Ukrainian Journal of Dermatology, Venerology, Cosmetology最新文献

{"title":"Modern approaches to treatment of chronic spontaneous urticaria in adult patients","authors":"O. Denysenko","doi":"10.30978/ujdvk2020-2-34","DOIUrl":"https://doi.org/10.30978/ujdvk2020-2-34","url":null,"abstract":"Objective — to study and analyze thematic publications on aspects of etiopathogenesis and modern approaches to the treatment of chronic spontaneous urticaria in adult patients. Materials and methods. A study and analysis of current domestic and foreign publications was conducted on aspects of the etiopathogenesis and treatment of chronic urticaria, including the recommendations of the National Health Service of the United Kingdom (NHS, 2020) for the treatment of chronic spontaneous urticaria in adult patients, based on principles of evidence­based medicine. Results and discussion. According to domestic and foreign publications, urticaria affects about 15—20 % of the population, while in recent years the number of chronic forms of dermatosis resistant to treatment (registered in about 2 % of the population) is increasing, which reduces the capability for work and quality of life of patients. In more than half of the patients the probable cause of chronic urticaria cannot be determined, which indicates the development of a spontaneous (idiopathic) form of dermatosis. First­line drugs for the treatment of chronic urticaria are non­sedative H1­antihistamines of the second generation, which, however, in many patients do not provide a positive clinical effect in standard doses. In the European recommendations, to increase the effectiveness of treatment of patients with torpid forms of chronic urticaria, it is proposed to increase the daily dose of antihistamines by 4 times. According to NHS recommendations (2020), created on evidence­based medicine, adult patients with chronic spontaneous urticaria are recommended to use a cost­ and clinically effective second­generation antihistamine cetirizine as first­line therapy which is prescribed step by step with increasing daily dose by 2—4 times. Conclusions. Chronic urticaria is a serious medical and social problem today. More than half of patients with chronic urticaria are those having spontaneous (idiopathic) form of dermatosis. H1­antihistamines of the second generation are the first­line therapy for chronic urticaria, but due to the lack of a positive effect in some patients when using their standard doses, it is recommended to increase their daily doses by 4 times. According to NHS recommendations (2020), adult patients with chronic spontaneous urticaria are recommended an efficient and cost­effective second­generation antihistamine cetirizine as first­line (dose­increasing) therapy.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86141255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To compare the clinical effectiveness of azithromycin vs doxycycline on the first follow-up visit of acne vulgaris patients","authors":"G. Butt","doi":"10.15406/jdc.2020.04.00155","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00155","url":null,"abstract":"Acne Vulgaris is a chronic inflammatory disorder of pilosebaceous unit which frequently affects the cosmetically important areas of the body like face, back, chest, neck, and upper arms. It is a multifactorial disease and its pathophysiology centres on the interplay of increased sebum production, follicular hyperkeratinisation, colonization with Propionibacterium Acnes and inflammation. There are many systemic modalities for the treatment of acne among which Azithromycin and Doxycycline are the commonly prescribed ones. With an aim to manage patients effectively a case-control study was conducted on 70 patients to compare the clinical effectiveness of both the drugs for the early symptomatic relief of moderate to severe inflammatory acne. Method This study was conducted at the outdoor of dermatology department at Punjab Rangers Teaching Hospital over a period of three months starting from August 2019 till the end of October. A total of 70 acne patients compatible with the inclusion criteria were enrolled and divided into two equal groups of cases and controls. The cases were prescribed Azithromycin 500mg once a day for first two weeks followed by 250mg once a day for the next two weeks, while the controls were prescribed Doxycycline 100 mg once a day. Both groups were treated for a period of four weeks and were assessed based on new lesion count and the settlement of older lesions to compare the clinical effectiveness of each drug. Results Based on the clinical assessment at the first follow-up after 4 weeks, it was observed that in the Azithromycin group 21 patients (60%) showed a good response with (more than 50%) clearance of the inflammatory pustules and nodules, 9 (26%) patients showed a moderate response between 30-50% and 5 (14%) patients showed a mild response between 20-30%. In Group B, 12 (34%) patients showed moderate response between 30- 50%, 12 (34%) patients showed mild response between 20-30%, while the remaining 11 (32%) patients were placed in the no response category with less than 20% improvement. Overall Azithromycin showed significantly better response, p-value < 0.001 than other group, p-value=0.014. Conclusion It was observed that Azithromycin has an earlier onset of action in the treatment of inflammatory acne as compared to Doxycycline. So, for patients where prompt results are desired Azithromycin has proven to be more effective as compared to Doxycycline.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73931341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences between family doctors and dermatologists in the diagnosis of potentially transmissible skin diseases among pool swimmers","authors":"P. Iordanis","doi":"10.15406/jdc.2020.04.00146","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00146","url":null,"abstract":"Introduction Due to the difficult financial conditions in Greece most of the prospective swimmers do not go to the dermatologist for their medical report regarding transmissible dermatological diseases They receive this report from their family doctors The purpose of this study was the evaluation of the ability of other specialties on recognizing and diagnosing transmissible dermatological diseases of swimmers nbsp Methods A total of people were examined The first group consisted of people who were examined for the first time in the medical office of the swimming pool and had no medical report about a transmissible dermatological disease The second group consisted of the remaining people who had a recent medical report from a family doctor certifying that they did not suffer from a transmissible dermatological disease nbsp Results The of the first group had some potentially transmissible dermatological disease while the corresponding percentage of the second group was Virtually one in two swimmers of the second group suffered from a potentially transmissible dermatological disease and had been diagnosed as healthy by a family doctor nbsp Conclusions There are issues with the diagnosis of dermatological diseases by non dermatologists since some lesions might not be recognized by General Practitioners or family doctors The reason for that might be the difficulty in the diagnoses of the dermatological diseases the training of other specialties in dermatological lesions and the financial status of the people examined nbsp nbsp Methods A total of people were examined The first group consisted of people who were examined for the first time in the medical office of the swimming pool and had no medical report about a transmissible dermatological disease The second group consisted of the remaining people who had a recent medical report from a family doctor certifying that they did not suffer from a transmissible dermatological disease nbsp Results The of the first group had some potentially transmissible dermatological disease while the corresponding percentage of the second group was Virtually one in two swimmers of the second group suffered from a potentially transmissible dermatological disease and had been diagnosed as healthy by a family doctor nbsp Conclusions There are issues with the diagnosis of dermatological diseases by non dermatologists since some lesions might not be recognized by General Practitioners or family doctors The reason for that might be the difficulty in the diagnoses of the dermatological diseases the training of other specialties in dermatological lesions and the financial status of the people examined nbsp","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88457920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophilic dermatoses: Sweet syndrome and gangrenous pyoderma. Literature review and own clinical observations","authors":"Y. Yehudina, S. Trypilka, I. Golovach","doi":"10.30978/ujdvk2020-1-103","DOIUrl":"https://doi.org/10.30978/ujdvk2020-1-103","url":null,"abstract":"Neutrophilic dermatoses are a heterogeneous group of inflammatory skin diseases that have unique clinical features, but are combined by the presence of a sterile, predominantly neutrophilic infiltrate at histopathological examination. Neutrophilic dermatoses include Sweet syndrome, gangrenous pyoderma, Behcet’s disease, neutrophilic urticaria, subcorneal pustular dermatosis, palmoplantaris pustulosis, acrodermatitis Allopo, acute generalized exentematous pustulosis, infant pustulosis, etc. The morphology of skin lesions associated with these diseases is heterogeneous, which makes diagnosis challenging. In addition, a thorough clinical evaluation of patients is necessary to exclude diseases that mimic these disorders and to diagnose potential concomitant infectious, inflammatory, and tumor processes. While some neutrophilic dermatoses may disappear spontaneously, most require treatment to achieve remission. A delay in diagnosis and treatment can lead to significant morbidity and even mortality in these patients. Glucocorticoids are the drugs of choice for the treatment of neutrophilic dermatoses. In case of their ineffectiveness, other biological disease-modifying antirheumatic drugs may be administered depending on the severity of the skin lesion, chronicity of the disease, the presence of systemic lesions, and refractory status. This work is devoted to epidemiology, etiopathogenesis, clinical features, diagnostic signs and modern methods of treating Sweet syndrome and gangrenous pyoderma based on a review of modern literature and our own clinical observations.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82855965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detrimental effects of perfumes, aroma & cosmetics","authors":"M. Athar","doi":"10.15406/JDC.2020.04.00149","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00149","url":null,"abstract":"Perfumes have been historically used primarily for fragrance. Aroma or fragrance has also been added to the cosmetics to make it more attractive. These fragrance products emit a range of chemicals including hazardous pollutants but the ingredients do not fully disclosed on the product label. Hence, they are found to cause various detrimental effects ion human health. The detrimental effects associated with the use of perfumes are contact dermatitis, contact urticaria, and photo allergy and photo toxicity. Detrimental effects of cosmetics are lungs disease, damage to reproductive organs, skin allergies, excessive hair problems, headache and cancer. The present review summarizes some of the harmful effects caused by the use of fragrance products including perfumes, aroma and cosmetics. Moreover, the preventive measures which have to be taken care of have also been discussed.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87241014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series of dupilumab-treated atopic dermatitis resulting in new onset psoriasis","authors":"Lauren Boudreaux","doi":"10.15406/jdc.2020.04.00158","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00158","url":null,"abstract":"Five male patients age ranged from 30-69 were each diagnosed with moderate-to-severe AD. They were initially treated with traditional topical and systemic therapies for atopic dermatitis such as topical steroids, calcineurin inhibitors, and oral immune suppressants. Ultimately, all patients required dupilumab with improvement noted in their first few months of treatment. Psoriaform dermatitis presented at varying timelines. In 4/5 cases, the diagnosis of presumed druginduced psoriasis was supported with biopsies and pathology consistent with the morphologic changes noted in clinic (Figure 1). In 4/5 cases patients were able to fully recover from psoriaform plaques when dupilumab was discontinued. In some cases, patients were able to restart Dupilumab without reoccurrence of psoriaform findings. However, in one case, the rash persisted despite several treatment attempts. (Table 2).","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90598687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedling with radiofrequency for improvement in neck skin laxity and texture","authors":"Joely Kaufman","doi":"10.15406/JDC.2020.04.00145","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00145","url":null,"abstract":"In recent years, the number of patients presenting with neck rhytides has been increasing. This increase is in part due to the availability of newer non-invasive technology to treat the normal aging process, but also due to the postural and behavioral changes of this generation where people adopt a head down posture in order to be able to use their computers or smartphones. We present the successful treatment of a case of anterior neck skin laxity and texture with microneedling and radiofrequency.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85568835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperimmunoglobulin E syndrome associated with nephrotic syndrome–case report","authors":"S. Elfaituri","doi":"10.15406/JDC.2020.04.00168","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00168","url":null,"abstract":"A 3 years old child with coarse facial appearance was suffered from generalized eczema associated with secondary infections and recurrent multiple skin abscesses since he was 1 year old. The dermatitis and infections was present to some degree at all times. The patient had wheezy chest, food (cow milk) allergy and recurrent attacks of otitis media, candidiasis and herpes simplex virus infection with Kaposi varicelliform eruption. There was positive consanguinity between parents and positive family history with his older brother -5 years old, had similar disease. Routine blood counts revealed leukocytosis with persistent eosinophilia (40%).Blood chemistry was normal. The serum IgE level was11.000IU/ml with normal levels of other immunoglobulin classes.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90933791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the effect of solar radiation on workers’ skin at different altitudes","authors":"P. Iordanis","doi":"10.15406/jdc.2020.04.00142","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00142","url":null,"abstract":"A great part of the Greek population works in the agriculture economy related to agriculture, livestock and fisheries. According to the Hellenic Statistical Authority, in 2013, the agriculture economy employed 1.218.000 people of which 939.000 were exclusively employed in this domain. A basic source of the Greek economy is tourism, especially in the summer months, with the number of workers in the sector reaching 400,000 in 2017. Therefore, it can be stated that approximately 1,600,000 Greek residents work either year-round or seasonal and especially in summer in outdoor work exposed to the sunlight radiation. The total number of sunny days in the country during a calendar year is large.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73537140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pasini-Pierini’s atrophoderma and frontal fibrosing alopecia: an unusual association in a young patient","authors":"A. Rasso, Z. Douhi, M. Bennani, S. Elloudi","doi":"10.15406/jdc.2020.04.00140","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00140","url":null,"abstract":"A young woman of 38 years old, followed for fibrosing frontal alopecia under topical coricide, she had presented hypo pigmented macules at the abdominal level, back and thigh, whose histology had concluded a Pasini-Pierini atrophodermia. The association between fibrosing frontal alopecia and Pasinipierini atrophodermia is to our knowledge never described, whose physiopathology is unknown need more studies to explain this association","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77273196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}