Urologia Internationalis最新文献

{"title":"Focus on the Blind Spot of Stone Disease: Analysis of Lower Urinary Tract Stone Interventions from 2006 to 2020 Using German Nationwide Inpatient Data.","authors":"Roman Herout, Juliane Putz, Angelika Borkowetz, Martin Baunacke, Rainer Koch, Christian Thomas, Johannes Huber, Christer Groeben","doi":"10.1159/000542750","DOIUrl":"10.1159/000542750","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to analyze contemporary treatment trends in bladder stone management in Germany over a 15-year period.</p><p><strong>Methods: </strong>We analyzed data from the nationwide German hospital billing database from 2006 to 2020. The significance of changes over time was evaluated via linear regression analysis.</p><p><strong>Results: </strong>Total case numbers of therapeutic interventions for lower urinary tract calculi increased from 6,770 in 2006 to 9,037 in 2020 (p < 0.001). Transurethral cystolithotripsy (TUCL) was the predominant procedure with increasing case numbers from 5,552 in 2006 to 7,699 in 2020 (p < 0.001). Also, the share of TUCL increased by 4% during the study period. TUCL with laser fragmentation was coded in 82 cases in 2006 and in 1,527 cases in 2020 (p < 0.001). Case numbers of percutaneous cystolithotripsy also increased over time from 406 to 430 cases (p = 0.005), but the share decreased by 20%. Inpatient shock wave lithotripsy is very rarely performed for bladder calculi with an average of 22 cases per year in all hospitals in Germany. Case numbers of open cystolithotomy (OCL) also increased from 614 cases in 2006 to 692 cases in 2020 (p = 0.006), but the share decreased by 15.5%. On average, 164 cases of stone removal from neobladders per year were performed, mainly transurethrally (47%) or via an open approach (21%). Case numbers of TUCL combined with transurethral resection of the prostate (TUR-P) declined from 1,712 in 2006 to 1,450 in 2020 (p = 0.014). However, this might be attributed to the concomitant rise of laser enucleation of the prostate with steadily increasing case numbers in Germany.</p><p><strong>Conclusion: </strong>We present contemporary population-based data on bladder stone treatment in Germany. TUCL is the predominant therapeutic modality with increasing case numbers, but OCL is still performed frequently. TUR-P is the procedure that is most often combined with TUCL.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"244-250"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Programmatic Approach to En Bloc Transurethral Enucleation of the Prostate with Bipolar System: A Single-Center Retrospective Report.","authors":"Peng Lai, Ying Lu, Weihong Lu, Fan Chao, Jianping Zhang","doi":"10.1159/000542514","DOIUrl":"10.1159/000542514","url":null,"abstract":"<p><strong>Introduction: </strong>This study presents a systematic approach for en bloc transurethral enucleation of the prostate utilizing a bipolar system (TUEB), evaluating its effectiveness and safety. Furthermore, the research aims to pinpoint risk factors contributing to early stress urinary incontinence (SUI) after undergoing en bloc TUEB.</p><p><strong>Methods: </strong>The en bloc TUEB procedure is visually demonstrated through images and videos. A retrospective analysis was conducted based on the data of 88 patients diagnosed with benign prostatic hyperplasia (BPH) who underwent en bloc TUEB between January 2018 and April 2023. Detailed perioperative and follow-up clinical data were collected and analyzed. Patients were categorized based on the occurrence of SUI, and their clinical characteristics were analyzed.</p><p><strong>Results: </strong>The mean surgical duration was 113.1 ± 50.0 min, resulting in an excised prostate gland weighing 58.0 ± 34.3 g and a hemoglobin drop of 14.3 ± 11.2 g/L. The average enucleation rate was 79.00 ± 11.01%, enucleation efficiency was 0.54 ± 0.26 g/min and prostate-specific antigen reduction rate was 42.08 ± 22.85%. There were no major complications during operation. Twenty-three patients (26.13%) developed early SUI after catheter removal, and 74% of them were in remission within 1 month. Importantly, no cases of persistent SUI were observed. Lower urinary tract symptoms (LUTSs) duration was significantly different between patients with and without postoperative SUI. Residual urine volume, International Prostate Symptom Score (IPSS), and Quality of Life (QoL) score were significantly improved in BPH patients after surgery (p < 0.05). Twelve months after surgery, only 2 patients (2.27%) had urethral stricture, although it recovered after transurethral dilation.</p><p><strong>Conclusions: </strong>En bloc TUEB is proven to be effective, practical, efficient, and safe with minimal complications. This procedure could be standardized and widely adopted. LUTS duration can predict the risk of early SUI.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"221-228"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between CT Renal Angiography of Live Kidney Donors and Intraoperative Findings: A Cross-Sectional Study.","authors":"Mzhda Sahib Jaafar, Naser Abdullah Mohammed, Shakhawan Hama Amin Said, Rawa Bapir, Dilan S Hiwa, Berun A Abdalla, Fahmi H Kakamad","doi":"10.1159/000541816","DOIUrl":"10.1159/000541816","url":null,"abstract":"<p><strong>Introduction: </strong>A comprehensive understanding of the renal vascular anatomy variations is paramount to a successful kidney transplant. This reduces vascular injury risks and minimizes ischemia duration, optimizing surgical outcomes. The current study aims to assess the accuracy of renal computed tomography angiography (CTA) findings of live renal donors by comparing them with intraoperative findings.</p><p><strong>Methods: </strong>This prospective cross-sectional study was conducted between October 2018 and February 2020. It included all healthy donors with two kidneys of normal size, shape, and position who were deemed suitable for nephrectomy. The CTA examinations were performed with the same protocol, which combined the vascular-excretory phase. Anatomical findings were recorded by a specialized radiologist. The CTA results were compared with intraoperative findings, which were documented by the transplantation team.</p><p><strong>Results: </strong>The study included 220 patients. The preoperative CTA was highly sensitive and accurate, reaching 99.5% and 98.6%, respectively, for single vessels and 100% sensitivity and accuracy for triple vessels, pelvicalyceal system, and ureter duplication. The sensitivity of CTA for double vessels (vein and artery) was 90% and 92.6%, respectively, while accuracy was 98.6% for both.</p><p><strong>Conclusion: </strong>CTA can be used to assess renal arteries and veins for potential renal donors with high accuracy. Although the CTA's minor, statistically nonsignificant discordance with the surgical findings regarding double arteries and veins, no artery or vein was missed on the CTA. Therefore, the sensitivity of CTA can reach 100%.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"270-277"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auto-Expandable Metallic Ureteral Stents for Complex Ureteral Stenosis: Long-Term Outcomes in a Tertiary Institution.","authors":"Marina Mata, Inés María Laso-García, Javier Lorca-Álvaro, Gemma Duque-Ruiz, Fernando Arias-Fúnez, Manuel Hevia, Enrique López-Pérez, Francisco Burgos-Revilla","doi":"10.1159/000542941","DOIUrl":"10.1159/000542941","url":null,"abstract":"<p><strong>Introduction: </strong>Auto-expandable ureteral stents can be an alternative to percutaneous nephrostomy (PCN) in refractory ureteral stenosis. Our aim was to analyse results and complications of ureteral stents in our centre.</p><p><strong>Methods: </strong>Retrospective review of OptiMed® expandable ureteral stents placed in our centre (1996-2022). Analysis of complications (Clavien-Dindo classification) was performed. Kaplan-Meier curves (long-rank test) to assess stent permeability and Cox regression for associated factors were performed.</p><p><strong>Results: </strong>Fifty-eight patients were included. Median follow-up was 36 months (11-82). Median age was 61 years (48-68). Most frequent aetiology of ureteral stenosis was malignancy in 30 cases (53.6%). The most common location of stricture was distal ureter in 44 (63.8%) ureteral strictures. Creatinine levels improved in 28 (48.3%) cases. Most common acute complication was urinary tract infection in 6 (3.4%) patients (Clavien-Dindo II). Twenty patients presented with stent obstruction. Fourteen (24.1%) were solved with double J stenting and 6 (10.3%) cases with PCN. Mean stent survival time was 50 months (34.3-65.8). By the end of follow-up, 23 (39.6%) patients were alive. Of those, 9 (39.1%) had a functioning stent. No association of any factor with patency of stent was found.</p><p><strong>Conclusions: </strong>Expandable ureteral stents are an alternative to PCN in fragile patients with refractory stenosis, which offers a better quality of life.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"285-290"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Surgical Therapy for Local Recurrence and Oligometastatic Urothelial Carcinoma of the Bladder: 20 Years of Experience in a Tertiary Center.","authors":"Mulham Al-Nader, Ulrich Krafft, Christopher Darr, Jochen Heß, Claudia Kesch, Lukas Püllen, Stephan Tschirdewahn, Umut-Ulas Yesilyurt, Aykhan Isgandarov, Boris Hadaschik, Osama Mahmoud","doi":"10.1159/000542982","DOIUrl":"10.1159/000542982","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of surgical therapy on selected patients with limited metastatic/recurrence burden has not yet been well studied. We investigated the outcome of surgical resection for patients with local recurrence only or oligometastatic urothelial carcinoma (UC) of the bladder.</p><p><strong>Methods: </strong>We identified patients with oligometastatic UC or local recurrence only after radical cystectomy who underwent surgical resection with curative intent between 2003 and 2022 at our center. Oligometastatic UC was defined as three or fewer resectable lesions, regardless of the number of organs involved. We studied the surgical outcome, progression-free survival (PFS) and overall survival (OS) in this selected group of patients.</p><p><strong>Results: </strong>A total of 39 patients were selected, including 18 (46%) with local recurrence and 21 (54%) with oligometastatic UC. Nine patients (23%) experienced intraoperative complications, all of whom belonged to the local recurrence group, while 8 patients (20.5%) experienced major postoperative complications, including 6 patients from the local recurrence group and 2 patients with oligometastatic disease. The median PFS following surgery was 19 months (95% CI; 2.5-35.5) with 1- and 3-year progression rates of 47% and 29%, while the median OS was 24 months (95% CI; 8.6-39.3) with 1- and 3-year survival rates of 51% and 30%. A significantly better median PFS was observed in the metastatic versus local recurrence group (35 vs. 8 months, p = 0.01). Similarly, a median OS of 41 months was observed in the metastatic group compared to only 12 months for the local recurrence group (p = 0.12). Overall, a better survival time of 30 months was observed in the metachronous group compared to 6 months in the synchronous group (p = 0.046). In a further analysis of the metastatic group, metachronous oligometastasis was associated with a longer survival of 43 months compared to 9 months for synchronous metastasis (p = 0.18). Some differences were not significant, which may be due to sample size.</p><p><strong>Conclusion: </strong>Our study shows reasonable surgical and survival outcomes of metastasectomy, especially in the metachronous subgroup, for UC without risk of higher perioperative morbidity. On the other hand, resection of local recurrence is associated with a higher risk of incomplete resection and higher intraoperative and postoperative morbidity without offering a survival benefit.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"337-345"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible Vacuum-Assisted Ureteral Access Sheath for Treating Impacted Ureteral Stones.","authors":"Yujun Chen, Heng Yang, Haibo Xi, Yue Yu, Wen Deng, Xiaochen Zhou, Gongxian Wang","doi":"10.1159/000542944","DOIUrl":"10.1159/000542944","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the feasibility and safety of using the novel flexible vacuum-assisted ureteral access sheath (FV-UAS) in flexible ureteroscope (F-URS) treatment of impacted non-distal ureteral stones.</p><p><strong>Methods: </strong>We analyzed data from patients who underwent FV-UAS treatment for impacted non-distal ureteral stones between January 2022 and September 2023. Perioperative parameters were evaluated, including operative time, ureteral injury, and complications. The FV-UAS have a 10-cm passive deflection segment at the distal end of the ureteral access sheath that can bend following the deflection of the F-URS, while also being connected to a vacuum device for aspiration.</p><p><strong>Results: </strong>A total of 62 consecutive patients (35 females) were included. Mean (range) patient age was 50.0 (29-75) years. Mean (range) largest stone size was 13.8 (9-16) mm. Mean (range) total time was 34.2 (18-46) min. In 57 patients (91.9%), no residual stones were detected in the renal, while 5 patients (8.1%) had residual stones smaller than 4 mm. A 5-tier classification quantified ureteral injury severity at stone impaction sites: grade 0 (n = 10); grade 1 (n = 47); grade 2 (n = 5); and grades 3 and 4 (n = 0). Nine patients (14.5%) underwent the placement of two double-J stents. Two patients (3.2%) developed postoperative fever requiring antibiotics and conservative management. Mean (range) postoperative hospital stay was 1.2 (1-2) day. At the 3-month follow-up, no ureteral strictures had occurred. No additional surgical interventions were necessary during the follow-up.</p><p><strong>Conclusion: </strong>The use of the FV-UAS for the treatment of impacted non-distal ureteral stones is a safe and effective surgical method.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"372-378"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Preferences and Fears: Misconceptions about Robotic-Assisted Surgery.","authors":"Christopher Hirtsiefer, Christopher Hirtsiefer, Mandy Ehrt, Roman Herout, Sherif Mehralivand, Juozas Vilimas, Martin Baunacke, Christian Thomas","doi":"10.1159/000544773","DOIUrl":"10.1159/000544773","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Robotic-assisted surgery (RAS) is widely adopted across surgical fields, notably urology, but patient knowledge remains limited, often shaped by misconceptions. Previous research indicates factors like age, profession, and technology use influence RAS perceptions. This study investigates public knowledge, preferences, and misconceptions about RAS within a German cohort.</p><p><strong>Methods: </strong>A cross-sectional survey at a university hospital's open house gathered responses from 339 participants prior to an RAS exhibition. The questionnaire assessed demographics, surgical preferences, and RAS knowledge. Statistical analyses, including t tests, chi-squared tests, ANOVA, and multivariate logistic regression, identified key associations.</p><p><strong>Results: </strong>A total of 71% (234) of participants favored RAS over conventional surgery, yet misconceptions persisted in 38% (122), particularly among pensioners (48% (46), p < 0.01). Misconceptions were linked to a preference for conventional surgery (43% (52) vs. 19% (36), p < 0.01). Surgical preference emerged as a significant predictor of misconception. Concerns included surgeon skill (41%, 141) and machine malfunction (39%, 132), with younger participants fearing human error and older individuals fearing technical failure (p < 0.01).</p><p><strong>Conclusion: </strong>This local study reveals strong public support for RAS but underscores prevalent misconceptions, especially among older adults, suggesting that addressing misconceptions could foster acceptance and informed decision-making.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"487-493"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separated Transfixing Uretero-Enteral Anastomosis Method in Robot-Assisted Radical Cystectomy with Ileal Conduit: Early Induction Experience.","authors":"Yasukazu Nakanishi, Yasukazu Nakanishi, Ryo Andy Ogasawara, Naoki Imasato, Minoru Inoue, Kohei Hirose, Ken Sekiya, Madoka Kataoka, Shugo Yajima, Hitoshi Masuda","doi":"10.1159/000545124","DOIUrl":"10.1159/000545124","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the initial outcomes of a novel transfixing uretero-enteral anastomosis technique in robot-assisted radical cystectomy (RARC) with ileal conduit in an intracorporeal urinary diversion (ICUD), focusing on its potential to reducing the incidence of uretero-enteric anastomotic stricture.</p><p><strong>Methods: </strong>The study subjects were 11 patients who underwent RARC and ileal conduit created as an ICUD at a single cancer center between 2022 and 2024. The technique involved opening the ventral side of the oral end of the separated ileum approximately 5 cm apart. Two small holes were made 2 cm from the oral end on the dorsal side, through which the ureter passed to the luminal side. The distal end of the ureter was spatulated, and four knotted sutures were placed at the base using 4-0 absorbable sutures. The distal end of the ureter was anchored using two knotted sutures, and the liberated portion was closed using 3-0 absorbable suture in a running fashion.</p><p><strong>Results: </strong>The median total operation time was 418 min (range: 269-467 min), with a median console time of 93 min (range: 80-129 min) for urinary diversion. Two patients required temporary stent reinsertion because of hydronephrosis; however, no pyelonephritis occurred. Two patients (18.2%) had complications of Clavien-Dindo classification 3 or higher, both of which only required temporary stent reinsertion. Postoperative renal function was preserved in all the patients.</p><p><strong>Conclusions: </strong>In our initial experience, the transfixing uretero-enteral anastomosis technique was successful in stabilizing anastomoses in ICUD.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"546-552"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Electrofulguration for Women with Recurrent Urinary Tract Infection on Quality of Life and Sexual Function.","authors":"Uğur Yılmaz, Cüneyd Sevinç, Orkunt Özkaptan, Cengiz Çanakcı, Uğur Yılmaz, Alkan Çubuk","doi":"10.1159/000543733","DOIUrl":"10.1159/000543733","url":null,"abstract":"<p><strong>Introduction: </strong>The primary objective of the study was to assess the impact of EF in women with rUTI on quality of life and sexual health.</p><p><strong>Methods: </strong>This prospective observational clinical study included 152 women who underwent EF because of rUTI and were followed for a minimum of 18 months. The SF-12 questionnaire and the Female Sexual Function Index (FSFI) are used to evaluate quality of life and sexual dysfunction. The Patient Global Impression of Improvement (PGI-I) scale was assessed to evaluate subjective cure. Endoscopic success was defined as complete resolution of previous lesions without new lesions seen during cystoscopy. Clinical success was defined as no urinary tract infections at the last follow-up; improvement as 1-2 treated infections/year; and failure as ≥3 treated infections/year. Chi-square test, Wilcoxon, and Student's paired t test were used.</p><p><strong>Results: </strong>Seventy patients (52.6%) were defined as cured with at least 1-year follow-up. The subjective cure rate was 71.4% (N = 95) according to PGI-I scores. Women had significantly higher average FSFI scores (p = 0.001) in the 1-year postoperative assessment. Overall, pathological mental health and physical health scores were significantly higher after the intervention (p = 0.00). Thirty-one (23.3%) patients improved clinically with <3 infections per year, and 32 (24.1%) patients failed with >3 infections per year. A total of 97 (74.4%) patients had endoscopic resolution on postoperative evaluation.</p><p><strong>Conclusion: </strong>EF resulted in clinical cure and improvement in the large majority of the patients. A significant proportion of the patients demonstrated enhanced sexual function and quality of life.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"494-500"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Prophylactic Treatment with Horseradish Root and Nasturtium Herb on Urinary Tract Infections in Individuals with Chronic Neurogenic Lower Urinary Tract Dysfunction: A Retrospective Cohort Study.","authors":"Andrea Martina Bieri, Jens Wöllner, Jürgen Pannek, Jörg Krebs","doi":"10.1159/000541248","DOIUrl":"10.1159/000541248","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent urinary tract infections (UTIs) are common in individuals with neurogenic lower urinary tract dysfunction (NLUTD) and greatly affect their quality of life. There is currently no established prophylactic measure based on evidence. We have therefore evaluated the effects of a horseradish root and nasturtium herb product on the frequency of UTIs in a retrospective cohort.</p><p><strong>Methods: </strong>Clinical data of patients with chronic NLUTD who were receiving the phytotherapeuticum for at least 12 months were analyzed. The number of UTIs was categorized as no UTIs, sporadic UTIs (1-2/year) and recurrent UTIs (≥3/year). The change in the annual number of patient-reported symptomatic UTIs and antibiotic prescriptions was investigated.</p><p><strong>Results: </strong>Data of 43 individuals (mean age 49 ± 13 years, median NLUTD duration 17.9 years) were analyzed. The proportion of individuals with recurrent UTIs decreased significantly (p < 0.0001) from 58.1% (42.1-73.0%) to 23.3% (11.8-38.6%) during phytotherapy, whereas the proportion of individuals without UTIs increased significantly (p = 0.001) from 14.0% (5.3-27.9%) to 39.5% (25.0-55.6%). In addition, there was a significant (p = 0.008) decrease in the number of antibiotic prescriptions.</p><p><strong>Conclusion: </strong>Prophylactic treatment with horseradish root and nasturtium herb seems to be a promising option for the prevention of UTIs.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}