Psoriatic onychodystrophy — modern treatment trends

V. Stepanenko, S. V. Ivanov, P. Fedorych
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Abstract

Objective — to conduct an in-depth search of foreign and national literary sources, in particular, reports about the results of randomized controlled clinical trials regarding the use of local combination drugs for the treatment of psoriatic onychodystrophy. The focus is on both short-term and long-term therapeutic effects, as well as minimizing the side effects. Materials and methods. We conducted the analysis of the world experience of using the local combination drug Onychocid® Emtrix for the treatment of psoriatic onychodystrophy and minimization of side effects by searching for data (2010—2021) in the Cochrane Library controlled tests by keywords: psoriasis, onychodystrophy; in PubMed, High Wire Press, Google Scholar — by terms of the catalog and medical subjects: psoriasis + onychodystrophy + treatment; reports of randomized controlled clinical trials, meta-analyses and literature reviews. Results and discussion. The modern view on the problem of psoriatic onychodystrophy, methods and approaches to the treatment of this pathology are presented.According to the analysis of the results of foreign and national studies, Onychocid® Emtrix is proved to be clinically efficient and safe as complex treatment for various clinical forms of psoriatic onychodystrophy. It contains a combination of propylene glycol, urea and lactic acid. Active substances, which are part of the drug, are synergists, which provides triple action of ingredients — combining moisturizing and keratolytic effects with antifungal properties. Most patients showed an early (in the 2nd to 4th week of use of the drug) improvement in the appearance of the affected nails. In the future, they observed thinning of nail plates, color restoration, disappearance of excessively keratinized nail tissue, tendency to the restoration of the integrity of nails. The use of this topical medication provided high compliance due to an excellent profile of tolerance and the possibility of application once a day. Conclusions. It has been proven that the modern medication of local action Onychocid® Emtrix is currently the most optimal treatment for psoriatic onychodystrophy which allows achieving a therapeutic effect both in monotherapy and in the standard complex schemes. Treatment of psoriatic onychodystrophy with Onychocid® Emtrix is more effective in comparison with standard therapy, contributes to a rapid partial or full restoration of the integrity of nail plates. The high effectiveness and safety of Onychocid® Emtrix give reason to recommend it for inclusion in the schemes of complex treatment of patients with psoriatic onychodystophy.
银屑病甲营养不良-现代治疗趋势
目的:深入检索国内外文献资料,特别是关于局部联合用药治疗银屑病甲营养不良的随机对照临床试验结果的报道。重点是短期和长期的治疗效果,以及尽量减少副作用。材料和方法。我们通过检索Cochrane图书馆对照试验数据(2010-2021年),以关键词:银屑病、甲营养不良;在PubMed, High Wire Press, Google Scholar -按目录和医学科目分类:牛皮癣+甲营养不良+治疗;随机对照临床试验、荟萃分析和文献综述报告。结果和讨论。本文介绍了银屑病甲营养不良问题的现代观点,以及治疗这种病理的方法和途径。通过对国内外研究结果的分析,证明Onychocid®Emtrix作为多种临床形式银屑病甲营养不良的综合治疗在临床上是有效和安全的。它含有丙二醇、尿素和乳酸的混合物。活性物质是药物的一部分,是增效剂,它提供了三重作用的成分-结合保湿和角质溶解作用与抗真菌特性。大多数患者表现出早期(在使用该药的第2至第4周)受影响指甲外观的改善。在未来,他们观察到甲板变薄,颜色恢复,过度角质化的指甲组织消失,指甲完整性恢复的趋势。由于良好的耐受性和每天应用一次的可能性,使用这种局部药物提供了高依从性。结论。事实证明,局部作用的现代药物Onychocid®Emtrix是目前银屑病甲营养不良的最佳治疗方法,它可以在单一治疗和标准复杂方案中实现治疗效果。与标准疗法相比,Onychocid®Emtrix治疗银屑病甲营养不良更有效,有助于快速部分或完全恢复甲板的完整性。Onychocid®Emtrix的高有效性和安全性使我们有理由推荐将其纳入银屑病甲突患者的复杂治疗方案中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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