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TNFR1 signaling is positively regulated by Jak-2 and c-Src via tyrosine phosphorylation TNFR1 信号通过酪氨酸磷酸化受 Jak-2 和 c-Src 的正向调节
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2677
Fatma Zehra HAPİL ZEVKLİLER, Fatma Ece Çopuroğlu, M. G. Ertosun, U. Mert, Derya Özeş, O. N. Özeş
{"title":"TNFR1 signaling is positively regulated by Jak-2 and c-Src via tyrosine phosphorylation","authors":"Fatma Zehra HAPİL ZEVKLİLER, Fatma Ece Çopuroğlu, M. G. Ertosun, U. Mert, Derya Özeş, O. N. Özeş","doi":"10.55730/1300-0152.2677","DOIUrl":"https://doi.org/10.55730/1300-0152.2677","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells 黑色素瘤细胞对 c-Src 抑制剂 Si162 敏感性的预后基因生物标志物
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2678
Seyhan Türk, A. Yilmaz, Ü. Malkan, Gulberk Ucar, Can Türk
{"title":"Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells","authors":"Seyhan Türk, A. Yilmaz, Ü. Malkan, Gulberk Ucar, Can Türk","doi":"10.55730/1300-0152.2678","DOIUrl":"https://doi.org/10.55730/1300-0152.2678","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theranostic potential of a novel aptamer specifically targeting HER2 in breast cancer cells 特异性靶向乳腺癌细胞中 HER2 的新型适配体的抗肿瘤潜力
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2680
Samet Uçak, Fulya Küçükcankurt, Nedret Altiok
{"title":"Theranostic potential of a novel aptamer specifically targeting HER2 in breast cancer cells","authors":"Samet Uçak, Fulya Küçükcankurt, Nedret Altiok","doi":"10.55730/1300-0152.2680","DOIUrl":"https://doi.org/10.55730/1300-0152.2680","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p CircRNA LDLR 通过 miR-449b-5p 靶向 CHD1 促进胃癌细胞增殖和有氧糖酵解
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2681
Fanye Zeng, JunTao Zhao, MengTing Tong, WenTing He, Nan Li, YuXiang Fan, YanHua Zhu, LiPing Zhang, HongLiang Zhang
{"title":"CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p","authors":"Fanye Zeng, JunTao Zhao, MengTing Tong, WenTing He, Nan Li, YuXiang Fan, YanHua Zhu, LiPing Zhang, HongLiang Zhang","doi":"10.55730/1300-0152.2681","DOIUrl":"https://doi.org/10.55730/1300-0152.2681","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergent Proteomic Profiles of Opium Poppy Cultivars 罂粟栽培品种的不同蛋白质组图谱
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2684
Setenay Aykanat, Mine Türktaş
{"title":"Divergent Proteomic Profiles of Opium Poppy Cultivars","authors":"Setenay Aykanat, Mine Türktaş","doi":"10.55730/1300-0152.2684","DOIUrl":"https://doi.org/10.55730/1300-0152.2684","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats 新型多草药配方对运动大鼠骨骼肌抗氧化状态、炎症和肌肉信号蛋白的有益影响
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2682
Mehmet Tuzcu, Oğuzhan Özdemi̇r, C. Orhan, N. Şahin, Abhijeet Morde, M. Padigaru, P. Bhanuse, K. Şahin
{"title":"Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats","authors":"Mehmet Tuzcu, Oğuzhan Özdemi̇r, C. Orhan, N. Şahin, Abhijeet Morde, M. Padigaru, P. Bhanuse, K. Şahin","doi":"10.55730/1300-0152.2682","DOIUrl":"https://doi.org/10.55730/1300-0152.2682","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of thymol on oxidative stress and reelin signaling pathway in Alzheimer's disease model 百里酚对阿尔茨海默病模型中氧化应激和缰绳蛋白信号通路的影响
IF 2.2 4区 生物学
Turkish Journal of Biology Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2683
Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi
{"title":"Effect of thymol on oxidative stress and reelin signaling pathway in Alzheimer's disease model","authors":"Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi","doi":"10.55730/1300-0152.2683","DOIUrl":"https://doi.org/10.55730/1300-0152.2683","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ribosomal protein L8 regulates the expression and splicing pattern of genes associated with cancer-related pathways 核糖体蛋白L8调节与癌症相关途径相关基因的表达和剪接模式
4区 生物学
Turkish Journal of Biology Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2666
LEILEI XU, GUI YANG, BIN SONG, DONG CHEN, Akbar. Yunus, JIANGTAO CHEN, XIAOGANG YANG, ZHENG TIAN
{"title":"Ribosomal protein L8 regulates the expression and splicing pattern of genes associated with cancer-related pathways","authors":"LEILEI XU, GUI YANG, BIN SONG, DONG CHEN, Akbar. Yunus, JIANGTAO CHEN, XIAOGANG YANG, ZHENG TIAN","doi":"10.55730/1300-0152.2666","DOIUrl":"https://doi.org/10.55730/1300-0152.2666","url":null,"abstract":"Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were validated by quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay. Results: RPL8-OE inhibited cell proliferation and promoted cell apoptosis. RPL8 regulated the differential expression of many oncogenic genes and the occurrence of RASEs. Many DEGs and RASE genes (RASGs) were enriched in tumorigenesis and tumor progressionrelated pathways, including angiogenesis, inflammation, and regulation of cell proliferation. RPL8 could regulate the RASGs enriched in the negative regulation of apoptosis, consistent with its proapoptosis function. Furthermore, RPL8 may influence cancer-related DEGs by modulating the alternative splicing of transcription factors. Conclusion: RPL8 might affect the phenotypes of cancer cells by altering the transcriptome profiles, including gene expression and splicing, which provides novel insights into the biological functions of RPL8 in tumor development.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial transplantation and transfer: The promising method for diseases 线粒体移植和转移:治疗疾病的有前途的方法
4区 生物学
Turkish Journal of Biology Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2665
GÖKHAN BURÇİN KUBAT
{"title":"Mitochondrial transplantation and transfer: The promising method for diseases","authors":"GÖKHAN BURÇİN KUBAT","doi":"10.55730/1300-0152.2665","DOIUrl":"https://doi.org/10.55730/1300-0152.2665","url":null,"abstract":"Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice 醋栗花青素通过调节神经酰胺代谢减轻高脂饮食小鼠的胰岛素抵抗
4区 生物学
Turkish Journal of Biology Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2668
XIAN TANG, JUN GAO, JINPENG HUANG, CHENJUAN ZHANG, HONGWEI LIU, JIE WEI
{"title":"Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice","authors":"XIAN TANG, JUN GAO, JINPENG HUANG, CHENJUAN ZHANG, HONGWEI LIU, JIE WEI","doi":"10.55730/1300-0152.2668","DOIUrl":"https://doi.org/10.55730/1300-0152.2668","url":null,"abstract":"Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We used molecular docking technology to find the binding sites and binding energy of anthocyanins on CerS6. Real-time PCR was used to detect the effect of GA on the expression of IL-6 and TNF-α mRNA in HFD mice. The expression of S1P/Cer signaling pathway in HFD mice with IR was detected by Western Blot. Results: The results showed that GA could effectively inhibit visceral fat, liver index, the level of TC, TG and the level of LDL-C (p < 0.05), and improved HDL-C, GSH-Px and SOD (p < 0.05). GA decreased the level of insulin sensitivity index from -5.15 to -4.54 and improved insulin sensitivity and IR in HFD mice. The binding energy of anthocyanins on CerS6 was in the range of -8.2 to 5.2 kcal/ mol, with low energy parameters and good binding positions. GA could reduce mRNA levels of inflammatory factors IL-6 and TNF-α (p < 0.05), inhibit the expression of CerS6, PKCζ, PPARγ, CD36 (p < 0.05), and enhance the expression of SphK2, Akt, p-Akt/Akt, ISR (p < 0.05). Conclusion: This study investigated the effect and mechanism of GA on reducing ceramide content and reducing IR in mice, and provided an experimental basis for the prevention and treatment of obesity-related diseases.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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