Urologia Internationalis最新文献_第7页

Associations between Urinary Concentrations of Polycyclic Aromatic Hydrocarbons and Overactive Bladder in US Adults: Data from the National Health and Nutrition Examination Survey 2005-2016. 标题：美国成年人尿液中多环芳烃（PAHs）浓度与膀胱过度活动症（OAB）之间的关系：2005-2016年全国健康与营养调查（NHANES）数据。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1159/000536253

Shihang Pu, Qi Li, Zhijun Tao, Songbo Wang, Xiangyu Meng, Shangqian Wang, Zengjun Wang

{"title":"Associations between Urinary Concentrations of Polycyclic Aromatic Hydrocarbons and Overactive Bladder in US Adults: Data from the National Health and Nutrition Examination Survey 2005-2016.","authors":"Shihang Pu, Qi Li, Zhijun Tao, Songbo Wang, Xiangyu Meng, Shangqian Wang, Zengjun Wang","doi":"10.1159/000536253","DOIUrl":"10.1159/000536253","url":null,"abstract":"Introduction: Polycyclic aromatic hydrocarbons (PAHs) are a group of chemicals that can induce oxidative stress and related cytotoxicity. Whether urinary concentrations of PAHs have effects on overactive bladder (OAB) in the general population is still unclear. This study investigated the associations between urinary PAHs and OAB.Methods: 7,146 adults aged over 20 who participated in the US National Health and Nutrition Examination Survey 2005-2016 were studied. The impact of the six PAHs on OAB was evaluated by multivariate logistic regression, and percent changes related to different quartiles of those six PAH levels were calculated. Confounders including age, logarithmic urinary creatinine, gender, race, body mass index, educational level, marriage, poverty income ratio, diabetes, hypertension, and metabolic syndrome were controlled.Results: There is a significant positive correlation between urinary concentrations of the six PAHs we include in the study and the occurrence of OAB. Furthermore, individuals with higher PAH levels also reported a more severe OAB symptom score (OABSS).Conclusions: Our findings revealed that adult men in the USA with higher urinary PAHs had a higher risk of OAB incidence. These findings suggest the importance of strong environmental regulation of PAHs to protect population health. However, the underlying mechanisms still need further exploration.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"137-145"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma. 细胞周期蛋白 A2 表达作为肌肉浸润性上尿路上皮癌的预测性生物标记物。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.1159/000536184

Margarete Teresa Walach, Katja Nitschke, Matthias Groß-Weege, Johannes Großhans, Lukas Wildner, Luca Pause, Jonas Jarczyk, Frederik Wessels, Manuel Neuberger, Karl-Friedrich Kowalewski, Maximilian Christian Kriegmair, Zoran V Popovic, Timo Gaiser, Thomas Stefan Worst, Philipp Nuhn

{"title":"Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma.","authors":"Margarete Teresa Walach, Katja Nitschke, Matthias Groß-Weege, Johannes Großhans, Lukas Wildner, Luca Pause, Jonas Jarczyk, Frederik Wessels, Manuel Neuberger, Karl-Friedrich Kowalewski, Maximilian Christian Kriegmair, Zoran V Popovic, Timo Gaiser, Thomas Stefan Worst, Philipp Nuhn","doi":"10.1159/000536184","DOIUrl":"10.1159/000536184","url":null,"abstract":"Introduction: The aim was to evaluate the prognostic value of altered Cyclin A2 (CCNA2) gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival.Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of CCNA2, MKI67, and p53 was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of CCNA2 expression with MKI67 and p53.Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high CCNA2 expression levels showed longer OS (HR 0.33; 95% CI: 0.15-0.74; p = 0.0073). Multivariable Cox regression analyses identified CCNA2 overexpression (HR 0.37; 95% CI: 0.16-0.85; p = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17-0.87; p = 0.0168) to be independent predictors for longer OS. CCNA2 expression correlated positively with MKI67 expression (Rho = 0.4376, p = 0.0005).Conclusion: Low CCNA2 expression is significantly associated with worse OS. Thus, CCNA2 might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"128-136"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Efficacy of AI Chatbots as Tutors in Urology: A Comparative Analysis of Responses to the 2022 In-Service Assessment of the European Board of Urology. 评估人工智能聊天机器人作为泌尿外科导师的功效：对欧洲泌尿外科委员会 2022 年在职评估答复的比较分析。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-30 DOI: 10.1159/000537854

Matthias May, Katharina Körner-Riffard, Lisa Kollitsch, Maximilian Burger, Sabine D Brookman-May, Michael Rauchenwald, Martin Marszalek, Klaus Eredics

{"title":"Evaluating the Efficacy of AI Chatbots as Tutors in Urology: A Comparative Analysis of Responses to the 2022 In-Service Assessment of the European Board of Urology.","authors":"Matthias May, Katharina Körner-Riffard, Lisa Kollitsch, Maximilian Burger, Sabine D Brookman-May, Michael Rauchenwald, Martin Marszalek, Klaus Eredics","doi":"10.1159/000537854","DOIUrl":"10.1159/000537854","url":null,"abstract":"Introduction: This study assessed the potential of large language models (LLMs) as educational tools by evaluating their accuracy in answering questions across urological subtopics.Methods: Three LLMs (ChatGPT-3.5, ChatGPT-4, and Bing AI) were examined in two testing rounds, separated by 48 h, using 100 Multiple-Choice Questions (MCQs) from the 2022 European Board of Urology (EBU) In-Service Assessment (ISA), covering five different subtopics. The correct answer was defined as \"formal accuracy\" (FA) representing the designated single best answer (SBA) among four options. Alternative answers selected from LLMs, which may not necessarily be the SBA but are still deemed correct, were labeled as \"extended accuracy\" (EA). Their capacity to enhance the overall accuracy rate when combined with FA was examined.Results: In two rounds of testing, the FA scores were achieved as follows: ChatGPT-3.5: 58% and 62%, ChatGPT-4: 63% and 77%, and BING AI: 81% and 73%. The incorporation of EA did not yield a significant enhancement in overall performance. The achieved gains for ChatGPT-3.5, ChatGPT-4, and BING AI were as a result 7% and 5%, 5% and 2%, and 3% and 1%, respectively (p > 0.3). Within urological subtopics, LLMs showcased best performance in Pediatrics/Congenital and comparatively less effectiveness in Functional/BPS/Incontinence.Conclusion: LLMs exhibit suboptimal urology knowledge and unsatisfactory proficiency for educational purposes. The overall accuracy did not significantly improve when combining EA to FA. The error rates remained high ranging from 16 to 35%. Proficiency levels vary substantially across subtopics. Further development of medicine-specific LLMs is required before integration into urological training programs.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"359-366"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Squamous Cell Carcinoma of the Urinary Bladder: Urgent Call for New Therapies. 转移性膀胱鳞状细胞癌：迫切需要新疗法。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.1159/000534858

Séverine Banek, Benedikt Hoeh, Cristina Cano Garcia, Florestan Koll, Jens Köllermann, Felix K H Chun, Philipp Mandel, Luis A Kluth, Mike Wenzel

{"title":"Metastatic Squamous Cell Carcinoma of the Urinary Bladder: Urgent Call for New Therapies.","authors":"Séverine Banek, Benedikt Hoeh, Cristina Cano Garcia, Florestan Koll, Jens Köllermann, Felix K H Chun, Philipp Mandel, Luis A Kluth, Mike Wenzel","doi":"10.1159/000534858","DOIUrl":"10.1159/000534858","url":null,"abstract":"Background: Squamous cell carcinoma (SCC) of the urinary bladder is the most common non-urothelial variant histology. Currently, upfront radical cystectomy is the gold standard for non-metastatic SCC of the bladder. However, several studies have shown that SCC of the bladder is associated with higher aggressiveness and worse survival outcomes, such as progression-free and cancer-specific survival, relative to the urothelial histological subtype. Moreover, metastatic SCC seems to poorly respond to systemic treatments and/or radiotherapy.Summary: This review summarizes the current knowledge and medical evidence regarding local and systematic treatment of mSCC of the bladder, including a case series of four initially locally advanced and later metastatic SCC patients of our tertiary care hospital.Key messages: Despite being the second most common variant histology of bladder cancer, current therapies for SCC do not provide satisfactory therapeutic responses.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Impact and Management of Incidental Renal Findings on Pre-TAVI CT Scan from the Urologist's Perspective. 从泌尿科医生的角度看 TAVI 术前 CT 扫描附带肾脏检查结果的临床影响和管理。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI: 10.1159/000537808

Stefanie Ziewers, Nikita Druva Fischer, Jan Hendrik Börner, Lilly Kaufmann, Alexander Tamm, Yang Yang, Florian Jungmann, Robert Dotzauer, Peter Sparwasser, Thomas Hoefner, Igor Tsaur, Axel Haferkamp, Rene Mager

{"title":"Clinical Impact and Management of Incidental Renal Findings on Pre-TAVI CT Scan from the Urologist's Perspective.","authors":"Stefanie Ziewers, Nikita Druva Fischer, Jan Hendrik Börner, Lilly Kaufmann, Alexander Tamm, Yang Yang, Florian Jungmann, Robert Dotzauer, Peter Sparwasser, Thomas Hoefner, Igor Tsaur, Axel Haferkamp, Rene Mager","doi":"10.1159/000537808","DOIUrl":"10.1159/000537808","url":null,"abstract":"Introduction: The aim of the study was to investigate prevalence and impact of incidental renal masses (IRMs) accompanying increasing computed tomography (CT) work-up for symptomatic aortic valve stenosis (sAVS) of the elderly with regard to the relevance of urological consultation for overall survival (OS).Methods: A retrospective analysis of pre-transcatheter aortic-valve implantations (TAVIs) CT scans of patients with sAVS (N = 1,253) harboring IRM was performed for 2014-2019. According to the clinical management, groups 1 (urologic consultation) and 2 (findings ignored) were formed and analyzed in terms of OS.Results: The prevalence of IRM was 9% (119/1,253). In 19% (23/119), urological advice was sought (group 1). At baseline, group 1 showed a significantly higher rate of malignancy-specific lesions compared to 2 (p < 0.01). Other clinical parameters (e.g., age, cardiological scores, comorbidities) did not differ between groups (p > 0.05). In group 1, 4 (17%) findings were histologically confirmed, of which 3 (13%) underwent surgery. There was no significant difference in median OS at a median follow-up of 24.7 months between groups 1 and 2 with 35.7 (95% CI, 5.9; 65.4) and 47.4 months (95% CI, 33.0; 61.7), respectively (p = 0.4). In Cox regression analysis, chronic kidney disease but not urologic work-up or chronic obstructive pulmonary disease or heart failure emerged as an independent unfavorable predictor of OS (HR 2.44, 95% CI 1.37; 4.36, p = 0.003).Conclusion: For the first time, a TAVI population with IRM was analyzed from the urologist's perspective. Urologic co-evaluation and work-up does not confer a significant benefit in terms of OS in this particular population.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"219-225"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Uric Acid Stone Detection: Integrating Deep Learning with CT Imaging and Clinical Assessments in the Upper Urinary Tract. 尿酸结石检测的进展：深度学习与上尿路 CT 成像和临床评估的整合。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-02 DOI: 10.1159/000538133

Lichen Jin, Zongxin Chen, Yizhang Sun, Zhen Tian, Xincheng Yi, Yuhua Huang

{"title":"Advancements in Uric Acid Stone Detection: Integrating Deep Learning with CT Imaging and Clinical Assessments in the Upper Urinary Tract.","authors":"Lichen Jin, Zongxin Chen, Yizhang Sun, Zhen Tian, Xincheng Yi, Yuhua Huang","doi":"10.1159/000538133","DOIUrl":"10.1159/000538133","url":null,"abstract":"Introduction: Among upper urinary tract stones, a significant proportion comprises uric acid stones. The aim of this study was to use machine learning techniques to analyze CT scans and blood and urine test data, with the aim of establishing multiple predictive models that can accurately identify uric acid stones.Methods: We divided 276 patients with upper urinary tract stones into two groups: 48 with uric acid stones and 228 with other types, identified using Fourier-transform infrared spectroscopy. To distinguish the stone types, we created three types of deep learning models and extensively compared their classification performance.Results: Among the three major types of models, considering accuracy, sensitivity, and recall, CLNC-LR, IMG-support vector machine (SVM), and FUS-SVM perform the best. The accuracy and F1 score for the three models were as follows: CLNC-LR (82.14%, 0.7813), IMG-SVM (89.29%, 0.89), and FUS-SVM (29.29%, 0.8818). The area under the curves for classes CLNC-LR, IMG-SVM, and FUS-SVM were 0.97, 0.96, and 0.99, respectively.Conclusion: This study shows the feasibility of utilizing deep learning to assess whether urinary tract stones are uric acid stones through CT scans, blood, and urine tests. It can serve as a supplementary tool for traditional stone composition analysis, offering decision support for urologists and enhancing the effectiveness of diagnosis and treatment.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"234-241"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Caudal Block and Sacral Erector Spina Block for Postoperative Analgesia following Pediatric Circumcision: A Double-Blind, Randomized Controlled Trial. 比较尾椎阻滞和骶棘肌阻滞对小儿包皮环切术后镇痛的效果：双盲随机对照试验。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-16 DOI: 10.1159/000538323

Volkan Özen, Ayça Sultan Şahin, Elif Aybike Ayyıldız, Mehmet Eren Açık, Tayfun Eyileten, Nurten Özen

{"title":"Comparison of Caudal Block and Sacral Erector Spina Block for Postoperative Analgesia following Pediatric Circumcision: A Double-Blind, Randomized Controlled Trial.","authors":"Volkan Özen, Ayça Sultan Şahin, Elif Aybike Ayyıldız, Mehmet Eren Açık, Tayfun Eyileten, Nurten Özen","doi":"10.1159/000538323","DOIUrl":"10.1159/000538323","url":null,"abstract":"Introduction: Caudal block (CB) and erector spina plane block (ESPB) have been shown to provide effective postoperative analgesia following circumcision. Our aim was to compare the analgesic efficacy of sacral ESPB and CB, as well as the time to first analgesic requirement and postoperative complications.Methods: Patients aged 1-7 years in the ASA I-II group, who were scheduled for circumcision, were included in the study. Blocks were performed under general anesthesia before the operation. Postoperative pain was evaluated using the Face, Legs, Activity, Cry, and Consolability (FLACC) scores. Analgesic requirements in the first 24 h postsurgery, the time of first analgesia requirement, and postoperative complications were recorded.Results: A total number of 150 patients were included in the study. In the CB group, urinary retention was observed. No side effects were observed in the sacral ESPB group. The 4th and 6th h postoperative FLACC scores were lower in the ESP group. The number of analgesic consumption in the first 24 h postsurgery was significantly lower in the ESPB group (p < 0.001).Conclusion: Based on our results, sacral ESPB performed with ultrasonography is a simple and safe regional anesthesia method that can be used to provide effective postoperative analgesia for circumcision.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"292-297"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor Regarding the Article "Listening to Music during Outpatient Cystoscopy Reduces Pain and Anxiety and Increases Satisfaction: Results from a Prospective Randomized Study". 致编辑的信，内容涉及 "门诊膀胱镜检查时听音乐可减轻疼痛和焦虑，提高满意度：前瞻性随机研究的结果 "一文的编辑来信。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI: 10.1159/000539297

Recep Burak Degirmentepe

引用次数: 0

Factors Considered by Experienced Urologists when Selecting Alpha-Blockers for Patients with Lower Urinary Tract Symptoms or Benign Prostatic Hyperplasia according to Age. 经验丰富的泌尿科医生在根据年龄为下尿路症状或良性前列腺增生患者选择α-受体阻滞剂时考虑的因素。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-05-16 DOI: 10.1159/000539313

Hyomyoung Lee, Jung Hoon Lee, Min Soo Choo, Min Chul Cho, Hwancheol Son, Hyeon Jeong, Sangjun Yoo

{"title":"Factors Considered by Experienced Urologists when Selecting Alpha-Blockers for Patients with Lower Urinary Tract Symptoms or Benign Prostatic Hyperplasia according to Age.","authors":"Hyomyoung Lee, Jung Hoon Lee, Min Soo Choo, Min Chul Cho, Hwancheol Son, Hyeon Jeong, Sangjun Yoo","doi":"10.1159/000539313","DOIUrl":"10.1159/000539313","url":null,"abstract":"Introduction: The objectives of the study were to examine the opinions of urology specialists on whether there are actual differences in efficacy among α1-blockers and to identify the factors that should be considered when prescribing these medications according to age.Methods: We surveyed 50 South Korean urology specialists with over 3 years of clinical experience in secondary or tertiary hospitals in July-August 2021. The survey covered urologists' demographics, awareness of α1-blocker prescription differences, and key factors in α1-blocker selection based on LUTS severity and patient age.Results: Overall, 82% of the respondents believed that there were differences in the efficacy of α1-blockers in actual practice according to age. Over 90% of the respondents agreed on the need for head-to-head comparison studies to compare the effects of different α1-blockers. Regardless of the severity of LUTS, urologists prioritize cardiovascular side effects when prescribing α1-blockers to patients aged ≥70 years. Further, 19% of the urologists prioritized ejaculatory side effects for mild-to-moderate LUTS and 9% for severe LUTS (p < 0.001).Conclusions: This study shows that head-to-head studies comparing the efficacy of different α1-blockers are highly valuable for the real-world clinical application of α1-blockers. Notably, urologists prioritize cardiovascular and ejaculatory side effects in older and younger patients while prescribing α1-blockers, respectively.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"434-441"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Inflammatory Index: A Promising Non-Invasive Marker for the Prediction of Response to Neoadjuvant Chemotherapy prior to Cystectomy. 全身炎症指数：预测膀胱切除术前新辅助化疗反应的前景看好的非侵入性标志物。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-02-17 DOI: 10.1159/000537894

Levent Ozcan, Emre Can Polat, Caner Baran, Ahmet Boylu, Mustafa Erkoc, Alper Otunctemur

{"title":"Systemic Inflammatory Index: A Promising Non-Invasive Marker for the Prediction of Response to Neoadjuvant Chemotherapy prior to Cystectomy.","authors":"Levent Ozcan, Emre Can Polat, Caner Baran, Ahmet Boylu, Mustafa Erkoc, Alper Otunctemur","doi":"10.1159/000537894","DOIUrl":"10.1159/000537894","url":null,"abstract":"Introduction: The main challenge to the optimal use of neoadjuvant chemotherapy (NAC) is the difficulty in selecting patients who may or may not benefit from NAC. Our aim in this study was to investigate whether the Systemic Inflammatory Index (SII) predicts response to chemotherapy in patients who receive NAC prior to cystectomy.Methods: We retrospectively analysed the data of patients who underwent NAC followed by cystectomy at our institution between January 2010 and September 2015 and whose 5-year follow-up was completed. All patients who underwent diagnostic biopsy with complete transurethral resection of bladder tumour at our hospital and whose pathology result was muscle-invasive transitional cell carcinoma were included in the study. At least 3 courses of gemcitabine/cisplatin NAC were given to all patients. A pathological response was defined as a reduction in cystectomy to a lower pathological stage after NAC.Results: The SII was 320.8 ± 51 in the responders and 388.28 ± 50 in the non-responders. SII optimal cut-off of 350 was determined. The sensitivity and specificity of SII in predicting response were found to be 80% and 83%, respectively. Low SII (<350) was found to be a significant predictor of response compared with the other factors on multivariate analysis. The mean overall survival time was 55.4 months in patients with a low SII value and 40.3 months in the high SII group.Conclusion: SII, together with known clinicopathological factors and newer genetic and molecular markers, can be used to select patients for NAC.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"226-233"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0