Transplant Infectious Disease最新文献_第3页

Mortality Associated With Cytomegalovirus Reactivation After Umbilical Cord Blood HCT. 脐带血HCT后巨细胞病毒再激活与死亡率相关。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-08-19 DOI: 10.1111/tid.70091

Julian Lindsay, Danniel Zamora

引用次数: 0

Epidemiology of Invasive Fungal Diseases After Solid-Organ and Hematopoietic Cell Transplantation: Insights From a Large US Cohort (2018-2022). 实体器官和造血细胞移植后侵袭性真菌疾病的流行病学：来自美国大型队列（2018-2022）的见解

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-08-17 DOI: 10.1111/tid.70095

Shuo Wang, Jiwei Yang

引用次数: 0

Adenovirus Burden in Allogeneic Hematopoietic Stem Cell Transplantation: Monitoring Versus Symptoms-Based Testing-A Cost-Effectiveness Analysis. 异基因造血干细胞移植中的腺病毒负担：监测与基于症状的检测-成本-效果分析

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-08-08 DOI: 10.1111/tid.70089

Estela Giménez, José Luis Piñana, Eliseo Albert, Ignacio Torres, Ariadna Pérez, Juan Carlos Hernández-Boluda, Carlos Solano, David Navarro

{"title":"Adenovirus Burden in Allogeneic Hematopoietic Stem Cell Transplantation: Monitoring Versus Symptoms-Based Testing-A Cost-Effectiveness Analysis.","authors":"Estela Giménez, José Luis Piñana, Eliseo Albert, Ignacio Torres, Ariadna Pérez, Juan Carlos Hernández-Boluda, Carlos Solano, David Navarro","doi":"10.1111/tid.70089","DOIUrl":"https://doi.org/10.1111/tid.70089","url":null,"abstract":"Background: Adenovirus infection (AdVi) causes significant morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients.Methods: This retrospective study of 131 patients (2020-2024) compared systematic monitoring in high-risk patients versus symptom-based testing in standard-risk patients.Results: The 1-year incidence of AdV DNAemia was 19.8%, with AdV disease at 5.3%, being higher in the routine monitoring cohort (26%) than in the symptom-based cohort (11%, p = 0.031). Neither infection nor monitoring strategy impacted outcomes. The machine learning model identified predictive factors for early AdV DNAemia: age (50-65 years), diagnosis of acute leukemia or myelodysplastic syndrome, transplant from an HLA-matched unrelated or haploidentical donor, and non-myeloablative conditioning. Cost-effectiveness analysis showed that risk-based testing was optimal (€149 per additional detected case), while universal monitoring was excessively costly (€1006 per additional detected case).Conclusion: In conclusion, although AdVi was common, routine monitoring did not improve outcomes and was financially burdensome, suggesting that a machine learning-driven risk-based testing strategy enhances cost-effectiveness while ensuring timely AdV detection and intervention.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70089"},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients with Human Immunodeficiency Virus. 人类免疫缺陷病毒受体肺移植的实践趋势和结果。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-08-08 DOI: 10.1111/tid.70090

Zeba Nauroz, Jessica M Ruck, Pali Shah, Errol Bush, William Werbel, Sarath Raju, Vagish Hemmige, Ghady Haidar, Allan B Massie, Dorry L Segev, Christine M Durand, Mary G Bowring

{"title":"Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients with Human Immunodeficiency Virus.","authors":"Zeba Nauroz, Jessica M Ruck, Pali Shah, Errol Bush, William Werbel, Sarath Raju, Vagish Hemmige, Ghady Haidar, Allan B Massie, Dorry L Segev, Christine M Durand, Mary G Bowring","doi":"10.1111/tid.70090","DOIUrl":"https://doi.org/10.1111/tid.70090","url":null,"abstract":"Background: People with human immunodeficiency virus (HIV) are at an increased risk for end-stage lung disease, for which lung transplantation (LT) may be necessary.Methods: We aimed to characterize the national practice patterns of LT in recipients with HIV (HIV R+) and post-LT outcomes, including rejection in the US over time. Using the Scientific Registry of Transplant Recipients data (from January 1, 2004, to December 1, 2024, for practice patterns and from January 1, 2016, to December 1, 2024, for outcomes), we compared 96 adult HIV R+ to 42 341 LT recipients without HIV (HIV R-). We examined the association between HIV and outcomes using Gini coefficients, Cox regression, and modified Poisson regression before and after 2020.Results: HIV R+ LTs increased from 0.1% in 2004 to 0.4% of LTs in 2024 (p = 0.07). Pre-2020, 18 centers performed 80% of HIV R+ LTs (Gini = 0.78); post-2020, 14 centers performed 80% of HIV R+ LTs (Gini = 0.76), indicating no expansion of the practice across centers. HIV R+ did not have an increased risk of mortality (adjusted hazard ratio pre-2020: 0.91 [95% confidence interval 0.41-1.62], p = 0.7 and post-2020: 1.05 [0.49-3.25], p = 0.8), or increased risk of 1-year rejection rate (adjusted relative risk pre-2020: 0.60 [0.20-1.77], p = 0.3, and post-2020: 0.77 [0.26-2.2], p = 0.6).Conclusions: Increasing numbers of HIV R+ LTs and comparable outcomes to those without HIV are encouraging, yet few centers perform these transplants.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70090"},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Nucleoside Diphosphate-Linked Moiety X-Type Motif 15 Variants With Neutropenia During Antiviral Therapy for Cytomegalovirus Disease in Pediatric Liver Transplant Recipients. 儿童肝移植受者巨细胞病毒病抗病毒治疗期间核苷二磷酸连接片段x型Motif 15变异与中性粒细胞减少的关系

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-29 DOI: 10.1111/tid.70079

Ken-Ichi Iwata, Yuka Torii, Yuto Fukuda, Kazunori Haruta, Makoto Yamaguchi, Takako Suzuki, Yasuhiro Ogura, Jun-Ichi Kawada

{"title":"Associations of Nucleoside Diphosphate-Linked Moiety X-Type Motif 15 Variants With Neutropenia During Antiviral Therapy for Cytomegalovirus Disease in Pediatric Liver Transplant Recipients.","authors":"Ken-Ichi Iwata, Yuka Torii, Yuto Fukuda, Kazunori Haruta, Makoto Yamaguchi, Takako Suzuki, Yasuhiro Ogura, Jun-Ichi Kawada","doi":"10.1111/tid.70079","DOIUrl":"https://doi.org/10.1111/tid.70079","url":null,"abstract":"Background: Cytomegalovirus (CMV) infection in pediatric liver transplant recipients is a major concern. Ganciclovir (GCV) and valganciclovir (VGCV) are the first-line treatment agents; however, neutropenia is a common adverse effect. Nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants are linked to thiopurine-induced myelosuppression; however, their associations with GCV/VGCV-induced cytotoxicity remain unclear. We aimed to examine the association between loss-of-function variants of the NUDT15 genotype and drug-related adverse reactions in pediatric transplant recipients, specifically liver transplant recipients, treated with GCV/VGCV.Methods: We retrospectively analyzed data from pediatric liver transplant recipients treated with GCV/VGCV for CMV disease or infection between 2012 and 2022. Patients were genotyped for NUDT15 R139C, R139H, and V18I variants, and hematological outcomes were compared between the normal and variant groups.Results: Of 40 patients, 10 (25%) harbored NUDT15 variants. The incidence rate of neutropenia (60% vs. 7%; p < 0.01) and percentage decrease in neutrophil count (-65.1% vs. -45.9%; p = 0.02) were significantly higher in the variant group than in the normal group. No significant differences were observed in the incidence of leukopenia, anemia, thrombocytopenia, hepatic toxicity, or renal toxicity.Conclusion: NUDT15 variants were associated with an increased risk of neutropenia in pediatric liver transplant recipients receiving GCV/VGCV treatment. Genetic screening before treatment initiation may help optimize antiviral therapy, minimize hematological toxicity, and improve patient management. Further studies are needed to refine the treatment strategies.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70079"},"PeriodicalIF":2.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Viruses at Time of Lung Transplant and the Relationship to Primary Graft Dysfunction. 肺移植时呼吸道病毒及其与原发性移植物功能障碍的关系。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-28 DOI: 10.1111/tid.70078

Laura van den Bosch, Karina Kaur, Rhea Varughese, Alim Hirji, Jason Weatherald, Justin Weinkauf, Dale Lien, Oscar Fernandez Garcia, Carlos Cervera Alvarez, Karen Doucette, Dima Kabbani, Kieran Halloran

{"title":"Respiratory Viruses at Time of Lung Transplant and the Relationship to Primary Graft Dysfunction.","authors":"Laura van den Bosch, Karina Kaur, Rhea Varughese, Alim Hirji, Jason Weatherald, Justin Weinkauf, Dale Lien, Oscar Fernandez Garcia, Carlos Cervera Alvarez, Karen Doucette, Dima Kabbani, Kieran Halloran","doi":"10.1111/tid.70078","DOIUrl":"https://doi.org/10.1111/tid.70078","url":null,"abstract":"Background: Primary graft dysfunction (PGD) is a form of immediate post-transplant acute lung injury associated with increased risk of mortality, and it is possible that respiratory viruses (RVs) at the time of transplant may augment this.Methods: We retrospectively studied all adult lung transplant recipients transplanted in our program from 2017 to 2020, with a primary outcome of grade 3 PGD (PGD3), defined as edema on chest X-ray and arterial oxygen/fraction of inspired oxygen ratio <200 at 48- or 72-h post-transplant. RV status was assessed by nucleic acid amplification test on routine bronchoscopic specimens performed on day 1 post-transplant. During the pandemic, severe acute respiratory syndrome coronavirus 2 was sampled in all donors and recipients and precluded transplant. Chi-square tests and logistic regression were used to evaluate the association between RV status and PGD3.Results: A total of 229 patients met criteria for inclusion, and 63 patients (27%) were RV+. Twenty-seven patients (12%) developed PGD3 at 48- or 72-h. RV+ was not associated with a difference in PGD3 risk adjusted for donor age, use of cardiopulmonary bypass, or body mass index >30 (odds ratio 0.93 [95% confidence interval 0.38-2.49; p = 0.8845]).Conclusions: Perioperative RVs were not associated with a difference in the risk of PGD3 in our cohort. This may have implications for donor and recipient selection and preoperative evaluation.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70078"},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonization by Vancomycin-Resistant Enterococci in Liver Transplantation: Risk Factors and Survival Impact. 万古霉素耐药肠球菌在肝移植中的定植：危险因素和生存影响。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-22 DOI: 10.1111/tid.70072

Nathalia Neves Nunes, Lohayne Alves Ferreira, Fernanda Spadão, Alice Tung Wan Song, Debora Raquel Benedita Terrabuio, Luiz Augusto Carneiro D'Albuquerque, Edson Abdala, Maristela Pinheiro Freire

{"title":"Colonization by Vancomycin-Resistant Enterococci in Liver Transplantation: Risk Factors and Survival Impact.","authors":"Nathalia Neves Nunes, Lohayne Alves Ferreira, Fernanda Spadão, Alice Tung Wan Song, Debora Raquel Benedita Terrabuio, Luiz Augusto Carneiro D'Albuquerque, Edson Abdala, Maristela Pinheiro Freire","doi":"10.1111/tid.70072","DOIUrl":"https://doi.org/10.1111/tid.70072","url":null,"abstract":"Background: Vancomycin-resistant enterococci (VRE) are multidrug-resistant microorganisms (MDRO) commonly isolated in liver transplant recipients and potentially associated with worse outcomes. We aimed to identify risk factors associated with VRE colonization in liver transplantation (LT) and its impact on posttransplant survival.Methods: This is a retrospective cohort that included all adults who underwent LT between 2010 and 2022 at a tertiary-level hospital in São Paulo, Brazil. Multivariate analyses were performed using logistic regression for VRE colonization risk and Cox regression for 180-day survival.Results: A total of 1209 patients were included, 119 patients (9.8%) were colonized with VRE at LT, while 175 (14.5%) were colonized after LT, 77 (6.4%) patients developed VRE infection after LT. In the multivariate analysis, use of SBP prophylaxis, presence of acute-on-chronic liver failure, hepatitis B virus infection, ASA score, length of hospital stay and MELD score were all associated with VRE colonization before LT. For VRE colonization after LT, the predictors were length of hospital stay before LT, MELD score, carbapenem-resistant Gram-negative colonization, intraoperative bleeding and re-transplantation. Note that 180-day mortality rate among VRE colonization and infection was, respectively, 33.6% and 50.6% compared to 17.8% of non-colonized patients, and this difference was not statistically significant after adjustment for confounders in multivariate analysis.Conclusion: VRE colonization or infection had no impact on survival in a large cohort of liver transplantrecipients.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70072"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Missed Opportunities for HPV Vaccination in Solid Organ Transplant Recipients: Insights From a High-Risk Dermatologic Cohort. 实体器官移植受者错过接种HPV疫苗的机会：来自高危皮肤病学队列的见解。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-22 DOI: 10.1111/tid.70085

Alice J Lin, Kevin T Savage, Melissa Pugliano-Mauro

引用次数: 0

Hepatitis B Virus Donor Positive to Recipient Negative (D+/R-) Heart and Lung Transplantation: Analysis From the Organ Procurement and Transplantation Network. 乙型肝炎病毒供体阳性对受体阴性（D+/R-）心肺移植：来自器官获取和移植网络的分析

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-22 DOI: 10.1111/tid.70054

Sara Belga, Robert C Wright, Stephen B Lee, Christine M Durand, Karen Doucette

{"title":"Hepatitis B Virus Donor Positive to Recipient Negative (D+/R-) Heart and Lung Transplantation: Analysis From the Organ Procurement and Transplantation Network.","authors":"Sara Belga, Robert C Wright, Stephen B Lee, Christine M Durand, Karen Doucette","doi":"10.1111/tid.70054","DOIUrl":"https://doi.org/10.1111/tid.70054","url":null,"abstract":"Introduction: In nonendemic areas, transplantation from donors with hepatitis B virus (HBV) to recipients without HBV (D+/R-) has been proposed to expand the donor pool; however, data are limited. We aimed to evaluate the epidemiology of HBV in thoracic organ donors, assess HBV-related thoracic organ nonuse, and determine the impact of HBV D+/R- in recipient outcomes.Methods: Adult first-time heart and lung transplant recipients with negative hepatitis B surface antigen (HBsAg) and HBV nucleic acid testing (NAT) were identified through the Organ Procurement and Transplantation Network between January 2004 and December 2022. Multivariable Cox regression models were built to assess the relationship of donor HBV status with death and graft failure.Results: Our final cohort included 64,514 thoracic organ transplant recipients, 53 HBV D+/R- (0.1%) versus 64,461 (99.9%) HBV D-/R-, including 34,547 (53.5%) heart and 29,967 lung (46.5%) transplants. Donors with positive HBsAg or HBV NAT tests represented 0.31% of the donor pool. There were no reported cases of thoracic organ nonuse due to hepatitis, nor were there differences in the rates of HBV-NAT or HBsAg positivity in used versus nonused thoracic organs. In multivariable modeling, HBV D+/R- was not associated with increased hazard of death (adjusted hazard ratio (aHR), 0.80 [95% CI, 0.30-2.13], p = 0.652) or graft failure (aHR, 0.73 [95% CI, 0.27-1.93], p = 0.522) at 1-year.Conclusions: HBV D+/R- thoracic organ transplantation does not appear to have a deleterious impact on recipient or graft survival. However, more data are needed to determine the long-term risk of donor-derived HBV infection and define the optimal management strategies.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70054"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Repeated Non-Fatal Infections on Quality of Life and Graft Function in ABO-Incompatible Kidney Transplants. 反复非致死性感染对abo血型不相容肾移植患者生活质量和移植物功能的影响。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-07-22 DOI: 10.1111/tid.70084

Federica Bocchi, Isabelle Binet, Dela Golshayan, Fadi Haidar, Cédric Hirzel, Thomas Müller, Thomas Schachtner, Daniel Sidler

{"title":"Impact of Repeated Non-Fatal Infections on Quality of Life and Graft Function in ABO-Incompatible Kidney Transplants.","authors":"Federica Bocchi, Isabelle Binet, Dela Golshayan, Fadi Haidar, Cédric Hirzel, Thomas Müller, Thomas Schachtner, Daniel Sidler","doi":"10.1111/tid.70084","DOIUrl":"https://doi.org/10.1111/tid.70084","url":null,"abstract":"Background: Kidney transplantation (KT) is the preferred treatment for kidney failure, with living donor KT (LDKT) offering better outcomes and improved quality of life (QOL) than deceased donor KT. ABO incompatibility (ABOi) once restricted LDKT, but desensitization protocols now enable ABOi LDKT, expanding the donor pool with favorable outcomes. However, added risks of ABOi remain debated. We examined the impact of repeated infections on graft loss and death in both ABO-compatible (ABOc) and ABOi LDKT recipients.Methods: Retrospective, nationwide Swiss Transplant Cohort Study from May 2008 to December 2022, including all ABOi LDKT patients. Clinically relevant infections (viral, bacterial, fungal, and parasitic) were analyzed as repeated adverse events.Results: Among 227 ABOi LDKT and 1172 ABOc recipients, 13% (183/1399) had ≥ 2 significant infections within the first 6 months. ABOi was independently associated to a higher infection risk (HR 1.21, 95% CI 1.10-1.34, p < 0.001). Patients with early recurrent infections were older, often female, and had ABOi LDKT. Patients with ≥ 2 infections faced increased risks of graft loss, lower eGFR, and reduced QOL.Conclusion: ABOi LDKT patients face a higher risk of recurrent infections, especially within 6 months post-KT, associated with reduced allograft function and lower QOL.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70084"},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0