Translational Psychiatry最新文献

{"title":"Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula.","authors":"Simon Knobloch, Theresa Jansen, Lara Caroline Hille, Madeleine Müller, Leonie Rumpf, Christian Francis Lewis Bauer, Jan Haaker","doi":"10.1038/s41398-026-04492-7","DOIUrl":"10.1038/s41398-026-04492-7","url":null,"abstract":"<p><p>By observing others' experiences, humans learn about threats while avoiding firsthand dangers. Yet, previous neuroscience research has focused on observational threats that are predictable. In firsthand learning, temporally predictable and unpredictable threats can be mechanistically discerned. In this study, we developed a novel observational paradigm in which participants learned from predictable and unpredictable observational threats, as well as a no-threat condition. Participants encountered the same conditions during an expression phase to investigate how the brain encodes predictive and unpredictive threat cues observed in others. Participants in Experiment 1 (n = 20, 14 female, 6 male) and Experiment 2 (n = 23, 9 female, 1 non-binary, 13 male) successfully learned threat contingencies, showing heightened threat expectations for predictive cues and unpredictable condition-onsets. Behavioral findings converged with neural (fMRI, Experiment 2) responses in the anterior insula during the expression phase. Reflecting the dynamic process of learning, amygdala activation in response to predictive threat cues displayed a linear decrease across trials. Interestingly, BOLD responses to others' pain that was predictable, were enhanced within the amygdala, insula and hippocampus, compared to unpredictable conditions. Our findings suggest that humans can learn to resolve temporal threat uncertainty, through the observation of others. The present work thereby contributes to understanding the social aspects of fear and anxiety disorders.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute effects of ketamine on neural correlates of reward processing.","authors":"Elisa Briem, Peter Stöhrmann, Gregor Dörl, Christian Milz, Gabriel Schlosser, Manfred Klöbl, Murray Reed, Matthieu Atger, Clemens Schmidt, Samantha Graf, Maximilian Kathofer, Godber Mathis Godbersen, Julia Sophia Crone, Rupert Lanzenberger, Marie Spies","doi":"10.1038/s41398-026-04485-6","DOIUrl":"10.1038/s41398-026-04485-6","url":null,"abstract":"<p><p>Ketamine induces a sequence of temporally distinct effects on brain function, yet its impact on reward processing beyond the acute post-administration phase remains unclear. In this single-blind, placebo-controlled, crossover study, 28 healthy participants received 0.5 mg/kg racemic ketamine or placebo via a 40 min intravenous infusion. Functional magnetic resonance imaging was acquired approximately 5 h post-infusion during the Monetary Incentive Delay (MID) task, targeting the subacute phase after resolution of acute dissociative effects. Plasma concentrations of ketamine and norketamine were obtained for pharmacokinetic modeling and area under the curve estimation. At 5 h post-administration, ketamine did not significantly modulate brain activation during the MID task in either ROI-based or whole-brain analyses, despite measurable subjective drug effects. Pharmacokinetic modeling yielded ketamine and norketamine concentration-time profiles consistent with expected pharmacokinetic patterns, however, neither individual drug exposure nor psychometric measures showed robust associations with MID task-related neural activation. These findings suggest an absence of detectable task-evoked effects under the present methodological conditions. When considered alongside prior work, they are consistent with the possibility that ketamine's effects on reward circuitry are time-sensitive and may be more prominent during the acute post-administration phase or in clinical populations with pre-existing reward dysfunction.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific structural connectomic differences of deep brain stimulation targets in treatment-resistant obsessive-compulsive disorder patients.","authors":"Rene Marquez-Franco, Luis Ruelas, Ricardo Loução, Rabea Schmahl, Fátima Ximena Cid Rodríguez, Petra Heiden, Jens Kuhn, Anne Koy, Veerle Visser-Vandewalle, Pablo Andrade","doi":"10.1038/s41398-026-04441-4","DOIUrl":"10.1038/s41398-026-04441-4","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) is an established therapy for treatment-resistant obsessive-compulsive disorder (trOCD), yet clinical outcomes vary. This is partly due to differential cortico-striato-thalamo-cortical networks (CSTC) engagement across stimulation in relevant anatomical regions. This study compared the structural and functional connectivity profiles of three relevant anatomical-regions that have also served as target for DBS in different centers for trOCD: the nucleus accumbens/anterior-limb of the internal-capsule (NAc/ALIC), the medial forebrain bundle (MFB), and the anteromedial subthalamic nucleus (amSTN). We analysed in a retrospective, observational, single-center cohort the structural connectivity on patient-specific space, using structural and diffusion MRI data from 22 trOCD patients treated with NAc/ALIC DBS at the University Hospital Cologne. For this end, Whole-brain probabilistic-tractography using single-shell-three-tissue constrained-spherical-deconvolution was applied to reconstruct patient-specific structural connectivity matrices. From whole-brain tractograms, target-specific streamline subsets were selected using ROI-based inclusion criteria using 2 mm radius spheric stereotactic ROIs representing clinically relevant trOCD-DBS target regions. Afterwards, Structural connectivity matrices were extracted using Spherical-deconvolution informed filtering of tractograms (SIFT) streamline count, fractional anisotropy (FA), and mean diffusivity (MD) across 13 cortico-subcortical regions implicated in OCD pathophysiology. Thereafter, we characterized each target's connectivity to key OCD functional networks derived from meta-analytic functional connectivity maps. NAc/ALIC demonstrated stronger structural fronto-limbic connectivity: medial-orbitofrontal cortex, anterior-cingulate, insula, and accumbens (p < 0.0001), associated with the affect (AN), salience (SN), default-mode (DMN), and reward-motivation (RMN) networks anatomical hubs. The MFB predominantly connected with reward-related regions: pallidum and rostral-middle-frontal cortex (p < 0.0001). The amSTN showed to be mainly connected to SN and the cognitive/motor control network (CMCN): precentral and paracentral gyri (p < 0.0001). These exploratory findings suggest that clinically relevant trOCD-DBS targets may engage distinct but partially overlapping tractography derived structural networks and meta-analytic functional networks. The observed connectivity profiles may help generate hypotheses about symptom-specific networks for future DBS planning. Overall, these results support the proof-of-concept value of patient-specific probabilistic tractography in trOCD. However, prospective validation in independent, multicentric trials remains necessary before clinical translation.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing the motivation for mental work with temporal interference stimulation.","authors":"Gizem Vural, Sarina Drexler, Daniel Keeser, Alexander Soutschek","doi":"10.1038/s41398-026-04449-w","DOIUrl":"10.1038/s41398-026-04449-w","url":null,"abstract":"<p><p>Successful goal-directed behavior often requires the exertion of effortful control processes. The striatum is thought to play a key role in determining whether a goal is worth the required cognitive effort, but whether and how the striatum causally influences effort-based decisions in humans remains unclear. Here, we address this gap by employing transcranial temporal interference stimulation (tTIS), a novel non-invasive brain stimulation technique capable of targeting deeper brain regions. In particular, we applied striatum-targeted tTIS to healthy participants performing an effort-based decision task during functional MRI scanning. Supporting the idea that the striatum encodes both the benefits and costs of actions, we found that, on the behavioral level, striatum-targeted tTIS increased the sensitivity to both reward magnitudes and effort costs. At the neural level, this was mirrored by stronger representations of effort demands in the striatum under stimulation as well as by enhanced functional coupling between the striatum and the anterior cingulate cortex, a region at the intersection of motivation and cognition. Together, our findings provide insights into how striatum-targeted stimulation influences trade-offs between rewards and effort costs, informing neural accounts of motivated cognition and suggesting novel neural interventions for the treatment of amotivation.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: a systematic review and meta-analysis.","authors":"Teya Petrova, Andreas Øy Tennfjord, Daniela Cavero, Aisling Holohan, Melissa Kizilkaya, Ava Ebrahimian-Roodbari, Inès Lepreux, Marie Reimer, Lucia Sideli, Romayne Gadelrab, Giulia Trotta, Victoria Rodriguez, Ole A Andreassen, Paul Klauser, Luis Alameda, Monica Aas","doi":"10.1038/s41398-026-04457-w","DOIUrl":"10.1038/s41398-026-04457-w","url":null,"abstract":"<p><strong>Background: </strong>Brain abnormalities related to childhood adversity (CA) have been reported across clinical presentations in psychotic disorder (PD) and bipolar disorder (BD). This systematic review and meta-analysis examined gray matter volume (GMV) alterations linked to CA in PD and BD.</p><p><strong>Methods: </strong>A PRISMA-compliant systematic review was conducted (PROSPERO ID: CRD42022351133). The EMBASE, MEDLINE, and PsycINFO databases were searched from inception to June 2024 for studies investigating CA and structural brain imaging in PD and BD. Study quality was assessed with the Newcastle Ottawa Scale (NOS). Data were extracted and synthesized accounting for sex differences and CA subtypes with brain findings categorized by the presence and direction of associations. Meta-analyses were performed for hippocampal and amygdala volumes.</p><p><strong>Results: </strong>In the systematic review (k = 29), 3056 participants with PD and BD (mean age = 36.6 ± 16.1; 47% female), published between 2011 and 2023, were included. Study quality was fair, with high heterogeneity. Most studies reported significant negative associations between CA and GMV, especially in prefrontal regions, while findings for the hippocampus and amygdala were largely null or inconsistent. Meta-analyses of a study subset identified no significant association between CA and hemisphere-specific and combined volumes of the hippocampus (k = 5; p ≥ 0.66) or amygdala (k = 4; p ≥ 0.87).</p><p><strong>Conclusion: </strong>CA was not consistently associated with hippocampal or amygdala volume alterations in PD and BD. More consistent evidence emerged for reduced GMV in prefrontal regions, suggesting that neurobiological impact of CA may be more robustly captured at the cortical level.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cracks in the foundation: disrupted epistemic trust as a link between trauma, PTSD and disturbances in self-organization.","authors":"Eileen Lashani, Peter Fonagy, David Riedl, Hanna Kampling, Johannes Kruse, Astrid Lampe, Veronika Engert, P Read Montague, Elmar Brähler, Jörg M Fegert, Cedric Sachser, Tobias Nolte","doi":"10.1038/s41398-026-04442-3","DOIUrl":"10.1038/s41398-026-04442-3","url":null,"abstract":"<p><p>Traumatic experiences profoundly impact mental and physical health, alongside an individual's trust in their social environment. Disruptions in epistemic trust - the capacity to evaluate and trust socially communicated information - are theorized to increase vulnerability to psychopathology by impairing social learning. This cross-sectional study investigated associations between trauma characteristics and epistemic stance using self-report data from a representative German sample (N = 2 519). We examined relationships among trauma type, age at trauma, epistemic stance, PTSD and cPTSD. Neither trauma type nor timing alone predicted epistemic stance. However, their interaction revealed that early relational trauma demonstrated the strongest association with epistemic disruption. Within epistemic stance, heightened credulity mediated associations between trauma and both PTSD and cPTSD symptoms. These findings align with the hypothesis that the association between trauma exposure and epistemic stance depends on trauma type and timing, with early relational trauma showing the strongest links to epistemic disruption and related psychopathology. This differentiated perspective on trauma characteristics highlights epistemic stance as a potential mechanism that may advance developmental models of psychopathology and future clinical research.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What can case-control comparisons of neural drug cue reactivity tell us about addiction? A neuroimaging meta-analysis.","authors":"Maximilian Fascher, Krzysztof Krasowski, Markus Muehlhan","doi":"10.1038/s41398-026-04458-9","DOIUrl":"https://doi.org/10.1038/s41398-026-04458-9","url":null,"abstract":"<p><p>Neural drug cue reactivity (DCR) is a central paradigm in addiction neuroscience for probing how drug cues acquire excessive motivational salience in substance use disorders (SUDs). However, the field faces challenges in clinical translation, replicability, and within-group designs are susceptible to visual confounding due to stimulus matching. A complementary approach is to examine case-control contrasts to identify SUD-specific neural architecture while mitigating effects of task-design variability. We conducted a systematic literature search and an activation likelihood estimation (ALE) meta-analysis to identify convergence effects in the contrast drug > control cues between SUD and control groups. ALE results were supplemented by assessing behavioural domains, meta-analytic connectivity profiles, robustness to publication bias, and study-level modulators using penalised logistic regression. The ALE analysis revealed one reliable convergence cluster in the ventral anterior cingulate cortex (vACC), associated with reward, reasoning, and social cognition. Penalised logistic regression indicated that contributions to this cluster were less likely in alcohol DCR-studies and were sensitive to matching conditions for human content. vACC DCR effects contrasted with neutral control cues were invariant across abstinence periods, whereas vACC DCR contrasted with natural reward cues declined with longer abstinence. This meta-analysis replicates context-sensitive SUD-specific DCR convergence in vACC regions intersecting reward pathways and the default-mode network, while reliable striatal convergence was not observed. The review recapitulates these results by discussing current challenges in balancing personalisation and standardisation, the use of motivationally inert versus salient comparators, and argues for careful deliberation when inferring evidence for hyperreactive reward responses.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-analytical considerations in the interpretation of plasma SCFA profiles.","authors":"Boushra Dalile, Kristin Verbeke","doi":"10.1038/s41398-026-04470-z","DOIUrl":"10.1038/s41398-026-04470-z","url":null,"abstract":"","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective interoception impairments and treatment effects in borderline personality disorder.","authors":"Jella Voelter, Danilo Postin, Christina Müller, Mandy Roheger, André Schulz, Robin Bekrater-Bodmann, René Hurlemann, Dirk Scheele","doi":"10.1038/s41398-026-04414-7","DOIUrl":"10.1038/s41398-026-04414-7","url":null,"abstract":"<p><p>Patients with borderline personality disorder (BPD) suffer from severe emotional dysregulation and disturbances in body image and self-perception. Interoception, the processing and perception of internal body signals, is closely linked to emotional processing, but it remains unclear whether BPD impairs specific interoceptive facets and how these deficits respond to treatment. We investigated two key interoceptive facets, accuracy and attention, in BPD patients and healthy controls (HC) using self-report and objective measures before (n_BPD=55,n_HC = 31) and after (n_BPD=37,n_HC = 31) four-week residential Dialectical Behavior Therapy (DBT)/a waiting interval. Interoceptive accuracy and its metacognitive awareness were evaluated using a heartbeat discrimination task, while interoceptive attention was measured through questionnaires, intensity ratings, and uni- and multivariate neural responses during a functional magnetic resonance imaging (fMRI) interoceptive attention task. Before DBT, BPD patients showed reduced self-reported interoceptive attention, which was associated with more interpersonal problems. Patients further exhibited higher similarity in activity patterns evoked by cardiac interoceptive and exteroceptive attention in the insular and dorsal anterior cingulate cortex. There were no significant group differences in behavioral or self-reported interoceptive accuracy or metacognitive awareness. However, behavioral interoceptive accuracy was impaired in BPD patients with more severe symptoms. After four-week residential DBT, self-reported interoceptive attention significantly improved, while other interoceptive facets showed no significant changes. Our findings indicate that BPD involves selective interoceptive attention disturbances, with only self-reported measures responding to treatment. These results support multifaceted assessments of interoception and the potential benefit of interoceptive attention training for all BPD patients, with additional accuracy training in more severe cases.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social disconnection integrates genetic and proteomic risks in suicidal ideation and depression.","authors":"Sihong Li, Zhongting Huang, Hui Chen, Xianliang Chen, Huajia Tang, Yanyue Ye, Jijun Zhu, Shenghan Wang, Pan Li, Shunjie Zhang, Haowen Zhuang, Weixin Liu, Fuqiang Cai, Zhijian Song, Yuxin Liu, Jiansong Zhou, Junfang Chen","doi":"10.1038/s41398-026-04276-z","DOIUrl":"10.1038/s41398-026-04276-z","url":null,"abstract":"<p><p>Suicidal ideation (SI) and major depressive disorder (MDD) are complex psychiatric conditions arising from the interplay of genetic liability, molecular processes, and psychosocial factors. While these dimensions have been extensively studied in isolation, their joint contribution to SI and MDD remains unclear. This study integrates multi-modal data to elucidate these synergistic effects and develop robust models for individual-level risk stratification. Leveraging longitudinal multi-modal data from 13,085 UK Biobank participants, we integrated genomic, proteomic, and social connection profiles. We developed interpretable risk scores using a rigorous supervised machine learning framework encompassing diverse linear and ensemble classifiers. Permutation importance was employed to quantify feature contributions and derive transparent, weighted risk metrics across diverse classifiers. These scores were validated through association, interaction, and mediation analyses. Social connection-based risk scores significantly differentiated cases and controls across the two suicidal ideation phenotypes at 2017 and 2023 with cross-sectional analyses (AUCs: 0.70 - 0.73), outperforming proteomic-only models. Functional dimensions of social connection emerged as the most informative predictors. Longitudinal analyses revealed that social risk scores at baseline predicted suicidal ideation onset six years later, independent of demographic covariates. Interaction analyses demonstrated that polygenic risk for suicide attempt significantly interacted with both social and proteomic risk features in relation to depression. Structural equation models further confirmed that social disconnection acts as a key mediator linking genetic predisposition to MDD and SI. Social disconnection is a critical risk factor mediating the impact of genetic vulnerability on psychiatric outcomes. Integrating social, genetic, and molecular data supports a multilevel framework for risk stratification and highlights the potential of socially oriented interventions to mitigate biological risk.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}