Translational Vision Science & Technology最新文献

{"title":"Smartphone-Based Automated Quantification of Bulbar Conjunctival Hyperemia Using Vessel Density Mapping.","authors":"Giovanni Rubegni, Mario Fruschelli, Martina Mugnai, Tommaso Padula, Francesco Cappellani, Niccolò Castellino, Alessandro Avitabile, Alessio Luschi, Karl Mercieca, Gian Marco Tosi","doi":"10.1167/tvst.15.9.6","DOIUrl":"10.1167/tvst.15.9.6","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a smartphone application (Conjunctiva VD) that objectively quantifies bulbar conjunctival hyperemia by estimating the conjunctival vessel density (VD) within a user-defined region of interest (ROI).</p><p><strong>Methods: </strong>A total of 100 conjunctival images from 2 public datasets were analyzed. An external imaging technician selected images meeting predefined quality criteria and delineated an inferior bulbar conjunctival ROI within the app. After ROI selection, the application automatically resized each ROI to 2100 × 1800 pixels and performed on-device vessel segmentation using a fixed computer-vision pipeline to compute the VD (%). Three expert ophthalmologists independently graded hyperemia on the technician-defined ROI using the scale (0-4) and provided a subjective percentage estimate of the VD. The inter-rater agreement (the quadratic-weighted κ for Efron grading and the intraclass correlation coefficient for the subjective VD) and associations between the VDs and the expert assessments (Spearman's ρ) were evaluated.</p><p><strong>Results: </strong>The inter-rater agreement was high for the Efron grading (quadratic-weighted κ = 0.854-0.885), with a similarly high reliability for the subjective VD estimation (intraclass correlation coefficient = 0.910; 95% confidence interval, 0.877-0.935). The application-derived VD correlated strongly with Efron grades across graders (Spearman's ρ = 0.780-0.807; all P < 0.001) and with the expert-estimated VD (ρ = 0.814-0.843; all P < 0.001).</p><p><strong>Conclusions: </strong>A lightweight smartphone application can provide an objective VD metric that shows a strong association with an expert clinical assessment of conjunctival hyperemia.</p><p><strong>Translational relevance: </strong>A portable, widely available smartphone-based tool for objective hyperemia quantification may lower barriers to point-of-care use and enable scalable applications in outpatient triage, longitudinal monitoring, and teleophthalmology.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"6"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Vascular Remodeling After Loading Injections of Faricimab in Diabetic Macular Edema.","authors":"Jounghan Kim, Ye Eun Han, Yoon Jeon Kim, Junyeop Lee","doi":"10.1167/tvst.15.9.8","DOIUrl":"10.1167/tvst.15.9.8","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated choroidal structural changes in patients with diabetic macular edema (DME) after a loading phase of 3 monthly intravitreal faricimab injections.</p><p><strong>Methods: </strong>This retrospective cohort study included treatment-naïve patients with newly diagnosed DME who received 3 monthly intravitreal injections of faricimab. Researchers analyzed data from patients with available follow-up at 1 month after the third injection. Assessments included best-corrected visual acuity, central retinal thickness (CRT), and subfoveal choroidal thickness (SFCT). Hyper-reflective choroidal foci, and the choroidal vascularity index (CVI) of Sattler's and Haller's layers were assessed using enhanced depth imaging optical coherence tomography within a 1.5-mm zone.</p><p><strong>Results: </strong>A total of 24 eyes from 24 treatment-naïve patients were included. After the loading phase, best-corrected visual acuity improved significantly, and both CRT and SFCT decreased markedly. The number of hyper-reflective choroidal foci remained unchanged, and the CVI of Haller's layer increased significantly. No ocular or systemic adverse events occurred during the study period.</p><p><strong>Conclusions: </strong>Loading-phase treatment with faricimab produced functional and anatomical improvements in the retina and choroid of patients with DME. These findings suggest that faricimab may contribute to choroidal vascular remodeling in addition to resolving retinal fluid.</p><p><strong>Translational relevance: </strong>This study shows that observed associations in imaging biomarkers after faricimab loading, such as SFCT and CVI, may provide additional clinical insights for individualized patient assessment in real-world settings, supporting the use of choroidal imaging as a complementary tool for managing diabetic macular edema.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"8"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Visualization of Choroidal Defects in Focal Choroidal Excavation With Near-Infrared Autofluorescence: Multimodal Imaging Study.","authors":"Yuta Nakanishi, Shin Kadomoto, Tomoaki Sakamoto, Takahiro Kogo, Yuki Muraoka, Masayuki Hata, Akitaka Tsujikawa","doi":"10.1167/tvst.15.9.10","DOIUrl":"10.1167/tvst.15.9.10","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the spatial concordance of autofluorescence abnormalities on near-infrared fundus autofluorescence (NIRAF) and short-wavelength fundus autofluorescence (SWAF) with the area of focal choroidal excavation (FCE) defined on en face optical coherence tomography (OCT).</p><p><strong>Methods: </strong>In this retrospective cross-sectional observational study, a 6 × 6-mm en face swept-source OCT image centered on the fovea was used to define the structural FCE area on a choroidal slab. After image registration, areas of abnormal autofluorescence, including hypoautofluorescence and hyperautofluorescence, were delineated on SWAF and NIRAF. Spatial concordance between the en face OCT-defined FCE area and the abnormal autofluorescence areas was evaluated using the Dice similarity coefficient (DSC).</p><p><strong>Results: </strong>Twenty eyes of 20 patients with conforming-type FCE were included. The mean FCE area was 0.708 ± 0.571 mm2 on en face OCT, 1.174 ± 1.196 mm2 on NIRAF (P = 0.534 vs. en face OCT), and 0.152 ± 0.203 mm2 on SWAF (P < 0.001 vs. en face OCT). Spatial concordance with en face OCT was significantly greater for NIRAF (DSC, 0.654 ± 0.187) than for SWAF (DSC, 0.160 ± 0.214; P < 0.001). NIRAF detected abnormal autofluorescence corresponding to the FCE area in all eyes, whereas SWAF failed to detect any abnormality in six eyes (30%).</p><p><strong>Conclusions: </strong>FCE-associated abnormalities on NIRAF showed greater spatial concordance with the FCE area defined on en face OCT than those on SWAF.</p><p><strong>Translational relevance: </strong>NIRAF offers a reproducible, noninvasive means of spatially mapping melanin-associated autofluorescence abnormalities, supporting more precise multimodal characterization of FCE.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"10"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-Source Software Suite for Cell Detection and Segmentation in Adaptive Optics Retinal Imaging.","authors":"Vineeta Das, Tao Liu, Andrei Volkov, Jianfei Liu, Joanne Li, Nancy Aguilera, Johnny Tam","doi":"10.1167/tvst.15.8.22","DOIUrl":"10.1167/tvst.15.8.22","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to present a suite of open-source software tools for automated and interactive annotation (detection and segmentation) of retinal cells from adaptive optics (AO) images.</p><p><strong>Methods: </strong>Three related software packages were developed, implementing machine learning (ML) approaches for cone photoreceptor detection and segmentation and retinal pigment epithelial (RPE) cell detection in AO images. The software packages were designed to have interactive features allowing multiple users to adjust annotations for systematic grading.</p><p><strong>Results: </strong>The software packages have been extensively tested for usability to enable reliable annotation of cells in AO images.</p><p><strong>Conclusions: </strong>This open-source software suite provides tools for quantitative analysis of retinal cells across different AO modalities, supporting reproducible and standardized measurements across studies and imaging platforms.</p><p><strong>Translational relevance: </strong>By lowering technical barriers to AO image analysis, these tools enable broader adoption of cellular resolution biomarkers in retinal research and clinical studies, including longitudinal monitoring and therapeutic evaluation.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"22"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.","authors":"Giovana Rosa Gameiro, Andrew Hoover, Paulo Schor, Hong Jiang, Jianhua Wang","doi":"10.1167/tvst.15.8.7","DOIUrl":"10.1167/tvst.15.8.7","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize retinal neurovascular alterations in Alzheimer's disease (AD) and mild cognitive impairment (MCI) and examine structure-function relationships.</p><p><strong>Methods: </strong>Eighty-two participants (28 with AD, 21 with MCI, and 33 cognitively normal controls) underwent retinal imaging. Retinal blood flow (RBF) was measured using a function imager. Retinal vessel density (RVD), retinal vessel length density (RVLD), vessel width, and capillary perfusion density (CPD) were quantified with optical coherence tomography (OCT) angiography and retinal tissue volume (RTV) with ultra-high-resolution OCT. Derived metrics included retinal tissue perfusion (RTP), retinal capillary flow index (RCF), and volumetric vessel density. Group comparisons and age-adjusted correlations were performed.</p><p><strong>Results: </strong>Compared with controls, the combined AD + MCI group had significantly lower RBF (3.18 ± 1.02 vs. 4.22 ± 0.79 nL/s; P < 0.001), RCF (0.21 ± 0.07 vs. 0.26 ± 0.04 nL/s/mm; P < 0.001), and RTP (2.89 ± 0.94 vs. 3.86 ± 0.77 nL/s/mm3; P < 0.001). Morphometric indices of the perfused capillary network and retinal tissue volume (RVD, RVLD, CPD, vessel width, RTV) did not differ (all P > 0.05). In AD + MCI, RBF was not associated with structural or morphometric microvascular metrics, whereas controls exhibited age-adjusted correlations between RBF and vessel density and length density.</p><p><strong>Conclusions: </strong>AD and MCI are characterized by reduced retinal perfusion and capillary flow index despite preserved network density and retinal tissue volume, suggesting altered retinal hemodynamic-morphometric relationships.</p><p><strong>Translational relevance: </strong>Hemodynamic retinal imaging detects early perfusion impairment in AD and MCI before changes in microvascular network density or retinal tissue volume, offering a noninvasive biomarker for detection and therapeutic monitoring.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"7"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Dopaminergic Agonists in Geographic Atrophy: Converging Evidence From Clinical and Experimental Data.","authors":"Induvahi Veernala, Kyle S Chan, Harrshavasan T S Congivaram, Andrea S Cuamatzi-Castelan, Amrita Rajesh, Joyce Gong, Olivia C Ide, Jeremy A Lavine","doi":"10.1167/tvst.15.8.10","DOIUrl":"10.1167/tvst.15.8.10","url":null,"abstract":"<p><strong>Purpose: </strong>Levodopa (L-DOPA) is an emerging drug repurposing candidate for age-related macular degeneration (AMD). Basic and clinical studies identify a potential role for L-DOPA to prevent and treat neovascular AMD. However, only one prior study has been performed in geographic atrophy (GA).</p><p><strong>Methods: </strong>We performed a retrospective cohort analysis from the Sight Outcomes Research Collaborative database, including eyes with a diagnosis of early- or intermediate-stage AMD in 1 eye. We compared eyes exposed to any dopamine agonist (DA), dopamine receptor D2 agonist, and L-DOPA with eyes with no DA exposure using propensity score matching and survival analysis with multivariable Cox proportional hazard models with new GA development as our primary outcome. Mice were treated with intraperitoneal NaIO3 to induce GA-like pathology. We compared L-DOPA with phosphate-buffered saline-treated controls in both pigmented and albino mice. We quantified retinal thickness by optical coherence tomography, and performed immunofluorescence to quantify choriocapillaris and retinal pigment epithelium density.</p><p><strong>Results: </strong>Any DA, dopamine receptor D2, and L-DOPA exposure were not associated with new-onset GA. NaIO3 treatment caused retinal thinning, choriocapillaris loss, and retinal pigment epithelium degeneration, which were not rescued by L-DOPA treatment in pigmented nor albino mice.</p><p><strong>Conclusions: </strong>In both retrospective database analysis and preclinical models, DA had no effect upon GA pathology.</p><p><strong>Translational relevance: </strong>Further investigation of levodopa may be more appropriately directed toward neovascular age-related macular degeneration, rather than geographic atrophy, where preclinical, retrospective, epidemiologic, and prospective data suggest a benefit.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"10"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Disease Progression Using Widefield Optical Coherence Tomography in the Nonhuman Primate Experimental Glaucoma Model.","authors":"Varsha Venkata Srinivasan, Louvenia Carter-Dawson, Michael Kalloniatis, Nimesh B Patel","doi":"10.1167/tvst.15.8.16","DOIUrl":"10.1167/tvst.15.8.16","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether there is detectable thinning of the ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) across all eccentricities of a 55° × 45° widefield optical coherence tomography (OCT) scan in the nonhuman primate experimental glaucoma model.</p><p><strong>Methods: </strong>Eight rhesus monkeys (Macaca mulatta) with unilateral experimental glaucoma were monitored longitudinally using widefield OCT. GCIPL and RNFL thickness maps were generated, and longitudinal disease changes were quantified using Z-score maps with 1° × 1° super pixel granularity. For validation, the correspondence between GCIPL volume (mm3) and histologically determined retinal ganglion cell (RGC) counts was determined for 1 mm retinal samples in four longitudinally monitored animals and three additional animals from a separate study.</p><p><strong>Results: </strong>The Z-score maps from follow-up scan sessions demonstrated significant RNFL thinning across the retina, whereas GCIPL thinning was limited to the central 12° in eyes with experimental glaucoma. For the five eccentricities sampled for histology, GCIPL volume was a predictor of RGC counts (F = 44.14, P < 0.01). The linear mixed-effects model, which included eccentricity and disease state, accounted for a substantial portion of the variance (R2 = 0.72). For locations 12.7° and greater, the GCIPL is at a floor in healthy eyes as illustrated by the clustering of disease and control data.</p><p><strong>Conclusions: </strong>Widefield imaging has the potential to quantitatively monitor RNFL wedge defects across a 55° scanned region. GCIPL thickness is a valuable measure of local RGC content in the macular region, but its value for monitoring disease in the periphery is less significant.</p><p><strong>Translational relevance: </strong>Widefield OCT enables the quantification of retinal ganglion cell associated loss for the extent of the retina tested by visual fields.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"16"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Field-of-View for Type-1 Retinopathy of Prematurity via Multiple Instance Learning.","authors":"Wen-Hsi Lan, Chia-Ling Tsai, Wei-Chi Wu","doi":"10.1167/tvst.15.8.13","DOIUrl":"10.1167/tvst.15.8.13","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to cut down on screening time and costs, this study optimizes field-of-view (FOV) combinations for classifying type-1 retinopathy of prematurity (ROP) through multiple-instance learning (MIL) that models clinical decision making.</p><p><strong>Methods: </strong>The dataset included 1420 photographs of 284 eyes (204 eyes from Chang Gung Memorial Hospital [CGMH] and 80 eyes from Osaka University), each eye containing five FOVs (temporal, nasal, central, superior, and inferior). We evaluated various FOV combinations and compared two MIL fusion strategies, feature-level and outcome-level, to identify the most effective approach. Feature-level learns a joint representation across views, whereas outcome-level aggregates the predicted probabilities from each view at the decision stage. Model performance was evaluated using five-fold cross-validation, with metrics including accuracy, precision, recall, F1-score, and area under the curve (AUC).</p><p><strong>Results: </strong>The feature-level MIL significantly outperformed the outcome-level MIL in all combinations and metrics except the superior view (P < 0.05). Among FOV combinations, the temporal, nasal, and central set achieved the highest performance (accuracy = 0.892 ± 0.043, F1-score = 0.831 ± 0.097). Horizontal (temporal and nasal) and central views individually showed stronger diagnostic power, comparable to multi-view settings, whereas vertical (superior and inferior) views performed significantly worse.</p><p><strong>Conclusions: </strong>The feature-level MIL model effectively simulates clinical decision making for type-1 ROP classification. Temporal, nasal, and central views, as well as their combination, achieved superior performance over vertical views or their combination. Notably, feature-level MIL outperformed outcome-level MIL, underscoring the critical role of information fusion strategy.</p><p><strong>Translational relevance: </strong>Clinically aligned MIL with optimized FOV selection enables more efficient artificial intelligence (AI)-assisted telemedicine screening for retinopathy of prematurity.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"13"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment Measurement Dataset Using Ultrasound Biomicroscopy Image Analysis.","authors":"Taylor Kolosky, He Eun Forbes, Moran R Levin, Camilo Martinez, William P Madigan, Janet L Alexander","doi":"10.1167/tvst.15.8.19","DOIUrl":"10.1167/tvst.15.8.19","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to provide a comprehensive, quantitative dataset of anterior segment (AS) parameters obtained from ultrasound biomicroscopy (UBM) images to support research in ocular development, disease characterization, and image-based analysis.</p><p><strong>Methods: </strong>UBM images were prospectively collected from 185 eyes of 138 participants aged 3 weeks to 26 years (median = 17 months), encompassing diagnoses such as healthy controls, primary congenital glaucoma (PCG), glaucoma following cataract surgery (GFCS), congenital cataract, traumatic cataract, Lowe syndrome, and Sturge-Weber syndrome (SWS)-associated glaucoma. Twenty-seven quantitative AS parameters were measured from deidentified images using ImageJ software following a standardized protocol.</p><p><strong>Results: </strong>The resulting dataset includes demographic and diagnostic metadata paired with quantitative UBM-derived parameters for each eye. The dataset is provided in comma-separated value (CSV) format with an accompanying data dictionary.</p><p><strong>Conclusions: </strong>This dataset provides one of the most extensive collections of quantitative pediatric AS measurements obtained by UBM, enabling characterization of age- and disease-related anatomic variation and facilitating reproducible secondary analyses.</p><p><strong>Translational relevance: </strong>This open-source pediatric UBM dataset establishes a foundation for studies of ocular growth, disease mechanisms, and surgical planning, and provides a valuable resource for the development and validation of automated image analysis and machine learning models in pediatric AS imaging.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"19"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Choroidal Structural Parameters and Cone Photoreceptors in Young High Myopia.","authors":"Jingtao Yu, Zixun Wang, Luqiang Wang, Tingyu Zhang, Xiaoling Zhang, Zhiqing Li, Bei Du, Ruihua Wei","doi":"10.1167/tvst.15.8.21","DOIUrl":"10.1167/tvst.15.8.21","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association between choroidal structural parameters and cone photoreceptor characteristics in young individuals with different degrees of myopia and to assess whether choroidal thickness (CT) may indicate early photoreceptor alterations in high myopia (HM).</p><p><strong>Methods: </strong>Ninety-three participants aged 18 to 28 years were classified as nonmyopic, mildly to moderately myopic, or highly myopic. CT and choroidal vascularity index (CVI) were measured using swept-source optical coherence tomography angiography. Cone metrics were quantified using adaptive optics scanning laser ophthalmoscopy with automated segmentation. Cone measurements were averaged across sampling locations to derive an overall value per eye. Group comparisons and associations were analyzed using appropriate parametric or nonparametric tests, correlation analysis, and multivariable linear regression.</p><p><strong>Results: </strong>CT decreased progressively with increasing myopia across all macular regions (P < 0.001), while CVI showed no significant differences. Cone density was reduced in HM, with increased spacing and reduced regularity (P < 0.001). In unadjusted analyses, cone density was positively associated with CT (r = 0.313 to 0.394, P < 0.01). Each 1-µm increase in CT corresponded to an increase of approximately 10 to 12 cells/mm² in cone density.</p><p><strong>Conclusions: </strong>Young HM eyes show concurrent reductions in CT and cone integrity, while CVI remains relatively stable. The observed associations likely reflect shared structural changes related to axial elongation rather than independent effects of CT.</p><p><strong>Translational relevance: </strong>CT may serve as a practical structural biomarker for early retinal alterations in HM.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 8","pages":"21"},"PeriodicalIF":2.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}