架起通往多路分子诊断的桥梁。

IF 14.9 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-08-22 DOI:10.1016/j.tibtech.2025.07.032

Cansu Pinar Yenice, Ciara K O'Sullivan

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引用次数: 0

摘要

桥式核酸扩增利用表面连接的正向和反向引物，允许在二维表面上以空间控制的方式进行扩增，促进多重反应，用于从个性化医学到高级法医的各种应用中检测核酸靶标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bridging the path to multiplexed molecular diagnostics.

Bridge amplification of nucleic acids exploits the use of surface-tethered forward and reverse primers to allow amplification to occur on a 2D surface, in a spatially controlled manner, facilitating multiplexed reactions for the detection of nucleic acid targets with a variety of applications from personalized medicine to advanced forensics.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).