CPK) in the blood upon detection of the A6986G mutation of the cytochrome gene and SLCO1B1 (c.521T>C) gene of the transport protein OATP1B1. In the studied Kazakh population, the presence of a homozygous mutant SLCO1B1 gene of the transport protein can be recommended as a genetic marker for the undesirability of using antihypercholesterolemic therapy with statins, which simultaneously leads to a decrease in the effectiveness of treatment and an increase in the risk of side effects.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9865440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Spontaneous Twinning Recorded By Time-Lapse. 早期自发孪晶记录的时间推移。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-06-01 Epub Date: 2023-09-01 DOI: 10.1017/thg.2023.24

Roberto Matorras, Alberto Vendrell, Marcos Ferrando, Zaloa Larreategui

{"title":"Early Spontaneous Twinning Recorded By Time-Lapse.","authors":"Roberto Matorras, Alberto Vendrell, Marcos Ferrando, Zaloa Larreategui","doi":"10.1017/thg.2023.24","DOIUrl":"10.1017/thg.2023.24","url":null,"abstract":"Monozygotic twins (MZT) are 2.5 times more frequent in ART than in natural conceptions. A number of ART-related mechanisms have been probably linked with MZT. Studies that retrospectively analyze the time-lapse (TL) records resulting in MZT suggest that some morphokinetic traits of the inner cell mass and the trophectoderm could be predictors of MZT, but results are controversial. We present the complete TL record of one case of MZT that split itself at the very moment of the division into two cells, with one of the cells coming out through a hole in the zona pellucida (ZP). Both resulting embryos developed normally, and were vitrified. It is suggested that the hole in the ZP may facilitate the extrusion of some cells of the <day 4 embryo and that this cell development is not constrained by being inside the ZP. Despite the lack of the inhibition of the ZP itself or the influence of the other embryo cells, the totipotent cell was then able to develop correctly from the start. Moreover, the embryo inside the ZP compensated for the loss of this cell apparently without problems. Our findings are discussed in the context of previous literature and ethical problems are addressed.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":"26 3","pages":"215-218"},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and Environmental Correlation Analysis of Serum Creatinine Levels in Chinese Twins. 中国双胞胎血清肌酸水平的遗传与环境相关性分析。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-06-01 Epub Date: 2023-05-12 DOI: 10.1017/thg.2023.20

Anni Wang, Tianhao Zhang, Jingxian Li, Weijing Wang, Chunsheng Xu, Haiping Duan, Xiaocao Tian, Dongfeng Zhang

{"title":"Genetic and Environmental Correlation Analysis of Serum Creatinine Levels in Chinese Twins.","authors":"Anni Wang, Tianhao Zhang, Jingxian Li, Weijing Wang, Chunsheng Xu, Haiping Duan, Xiaocao Tian, Dongfeng Zhang","doi":"10.1017/thg.2023.20","DOIUrl":"10.1017/thg.2023.20","url":null,"abstract":"Almost all creatinine is excreted by the kidney in individuals. Serum creatinine concentration, a widely used renal function index in clinical practice, can be affected by both genetic and environmental factors, as evidenced by current research exploring the relationship between these factors and kidney function. However, few studies have explored the heritability of serum creatinine in Asian populations. Therefore, we explored the genetic and environmental factors that affect the serum creatinine level in Asian populations. Participants in this study came from the Qingdao Twin Registry in China, and 374 pairs of twins were included, of which 139 pairs were dizygotic twins, whose ages ranged from 40 to 80 years old, and the serum creatinine level ranged from 10 to 126 μmol/L. Structural equation models were constructed using Mx software to calculate heritability, with adjusted covariates being age, sex, and body mass index. The results of heritability analysis showed that ACE was the best fit model. Serum creatinine level is influenced by genetic and environmental factors. The result of heritability was 35.44%, and the influence of shared environmental factors accounted for 52.13%. This study provided the relevant basis for future research on genetic and environmental factors affecting serum creatinine levels in Asian populations.","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":"26 3","pages":"219-222"},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10575591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THG volume 26 issue 3 Cover. THG 26卷第3期封面。

IF 0.9 4区医学

Twin Research and Human Genetics Pub Date : 2023-06-01 DOI: 10.1017/thg.2023.43

引用次数: 0