Transplant Infectious Disease最新文献

{"title":"A Case of Disseminated Encephalitozoon cuniculi in a Lung Transplant Recipient: Microsporidiosis in the Era of Molecular Diagnostics.","authors":"Lee S Gottesdiener, Clare DeLaurentis, Marcus R Pereira","doi":"10.1111/tid.70325","DOIUrl":"https://doi.org/10.1111/tid.70325","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70325"},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Donor Pool: Successful Single Lung Transplant of a Hepatitis C Seropositive Donor to a Recipient With HIV and Pulmonary Fibrosis.","authors":"Harris Z Whiteson, Sangita Goel, Melissa Lesko, Bonnie E Lonze, Sapna A Mehta","doi":"10.1111/tid.70327","DOIUrl":"https://doi.org/10.1111/tid.70327","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70327"},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Administrative Health Data for Identifying Cytomegalovirus Infection After Solid Organ Transplantation.","authors":"Zachary A Yetmar, Thomas J Rust, Raymund R Razonable, Monica George-Palop, Christine E Koval, Wayne Tsuang","doi":"10.1111/tid.70331","DOIUrl":"https://doi.org/10.1111/tid.70331","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) infection is among the most common infections after solid organ transplantation and leads to high rates of morbidity and mortality. With the proliferation of large, claims-based datasets, there is a need to assess the validity of ICD-10-CM codes in identifying CMV infection.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of solid organ transplant recipients (SOTRs) from a regional health system who underwent first transplantation between January 1, 2016, and June 30, 2025, had at least 30 days of post-transplant follow-up, and had known donor/recipient CMV serostatus. We performed cross-sectional and time-to-event analyses comparing the test performance of B25 ICD-10-CM codes in identifying CMV infection, clinically significant CMV infection (csCMVi), CMV disease, and CMV DNA reaching various thresholds.</p><p><strong>Results: </strong>Of 8169 SOTRs, 3084 (37.8%) had B25 coded during follow-up. In addition, 4287 (52.5%) developed CMV infection, 2356 (28.8%) csCMVi, 297 (3.6%) CMV disease, and 1669 (20.4%) CMV DNA ≥ 1000 IU/mL. B25 codes were most specific to any CMV infection (88.5%), most sensitive to CMV DNA ≥ 100 000 IU/mL (98.2%), and csCMVi had the highest Youden's Index (0.651; sensitivity 84.1%, specificity 81.0%). Multivariable Cox regression provided similar results but with variations in effect measure between ICD-10-CM codes and clinical CMV definitions.</p><p><strong>Conclusions: </strong>ICD-10-CM codes showed modest performance in identifying CMV infection, most closely resembling csCMVi. ICD-10-CM codes poorly reflect CMV severity, however, and may overestimate CMV infection by some clinical definitions. These limitations should be considered when using CMV diagnosis codes for claims-based studies of SOTRs.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70331"},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effectiveness of the Recombinant Zoster Vaccine in Kidney Transplant Recipients-But Wait…There's More!","authors":"Eric Bhaimia, Jae Hyung Jung","doi":"10.1111/tid.70326","DOIUrl":"https://doi.org/10.1111/tid.70326","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70326"},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial Blood Microbiome Profiles in Kidney Transplant Recipients Reveal Evidence of Circulating Gut and Non-Gut Derived Microbial DNA.","authors":"Alex DeVito, Ananda L Kimm-Drapeau, William J Higgins, Mia Montecillo, Matthew N Bernstein, Sheavonnie Wright, Carol Li, Isha Bal, Darshana M Dadhania, Friederike Selbach, John R Lee","doi":"10.1111/tid.70323","DOIUrl":"10.1111/tid.70323","url":null,"abstract":"<p><strong>Background: </strong>In this study, we sought to investigate the utility of 16S rRNA gene sequencing of whole blood in kidney transplant recipients and to assess a link between the gut microbiota and the blood microbiota.</p><p><strong>Methods: </strong>We recruited 63 kidney transplant recipients who provided 163 whole blood specimens over the first 140 days after transplantation. We profiled the blood microbiome using 16S rRNA gene sequencing of the V4-V5 hypervariable region. We additionally evaluated the gut microbiota via metagenomic sequencing in a subset of kidney transplant recipients who had matched blood specimens.</p><p><strong>Results: </strong>We generated a median of 19 959 sequences per blood specimen. We discovered that most whole blood microbiome profiles consisted of mitochondrial DNA (mean relative blood abundance greater than 99%) with minimal microbial DNA detected. Out of the 163 blood specimens, 83 (51%) had detectable microbial 16S rRNA sequences and there were 92 distinct taxa detected at the genus level. Among the 51 kidney transplant recipients, blood microbial 16S sequences were persistently detected in 10 kidney transplant recipients over time, intermittently detected in 29 kidney transplant recipients over time, and not detected in 12 kidney transplant recipients over time. Among 76 matched blood-fecal specimens, 9 blood specimens had detectable gut microbial 16S sequences, which were also detected in 3 of the 9 fecal specimens.</p><p><strong>Conclusion: </strong>Our study finds minimal detection of bacterial DNA in the blood microbiome in kidney transplant recipients and evidence of gut bacterial DNA in the bloodstream of kidney transplant recipients.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70323"},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Fungal Infections in Heart Transplants: A 10-Year, Single Centre Retrospective Cohort Study From Subtropical Australia.","authors":"Angus Lane, Karen Hay, John McNamara, Alex Chaudhuri, Andrew Burke, Robert Horvath, Maryam Khorramshahi Bayat, Kanthi Vemuri","doi":"10.1111/tid.70315","DOIUrl":"10.1111/tid.70315","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in solid organ transplant recipients. However, their epidemiology in Australian heart transplant cohorts remains poorly defined. We aimed to determine the incidence, microbiological profile, diagnostic performance, and survival outcomes associated with IFIs in heart transplant recipients.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of all heart transplant patients who were diagnosed with an IFI between January 1, 2014 and February 29, 2024 at a single center in Queensland, Australia. Patient characteristics, details of transplant hospitalization, antifungal prophylaxis, microbiology, and treatment of fungal infections were described.</p><p><strong>Results: </strong>Of 73 patients with suspected IFI, 48 met criteria for possible 19% (n = 9), probable 27% (n = 13), or proven 54% (n = 26) infection. Aspergillus 33% (n = 16), Candida 17% (n = 8), Scedosporium 13% (n = 6), and polymicrobial infections 8% (n = 4) were most common. Median time to IFI diagnosis was 7 months post-transplant. Of 148 patients who received heart transplants at the center between January 2014 and February 2024, 32 developed IFI; estimated incidence was 49 (95% CI: 35-70) per 1000 person years. Among those who died (n = 21), median time from transplant to death was 5.75 years. Baseline Charlson comorbidity index was the only variable significantly associated with all-cause mortality (p = 0.041).</p><p><strong>Conclusion: </strong>IFIs in heart transplant recipients frequently occur beyond the first year posttransplant. Higher Charlson scores were associated with reduced survival. These findings support the need for tailored prophylaxis strategies and improved diagnostic algorithms in preventing posttransplant IFI.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70315"},"PeriodicalIF":2.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactogenicity and Immunogenicity of RSV Vaccines in Immunocompromised Individuals With Hematological Malignancies.","authors":"Alisse Hannaford, Zoe Swank, Simon D van Haren, Natalie Izaguirre, Caitlin Syphurs, Zhou Lan, Bridget Yates, Urwah Kanwal, Grace Valentine, Ella Woehl, David Regan, Hannah Levine, Alexandra Tong, Maria Shehata, Fathia Oladipupo, Colleen Sedney, Kevin Ryff, Sanya Thomas, Joann Diray-Arce, Xiaofang Li, Kimberly A Dufresne, Lindsey A Parisi, Aidan Eustace, Louise Hansen, David R Walt, Ofer Levy, Amar Kelkar, Robert J Soiffer, Vincent T Ho, Lindsey R Baden, Nicolas C Issa, Ann E Woolley, Amy C Sherman","doi":"10.1111/tid.70316","DOIUrl":"https://doi.org/10.1111/tid.70316","url":null,"abstract":"<p><strong>Background: </strong>Adults with hematologic malignancy (HM) are at increased risk for severe respiratory syncytial virus (RSV) infection. Immunogenicity and durability data of prefusion F-based RSV vaccines in HM remain limited.</p><p><strong>Methods: </strong>In a prospective cohort, adults with HM and healthy controls (HCs) received one RSV vaccine (adjuvanted RSVPreF3 or non-adjuvated RSVpreF). Serum was collected pre-vaccination and at 1, 3, and 6-months for anti-fusion glycoprotein (FGP) IgG to RSV A/B; 7-day reactogenicity was assessed. A subset (n = 13) underwent T-cell analyses for RSV F-specific CD4⁺ and CD8⁺ T-cell responses.</p><p><strong>Results: </strong>Fifty-five HM participants and 16 HCs were enrolled; 60% had prior hematopoietic cell transplantation. Mild reactogenicity occurred in ∼25%, with no severe events reported. Anti-FGP titers were higher in HCs than HM at all visits (all p < 0.01); RSV-A median titers were 0.153 versus 0.055 Normalized average enzymes per bead (nAEB) at baseline and 1.154 versus 0.113 (nAEB) at 1 month (HC vs. HM). Within HM, anti-FGP increased at 1 month for RSV A and B but waned thereafter; RSV-A remained above baseline at 3 months only, and RSV-B was not sustained beyond 1 month. Baseline-to-1-month fold changes were similar between HM and HCs. RSV F-specific CD4⁺ and CD8⁺ T cells increased at 1 month (p = 0.027; p = 0.031), with CD8⁺ responses also increased at 3 months (p = 0.006). One RSV infection occurred 5 days post-vaccination.</p><p><strong>Conclusions: </strong>RSV vaccination was well tolerated and induced early humoral and cellular responses in HM, but antibody magnitude and durability were reduced compared with HCs, supporting the need to optimize vaccination strategies for HM populations.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70316"},"PeriodicalIF":2.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond a One-Size-Fits-All Approach: RSV Vaccination in Immunocompromised Patients.","authors":"Kar Yee Yong, Victoria G Hall","doi":"10.1111/tid.70310","DOIUrl":"https://doi.org/10.1111/tid.70310","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70310"},"PeriodicalIF":2.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant Infectious Diseases Tracks-Leveraging General ID Training to Build TID Expertise.","authors":"Jessica S Tischendorf, Daniel J Minter, Rosy Priya Kodiyanplakkal, Chelsea Gorsline","doi":"10.1111/tid.70318","DOIUrl":"https://doi.org/10.1111/tid.70318","url":null,"abstract":"<p><p>The number of transplant infectious disease (TID) training opportunities has grown over the past decade, and training experiences are heterogeneous. Formal TID fellowships are increasingly sought after; however, not all fellowship programs have the means to administer such fellowships, and not all fellows desire additional year(s) of training. TID training tracks embedded within an existing 2- or 3-year general infectious diseases (ID) fellowship training programs offer an opportunity for general ID fellows to gain more TID experience while requiring fewer programmatic resources than a standalone TID fellowship. Here we review experiences from four TID training tracks in the United States, offering insights into clinical and fellowship settings, track requirements and curricula, and facilitators and barriers to managing TID training tracks. These experiences can inform future efforts to develop TID training tracks and harmonize experiences across institutions.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70318"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunity by Design: Engineering Pathogen-Specific Protection After Transplantation.","authors":"Catherine Jacob-Dolan, Ashmitha Thomas, Gemma Reynolds","doi":"10.1111/tid.70320","DOIUrl":"https://doi.org/10.1111/tid.70320","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70320"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}