The state of the enzyme level of antioxidant protection and its nonspecific correction in patients with eczema

М.Kh.M. Khwaileh, Y. Andrashko
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Abstract

The variety of developmental mechanisms creates significant difficulties in choosing adequate directions of therapeutic tactics. Priority pathogenetic links, in particular, changes in the state of antioxidant protection, remain insufficiently studied. Objective — determination of the activity of the enzyme level of the antioxidant protection and the development of nonspecific correction of the established violations. Materials and methods. Under observation there were 52 patients with eczema (27 men and 25 women) aged 19 to 57 years. 16 of them were diagnosed with idiopathic, 21 — with infectious (microbial) and 15 — with infectious (mycotic) forms of dermatosis. The control group consisted of 20 healthy persons. The activity of catalase, glutathione peroxidase and superoxide dismutase (SOD) in blood serum was determined. Results and discussion. It has been established that patients with eczema have a labile nature of changes in the enzymatic activity of antioxidant protection, depending on the clinical form of dermatosis. Its total suppression was ascertained only in the presence of mycogenic sensitization. To eliminate the identified violations, PRP therapy and tacrolimus (Protopic) were prescribed, the use of which as part of complex therapy made it possible not only to achieve correction of pathogenetic changes, but also to significantly improve the clinical course of dermatosis. Conclusions. It is advisable to determine the activity of superoxide dismutase, the activity of catalase and glutathione peroxidase to assess the state of the enzyme link of the antioxidant defense in patients with eczema. The inclusion of PRP therapy and tacrolimus (Protopic) in the treatment allows correcting the state of the enzyme link of antioxidant protection and the clinical course of dermatosis. The activity of catalase, glutathione peroxidase and superoxide dismutase can serve as one of the criteria of the effectiveness of treatment prescribed for patients with eczema.
湿疹患者抗氧化保护酶水平状况及其非特异性校正
发育机制的多样性在选择适当的治疗策略方向方面造成了重大困难。优先的致病联系,特别是抗氧化保护状态的变化,仍然没有得到充分的研究。目的:测定酶的活性水平对抗氧化的保护作用,并发展非特异性纠正已建立的违规行为。材料和方法。本组共52例湿疹患者,男27例,女25例,年龄19 ~ 57岁。其中16例诊断为特发性皮肤病,21例诊断为感染性(微生物)皮肤病,15例诊断为感染性(真菌)皮肤病。对照组为20名健康人。测定血清过氧化氢酶、谷胱甘肽过氧化物酶和超氧化物歧化酶(SOD)的活性。结果和讨论。已经确定,湿疹患者抗氧化保护酶活性的变化具有不稳定的性质,这取决于皮肤病的临床形式。它的完全抑制是确定只有在存在真菌原致敏。为了消除已发现的违规行为,使用PRP治疗和他克莫司(Protopic),将其作为复杂治疗的一部分,不仅可以实现病理改变的纠正,而且可以显着改善皮肤病的临床病程。结论。测定湿疹患者体内超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性,评价抗氧化防御酶链的状态是可取的。在治疗中纳入PRP治疗和他克莫司(Protopic)可以纠正抗氧化保护的酶链状态和皮肤病的临床病程。过氧化氢酶、谷胱甘肽过氧化物酶和超氧化物歧化酶的活性可作为湿疹患者治疗效果的标准之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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