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Nitroplasts suggest the creation of artificial nitrogen-fixing eukaryotes. 硝基酵母建议创造人工固氮真核生物。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-06-14 DOI: 10.1016/j.tibtech.2024.06.002
Weihe Rong, Liangcai Lin, Guokun Wang
{"title":"Nitroplasts suggest the creation of artificial nitrogen-fixing eukaryotes.","authors":"Weihe Rong, Liangcai Lin, Guokun Wang","doi":"10.1016/j.tibtech.2024.06.002","DOIUrl":"10.1016/j.tibtech.2024.06.002","url":null,"abstract":"<p><p>It is believed that nitrogen-fixing eukaryotes do not exist in nature, and constructing such eukaryotes is extremely challenging. Coale et al., however, have identified the first eukaryote capable of fixing nitrogen through a nitroplast organelle. Understanding the eukaryotic nitrogen-fixing machinery may advance the development of artificial nitrogen-fixing crops and industrial yeasts.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging marine biotechnology for an All-Atlantic sustainable blue economy. 利用海洋生物技术促进全大西洋可持续蓝色经济。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-01-17 DOI: 10.1016/j.tibtech.2023.12.011
Cristiane Thompson, Alice C Ortmann, Thulani Makhalanyane, Fabiano Thompson
{"title":"Leveraging marine biotechnology for an All-Atlantic sustainable blue economy.","authors":"Cristiane Thompson, Alice C Ortmann, Thulani Makhalanyane, Fabiano Thompson","doi":"10.1016/j.tibtech.2023.12.011","DOIUrl":"10.1016/j.tibtech.2023.12.011","url":null,"abstract":"<p><p>Despite the lack of research, development, and innovation funds, especially in South Atlantic countries, the Atlantic is suited to supporting a sustainable marine bioeconomy. Novel low-carbon mariculture systems can provide food security, new drugs, and climate mitigation. We suggest how to develop this sustainable marine bioeconomy across the entire Atlantic.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction-to-synthesis: the dominant approach to genome-scale synthetic biology. 还原合成：基因组规模合成生物学的主流方法。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-02-28 DOI: 10.1016/j.tibtech.2024.02.008
Kangsan Kim, Donghui Choe, Suhyung Cho, Bernhard Palsson, Byung-Kwan Cho
{"title":"Reduction-to-synthesis: the dominant approach to genome-scale synthetic biology.","authors":"Kangsan Kim, Donghui Choe, Suhyung Cho, Bernhard Palsson, Byung-Kwan Cho","doi":"10.1016/j.tibtech.2024.02.008","DOIUrl":"10.1016/j.tibtech.2024.02.008","url":null,"abstract":"<p><p>Advances in systems and synthetic biology have propelled the construction of reduced bacterial genomes. Genome reduction was initially focused on exploring properties of minimal genomes, but more recently it has been deployed as an engineering strategy to enhance strain performance. This review provides the latest updates on reduced genomes, focusing on dual-track approaches of top-down reduction and bottom-up synthesis for their construction. Using cases from studies that are based on established industrial workhorse strains, we discuss the construction of a series of synthetic phenotypes that are candidates for biotechnological applications. Finally, we address the possible uses of reduced genomes for biotechnological applications and the needed future research directions that may ultimately lead to the total synthesis of rationally designed genomes.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA-guided genome engineering: paradigm shift towards transposons. RNA 引导的基因组工程：向转座子的范式转变。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-03-04 DOI: 10.1016/j.tibtech.2024.02.006
Chin-Wei Chang, Vy Anh Truong, Nam Ngoc Pham, Yu-Chen Hu
{"title":"RNA-guided genome engineering: paradigm shift towards transposons.","authors":"Chin-Wei Chang, Vy Anh Truong, Nam Ngoc Pham, Yu-Chen Hu","doi":"10.1016/j.tibtech.2024.02.006","DOIUrl":"10.1016/j.tibtech.2024.02.006","url":null,"abstract":"<p><p>CRISPR-Cas systems revolutionized the genome engineering field but need to induce double-strand breaks (DSBs) and may be difficult to deliver due to their large protein size. Tn7-like transposons such as CRISPR-associated transposons (CASTs) can be repurposed for RNA-guided DSB-free integration, and obligate mobile element guided activity (OMEGA) proteins of the IS200/IS605 transposon family have been developed as hypercompact RNA-guided genome editing tools. CASTs and OMEGA are exciting, innovative genome engineering tools that can improve the precision and efficiency of editing. This review explores the recent developments and uses of CASTs and OMEGA in genome editing across prokaryotic and eukaryotic cells. The pros and cons of these transposon-based systems are deliberated in comparison to other CRISPR systems.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR activation screens: navigating technologies and applications. CRISPR 激活筛选：技术与应用导航。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-03-15 DOI: 10.1016/j.tibtech.2024.02.007
Teleri Clark, Matthew A Waller, Lipin Loo, Cesar L Moreno, Christopher E Denes, G Gregory Neely
{"title":"CRISPR activation screens: navigating technologies and applications.","authors":"Teleri Clark, Matthew A Waller, Lipin Loo, Cesar L Moreno, Christopher E Denes, G Gregory Neely","doi":"10.1016/j.tibtech.2024.02.007","DOIUrl":"10.1016/j.tibtech.2024.02.007","url":null,"abstract":"<p><p>Clustered regularly interspaced short palindromic repeats (CRISPR) activation (CRISPRa) has become an integral part of the molecular biology toolkit. CRISPRa genetic screens are an exciting high-throughput means of identifying genes the upregulation of which is sufficient to elicit a given phenotype. Activation machinery is continually under development to achieve greater, more robust, and more consistent activation. In this review, we offer a succinct technological overview of available CRISPRa architectures and a comprehensive summary of pooled CRISPRa screens. Furthermore, we discuss contemporary applications of CRISPRa across broad fields of research, with the aim of presenting a view of exciting emerging applications for CRISPRa screening.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concepts and new developments in droplet-based single cell multi-omics. 基于液滴的单细胞多组学的概念和新发展。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 DOI: 10.1016/j.tibtech.2024.07.006
Arthur Chow, Caleb A Lareau
{"title":"Concepts and new developments in droplet-based single cell multi-omics.","authors":"Arthur Chow, Caleb A Lareau","doi":"10.1016/j.tibtech.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.07.006","url":null,"abstract":"<p><p>Single cell sequencing technologies have become a fixture in the molecular profiling of cells due to their ease, flexibility, and commercial availability. In particular, partitioning individual cells inside oil droplets via microfluidic reactions enables transcriptomic or multi-omic measurements for thousands of cells in parallel. Complementing the multitude of biological discoveries from genomics analyses, the past decade has brought new capabilities from assay baselines to enable a deeper understanding of the complex data from single cell multi-omics. Here, we highlight four innovations that have improved the reliability and understanding of droplet microfluidic assays. We emphasize new developments that further orient principles of technology development and guidelines for the design, benchmarking, and implementation of new droplet-based methodologies.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond waste: understanding urine's potential in precision medicine. 超越废物：了解尿液在精准医疗中的潜力。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-08-01 Epub Date: 2024-02-17 DOI: 10.1016/j.tibtech.2024.01.009
Pengfei Yu, Carol Christine Bosholm, Hainan Zhu, Zhongping Duan, Anthony Atala, Yuanyuan Zhang
{"title":"Beyond waste: understanding urine's potential in precision medicine.","authors":"Pengfei Yu, Carol Christine Bosholm, Hainan Zhu, Zhongping Duan, Anthony Atala, Yuanyuan Zhang","doi":"10.1016/j.tibtech.2024.01.009","DOIUrl":"10.1016/j.tibtech.2024.01.009","url":null,"abstract":"<p><p>Urine-derived stem cells (USCs) are a promising source of stem cells for cell therapy, renal toxicity drug testing, and renal disease biomarker discovery. Patients' own USCs can be used for precision medicine. In this review we first describe the isolation and characterization of USCs. We then discuss preclinical studies investigating the use of USCs in cell therapy, exploring the utility of USCs and USC-derived induced pluripotent stem cells (u-iPSCs) in drug toxicity testing, and investigating the use of USCs as biomarkers for renal disease diagnosis. Finally, we discuss the challenges of using USCs in these applications and provide insights into future research directions. USCs are a promising tool for advancing renal therapy, drug testing, and biomarker discovery. Further research is needed to explore their potential.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable biofabrication: from bioprinting to AI-driven predictive methods. 可持续生物制造：从生物打印到人工智能驱动的预测方法。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-07-27 DOI: 10.1016/j.tibtech.2024.07.002
Miriam Filippi, Manuel Mekkattu, Robert K Katzschmann
{"title":"Sustainable biofabrication: from bioprinting to AI-driven predictive methods.","authors":"Miriam Filippi, Manuel Mekkattu, Robert K Katzschmann","doi":"10.1016/j.tibtech.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.07.002","url":null,"abstract":"<p><p>Biofabrication is potentially an inherently sustainable manufacturing process of bio-hybrid systems based on biomaterials embedded with cell communities. These bio-hybrids promise to augment the sustainability of various human activities, ranging from tissue engineering and robotics to civil engineering and ecology. However, as routine biofabrication practices are laborious and energetically disadvantageous, our society must refine production and validation processes in biomanufacturing. This opinion highlights the research trends in sustainable material selection and biofabrication techniques. By modeling complex biosystems, the computational prediction will allow biofabrication to shift from an error-trial method to an efficient, target-optimized approach with minimized resource and energy consumption. We envision that implementing bionomic rationality in biofabrication will render bio-hybrid products fruitful for greening human activities.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming naturally evolved switches for Streptomyces chassis development. 为链霉菌底盘开发重编程自然进化开关。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-07-24 DOI: 10.1016/j.tibtech.2024.07.001
Hao Yan, Shanshan Li, Weishan Wang
{"title":"Reprogramming naturally evolved switches for Streptomyces chassis development.","authors":"Hao Yan, Shanshan Li, Weishan Wang","doi":"10.1016/j.tibtech.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.07.001","url":null,"abstract":"<p><p>The Streptomyces chassis serves as an important platform for efficient biomanufacture of diverse secondary metabolite (SM) compounds, but the current chassis lacks compatibility for integration of these SM biosynthetic pathways reliably and consistently. This forum discusses harnessing naturally evolved multifaceted switches to reprogram the Streptomyces chassis for biomanufacturing applications.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating bicarbonate-based microalgal production with alkaline sewage for ocean negative carbon emissions. 将基于碳酸氢盐的微藻生产与碱性污水相结合，实现海洋负碳排放。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-07-23 DOI: 10.1016/j.tibtech.2024.06.015
Chenba Zhu, Chen Hu, Jihua Liu, Zhanyou Chi, Nianzhi Jiao
{"title":"Integrating bicarbonate-based microalgal production with alkaline sewage for ocean negative carbon emissions.","authors":"Chenba Zhu, Chen Hu, Jihua Liu, Zhanyou Chi, Nianzhi Jiao","doi":"10.1016/j.tibtech.2024.06.015","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.06.015","url":null,"abstract":"<p><p>Using sewage (wastewater) for ocean alkalinity enhancement (OAE) has been considered as one promising ocean negative carbon emissions (ONCE) approach due to its high carbon sequestration efficiency and low environmental risk. To make this process more profitable and sustainable, this perspective proposes to integrate bicarbonate-based microalgal production and sewage alkalinity enhancement for ONCE. In this concept, the spent aqueous alkaline bicarbonate-based microalgal medium is cheap or even free for OAE, while the produced microalgae with high value-added compositions make this process more profitable. To make the proposed idea more efficient and sustainable, the prospects for its future development are also discussed in this opinion article. This perspective provides a novel and practical idea for achieving efficient carbon neutralization and high economic value simultaneously.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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