Ukrainian Journal of Dermatology, Venerology, Cosmetology最新文献

{"title":"Topical therapy of onychomycosis in patients with psoriasis","authors":"K. Suprun, I.O. Oliynyk","doi":"10.30978/ujdvk2021-2-57","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-57","url":null,"abstract":"Objective — to study the effectiveness of the method of treating onychomycosis using only local agents in patients suffering from psoriasis and having contraindications to the use of systemic antifungal agents. \u0000Materials and methods. The study involved 52 patients with psoriasis and lesions of the nail plates, aged 21 to 67 years. The duration of the disease was from 1 to 27 years.To verify the fungal infection of the nail plates, a microscopic examination of nail scales with 20 % KOH and molecular genetic studies using pan-fungal primers were carried out.Among 52 examined patients with psoriasis who had clinical signs of lesions of the nail plates, there were 37 people with mycotic infection lesions of the nail plates.Due to the somatic burden, the use of systemic antifungal agents was contraindicated. Treatment of onychomycosis in such patients was carried out using only local therapy and sanitary-hygienic measures. As a topical antifungal therapy, 1 % solution and 1 % cream of naftifine hydrochloride were prescribed in combination with drugs that improve the structure of the nail plates (Volvit, 5 mg once a day and Cytoflavin, 2 tablets 2 times a day for 1.5 months). \u0000Results and discussion. 1 month after the beginning of the use of the proposed method for the treatment of nail fungal infection in case of psoriasis of the scales of the nail plates, mycelium and fungal spores were absent in 6 (16.2 %) patients with distal lesions of the nail plates. After 4 months of treatment they were absent in 16 (43.4 %) patients with distal-lateral lesions of the nail plates, after 6 months — in 21 (56.7 %) patients, after 9 months — in 26 (70.2 %) patients. \u0000Conclusions. The proposed complex method is quite effective and of higher priority for the treatment of onychomycosis in patients with comorbid conditions that make it impossible to treat a fungal infection with systemic antimycotics.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79445796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriatic onychodystrophy — modern treatment trends","authors":"V. Stepanenko, S. V. Ivanov, P. Fedorych","doi":"10.30978/ujdvk2021-2-43","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-43","url":null,"abstract":"Objective — to conduct an in-depth search of foreign and national literary sources, in particular, reports about the results of randomized controlled clinical trials regarding the use of local combination drugs for the treatment of psoriatic onychodystrophy. The focus is on both short-term and long-term therapeutic effects, as well as minimizing the side effects. \u0000Materials and methods. We conducted the analysis of the world experience of using the local combination drug Onychocid® Emtrix for the treatment of psoriatic onychodystrophy and minimization of side effects by searching for data (2010—2021) in the Cochrane Library controlled tests by keywords: psoriasis, onychodystrophy; in PubMed, High Wire Press, Google Scholar — by terms of the catalog and medical subjects: psoriasis + onychodystrophy + treatment; reports of randomized controlled clinical trials, meta-analyses and literature reviews. \u0000Results and discussion. The modern view on the problem of psoriatic onychodystrophy, methods and approaches to the treatment of this pathology are presented.According to the analysis of the results of foreign and national studies, Onychocid® Emtrix is proved to be clinically efficient and safe as complex treatment for various clinical forms of psoriatic onychodystrophy. It contains a combination of propylene glycol, urea and lactic acid. Active substances, which are part of the drug, are synergists, which provides triple action of ingredients — combining moisturizing and keratolytic effects with antifungal properties. Most patients showed an early (in the 2nd to 4th week of use of the drug) improvement in the appearance of the affected nails. In the future, they observed thinning of nail plates, color restoration, disappearance of excessively keratinized nail tissue, tendency to the restoration of the integrity of nails. The use of this topical medication provided high compliance due to an excellent profile of tolerance and the possibility of application once a day. \u0000Conclusions. It has been proven that the modern medication of local action Onychocid® Emtrix is currently the most optimal treatment for psoriatic onychodystrophy which allows achieving a therapeutic effect both in monotherapy and in the standard complex schemes. Treatment of psoriatic onychodystrophy with Onychocid® Emtrix is more effective in comparison with standard therapy, contributes to a rapid partial or full restoration of the integrity of nail plates. The high effectiveness and safety of Onychocid® Emtrix give reason to recommend it for inclusion in the schemes of complex treatment of patients with psoriatic onychodystophy.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88992630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The state of the enzyme level of antioxidant protection and its nonspecific correction in patients with eczema","authors":"М.Kh.M. Khwaileh, Y. Andrashko","doi":"10.30978/ujdvk2021-2-5","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-5","url":null,"abstract":"The variety of developmental mechanisms creates significant difficulties in choosing adequate directions of therapeutic tactics. Priority pathogenetic links, in particular, changes in the state of antioxidant protection, remain insufficiently studied. \u0000Objective — determination of the activity of the enzyme level of the antioxidant protection and the development of nonspecific correction of the established violations. \u0000Materials and methods. Under observation there were 52 patients with eczema (27 men and 25 women) aged 19 to 57 years. 16 of them were diagnosed with idiopathic, 21 — with infectious (microbial) and 15 — with infectious (mycotic) forms of dermatosis. The control group consisted of 20 healthy persons. The activity of catalase, glutathione peroxidase and superoxide dismutase (SOD) in blood serum was determined. \u0000Results and discussion. It has been established that patients with eczema have a labile nature of changes in the enzymatic activity of antioxidant protection, depending on the clinical form of dermatosis. Its total suppression was ascertained only in the presence of mycogenic sensitization. To eliminate the identified violations, PRP therapy and tacrolimus (Protopic) were prescribed, the use of which as part of complex therapy made it possible not only to achieve correction of pathogenetic changes, but also to significantly improve the clinical course of dermatosis. \u0000Conclusions. It is advisable to determine the activity of superoxide dismutase, the activity of catalase and glutathione peroxidase to assess the state of the enzyme link of the antioxidant defense in patients with eczema. The inclusion of PRP therapy and tacrolimus (Protopic) in the treatment allows correcting the state of the enzyme link of antioxidant protection and the clinical course of dermatosis. The activity of catalase, glutathione peroxidase and superoxide dismutase can serve as one of the criteria of the effectiveness of treatment prescribed for patients with eczema.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89899669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief outline of the history of world epidemics-­­pandemics. Part III. The half forgotten viral debut","authors":"К.V. Коlyadenko, O. Fedorenko","doi":"10.30978/ujdvk2021-2-85","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-85","url":null,"abstract":"A little more than a hundred years ago, the humanity plunged into the second wave of «the Spanish flu» just like in the spring of 2021 it plunged into the second wave of coronavirus. Despite the significant biological and virological differences between COVID-19 coronavirus and the Spanish flu, already known to us in the second year of the pandemic, the obvious significant similarity in the dynamics of the epidemiological scenarios of both pandemics is striking.It is officially believed that the epidemic in Europe began in the last months of the deadly First World War (1914—1918). Its development and the next catastrophic spread were caused by: unsanitary conditions, poor nutrition, overcrowding in trenches and refugee camps, the demobilization and the return of soldiers home, as also the rapid development of vehicles at the beginning of the 20th century (trains, cars, high-speed ships). The Spanish flu, caused by the H1N1 virus, had several «waves». It is difficult to estimate the exact number of those who had the Spanish flu, but presumably, this is 500—550 million people. About 25 million people died (some studies indicate a figure of 50 or even 100 million). Unfortunately, the mankind quickly forgot about this viral pandemic and consequently was objectively compelled, after a hundred years, to unexpectedly make the same mistake again and introduce quarantine as the only way to limit the further spread of the next viral pandemic of mankind. The Spanish flu significantly influenced all the further development of medicine. While before the deadly pandemic the private medical practice was widespread, in the process of its overcoming, the formation of the modern international health care system took place. In 1919, the International Bureau for Epidemic Control was founded in Vienna.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85933088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphism of exanthema, caused by SARS­Cov­2 virus (clinical case)","authors":"T. Svyatenko, V. Mavrutenkov, T. Haiduk, O. I. Haiduk, T. Mavrutenkova","doi":"10.30978/ujdvk2021-2-34","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-34","url":null,"abstract":"Objective — to improve the clinical diagnosis and management of the new coronavirus disease by describing a clinical case of viral exanthema as a result of infection with a new strain of SARS-CoV-2. \u0000Materials and methods. A description is presented of the clinical symptoms and features of skin lesions in the new coronavirus disease in a patient with probable Grover’s disease diagnosed during a pathological examination of a biopsy specimen of the affected skin. \u0000Results and discussion. The clinical diversity of the strain of the new SARS-CoV-2 coronavirus is due to the fact that coronavirus infection is a systemic viral infection that can affect any organ and system. The pathogenesis of these lesions is due to two mechanisms: direct virus damage to the body’s cells and the emergence of an immunopathological process that resembles systemic vasculitis. The ambivalence of immunopathogenesis is reflected in this clinical case.Several factors of the occurrence of dermatological lesions in a patient with a polymorphic rash with SARS-CoV-2 infection have been identified: chemical (sensitization due to working with chemical compounds), physical (mechanical pressure during the performance of professional duties), immunopathological (tendency to hyperergic reactions of the dermis) and thermal, which could provoke the appearance of signs of Grover’s disease. At the same time, the systemic viral infection with SARS-CoV-2 was a trigger for the immunopathological processes, manifested by skin lesions. \u0000Conclusions. Currently, there are no significant predictors of the course of coronavirus disease and the occurrence of complications. Therefore, a patient who has had a coronavirus infection should be advised a follow up (communication with a doctor) for 12 weeks. A patient with any dermatological pathology should be examined for specific markers of COVID-19. In the differential diagnosis discourse of the dermatological disease, COVID-19 should always be considered as a possible cause until proven otherwise. During therapy, vitamins, immunomodulators, antibiotics that do not have an evidence base should not be routinely prescribed to all patients, especially those who are at risk of developing immunopathological reactions due to occupational or toxicological anamnesis.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81697018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of interpretation of data of light and spectral dermatoscopy in patients with actinic keratosis","authors":"M. Zapolsky, M. Lebediuk, Yu.V. Tepliuk, N. B. Prokofyeva","doi":"10.30978/ujdvk2021-2-62","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-62","url":null,"abstract":"Actinic keratosis (AK) is a common disease that is formed as a result of excessive insolation of exposed skin areas. One of the possible options for the development of the disease is the transformation of AK into squamous cell carcinoma. The timely diagnosis of suspicious areas of AK with their subsequent excision and histological examination has great importance in the prevention of neoplastic transformations of the skin.The aim of our study was to identify dermatoscopic patterns of the initial stages of neoplastic transformation of actinic keratosis and a comparative analysis of the diagnostic effectiveness of digital dermatoscopy, two­color spectral dermatoscopy in relation to histological examination in a group of individuals suffering from actinic keratosis.There were 49 patients with AK under our supervision. All suspected cases of keratosis were additionally examined histologically. We analyzed the features of clinical forms and modified existing diagnostic methods. To expand the diagnostic capabilities of standard dermatoscopy, studies were performed in different ranges of light. Spectral dermatoscopy allowed estimating the potential foci of neoplastic transformation in blue and green light field (standard illumination range was suppressed). Particular attention was paid to areas of increased keratinization, areas of excessive vascularization with a predominance of superficial capillary network, micro­ulcers with loose edges that contrast well with the green spectrum, as well as dynamic changes in color in one field of study for 30 days.It was found that the use of spectral dermatoscopy increases the diagnostic capabilities of AK and allows identifying more accurately the early signs of neoplastic transformations associated with both pathological neoangiogenesis («strawberry» pattern, glomerular network) and pathological proliferation (pseudogranulations, pathological keratinization, etc.).","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89030455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually transmitted infections in the penitentiary system (analysis of scientific publications and own data)","authors":"G. Mavrov, T. Osinska, Y. Shcherbakova, D. Kurushin, I.V. Kalashnikovа","doi":"10.30978/ujdvk2021-2-79","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-79","url":null,"abstract":"Objective — assessing the current prevalence of sexually transmitted infections (STIs) and HIV in prisons in the context of a holistic consideration of the problem, and taking into account our own pilot studies on the prevalence of herpes simplex virus infection type 1 (HSV-1) and disorders of the psycho-emotional state of patients. \u0000Materials and methods. The search was carried out in accordance with the recommendations of PRISMA 2009, 2020 (The Preferred Reporting Items for Systematic reviews and Meta-Analyses). The data of own research of 33 convicted men and 29 women are also presented. \u0000Results and discussion. Among 33 convicted men, IgM HSV-1 markers were diagnosed in 6.7 % cases, and among 29 women — in 4.9 % cases, IgG HSV-1 markers — in 92.8 % and 96.9 % cases, respectively. In the process of assessing the psycho-emotional state of patients with HSV-1 markers, the average scores on the scale of anxiety and depression (HADS) ranged from 7.6 to 8.9 points, which directly correlated with the duration of the disease, the number of exacerbations and rash in the labial, genital and perianal areas (61.9—71.4 %).Despite the difficult material, logistical and sanitary conditions in penitentiaries, they may be more favorable to the vast majority of convicts than the way of life they lived in freedom, given the fact that vulnerable groups often do not have adequate access to health care services. For most of them, imprisonment is an opportunity to get the treatment, preventive measures and basic health information they need. \u0000Conclusions. The significant prevalence of STIs/HIV in the penitentiary institutions of the world has been confirmed. Among convicts in Ukraine, serological markers of HSV-1 are quite common.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79405507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern diagnostics of microsporia","authors":"S. Lavrushko, V. Stepanenko","doi":"10.30978/ujdvk2021-2-16","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-16","url":null,"abstract":"Objective — to develop a method of modern molecular genetic diagnosis of microsporia in children based on polymerase chain reaction (PCR), which will allow identification of the pathogen of Microsporum canis at the DNA level. \u0000Materials and methods. The study included 40 patients with microsporia of smooth skin, scalp, scalp and smooth skin. The biological materials for the research were scales from the smooth skin and scalp, hair from the scalp of patients with microsporia. A study of 40 samples of biological material was carried out in patients with microsporia of smooth skin, microsporia of the scalp, microsporia of the scalp and smooth skin. At the first stage, DNA isolation of Microsporum canis was carried out. Then PCR was carried out to increase the copies of the DNA region using specific primers. The final step was typing 40 samples of clinical material of patients. \u0000Results and discussion. PCR diagnostics made it possible to identify the DNA of Microsporum canis in all 40 samples of biological material of patients with microsporia. In our study, we developed a PCR-based method for diagnosing microsporia, which uses a set of two MC primers (regions of the beta tubulin gene of Microsporum canis). For internal control of the course of amplification and the quality of biomaterial sampling, specific primers of APOE (a region of the human apolipoprotein E gene) were also used. \u0000Conclusions. In order to improve the precise specific diagnosis of microsporia in children, a method of modern molecular genetic diagnostics based on polymerase chain reaction (PCR) has been developed, which allows identification of the Microsporum canis pathogen at the DNA level. Analysis of the molecular structure of the genome of Microsporum canis proved that the most objective diagnosis of microorganisms is the PCR method. The developed method of DNA diagnostics based on PCR using specific primers can be included in the algorithm for detecting Microsporum canis in humans.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72652187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of treatment and prognosis of acute and chronic eczema in patients with manifestations of intestinal dysbiosis","authors":"L. V. Fominа, A. Dashchuk, E. Dobrzhanska","doi":"10.30978/ujdvk2021-2-10","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-10","url":null,"abstract":"Objective — the purpose of the work is to increase the effectiveness of treatment of patients with acute and chronic eczema by developing effective comprehensive corrective therapy based on the study of the immune defense system. \u0000Materials and methods. 47 patients with acute and chronic eczema before and after treatment were selected for the study. To assess the effectiveness of therapy in these patients, we evaluated the data of biochemical studies, indicators of cellular and humoral immunity, as well as the degree of changes in indicators of the microbiota of the colon cavity. \u0000Results and discussion. The most informative indicators of cellular and humoral immunity of patients with acute and chronic eczema in the acute stage, accompanied by manifestations of intestinal dysbiosis are determined: CD3+-lympho­cytes, IFN-γ, IL-4, IL-6 and IgA. The monitoring of these indicators is necessary and sufficient for controlling the effectiveness of prevention and treatment of this group of patients.According to the results of bacteriological examination of feces in all patients, the presence of dysbiosis of the colon of I—IV degrees was established. Patients with eczema also had a significantly lower content of bifidobacteria and lactobacilli in the colon cavity (by 2.09 and 2.58 times, respectively), bacteroids (by 1.96 times) and the total number of Escherichia coli (by 2.56 times) against the background of a larger number of Escherichia coli with enzymatic properties, opportunistic enterobacteria, enterococci and fungi of the genus Candida (by 1.87, 14.4, 4.20 and 3.22 times, respectively). After the treatment with the addition of pro- and prebiotics of the patients of the main group, the manifestations of dysbiosis of the colon were eliminated, while in the patients of the control group, the manifestations of dysbiosis persisted: lower content of bifidobacteria and lactobacilli in the colon cavity (by 1.82 and 2.32 times, respectively), bacteroids (by 1.2 times) and the total number of Escherichia coli (by 1.48 times) against the background of a bigger number of Escherichia coli with enzymatic properties, opportunistic enterobacteria, enterococci and fungi of genus Candida (by 1.32, 12.3, 3.24 and 2.85 times, respectively). \u0000Conclusions. The treatment aimed at normalizing the gastrointestinal tract and increasing the patient’s immunity, has an activating and stimulating effect on the therapeutic treatment complex of a patient with eczema. The addition of pro and prebiotics contributed to a significant reduction in the duration of treatment in patients compared with the indicator in individuals who received only conventional pathogenetic therapy.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73577500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proliferative function of endothelium in local scleroderma, gender and age characteristics of the disease","authors":"Al­-Omary Obadeh Mahmoud, S. Bondar","doi":"10.30978/ujdvk2021-2-25","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-25","url":null,"abstract":"Objective — to investigate the variability of vascular endothelial growth factor (VEGF) in localized scleroderma (LS), characteristics of the disease in different age groups.\u0000Materials and methods. The study included the clinical evaluation of 78 patients (27 men, 51 women) with localized scleroderma aged (43.2 ± 7.28) years. All patients underwent clinical, laboratory, and enzyme immunoassay investigation of VEGF. The criteria for inclusion in the study were: the presence of localized scleroderma and the absence of signs of a systemic process.\u0000Results and discussion. It has been proven that localized scleroderma is gender­related, more often recorded in women (65.4 %, p < 0.05), with an attributive risk of 50.0 % compared to men. \u0000Late diagnosis of the disease was proven in 78.2 % of patients. The age and gender characteristics of this pathology were determined — men are more likely to get sick at a young age (up to 20 years; 22.2 % of the surveyed), however, women over the age of 55 prevail (p < 0.05). Women sought dermatological help earlier compared to men (29.4 %; p < 0.05), but had a higher risk of early progression (p < 0.05).\u0000Among the clinical forms of localized scleroderma, most of the cases (70.5 %) were of the plaque form. In 15.4% of cases, a linear form was diagnosed, in 9.0% ­ lichen sclerosus, in 5.1 % — Pasini—Pierini idiopathic atrophoderma. The plaque form of LS was significantly more often detected in women (80.3 %), and the linear form and lichen sclerosus — in men (22.2 % each). The average number of lesions was 2.8 ± 1.12. Three lesions were found in almost half (43.6 %) of the patients, one lesion – in 23.1%, two lesions – in 16.7%, four lesions – in 11.5%. Five or more lesions were present in 4 (5.1 %) patients.\u0000It has been found that the highest content of VEGF was observed in classic plaque form (p < 0.05), the lowest — in Pasini—Pierini idiopathic atrophoderma (p < 0.05). U­shaped age dependence of the disease was determined: high content of VEGF­A in patients under the age of 20 (p < 0.05), with a significant decrease of VEGF­A in patients aged 20—35 years (p < 0.05) and further increase in those aged 35 to 55 years (p < 0.05).\u0000It was established that VEGF­A level increased at patients with early progression of the disease — in the first 2 years after the start of clinical manifestations against the group of patients with slow progression — more than 6 years (p < 0.05). In assessment of gender dependence, we found a higher content of VEGF­A in female patients compared to male patients (p < 0.05).\u0000Conclusions. Localized scleroderma has gender and age­related characteristics and is 50.0 % more often recorded in women. Among men, young patients predominate. Studying the pathogenesis of LS and assessing the proliferative function of the endothelium of the disease will make it possible to predict the course of the disease, improve the diagnosis and treatment.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89877865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}