{"title":"Advancing pilonidal sinus care through structured international collaboration: The PiloNERDs.","authors":"Dietrich Doll","doi":"10.47717/turkjsurg.2026.2026-2-31","DOIUrl":"10.47717/turkjsurg.2026.2026-2-31","url":null,"abstract":"","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":"42 2","pages":"154-155"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.","authors":"Vinod P Pusdekar, Gowardhan Dare, Pratik Bhojwani, Abhinav Humane, Vinit Yele, Nandini Virmani","doi":"10.47717/turkjsurg.2026.2025-9-30","DOIUrl":"10.47717/turkjsurg.2026.2025-9-30","url":null,"abstract":"<p><strong>Objective: </strong>Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen for clean elective surgeries remains debated.</p><p><strong>Material and methods: </strong>A hospital-based analytical cross-sectional study was conducted over a six-month period (March-August 2025) in the department of general surgery of a tertiary-care teaching hospital. Ninety-four consecutive patients undergoing clean elective surgeries were enrolled and allocated to two groups: Group A (n=52) received a single intravenous (IV) dose of cefotaxime 30 minutes prior to incision, and Group B (n=42) received postoperative multidose oral antibiotics according to institutional protocol. Baseline demographic and clinical data were recorded, and patients were monitored for signs of SSI, including fever, tachycardia, redness, and wound discharge.</p><p><strong>Results: </strong>The mean age of Group A participants was 28.3±5.9 years compared to 36.4±7.3 years in Group B (p=0.042), though other socio-demographic variables were comparable. The overall incidence of SSI signs was low in both groups. Fever occurred in 13.4% of Group A and 14.2% of Group B; tachycardia occurred in 9.6% and 7.1%; redness in 1.9% and 7.1%; and wound discharge in 3.8% and 2.3% in Groups A and B, respectively; none of these differences were statistically significant (p>0.05 for all).</p><p><strong>Conclusion: </strong>Single-dose IV prophylaxis was as effective as postoperative multi-dose oral antibiotics in preventing SSIs in clean elective surgeries. Short-course prophylaxis is sufficient in this setting and supports rational antibiotic stewardship.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":"42 2","pages":"233-238"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-05-08DOI: 10.47717/turkjsurg.2026.2025-9-23
Çiğdem Benlice, Nur Ramoğlu, İsmail Ahmet Bilgin, Diğdem Arslan, Arda Ulaş Mutlu, İdris Vural, Sedat Gökay, Makbule Ayşegül Bağda, Bilgi Baca
{"title":"The ergonomic impact of robotic vs. laparoscopic surgery on operating room nurses: A multicenter survey analysis.","authors":"Çiğdem Benlice, Nur Ramoğlu, İsmail Ahmet Bilgin, Diğdem Arslan, Arda Ulaş Mutlu, İdris Vural, Sedat Gökay, Makbule Ayşegül Bağda, Bilgi Baca","doi":"10.47717/turkjsurg.2026.2025-9-23","DOIUrl":"10.47717/turkjsurg.2026.2025-9-23","url":null,"abstract":"<p><strong>Objective: </strong>Robotic surgery is increasingly used across specialties, yet its ergonomic impact on operating room nurses remains underexplored. This multicenter study aimed to evaluate the ergonomic challenges and musculoskeletal discomfort among scrub nurses during robotic surgery and to compare these outcomes with laparoscopic procedures, with additional analysis based on years of robotic surgery experience.</p><p><strong>Material and methods: </strong>This cross-sectional, multicenter, questionnaire-based study was conducted between January and February 2025, among scrub nurses with experience in robotic surgery from multiple centers. Ergonomic perceptions, physical strain, musculoskeletal discomfort, and comparisons between robotic and laparoscopic surgery were assessed. Nurses were stratified into less than and more than 5 years of robotic surgery experience, and comparative statistical analyses were performed.</p><p><strong>Results: </strong>Most nurses rated the robotic operating environment as comfortable (69.6%), and 56.4% reported reduced workload compared with laparoscopy. Physical strain was reported by 30.9%, most commonly during instrument exchange. Musculoskeletal discomfort predominantly affected the neck, back, and shoulders. Shoulder pain was significantly more common among nurses with >5 years of experience (70% vs. 33.3%, p=0.008). Although 71.4% reported ergonomic support from robotic systems, 85.7% had not received ergonomic training.</p><p><strong>Conclusion: </strong>Robotic surgery is perceived by scrub nurses as ergonomically more favorable than laparoscopic surgery; however, substantial musculoskeletal discomfort persists, particularly among more experienced nurses and in the absence of ergonomic training. These findings suggest a potential cumulative ergonomic burden and highlight the need for structured ergonomic education and system-level interventions.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"207-213"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-02-03DOI: 10.47717/turkjsurg.2026.2025-11-37
Ozan Barış Namdaroğlu, Ahmet Cem Esmer, Selen Öztürk, Saltuk Yıldız, Korhan Tuncer, Göksever Akpınar, Hilmi Yazıcı
{"title":"Early risk stratification of acute diverticulitis using procalcitonin, CRP, and CT imaging: A retrospective analysis.","authors":"Ozan Barış Namdaroğlu, Ahmet Cem Esmer, Selen Öztürk, Saltuk Yıldız, Korhan Tuncer, Göksever Akpınar, Hilmi Yazıcı","doi":"10.47717/turkjsurg.2026.2025-11-37","DOIUrl":"10.47717/turkjsurg.2026.2025-11-37","url":null,"abstract":"<p><strong>Objective: </strong>Distinguishing mild (Hinchey 1a/1b/2) from severe (Hinchey 3/4) diverticulitis is critical for appropriate management. This study evaluated the predictive value of inflammatory biomarkers and imaging features for early risk stratification.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of patients with acute diverticulitis between 2017 and 2024 at the hospital's general surgery department. Receiver operating characteristic analysis was used to determine optimal cut-off values for C-reactive protein (CRP) and procalcitonin, while computed tomography (CT) findings were assessed for their discriminative capacity.</p><p><strong>Results: </strong>A total of 72 patients were included in the study. There were 59 patients in the mild diverticulitis group and 13 patients in the severe diverticulitis group. Patient demographics were similar between the groups. Procalcitonin demonstrated superior predictive performance [area under the curve (AUC) 0.795] compared to CRP (AUC 0.755). The cut-off values for procalcitonin and CRP were 0.095 and 104.5, respectively. Specific CT patterns showed high specificity for severe disease. The combination of biomarkers and imaging criteria significantly improved diagnostic accuracy, with pelvic abscess localization emerging as a key indicator of severity.</p><p><strong>Conclusion: </strong>A biomarker-guided approach incorporating procalcitonin and targeted CT evaluation enables reliable early identification of severe diverticulitis. This strategy may enhance clinical decision-making regarding antibiotic selection and surgical consultation while reducing unnecessary interventions in mild cases.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"173-180"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-05-08DOI: 10.47717/turkjsurg.2026.2026-1-1
Ömer Çelik, Remzi Can Çakır
{"title":"Surgeons' preferences in the management of recurrence after laparoscopic inguinal hernia repair: A nationwide survey.","authors":"Ömer Çelik, Remzi Can Çakır","doi":"10.47717/turkjsurg.2026.2026-1-1","DOIUrl":"10.47717/turkjsurg.2026.2026-1-1","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate contemporary surgical approaches and decision-making patterns of general surgeons in the management of recurrent inguinal hernia following laparoscopic inguinal hernia repair (LIHR), with particular emphasis on recurrence timing, surgeon experience, and annual laparoscopic case volume.</p><p><strong>Material and methods: </strong>The questionnaire consisted of 26 items, including both multiple-choice and short-answer questions, and was designed to assess demographic characteristics, surgical experience, preferred surgical techniques, preoperative evaluation strategies, and management approaches for recurrent inguinal hernia following LIHR. Recurrences were classified as early (≤2 years) or late (>2 years) based on the postoperative time interval.</p><p><strong>Results: </strong>A total of 179 surgeons participated in the survey. Most respondents were male and had ≤10 years of surgical experience. Surgeons with higher annual laparoscopic hernia repair volumes were significantly more likely to prefer re-laparoscopic posterior approaches for both early and late recurrences, whereas surgeons with lower case volumes predominantly favored open anterior repair techniques (p<0.05). Surgical preferences also varied in female patients and according to the initial repair technique (transabdominal preperitoneal or total extraperitoneal). Nearly two-thirds of participants reported insufficient or only partially sufficient training in recurrent hernia repair, while the majority strongly agreed on the need for national or international clinical guidelines.</p><p><strong>Conclusion: </strong>Surgeon experience and annual laparoscopic case volume significantly influence the management of recurrent inguinal hernia following LIHR. As laparoscopic expertise increases, re-laparoscopic approaches are more frequently adopted. These findings highlight the need for standardized training programs and evidence-based guidelines to optimize the management of recurrent inguinal hernia after laparoscopic repair.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"220-226"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-03-04DOI: 10.47717/turkjsurg.2026.2025-8-16
Nuh Zafer Cantürk
{"title":"From science fiction to operating room: Representations of surgery and AI in film and their ethical implications.","authors":"Nuh Zafer Cantürk","doi":"10.47717/turkjsurg.2026.2025-8-16","DOIUrl":"10.47717/turkjsurg.2026.2025-8-16","url":null,"abstract":"<p><p>This paper examines the intricate relationship between surgical practice, artificial intelligence (AI), and science fiction movies, focusing on how imaginative storytelling has foreshadowed and influenced the development of modern medical technologies. Tracing the timeline from the Industrial Revolution to the digital era, it discusses key advancements such as robotic-assisted operations, virtual reality-based surgical education, augmented reality applications, and telehealth services. The analysis draws on well-known films-including Prometheus, 2001: A Space Odyssey, Star Wars, and Fantastic Voyage-to examine how cinema has portrayed autonomous surgical tools, ethical challenges, and the evolving interaction between humans and machines. These fictional examples are compared with real-world innovations like the Da Vinci robotic system, mobile messaging for remote consultations, and AI-driven diagnostic methods. The article also addresses broader cultural shifts, including the rise of patient-focused care, greater inclusion of women in surgical roles, and the prioritization of empathy and ethical reasoning in clinical practice. Ultimately, the study asserts that while technology continues to transform surgery, the human touch remains essential. A harmonious integration of advanced tools and compassionate care is necessary to sustain the ethical and humane foundations of surgical medicine.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"258-266"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2025-11-25DOI: 10.47717/turkjsurg.2025.2025-6-5
Ayten Saraçoğlu, Gül Çakmak, Bushra M Abdallah, Esra Yamansavcı, Kübra Çakar Yılmaz, Bedrettin Yıldızeli, Mustafa Yüksel, Zuhal Aykaç
{"title":"The effects of preoperative anaemia on postoperative complications in patients undergoing thoracic surgery: A prospective descriptive study.","authors":"Ayten Saraçoğlu, Gül Çakmak, Bushra M Abdallah, Esra Yamansavcı, Kübra Çakar Yılmaz, Bedrettin Yıldızeli, Mustafa Yüksel, Zuhal Aykaç","doi":"10.47717/turkjsurg.2025.2025-6-5","DOIUrl":"10.47717/turkjsurg.2025.2025-6-5","url":null,"abstract":"<p><strong>Objective: </strong>Preoperative anaemia is a risk factor for an increased requirement for blood and blood-product transfusions in patients undergoing thoracic surgery. Our aim was to study the association between preoperative anaemia and adverse outcomes in patients undergoing thoracic surgery.</p><p><strong>Material and methods: </strong>This was a prospective descriptive study of adult patients undergoing thoracic surgery. Patients were classified into preoperative anaemia (Group A: Hb <13 g/dL in males, <12 g/dL in females) and non-anaemia (Group B). Collected data included demographics, intraoperative parameters, laboratory values, and postoperative outcomes, including complications, transfusion requirements, intensive care unit stay, and length of hospital stay. Statistical analyses were conducted to assess differences between the groups.</p><p><strong>Results: </strong>A total of 104 patients were included: 29 with preoperative anaemia (Group A) and 75 with normal haemoglobin levels (Group B). Both groups were predominantly male. Patients with preoperative anaemia experienced significantly higher rates of intraoperative bleeding and perioperative crystalloid use, greater chest tube drainage volumes and longer durations, and increased postoperative pRBC transfusion requirements. Complications were more frequent in Group A than in Group B (31% vs. 8%, p=0.005) and hospital stays were longer (9.6±5.5 days vs. 7.7±4.7 days, p=0.014).</p><p><strong>Conclusion: </strong>This study highlights the significant impact of preoperative anaemia on patients undergoing thoracic surgery. Preoperative anaemia was associated with increased intraoperative bleeding, higher complication rates, and longer hospital stays. These findings emphasise the need for thorough preoperative evaluation and optimisation of anaemia to improve surgical outcomes.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"227-232"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-03-26DOI: 10.47717/turkjsurg.2026.2025-11-39
Mustafa Oruç, Melih Bayazıtlı, İbrahim Kılınç, Erdinç Çetinkaya
{"title":"The colorectal cancer screening gap in Türkiye: A tripartite survey of barriers among patients and surgeons.","authors":"Mustafa Oruç, Melih Bayazıtlı, İbrahim Kılınç, Erdinç Çetinkaya","doi":"10.47717/turkjsurg.2026.2025-11-39","DOIUrl":"10.47717/turkjsurg.2026.2025-11-39","url":null,"abstract":"<p><strong>Objective: </strong>Colorectal cancer (CRC) screening uptake in Türkiye remains suboptimal, despite the presence of a national screening program. Understanding whether barriers arise primarily from patient-related factors or system-level constraints is essential for effective policy planning. This study aimed to evaluate barriers to CRC screening across the screening pathway using patient, procedural, and provider perspectives.</p><p><strong>Material and methods: </strong>A descriptive cross-sectional study was conducted between January and June 2025 at a tertiary training and research hospital. Three distinct groups were surveyed: 100 screening-naïve outpatients aged 50-70 years, 100 patients undergoing diagnostic or screening colonoscopy, and 50 general surgeons performing or referring for colonoscopy. Study-specific questionnaires, pilot-tested for clarity but not formally validated, were used to assess screening awareness, attitudes, perceived barriers, and strategies for improvement. The data were analyzed descriptively.</p><p><strong>Results: </strong>Among screening-naïve outpatients, 54% had no prior awareness of CRC screening, and only 28% had received a physician recommendation for screening. Fear of a serious diagnosis (45%) and pain or discomfort (40%) were commonly reported concerns; however, most respondents indicated that these would not deter screening. Among patients undergoing colonoscopy, 77% underwent the procedure for symptoms rather than preventive screening, while post-procedure satisfaction was high. Surgeons predominantly identified system-level barriers, particularly long waiting times (90%) and an insufficient number of trained endoscopists (92%), as major limitations in effective screening delivery.</p><p><strong>Conclusion: </strong>The primary perceived barrier to CRC screening in Türkiye appears to be limited system capacity rather than patient reluctance. Improving screening uptake will likely require coordinated public awareness efforts, structured national reminder systems, and expansion of the number of adequately trained endoscopists, alongside endoscopy infrastructure.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"181-188"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-04-21DOI: 10.47717/turkjsurg.2026.2025-12-5
Burak Karamese, Sukru Toprak Durukan, Engin Bora Sana, Ruwida Sabouni, Ali Berke Uysal, Nadiye Sever, Ibrahim Vedat Bayoglu, Seyhan Hıdıroglu, Gokhan Tazegul
{"title":"Anxiety and screening attitudes in breast cancer patients and their first-degree relatives: A comparative pilot study.","authors":"Burak Karamese, Sukru Toprak Durukan, Engin Bora Sana, Ruwida Sabouni, Ali Berke Uysal, Nadiye Sever, Ibrahim Vedat Bayoglu, Seyhan Hıdıroglu, Gokhan Tazegul","doi":"10.47717/turkjsurg.2026.2025-12-5","DOIUrl":"10.47717/turkjsurg.2026.2025-12-5","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer is the most common type of cancer in women. Identifying women at risk of breast cancer and ensuring their participation in cancer screening programs have been shown to reduce mortality rates. Therefore, it is important to identify the determinants of attitudes toward breast cancer screening, among which anxiety may play a significant role. This study aimed to explore the screening attitudes and anxiety levels of women with breast cancer and those of their female first-degree relatives within a patient-relative dyadic framework.</p><p><strong>Material and methods: </strong>Breast cancer patients and their female first-degree relatives between the ages of 18-65 were included in this cross-sectional study as a patient-relative dyad. The patients were administered a socio-demographic questionnaire, the breast cancer worry scale, and the attitude towards cancer screening scale.</p><p><strong>Results: </strong>A total of 37 dyads participated in the study. The median age of the entire cohort was 47. Screening participation was reported in 37.1% (13/35) of patients pre-diagnosis and in 29.1% (7/24) of eligible relatives. A negative correlation was found between patients' anxiety and their relatives' screening attitudes (r=-0.395, p=0.016 Spearman's correlation), whereas a positive correlation was found between patients' attitudes and their relatives' attitudes (r=0.501, p=0.002 Spearman's correlation).</p><p><strong>Conclusion: </strong>Higher levels of anxiety in breast cancer patients were associated with less favorable screening attitudes among their relatives, whereas screening attitudes were positively correlated within patient-relative dyads. These findings suggest that anxiety and screening attitudes may cluster within patient-relative dyads. Further research is required to determine the clinical implications.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"189-195"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkish Journal of SurgeryPub Date : 2026-06-04Epub Date: 2026-05-04DOI: 10.47717/turkjsurg.2026.2025-12-4
Aleksandra Gavrilovska-Brzanov, Haris Sulejmani, Sasho Dohcev, Goce Spasovski, Nikola Georgievski, Aleksandar Trifunovski, Dimitar Trajkovski, Marija Jovanovski Srceva, Nikola Brzanov
{"title":"Kidney transplantation in Alport syndrome: A genotype-guided case series and literature review.","authors":"Aleksandra Gavrilovska-Brzanov, Haris Sulejmani, Sasho Dohcev, Goce Spasovski, Nikola Georgievski, Aleksandar Trifunovski, Dimitar Trajkovski, Marija Jovanovski Srceva, Nikola Brzanov","doi":"10.47717/turkjsurg.2026.2025-12-4","DOIUrl":"10.47717/turkjsurg.2026.2025-12-4","url":null,"abstract":"<p><p>Alport syndrome (AS) is a hereditary nephropathy caused by pathogenic variants in COL4A3, COL4A4, or COL4A5, leading to type IV collagen defects and progressive glomerular basement membrane dysfunction. Kidney transplantation provides excellent long-term outcomes; however, donor eligibility, genotype-specific prognosis, and post-transplant complications continue to raise important clinical considerations in the era of precision medicine. We present a comparative case series of three genetically confirmed patients with AS who underwent kidney transplantation: Two with X-linked disease and one with autosomal-dominant inheritance. Genetic, clinical, and immunologic findings were analyzed and contextualized within current literature and recommendations. All patients initially achieved functioning grafts. The autosomal-dominant case demonstrated stable long-term function under cyclosporine-based immunosuppression. Among the X-linked cases, one experienced coronavirus diease-2019-associated arterial thrombosis requiring graft nephrectomy and subsequently underwent successful deceased-donor transplantation one year later; the other developed late antibody-mediated rejection six years post-transplant, with partial recovery following corticosteroid therapy. Kidney transplantation is an effective treatment for AS when guided by molecular confirmation and careful donor evaluation. In this national case series of three patients, outcomes were generally favorable across inheritance types; however, vascular events and late humoral immune complications affected the long-term course of the graft and underscored the need for individualized surveillance.</p>","PeriodicalId":23374,"journal":{"name":"Turkish Journal of Surgery","volume":" ","pages":"251-257"},"PeriodicalIF":0.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}