Translational Vision Science & Technology最新文献

{"title":"Intraday and Interday Repeatability of Laser Speckle Contrast Imaging for Ocular Blood Flow Measurement in Healthy Subjects.","authors":"Xiaogang Wang, Giovana Rosa Gameiro, Andrew Hoover, Mariam Moarefi, Shuya Wang, Lian Duan, Xiaoming Wang, Hong Jiang, Jianhua Wang","doi":"10.1167/tvst.15.9.12","DOIUrl":"10.1167/tvst.15.9.12","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the intra- and interday repeatability of ocular blood flow velocity index (BFVi) measurements using a laser speckle contrast imaging device.</p><p><strong>Methods: </strong>BFVi measurements were obtained using XyCAM CRE (Vasoptic Medical Inc., Columbia, MD). Two imaging sessions were performed on the same day (26 eyes) and on different days (20 eyes). For optic nerve head-centered datasets, the analyzed regions included the overall field of view, the optic disc, and a standard temporal peripapillary region. For macula-centered datasets, the regions analyzed were the overall field of view, the foveal avascular zone, and the perifoveal region. For each region, heart rate-adjusted measurements of the peak, dip, and mean BFVi were assessed.</p><p><strong>Results: </strong>For intraday measurements of all the optic nerve head-centered parameters, the coefficients of variation (CVs) ranged from 4.8% to 8.5%, and the intraclass correlation coefficient ranged from 0.74 to 0.98. For all macula-centered parameters, the CVs ranged from 4.7% to 6.2%, and the ICCs ranged from 0.93 to 0.98. For the interday measurements of all the optic nerve head-centered parameters, the CVs ranged from 7.9% to 12.6%, and the ICCs ranged from 0.56 to 0.93. For all the macula-centered parameters, the CVs ranged from 8.6% to 15.0%, and the intraclass correlation coefficient ranged from 0.79 to 0.94.</p><p><strong>Conclusions: </strong>Laser speckle contrast imaging demonstrated strong intraday repeatability and reliability for BFVi measurement in healthy subjects, with good interday reliability for key parameters despite some variability.</p><p><strong>Translational relevance: </strong>Laser speckle contrast imaging shows promise for clinical use in ophthalmology due to its robust intraday and good interday reliability for ocular blood flow velocity measurements.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"12"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Small Treatment Zone Orthokeratology and Alternate-Day 0.01% Atropine for Axial Elongation Control in Rapidly Progressing Myopic Children.","authors":"Mengying Xu, Lili Jing, Lianghui Zhao, Yanyan Xiu, Xianli Du","doi":"10.1167/tvst.15.9.13","DOIUrl":"10.1167/tvst.15.9.13","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of small treatment zone (STZ) orthokeratology (ortho-K) combined with alternate-day 0.01% atropine to control axial elongation in rapidly progressing myopic children and identify associated optical predictors.</p><p><strong>Methods: </strong>This prospective randomized study included 105 children ages 8 to 12 years with axial elongation ≥0.20 mm during the initial 6 months of STZ ortho-K wear, assigned to ortho-K plus alternate-day 0.01% atropine (AOK) or ortho-K alone (OK) for 12 months. The primary outcome was axial length (AL) elongation. Other outcomes included pupil diameter (PD), intraocular pressure, visual quality, and adverse events. In the AOK group, corneal higher-order aberrations (HOAs) and pupil-zone defocus were assessed before and after atropine therapy.</p><p><strong>Results: </strong>AL elongation was lower in the AOK group than in the OK group at 3, 6, and 12 months (0.03 ± 0.06 vs. 0.09 ± 0.04; 0.09 ± 0.08 vs. 0.18 ± 0.07; and 0.20 ± 0.12 vs. 0.33 ± 0.09 mm, respectively; all P < 0.05). At 3 months, corneal HOAs and pupil-zone defocus increased in the AOK group (all P < 0.05). In AOK, multivariable regression identified baseline age, PD, and total pupil-zone defocus as independent predictors of 1-year AL elongation. Mild photophobia occurred in two participants, with no serious adverse events.</p><p><strong>Conclusions: </strong>Compared with STZ ortho-K alone, adding alternate-day 0.01% atropine further reduced axial elongation in rapidly progressing myopic children, with response associated with age and pupil-related optical factors, including PD and pupil-zone defocus.</p><p><strong>Translational relevance: </strong>Optimized lens design and atropine dosing may support precision optical-pharmacologic myopia control.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"13"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival of Patients With MBD4-Mutated Metastatic Uveal Melanoma Treated With Immune Checkpoint Inhibitors.","authors":"Natasha Honoré, Raphaël Sanchez, Sophie Piperno-Neumann, Gaëlle Pierron, Anaïs Le Ven, Alexandre Houy, Vincent Servois, Anne Vincent-Salomon, Pascale Mariani, Nathalie Cassoux, Alexandre Matet, Toulsie Ramtohul, Chrystelle Colas, Manuel Rodrigues","doi":"10.1167/tvst.15.9.19","DOIUrl":"10.1167/tvst.15.9.19","url":null,"abstract":"<p><strong>Purpose: </strong>The prognosis of metastatic uveal melanoma (mUM) remains poor, and immune checkpoint inhibitors (ICIs) show limited efficacy, with response rates typically below 5%. Tebentafusp, an immune therapy targeting the gp100 protein, is the first drug to improve overall survival (OS) in mUM. Somatic MBD4 deficiency induces a hypermutated phenotype in a fraction of UM cases and may predict benefit from ICIs.</p><p><strong>Methods: </strong>We retrospectively analyzed patients with mUM carrying somatic or germline MBD4 alterations and treated with ICIs at Institut Curie (Paris, France). Clinical characteristics, treatments, and outcomes were collected.</p><p><strong>Results: </strong>Twelve patients received ICIs (nine pembrolizumab, two ipilimumab + nivolumab, one pembrolizumab + lenvatinib). Most (83%) had M1a liver-only disease. The overall response rate was 50% (two complete, four partial) with a disease control rate of 83%. The median follow-up was 22 months (range, 9.9-116.8), and within this time frame median progression-free survival and OS were not reached. At 12 months, 73% of patients were progression free, and the estimated 2-year OS was 86%.</p><p><strong>Conclusions: </strong>We observed that, in patients with MBD4-mutated mUM, ICIs achieved a 50% response rate and prolonged survival, demonstrating strong and sustained clinical activity in this distinct molecular subgroup and exceeding outcomes reported with ICIs or tebentafusp.</p><p><strong>Translational relevance: </strong>Our findings support further evaluation of MBD4 mutation as a predictive biomarker and suggest that ICIs should be considered as a preferred first-line option in MBD4-mutated mUM.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"19"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in: Optimizing Field-of-View for Type-1 Retinopathy of Prematurity via Multiple Instance Learning.","authors":"","doi":"10.1167/tvst.15.9.16","DOIUrl":"10.1167/tvst.15.9.16","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"16"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-Widefield OCTA Mapping of Epiretinal Macrophage-Like Cells in Patients With Retinal Vein Occlusion.","authors":"Hongzhan Lin, Yingrui Liu, Zhaode Wu, Yumo Wang, Lan Zhou, Yong Xu, Jiayu Chen, Jingfa Zhang, Ming-Ming Yang","doi":"10.1167/tvst.15.9.9","DOIUrl":"10.1167/tvst.15.9.9","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the ultra-widefield distribution and morphology of epiretinal macrophage-like cells (eMLCs) in retinal vein occlusion (RVO) and assess their associations with retinal ischemia and macular edema.</p><p><strong>Methods: </strong>This cross-sectional study included 68 eyes with unilateral branch or central RVO and 68 unaffected fellow eyes as controls. All eyes underwent 24 × 20 mm ultra-widefield swept-source optical coherence tomography angiography (OCTA). The eMLC density and morphology were quantified using a machine-learning-based pipeline. Foveal avascular zone (FAZ) metrics, central subfield thickness (CST), and nonperfusion areas (NPAs) were analyzed. Exploratory duration-based subgroup analyses were also performed.</p><p><strong>Results: </strong>Compared with fellow eyes, RVO eyes showed higher eMLC density (3.69 [2.43] vs. 2.24 [1.12] cells/mm²), greater total eMLCs area (5.31 [3.83] vs. 2.87 [1.74] mm²), greater CST (411.50 [374.75] vs. 290.50 [35.00] µm), and larger FAZ area (0.360 [0.375] vs. 0.220 [0.165] mm²; all P < 0.001). Within-eye regional analyses showed lower eMLC density in the macular region than in the remaining retina (3.09 [1.57] vs. 4.06 [2.82] cells/mm²) and in NPAs than in the remaining retinal regions of the same image (2.39 [1.67] vs. 4.16 [1.89] cells/mm²; both P < 0.001). In RVO eyes, eMLC count was independently associated with disease duration, prior anti-VEGF injection number, and ischemic status.</p><p><strong>Conclusions: </strong>EMLCs are increased in RVO and show a spatially heterogeneous distribution pattern. In RVO eyes, eMLC count was associated with disease duration, prior anti-VEGF exposure, and ischemic status, whereas duration-based subgroup findings should be interpreted as exploratory.</p><p><strong>Translational relevance: </strong>Ultra-widefield OCTA-based eMLCs quantification may provide a clinically accessible imaging biomarker for inflammatory involvement in RVO.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"9"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Vascularity Index in Mild Cognitive Impairment.","authors":"Rachel D'Cunha, John Hsu, Jenny Melcher, Michael Zhu, Alex Choi, Alice Haystead, Arnav Sharma, Atharva Hudlikar, Rachel Song, Hans Ng, Sandra Stinnett, Rupesh Agrawal, Kim G Johnson, Dilraj S Grewal, Sharon Fekrat","doi":"10.1167/tvst.15.9.23","DOIUrl":"10.1167/tvst.15.9.23","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to determine whether retinal vascularity index (RVI) differs between individuals with mild cognitive impairment (MCI) and normal cognition, and to assess RVI as a novel ultra-widefield (UWF) implementation of retinal arteriovenous assessment.</p><p><strong>Methods: </strong>In a cross-sectional case-control study, UWF fundus color images from patients with MCI and cognitively healthy controls were analyzed using a semi-automated platform via the Comprehensive Ocular Imaging Network (COIN; ocularimaging.net). RVI was calculated as the ratio of arterial-to-venous cross-sectional area within a 47-degree region of interest (ROI) centered on the optic disc, with quadrant-based segmentation producing regional RVI values for 4 quadrants within the 47-degree ROI. Generalized estimating equations (GEEs) accounted for inter-eye correlation.</p><p><strong>Results: </strong>Fifty-five eyes of 38 patients with MCI and 89 eyes of 55 cognitively healthy patients were included. Mean RVI across the 47-degree ROI was reduced in MCI versus control eyes (0.524 vs. 0.730, P < 0.001) after adjusting for treated hypertension. Reduced RVI was also observed in each of the four quadrants in MCI compared with controls (P < 0.001). RVI showed good discriminative ability (area under the curve [AUC] = 0.86, sensitivity = 80%, and specificity = 79%) with good inter-grader reliability (intraclass correlation coefficient [ICC] = 0.840, 95% confidence interval [CI] = 0.686-0.943).</p><p><strong>Conclusions: </strong>Mean RVI across the 47-degree ROI was significantly lower in individuals with MCI compared with cognitively healthy controls.</p><p><strong>Translational relevance: </strong>RVI, derived from UWF imaging, may reflect retinal microvascular cross-sectional area differences associated with MCI. As an exploratory metric, further validation is needed before RVI can be used as a noninvasive tool to complement diagnostic approaches for MCI.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"23"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite Element Analysis of Extraocular Muscle and Adipose-Dominant Pathogenesis in Thyroid Eye Disease With Clinical Implications.","authors":"Zexi Sang, Pei Wang, Ru Lin, Xiuhong Li, Li Zhu, Yan Xun, Hongfeng Yuan","doi":"10.1167/tvst.15.9.22","DOIUrl":"10.1167/tvst.15.9.22","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the biomechanical mechanisms of muscle-predominant and adipose-predominant thyroid eye disease (TED) using a three-dimensional (3D) finite element analysis (FEA) model and validate findings through clinical outcomes.</p><p><strong>Methods: </strong>A 3D orbital FEA model was reconstructed from healthy computed tomography imaging. Extraocular muscle hypertrophy and adipose proliferation were simulated under fixed volumetric expansion. Optic nerve (ON) stress and globe displacement were measured across six simulation groups. For clinical validation, 36 patients with TED were retrospectively categorized as adipose type (AT) or muscle type (MT) based on muscle-to-orbital area ratios to compare dysthyroid optic neuropathy (DON) incidence.</p><p><strong>Results: </strong>Medial rectus hypertrophy generated the highest single-muscle ON stress (0.59 kPa). Muscle-predominant simulations produced higher peak ON stress than adipose-predominant simulations (1.40 vs. 0.18 kPa). Conversely, adipose expansion caused much greater globe displacement (4.34 vs. 1.53 mm), reflecting adipose-driven exophthalmos. Clinically, MT patients demonstrated a significantly higher DON rate than AT patients (83.3% vs. 22.2%, P < 0.001), aligning with FEA-predicted risk patterns.</p><p><strong>Conclusions: </strong>Muscle-predominant TED is the primary biomechanical driver of apical compression and DON risk. Adipose-predominant TED primarily causes exophthalmos with lower tractional stress on the optic nerve. Medial rectus hypertrophy is the most significant individual contributor to compressive load.</p><p><strong>Translational relevance: </strong>These biomechanical phenotypes help clinicians identify high-risk patients with DON (MT) who require urgent apical decompression, whereas AT patients may benefit more from volume reduction strategies focused on proptosis correction.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"22"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description and Evaluation of a Visual Acuity Assessment Paradigm Based on Spatial Frequency-Modulated Form Discrimination.","authors":"Jonathan Lansey, Indrani Sirivella, Rahul Negi, Shaun R Patel, Shrikant R Bharadwaj","doi":"10.1167/tvst.15.9.15","DOIUrl":"10.1167/tvst.15.9.15","url":null,"abstract":"<p><strong>Purpose: </strong>To describe and evaluate a visual acuity assessment paradigm based on spatial frequency-modulated form discrimination for induced and disease-driven vision loss.</p><p><strong>Methods: </strong>The Patterned-Optotype-in-Noise Task (POINT) consisted of arrow-shaped random noise patterns, each with a 1/f2 amplitude spectrum overlaid on a low-pass filtered background. Stimulus difficulty varied logarithmically across 22 levels by adjusting the background cutoff spatial frequency, relative to foreground. Monocular acuity was measured for POINT stimuli and letter optotypes in 20 adults (21-46 years) with 0-4D of induced blur and in 50 patients (9-77 years) with vision impairment from ocular pathologies/uncorrected refractive error.</p><p><strong>Results: </strong>The POINT demonstrated systematic loss in visual acuity with induced optical blur and eye pathologies, like the standard letter acuity test (P < 0.001). The losses with induced blur in the POINT followed standard Fourier optics predictions of spatial-frequency discrimination between the background and foreground pattern. The test-retest repeatability of POINT was also comparable to letter acuity testing (mean difference ± 95% limits of agreement: +0.04 units ± 0.2 units), but with limited agreement in the acuity measures obtained between the two tests.</p><p><strong>Conclusions: </strong>The POINT is a reliable technique for estimating visual acuity with induced and disease-driven vision loss. However, caution should be exercised when directly comparing these outcomes to standard letter acuity tests owing to fundamental differences in stimulus construction and task requirements.</p><p><strong>Translational relevance: </strong>The POINT offers a physiologically and theoretically grounded complement to standard assessment of visual acuity in clinical, research and public eye health settings.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"15"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BlinkNet-Q: A Deep Learning-Based Software for Real-Time Blink Rate Quantification and Incomplete-Blink Pattern Recognition.","authors":"Zhiqiang Xu, Jiahui Shen, Anran Liu, Jun Wen, Hongwen Li, Pedro Arriola-Villalobos, Minhui Wu, Jia Qu, Fan Lu, Liang Hu","doi":"10.1167/tvst.15.9.4","DOIUrl":"10.1167/tvst.15.9.4","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate a dual deep learning model (DLM)-based software (BlinkNet-Q) for near real-time quantification of blink rate and incomplete blinks using standard red-green-blue video.</p><p><strong>Methods: </strong>BlinkNet-Q integrated two DLMs: DLM-1 classified open-eye versus complete-blink frames, and DLM-2 differentiated complete from incomplete blinks. This proof-of-concept technical validation study included separate model development and independent testing cohorts. The development cohort comprised 15 participants (30 eyes), yielding 2953 annotated frames for training and internal validation, with participant-level data splitting. The testing cohort included 39 participants (39 eyes) and was used for final evaluation of the BlinkNet-Q. Frame-wise analysis with computer vision-based eye localization enabled automated blink quantification. Performance was assessed using classification metrics, regression-based metrics, intraclass correlation coefficient (ICC), and Bland-Altman analysis.</p><p><strong>Results: </strong>DLM-1 achieved an area under the curve (AUC) of 0.989 (95% confidence interval [CI], 0.932-0.993), and DLM-2 reached an AUC of 0.884 (95% CI, 0.854-0.963). The BlinkNet-Q showed strong agreement with manual counting for blink rate (ICC = 0.973; R² = 0.948; mean absolute error [MAE] = 1.262 blinks/min) and incomplete-blink ratio (ICC = 0.937; R² = 0.876; MAE = 0.059), with small mean biases under standardized recording conditions.</p><p><strong>Conclusions: </strong>BlinkNet-Q demonstrated the technical feasibility of automated blink rate and incomplete-blink quantification under standardized recording conditions, supporting its potential as a software prototype for blink assessment. Further external validation in diverse clinical populations is needed before clinical implementation.</p><p><strong>Translational relevance: </strong>BlinkNet-Q may support future development of accessible, camera-based blink assessment tools for ocular surface evaluation.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"4"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninterchangeability of Vessel Density Measurements Across Next-Generation SS-OCTA Systems.","authors":"Peter M Maloca, Philippe C Cattin, Nadja Inglin, Claudia Bruè, Pascal W Hasler, Simon Rothenbuehler, Hanna Zuche, Javier Zarranz-Ventura, Philippe Valmaggia","doi":"10.1167/tvst.15.9.24","DOIUrl":"10.1167/tvst.15.9.24","url":null,"abstract":"<p><strong>Purpose: </strong>Comparing swept-source optical coherence tomography angiography (OCTA) vessel density in the superficial and deep capillary plexuses across leading OCTA systems.</p><p><strong>Methods: </strong>OCTAs were acquired from healthy participants using two OCTA systems (BMizar 400 kHz and Yalkaid 100 kHz, TowardPi, Beijing, China) with scan sizes of 3 × 3, 6 × 6, 12 × 12, and 15 × 15 mm2. The vessel density was quantified using the manufacturer's software.</p><p><strong>Results: </strong>Across 30 subjects comprising 60 eyes and a total of 225 OCTA scans, significant interdevice differences were observed at the Early Treatment Diabetic Retinopathy Study sector level in all eight scan size × plexus comparisons (three-way analysis of variance; P < 1.16 × 10e-4). The mean BMizar vessel density values for the superficial and deep plexuses were 43.4% ± 1.6% and 44.9% ± 1.5%, 44.7% ± 2.7% and 47.9% ± 1.1%, 44.2% ± 1.3% and 45.7% ± 1.1%, and 42.4 ± 1.6 % and 44.3 ± 1.3% for the 3 × 3, 6 × 6, 12 × 12, and 15 × 15 mm² scans; the Yalkaid values were lower. BMizar showed greater vessel density than Yalkaid, particularly in 3 × 3 mm² deep slab scans, with differences of approximately 5% to 10%. Across scans larger than 3 × 3 mm², BMizar showed greater central vessel density; the peripheral patterns varied, with reversals favoring Yalkaid and greater border effects in larger fields of view.</p><p><strong>Conclusions: </strong>Despite interdevice differences, both devices showed consistent OCTA acquisition.</p><p><strong>Translational relevance: </strong>Device differences may affect clinical interpretation, longitudinal follow-up, and multicenter studies.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"15 9","pages":"24"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}