Twin Research and Human Genetics最新文献

筛选
英文 中文
Most Unusual Twin Pairs: A Look at Uterus Didelphys / Twin Research Reviews: Prenatal Aneuploidy Screening for Twin Pregnancies; Twin Conceptions by Same-Sex Male Couples; Legal Personality of Conjoined Twins; Twin Study of Cannabis Use / Human Interest and Importance: Being Taken for Twins Saved Sisters; Twin Children of Jailed Nobel Prize Winner; British ‘Biracial’ Twins; Triplets Born at Start of Russian Attack on Ukraine; Twins Born in Different Years 最不寻常的双胞胎配对:子宫畸形/双胞胎研究综述:双胞胎怀孕的产前非整倍体筛查;同性男性夫妇的双胞胎受孕;连体双胞胎的法律人格;关于大麻使用的双胞胎研究/人类利益和重要性:被当作双胞胎的姐妹得救了;被监禁的诺贝尔奖获得者的双胞胎子女;英国 "双亲 "双胞胎;在俄罗斯进攻乌克兰之初出生的三胞胎;不同年份出生的双胞胎
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-03-20 DOI: 10.1017/thg.2024.14
Nancy L. Segal
{"title":"Most Unusual Twin Pairs: A Look at Uterus Didelphys / Twin Research Reviews: Prenatal Aneuploidy Screening for Twin Pregnancies; Twin Conceptions by Same-Sex Male Couples; Legal Personality of Conjoined Twins; Twin Study of Cannabis Use / Human Interest and Importance: Being Taken for Twins Saved Sisters; Twin Children of Jailed Nobel Prize Winner; British ‘Biracial’ Twins; Triplets Born at Start of Russian Attack on Ukraine; Twins Born in Different Years","authors":"Nancy L. Segal","doi":"10.1017/thg.2024.14","DOIUrl":"https://doi.org/10.1017/thg.2024.14","url":null,"abstract":"<p>A review of an unusual twin type—twins born to women with two uteri (uterus didelphys)—is presented. This review is followed by summaries of recent research and perspectives concerning prenatal aneuploidy screening for twin pregnancies, twin conceptions by same-sex male couples, legal personality of conjoined twins, and a twin study of cannabis use. Interesting information about twins that has appeared in the media is also presented, namely how being taken for twins saved a pair of sisters; twin children of a jailed Nobel Prize winner, British ‘biracial’ twins, triplets born at the start of Russia’s attack on Ukraine, and twins born in different years.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":"13 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Sleep Quality in Spanish Twin Pregnancy: An Observational Single-Center Study 西班牙双胎妊娠的睡眠质量评估:单中心观察研究
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-03-20 DOI: 10.1017/thg.2024.13
María de la Calle, Jose L. Bartha, Abigail Martin Mens, Silvia M. Arribas, David Ramiro-Cortijo
{"title":"Assessment of Sleep Quality in Spanish Twin Pregnancy: An Observational Single-Center Study","authors":"María de la Calle, Jose L. Bartha, Abigail Martin Mens, Silvia M. Arribas, David Ramiro-Cortijo","doi":"10.1017/thg.2024.13","DOIUrl":"https://doi.org/10.1017/thg.2024.13","url":null,"abstract":"<p>Women with twin pregnancies experience greater sleep disturbance compared to women with singleton pregnancies. The aims of this study were to explore the sleep quality in women with twin pregnancies and to compare their sleep dimensions with coetaneous single pregnancies. This was an observational study in which women were enrolled at the end of pregnancy in the Obstetric Service of Hospital La Paz (Spain). The women were classified as single (<span>n</span> = 143) or twin pregnancy (<span>n</span> = 62). Pregnant women responded to the Pittsburgh Sleep Quality Index to evaluate sleep quality, latency, duration, efficiency, perturbance, use of medication, and daytime dysfunction. The higher the index, the greater the alteration of sleep quality. Without statistical differences, a poor sleep quality was higher in women with single (66.7%) than women with twin pregnancies (22.8%). The good sleeper slept 6.8 h/day in single pregnancy and 7.3 h/day in twin pregnancy. The sleep perturbation and dysfunctionality were higher in women with twin than single pregnancies. The use of medication to sleep was significantly lower in women with twin than single pregnancies. In women with twin pregnancy, the body weight gain during first trimester had a positive correlation with worse sleep quality and sleep perturbations. Twin pregnancy needed more than 7 h/day to have a high sleep quality, showing greater sleep perturbations and daytime dysfunction than single pregnancies. The control of gestational body weight can improve the sleep quality, disturbances, and duration in twin gestations. Sleep screening during pregnancy would be necessary to handle sleep issues and increase benefits in twin gestational outcomes.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":"40 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impossible Dream - Panmixia. 不可能实现的梦想 - Panmixia.
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-27 DOI: 10.1017/thg.2024.6
Alan E Stark
{"title":"The Impossible Dream - Panmixia.","authors":"Alan E Stark","doi":"10.1017/thg.2024.6","DOIUrl":"https://doi.org/10.1017/thg.2024.6","url":null,"abstract":"<p><p>This study starts with a simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies. The question of differentiating between random and non-random mating is explored by simulation. Sample mating proportions are generated using the model as base. The difficulty of differentiating between random and non-random mating is illustrated.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Twin Births and Survival in Bangladesh: An Analysis of Half a Century of Evidence. 孟加拉国双胞胎出生和存活趋势:对半个世纪证据的分析。
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-12 DOI: 10.1017/thg.2024.5
Kazi Zubair Hossain, Iftekhar Hasan
{"title":"Trends in Twin Births and Survival in Bangladesh: An Analysis of Half a Century of Evidence.","authors":"Kazi Zubair Hossain, Iftekhar Hasan","doi":"10.1017/thg.2024.5","DOIUrl":"https://doi.org/10.1017/thg.2024.5","url":null,"abstract":"<p><p>This study assessed the trends in twin births and their survival in Bangladesh by analyzing over a quarter million live births during 1970-2018, pooled from all eight rounds of the Bangladesh Demographic and Health Survey. In these five decades, the twinning rate increased by 1.5 times, from 5.8 to 8.6 twins per 1000 maternities. The decadal twinning rates varied across maternal age, parity, body mass index, household wealth index, and geographic region. The gap in decadal neonatal, infant, and under-five cumulative survival probability between singleton and multiple births was found to be closing, using Kaplan-Meier curves. Child mortality decreased by 80% and 60% in singleton and multiple births respectively. However, the absolute size of child mortality in multiple births remained six times higher than in singletons and was concentrated in the neonatal period. The share of multiple births surged in all types of child mortality. We predict a further and faster rise in multiple births in the coming decades in the face of upward trends in maternal age overlapping with higher parities, education, career prospects, contraceptive use, and the future demand-supply of assisted reproductive technology. A particular focus on the improvement of perinatal and neonatal care with wider availability is warranted. Otherwise, increased multiple births might raise child mortality and create public health challenges.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THG volume 27 issue 1 Cover. THG 第 27 卷第 1 期封面。
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-05-29 DOI: 10.1017/thg.2024.27
{"title":"THG volume 27 issue 1 Cover.","authors":"","doi":"10.1017/thg.2024.27","DOIUrl":"https://doi.org/10.1017/thg.2024.27","url":null,"abstract":"","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":"27 1","pages":"f1"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project. 荷兰终生抑郁症基因组研究:荷兰生物银行互联网合作(BIONIC)项目。
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-03-18 DOI: 10.1017/thg.2024.4
Floris Huider, Yuri Milaneschi, Jouke-Jan Hottenga, Mariska Bot, M Liset Rietman, Almar A L Kok, Tessel E Galesloot, Leen M 't Hart, Femke Rutters, Marieke T Blom, Didi Rhebergen, Marjolein Visser, Ingeborg Brouwer, Edith Feskens, Catharina A Hartman, Albertine J Oldehinkel, Eco J C de Geus, Lambertus A Kiemeney, Martijn Huisman, H Susan J Picavet, W M Monique Verschuren, Hanna M van Loo, Brenda W J H Penninx, Dorret I Boomsma
{"title":"Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project.","authors":"Floris Huider, Yuri Milaneschi, Jouke-Jan Hottenga, Mariska Bot, M Liset Rietman, Almar A L Kok, Tessel E Galesloot, Leen M 't Hart, Femke Rutters, Marieke T Blom, Didi Rhebergen, Marjolein Visser, Ingeborg Brouwer, Edith Feskens, Catharina A Hartman, Albertine J Oldehinkel, Eco J C de Geus, Lambertus A Kiemeney, Martijn Huisman, H Susan J Picavet, W M Monique Verschuren, Hanna M van Loo, Brenda W J H Penninx, Dorret I Boomsma","doi":"10.1017/thg.2024.4","DOIUrl":"10.1017/thg.2024.4","url":null,"abstract":"<p><p>In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on <i>Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition</i> (<i>DSM-5</i>) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, <i>N</i> = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping. For standardized phenotyping we developed the LIDAS (LIfetime Depression Assessment Survey), which then was used to measure MDD in 11 Dutch cohorts. Data from these cohorts were combined with diagnostic interview depression data from 5 clinical cohorts to create a dataset of <i>N</i> = 29,650 lifetime MDD cases (22%) meeting <i>DSM-5</i> criteria and 94,300 screened controls. In addition, genomewide genotype data from the cohorts were assembled into a genomewide association study (GWAS) dataset of <i>N</i> = 66,684 Dutch individuals (25.3% cases). Phenotype data include <i>DSM-5</i>-based MDD diagnoses, sociodemographic variables, information on lifestyle and BMI, characteristics of depressive symptoms and episodes, and psychiatric diagnosis and treatment history. We describe the establishment and harmonization of the BIONIC phenotype and GWAS datasets and provide an overview of the available information and sample characteristics. Our next step is the GWAS of lifetime MDD in the Netherlands, with future plans including fine-grained genetic analyses of depression characteristics, international collaborations and multi-omics studies.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"1-11"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome. 因双胎输血综合征接受胎儿镜手术的双胞胎胎儿代谢组的急性变化
IF 0.9 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-03-22 DOI: 10.1017/thg.2024.10
Braxton Forde, Samuel Martin, Miki Watanabe-Chailland, Foong-Yen Lim
{"title":"Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome.","authors":"Braxton Forde, Samuel Martin, Miki Watanabe-Chailland, Foong-Yen Lim","doi":"10.1017/thg.2024.10","DOIUrl":"10.1017/thg.2024.10","url":null,"abstract":"<p><p>Fetuses undergo major surgical stress as well as fluid shifts secondary to both twin-twin transfusion (TTTS) as well as the fetoscopic surgery for treatment of TTTS. While the pathophysiology of TTTS is understood, the acute metabolic changes that fetuses experience from fetoscopic surgery are not. We sought to evaluate the changes in recipient metabolomic profile secondary to TTTS surgery. Amniotic fluid was collected at the beginning and end of four TTTS surgical cases performed from 12/2022-2/2023. Samples were immediately processed and evaluated via NMR-based Metabolomics Facility protocol. In univariate analysis, 12 metabolites (glucose, lactate, and 10 key amino acids) showed statistically significant changes between the beginning and end of the surgery. Among these, 11 metabolites decreased at the end, while only lactate increased. Supervised oPLS-DA modeling revealed pyruvate and lactate as the two metabolites most impact on the variance between cases, and that 40% of metabolomic changes could be attributed directly to the timing that the sample was taken (i.e., if pre- or postoperatively). These results indicate significant metabolic changes in the recipient twin during fetoscopic surgery for TTTS. These findings of decreased glucose, increased lactate, and decreased amnio acids would indicate increased catabolism during surgery. This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"56-63"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary Trends of Polygenic Scores in European Populations From the Paleolithic to Modern Times. 从旧石器时代到现代欧洲人群多基因评分的进化趋势。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-03-06 DOI: 10.1017/thg.2024.8
Davide Piffer, Emil O W Kirkegaard
{"title":"Evolutionary Trends of Polygenic Scores in European Populations From the Paleolithic to Modern Times.","authors":"Davide Piffer, Emil O W Kirkegaard","doi":"10.1017/thg.2024.8","DOIUrl":"10.1017/thg.2024.8","url":null,"abstract":"<p><p>This study examines the temporal and geographical evolution of polygenic scores (PGSs) across cognitive measures (Educational Attainment [EA], Intelligence Quotient [IQ]), Socioeconomic Status (SES), and psychiatric conditions (Autism Spectrum Disorder [ASD], schizophrenia [SCZ]) in various populations. Our findings indicate positive directional selection for EA, IQ, and SES traits over the past 12,000 years. Schizophrenia and autism, while similar, showed different temporal patterns, aligning with theories suggesting they are psychological opposites. We observed a decline in PGS for neuroticism and depression, likely due to their genetic correlations and pleiotropic effects on intelligence. Significant PGS shifts from the Upper Paleolithic to the Neolithic periods suggest lifestyle and cognitive demand changes, particularly during the Neolithic Revolution. The study supports a mild hypothesis of Gregory Clark's model, showing a noticeable rise in genetic propensities for intelligence, academic achievement and professional status across Europe from the Middle Ages to the present. While latitude strongly influenced height, its impact on schizophrenia and autism was smaller and varied. Contrary to the cold winters theory, the study found no significant correlation between latitude and intelligence.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"30-49"},"PeriodicalIF":1.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partnership with the University of São Paulo Panel of Twins: A Four-City Tour and More / Twin Research Reviews: Twin Research on Binge Eating; Twins' Physical Outcomes Linked to Different Diets; Working Conditions and Sickness Absence in Swedish Twins; Facial Morphology Differences in Monozygotic Twins / Human Interest and Importance: Michigan Family Forced to Adopt Their Own Twins; Ethics of Hiring a Surrogate to Bear Twins; Twin Survivors of the Israel-Hamas War; Twin Pregnancy with Double Uterus; Three Twin Pairs on Same Women's Soccer Team. 与圣保罗大学双胞胎研究小组合作:四城之旅及其他/双胞胎研究综述:关于暴饮暴食的双胞胎研究;双胞胎的身体结果与不同的饮食有关;瑞典双胞胎的工作条件和病假;单卵双生双胞胎的面部形态差异/人类利益和重要性:密歇根家庭被迫收养自己的双胞胎;雇佣代孕者生双胞胎的伦理问题;以色列-哈马斯战争的双胞胎幸存者;双子宫双胞胎妊娠;三对双胞胎同在一支女子足球队。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-02-21 DOI: 10.1017/thg.2024.1
Nancy L Segal
{"title":"Partnership with the University of São Paulo Panel of Twins: A Four-City Tour and More / Twin Research Reviews: Twin Research on Binge Eating; Twins' Physical Outcomes Linked to Different Diets; Working Conditions and Sickness Absence in Swedish Twins; Facial Morphology Differences in Monozygotic Twins / Human Interest and Importance: Michigan Family Forced to Adopt Their Own Twins; Ethics of Hiring a Surrogate to Bear Twins; Twin Survivors of the Israel-Hamas War; Twin Pregnancy with Double Uterus; Three Twin Pairs on Same Women's Soccer Team.","authors":"Nancy L Segal","doi":"10.1017/thg.2024.1","DOIUrl":"10.1017/thg.2024.1","url":null,"abstract":"<p><p>This article begins with an overview of twin research in Brazil, initiated by the University of São Paulo Panel of Twins. I met with many new research collaborators and students while on a fall 2023 four-city lecture tour in that country. A meeting with a world-famous surgeon who recently separated craniopagus conjoined twin pairs is also described. This overview is followed by summaries of twin research on binge eating, twins' physical outcomes linked to different diets, working conditions and sickness absence in Swedish Twins and facial morphology differences in monozygotic twins. The final section of this article provides a sampling of human interest stories with important implications. They include a Michigan family forced to adopt their own twins, ethical issues surrounding the hiring of a surrogate to bear twins; twin survivors of the Israel-Hamas war, a twin pregnancy with a double uterus, and three twin pairs on the same women's soccer team.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"64-68"},"PeriodicalIF":1.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Hematological and Biochemical Disparities in Same-Sex and Opposite-Sex Females: A Cross-Sectional Twin Study in a Ghanaian Population. 探索同性和异性女性血液和生化差异:加纳人口中的双胞胎横断面研究。
IF 1 4区 医学
Twin Research and Human Genetics Pub Date : 2024-02-01 Epub Date: 2024-03-06 DOI: 10.1017/thg.2024.7
Moses Banyeh, Benjamin N Mayeem, Moses Kofi Woli, Augusta S Kolekang, Clement Binwatin Dagungong, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa
{"title":"Exploring Hematological and Biochemical Disparities in Same-Sex and Opposite-Sex Females: A Cross-Sectional Twin Study in a Ghanaian Population.","authors":"Moses Banyeh, Benjamin N Mayeem, Moses Kofi Woli, Augusta S Kolekang, Clement Binwatin Dagungong, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa","doi":"10.1017/thg.2024.7","DOIUrl":"10.1017/thg.2024.7","url":null,"abstract":"<p><p>There are sex-dependent differences in hematological and biochemical variables in adulthood attributed to the predominant effects of testosterone in males and estrogen in females. The Twin Testosterone Transfer (TTT) hypothesis proposes that opposite-sex females may develop male-typical traits due to exposure to relatively higher levels of prenatal testosterone than same-sex females. Additionally, prenatal testosterone exposure has been suggested as a correlate of current circulating testosterone levels. Consequently, opposite-sex females might exhibit male-typical patterns in their hematological and biochemical variables. Despite this hypothesis, routine laboratory investigations assign the same reference range to all females. Our cross-sectional study, conducted in Tamale from January to September 2022, included 40 twins, comprising 10 opposite-sex (OS) males (25%), 10 OS females (25%), and 20 same-sex (SS) females (50%), all aged between 18 and 27 years. Fasting venous blood samples were collected and analyzed using automated hematology and biochemistry laboratory analyzers. Results indicated that levels of hemoglobin, serum creatinine, gamma-glutamyl transferase, total protein, globulins, and total testosterone were significantly higher in OS males than OS females. Conversely, total cholesterol and low-density lipoprotein cholesterol were significantly higher in OS females than OS males. Unexpectedly, levels of low-density lipoprotein cholesterol and total testosterone were significantly higher in SS females than OS females. Contrary to expectations, opposite-sex females did not exhibit male-typical patterns in their hematological and biochemical variables. This suggests that the TTT effect may not occur or may not be strong enough to markedly affect hematological and biochemical variables in OS females.</p>","PeriodicalId":23446,"journal":{"name":"Twin Research and Human Genetics","volume":" ","pages":"50-55"},"PeriodicalIF":1.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信