杜匹单抗治疗的特应性皮炎导致新发牛皮癣的病例系列

Lauren Boudreaux
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引用次数: 1

摘要

5名年龄在30-69岁之间的男性患者被诊断为中度至重度AD。他们最初接受传统的局部和全身治疗特应性皮炎,如局部类固醇、钙调磷酸酶抑制剂和口服免疫抑制剂。最终,所有患者都需要dupilumab,并在治疗的前几个月得到改善。银屑病性皮炎出现在不同的时间线。在4/5的病例中,推测为药物性银屑病的诊断得到了与临床形态学变化一致的活检和病理的支持(图1)。在4/5的病例中,停用杜匹单抗后,患者能够从银屑病斑块中完全恢复。在某些情况下,患者能够重新开始Dupilumab而不会出现银屑病症状。然而,在一个病例中,尽管多次治疗尝试,皮疹仍然存在。(表2)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case series of dupilumab-treated atopic dermatitis resulting in new onset psoriasis
Five male patients age ranged from 30-69 were each diagnosed with moderate-to-severe AD. They were initially treated with traditional topical and systemic therapies for atopic dermatitis such as topical steroids, calcineurin inhibitors, and oral immune suppressants. Ultimately, all patients required dupilumab with improvement noted in their first few months of treatment. Psoriaform dermatitis presented at varying timelines. In 4/5 cases, the diagnosis of presumed druginduced psoriasis was supported with biopsies and pathology consistent with the morphologic changes noted in clinic (Figure 1). In 4/5 cases patients were able to fully recover from psoriaform plaques when dupilumab was discontinued. In some cases, patients were able to restart Dupilumab without reoccurrence of psoriaform findings. However, in one case, the rash persisted despite several treatment attempts. (Table 2).
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