Hyperimmunoglobulin E syndrome associated with nephrotic syndrome–case report

A 3 years old child with coarse facial appearance was suffered from generalized eczema associated with secondary infections and recurrent multiple skin abscesses since he was 1 year old. The dermatitis and infections was present to some degree at all times. The patient had wheezy chest, food (cow milk) allergy and recurrent attacks of otitis media, candidiasis and herpes simplex virus infection with Kaposi varicelliform eruption. There was positive consanguinity between parents and positive family history with his older brother -5 years old, had similar disease. Routine blood counts revealed leukocytosis with persistent eosinophilia (40%).Blood chemistry was normal. The serum IgE level was11.000IU/ml with normal levels of other immunoglobulin classes.