线粒体移植和转移:治疗疾病的有前途的方法

IF 1.1 4区生物学 Q3 BIOLOGY

Turkish Journal of Biology Pub Date : 2023-10-18 DOI:10.55730/1300-0152.2665

GÖKHAN BURÇİN KUBAT

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引用次数: 0

摘要

线粒体是真核细胞中提供细胞生物能量的细胞器。它负责线粒体三磷酸腺苷(ATP)的产生、细胞信号传导和活性、钙平衡、细胞存活、增殖、凋亡和自噬。线粒体移植是一种很有前途的疾病治疗方法，涉及使用分离的功能线粒体恢复线粒体功能障碍。本文的目的是提供有关天然线粒体转移过程的最新知识，线粒体移植的体外和体内应用，临床试验以及与线粒体移植相关的挑战。

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Mitochondrial transplantation and transfer: The promising method for diseases

Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.

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来源期刊

Turkish Journal of Biology BIOLOGY-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Biology is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK) and accepts English-language manuscripts concerning all kinds of biological processes including biochemistry and biosynthesis, physiology and metabolism, molecular genetics, molecular biology, genomics, proteomics, molecular farming, biotechnology/genetic transformation, nanobiotechnology, bioinformatics and systems biology, cell and developmental biology, stem cell biology, and reproductive biology. Contribution is open to researchers of all nationalities.