Translational Psychiatry最新文献_第3页

Resting-state brain age is associated with cognitive and sensorimotor abnormalities in schizophrenia spectrum disorders: a validation & longitudinal study. 静息状态脑年龄与精神分裂症谱系障碍的认知和感觉运动异常有关：一项验证和纵向研究。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-04 DOI: 10.1038/s41398-026-04426-3

Sebastian Volkmer, Stefan Fritze, Dilsa Cemre Akkoc Altinok, Geva Brandt, Ersoy Kocak, Julius Wiegert, Oksana Berhe, Yuchen Lin, Heike Tost, Andreas Meyer-Lindenberg, Dusan Hirjak, Emanuel Schwarz

{"title":"Resting-state brain age is associated with cognitive and sensorimotor abnormalities in schizophrenia spectrum disorders: a validation & longitudinal study.","authors":"Sebastian Volkmer, Stefan Fritze, Dilsa Cemre Akkoc Altinok, Geva Brandt, Ersoy Kocak, Julius Wiegert, Oksana Berhe, Yuchen Lin, Heike Tost, Andreas Meyer-Lindenberg, Dusan Hirjak, Emanuel Schwarz","doi":"10.1038/s41398-026-04426-3","DOIUrl":"10.1038/s41398-026-04426-3","url":null,"abstract":"Brain-age models use neuroimaging features to predict chronological age. The resulting brain-age gap (BAG), defined as predicted brain age minus chronological age, quantifies deviations from age-expected brain characteristics. Structural brain-age acceleration is well established in schizophrenia spectrum disorders (SSD), but the utility of resting-state functional connectivity (rs-FC)-based brain age remains unclear. Here, we trained rs-FC brain-age models on aggregated lifespan data from healthy controls (n ≈ 2200) and evaluated them in four independent SSD case-control cohorts. Across independent cohorts and two brain atlases, SSD showed higher FC-based BAG than healthy controls (β ≈ 0.4-0.6), indicating modest functional brain-age elevation at the group level. However, within SSD, more negative (younger appearing) BAG was associated with poorer cognitive performance, longer duration of illness, and higher neurological soft signs (NSS). Over 12-24 weeks, increases in BAG were associated with reductions in NSS motor coordination and hard signs. Together, these findings suggest that rs-FC brain age captures both a small case-control shift and a clinically relevant dimension within SSD that is not well described by uniform \"acceleration\". FC-based BAG may therefore reflect heterogeneity in network-level development and reorganization, with younger-appearing functional profiles potentially indexing greater neurodevelopmental burden.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in endocannabinoids and clinical course of adolescent non-suicidal self-injury. 青少年非自杀性自伤患者内源性大麻素的纵向变化与临床过程。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-03 DOI: 10.1038/s41398-026-04391-x

Marc D Ferger, Susanne Brodesser, Michael Kaess, Julian Koenig

{"title":"Longitudinal changes in endocannabinoids and clinical course of adolescent non-suicidal self-injury.","authors":"Marc D Ferger, Susanne Brodesser, Michael Kaess, Julian Koenig","doi":"10.1038/s41398-026-04391-x","DOIUrl":"10.1038/s41398-026-04391-x","url":null,"abstract":"Non-suicidal self-injury (NSSI) in adolescents has previously been linked to alterations in the endocannabinoid system. While increasing evidence supports endocannabinoid levels as potential biomarker in psychiatric care, little is known about their longitudinal trajectories over the course of treatment or in predicting clinical symptoms. This is the first study to investigate endocannabinoids in a longitudinal cohort of patients with NSSI, exploring associations with the development of symptoms over time. Plasma endocannabinoids and NSSI, using the German version of the Self-Injurious Thoughts and Behaviors Interview (SITBI-G), were assessed in n = 47 female adolescents with NSSI at both baseline and after one year of treatment (follow-up). Associations between endocannabinoid levels and clinical symptoms over time were analyzed. Anandamide (AEA) significantly decreased from baseline to follow-up while 2-arachidonoylglycerol (2-AG) increased after one year. While lower AEA levels have previously been reported in adolescents with NSSI, this longitudinal study found that AEA decreased over one year despite an overall improvement in NSSI symptoms. The overall pattern suggests that changes in circulating endocannabinoids do not closely correspond to symptom improvement. These findings indicate that circulating endocannabinoid levels change over time in adolescents with NSSI, but their complex and partly inconsistent associations with clinical symptoms limit their clinical utility as biomarkers.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder. 评估强迫症患者丘脑下刺激对后感觉的影响。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-03 DOI: 10.1038/s41398-026-04423-6

Audrey Kist, Michael Pereira, Ramla Msheik, Dorian Goueytes, Arnaud Pouchon, Stephan Chabardès, Julien Bastin, Mircea Polosan, Nathan Faivre

{"title":"Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder.","authors":"Audrey Kist, Michael Pereira, Ramla Msheik, Dorian Goueytes, Arnaud Pouchon, Stephan Chabardès, Julien Bastin, Mircea Polosan, Nathan Faivre","doi":"10.1038/s41398-026-04423-6","DOIUrl":"10.1038/s41398-026-04423-6","url":null,"abstract":"Most human studies on perceptual decision-making are correlational, and few addressed the causal role of the neural markers they identify. Here, we took the opportunity offered by deep brain stimulation to study the causal role of subthalamo-cortical networks on perceptual decision-making and perceptual monitoring. We asked participants with obsessive-compulsive disorder (OCD) treated with subthalamic stimulation to detect visual stimuli and provide confidence reports while we recorded scalp electroencephalography. Following a preregistered plan, we compared behavioural and neural results between patients off-stimulation and matched healthy controls and among patients on and off-stimulation to identify the effect of subthalamic stimulation on perceptual choices and metacognitive judgments. Our results indicate that patients off-stimulation detected visual stimuli similarly to matched healthy controls but provided poorer confidence judgments, indicative of a potential metacognitive alteration. Moreover, chronic subthalamic stimulation significantly reduced clinical symptoms, but acute stimulation changes did not impact visual detection, confidence, nor corresponding event-related potentials at the scalp level. We conclude that acute changes in subthalamic stimulation are insufficient to modify the potential metacognitive alterations observed in OCD.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder. 甲基苯丙胺使用障碍个体渴望变化的纵向脑动力学和预测。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-02 DOI: 10.1038/s41398-026-04401-y

Qing Song, Wenhan Yang, Zhe Du, Dongcheng Wang, Xinwen Wen, Jun Liu, Kai Yuan

{"title":"Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder.","authors":"Qing Song, Wenhan Yang, Zhe Du, Dongcheng Wang, Xinwen Wen, Jun Liu, Kai Yuan","doi":"10.1038/s41398-026-04401-y","DOIUrl":"10.1038/s41398-026-04401-y","url":null,"abstract":"Individuals with methamphetamine use disorder (MUD) exhibited functional and structural brain recovery during abstinence. However, longitudinal neural changes of large-scale brain networks after prolonged abstinence remain unclear. Here, energy landscape analysis was applied to resting-state fMRI to characterize dominant activity patterns in 41 healthy controls and 40 individuals with MUD at baseline and after prolonged abstinence. We compared the dynamic characteristics of these patterns across groups and stages. Support vector regression model was constructed using baseline dynamic indices to predict craving changes after prolonged abstinence. We found that individuals with MUD exhibited rigid brain dynamics, which were correlated with abnormal brain network coordination and behaviors. Following prolonged abstinence, neural flexibility showed partial improvement, and dynamic indices could predict longitudinal craving changes. We revealed atypical brain network dynamics and their partial recovery during prolonged abstinence in MUD and suggested that dynamic indices could serve as biomarkers for predicting craving changes.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health behaviours and telomere biology in severe mental disorders. 严重精神障碍的健康行为和端粒生物学。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-02 DOI: 10.1038/s41398-026-04362-2

Vid Mlakar, Marta Di Forti, Els F Halff, Deepak P Srivastava, Ibrahim Akkouh, Srdjan Djurovic, Carmen Martin-Ruiz, Daniel S Quintana, Viktoria Birkenæs, Nils Eiel Steen, Monica B E G Ormerod, Ole A Andreassen, Monica Aas

{"title":"Health behaviours and telomere biology in severe mental disorders.","authors":"Vid Mlakar, Marta Di Forti, Els F Halff, Deepak P Srivastava, Ibrahim Akkouh, Srdjan Djurovic, Carmen Martin-Ruiz, Daniel S Quintana, Viktoria Birkenæs, Nils Eiel Steen, Monica B E G Ormerod, Ole A Andreassen, Monica Aas","doi":"10.1038/s41398-026-04362-2","DOIUrl":"10.1038/s41398-026-04362-2","url":null,"abstract":"Alterations in telomere length (TL), a marker of cellular ageing, have been reported in individuals with severe mental disorders (SMD). Epidemiological studies of the general population have highlighted that unhealthy lifestyles may exacerbate telomere attrition. However, the impact of lifestyle on TL within the context of SMD remains unexplored. The study consisted of 410 participants (schizophrenia spectrum [n = 225] and affective disorder [n = 185]) collected as part of the Norwegian Thematically Organised Psychosis (TOP) study. Leukocyte TL was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR). Patients provided self-report data on six lifestyle domains including: diet, exercise, smoking, alcohol consumption, substance use, and coffee consumption. A global dichotomised (healthy vs unhealthy) lifestyle variable was created, as well as a health behaviour variable, indicating the level of unhealthy behaviours. Individuals with an unhealthy lifestyle had shorter TL compared to those with a healthy lifestyle (Cohen's d = 0.58, F = 8.62, p = 0.004). A relationship was observed between increasing number of unhealthy behaviours and shorter TL (F = 2.69, p = 0.02), adjusted for age, sex, ethnicity, trauma exposure, medication daily defined dose (DDD), years of education and diagnosis. In terms of base-pair loss, individuals with healthy lifestyles exhibited a roughly 6-year lower biological age, compared to individuals with unhealthy lifestyles. Our study indicates that a healthier lifestyle is associated with longer TL in SMD. This highlights the importance of health behaviours as potential clinical targets for ensuring healthier cellular ageing in psychiatric populations.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic stress leading gut microbiota dysbiosis and neuroinflammation promoted depressive disorder. 慢性应激导致肠道菌群失调和神经炎症促进抑郁症。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-09-01 DOI: 10.1038/s41398-026-04421-8

Xinhua Shen, Xiaofeng Jiang

{"title":"Chronic stress leading gut microbiota dysbiosis and neuroinflammation promoted depressive disorder.","authors":"Xinhua Shen, Xiaofeng Jiang","doi":"10.1038/s41398-026-04421-8","DOIUrl":"10.1038/s41398-026-04421-8","url":null,"abstract":"Chronic stress was known to contribute to gut microbiota dysbiosis and central neuroinflammation, yet the underlying mechanisms remain poorly understood. In this study, forty-eight male C57BL/6 mice were randomly assigned to three groups: control, chronic unpredictable mild stress (CUMS), and CUMS with probiotic intervention. Mice in the CUMS group were exposed to four weeks of unpredictable stressors, while those in the probiotic group received oral administration of Bifidobacterium triple viable capsules during the stress period. Behavioral assessments revealed pronounced depression-like behaviors in CUMS mice, which were significantly ameliorated by probiotic treatment. 16S rRNA sequencing demonstrated that CUMS reduced gut microbial α-diversity, altered β-diversity, elevated the Firmicutes/Bacteroidetes ratio, and decreased beneficial genera such as Bifidobacterium and Lactobacillus, while increasing the abundance of Escherichia. Probiotic supplementation effectively restored these microbial alterations to near-control levels. Intestinal barrier function was compromised in CUMS mice, as indicated by reduced proteins ZO-1 and Occludin, which partially reversed by probiotic treatment. In the hippocampus and prefrontal cortex, CUMS increased the levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), and upregulated microglial activation markers (Iba-1, iNOS, and COX-2) in the hippocampus. Probiotic intervention markedly suppressed these neuroinflammatory responses. Moreover, hippocampal CA1 neurons in CUMS mice exhibited structural disorganization, neuronal loss, and nuclear pyknosis, all of which were alleviated by probiotic administration. Collectively, these findings suggest that chronic stress disrupts the gut microbiota-gut-brain axis via microbial dysbiosis and intestinal barrier impairment, thereby promoting neuroinflammation and behavioral abnormalities.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder. 强迫症多基因风险评分的跨祖先和跨障碍可转移性。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-08-31 DOI: 10.1038/s41398-026-04395-7

Chun Il Park, Jaeyoung Kim, Woojae Myung, Sang-Hyuk Jung, Beomsu Kim, Sanghyeon Park, Jee In Kang, Hong-Hee Won, Se Joo Kim

{"title":"Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder.","authors":"Chun Il Park, Jaeyoung Kim, Woojae Myung, Sang-Hyuk Jung, Beomsu Kim, Sanghyeon Park, Jee In Kang, Hong-Hee Won, Se Joo Kim","doi":"10.1038/s41398-026-04395-7","DOIUrl":"10.1038/s41398-026-04395-7","url":null,"abstract":"Most genome-wide association studies (GWASs) of obsessive-compulsive disorder (OCD) have been conducted in European populations, limiting the understanding of OCD genetics across populations. Here, we investigated the cross-ancestry and cross-disorder transferability of European-derived polygenic risk scores (PRSs) for OCD in the first East Asian OCD cohort. We performed a GWAS in 532 Korean OCD cases and 4376 controls, followed by PRS analyses using European GWASs for OCD and 10 psychiatric disorders. The European-derived OCD PRS was significantly associated with Korean OCD status (best-fit R² = 1.17%). In multivariable models, PRSs for OCD (odds ratio [OR] = 1.28, 95% confidence interval [CI] = 1.13-1.45), schizophrenia (SCZ; OR = 1.17, 95% CI = 1.03-1.32), and anorexia nervosa (AN; OR = 1.17, 95% CI = 1.03-1.32) were independently associated with OCD. A stepwise multi-PRS model including PRSs for OCD, AN, SCZ, post-traumatic stress disorder, anxiety disorder, attention deficit hyperactivity disorder, and bipolar disorder (BD) yielded the highest predictive performance (incremental R² = 2.99%). Where available, we evaluated PRSs derived from East Asian, European, and combined populations. For BD and SCZ, PRSs derived from cross-ancestry meta-analysis GWASs showed the greatest predictive performance for OCD, outperforming single-ancestry PRSs (incremental R² = 2.84 and 1.28%, respectively). Our findings demonstrate cross-ancestry transferability of OCD polygenic risk and highlight substantial genetic overlap between OCD and other psychiatric disorders, particularly SCZ and AN. Together, they underscore the importance of including diverse ancestral populations in psychiatric genetics and suggest that transdiagnostic polygenic frameworks may provide deeper insight into the biological basis of OCD.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical dynamics in Angelman syndrome: novel insights from a preclinical mouse model. 天使综合征的皮质动力学：来自临床前小鼠模型的新见解。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-08-29 DOI: 10.1038/s41398-026-04254-5

Manuel Scorrano, Elena Montagni, Abenezer Tarekegne Legesse, Ludovica Iovino, Chiara De Cesari, Ilaria Tonazzini, Anna Letizia Allegra Mascaro, Laura Baroncelli

{"title":"Cortical dynamics in Angelman syndrome: novel insights from a preclinical mouse model.","authors":"Manuel Scorrano, Elena Montagni, Abenezer Tarekegne Legesse, Ludovica Iovino, Chiara De Cesari, Ilaria Tonazzini, Anna Letizia Allegra Mascaro, Laura Baroncelli","doi":"10.1038/s41398-026-04254-5","DOIUrl":"https://doi.org/10.1038/s41398-026-04254-5","url":null,"abstract":"Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of function in the maternally inherited UBE3A gene, leading to a spectrum of symptoms that include developmental delays, intellectual disability, and motor impairments. While genetic and molecular mechanisms of AS are increasingly well characterized, a critical gap remains in understanding how disruptions in neuronal connectivity at the circuit level contribute to its pathophysiology. Here, we aimed to address this gap by investigating cortical connectivity alterations in a mouse model of AS. Using wide-field calcium imaging, we monitored real-time neuronal activity across the entire dorsal cortex in awake animals. Our results revealed widespread cortical hyperconnectivity in AS mice compared to wild-type controls, particularly in regions involved in motor and sensory processing. Notably, this pattern of aberrant connectivity persisted across two distinct time points in adulthood, suggesting a stable and enduring network dysfunction. These findings indicate that the absence of UBE3A function drives persistent disruptions of functional connectivity, which may underlie key clinical manifestations of AS.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149273574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring serum biomarkers in paediatric psychiatry: the impact of NfL and GFAP. 探索血清生物标志物在儿科精神病学：NfL和GFAP的影响。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-08-26 DOI: 10.1038/s41398-026-04347-1

Marc Pawlitzki, Lars Masanneck, Laura Schlarbaum, Nicole Jankovic, Stefan Bittner, Falk Steffen, Jens Kuhle, Pascal Benkert, Jonathan Repple, Judith Bühlmeier, Anke Hinney, Johannes Hebebrand, Raphael Hirtz, Sven G Meuth, Lars Libuda, Manuel Föcker

{"title":"Exploring serum biomarkers in paediatric psychiatry: the impact of NfL and GFAP.","authors":"Marc Pawlitzki, Lars Masanneck, Laura Schlarbaum, Nicole Jankovic, Stefan Bittner, Falk Steffen, Jens Kuhle, Pascal Benkert, Jonathan Repple, Judith Bühlmeier, Anke Hinney, Johannes Hebebrand, Raphael Hirtz, Sven G Meuth, Lars Libuda, Manuel Föcker","doi":"10.1038/s41398-026-04347-1","DOIUrl":"10.1038/s41398-026-04347-1","url":null,"abstract":"Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) are biomarkers of neuroaxonal and astrocytic damage but remain understudied in adolescent psychiatric populations. This study investigated sNfL and GFAP levels in 412 adolescents diagnosed with anorexia nervosa (AN) (n = 52), depression (n = 237), and other psychiatric disorders (n = 123). We assessed their diagnostic utility, correlation with disease severity, and longitudinal changes during AN treatment. Biomarkers were measured using Single Molecule Array technology, with Z-scores derived from reference datasets. Compared to population norms, both biomarkers were elevated in AN (sNfL: 1.15 ± 1.17; GFAP: 1.50 ± 0.84) and in depression (sNfL: 0.34 ± 1.10; GFAP: 0.58 ± 1.00). Patients with AN showed significantly higher biomarker levels than those with depression or other psychiatric disorders; importantly, this distinction remained evident in sensitivity analyses restricted to underweight individuals with depression. In AN, sNfL levels correlated with baseline weight loss (β = -0.45, R² = 0.20) and declined significantly during treatment, while GFAP changes were less pronounced. Neither marker correlated with depressive symptom severity. Bootstrapped ROC analyses showed moderate-to-good discriminatory power (AUCs 0.70-0.84) for distinguishing AN from depression. These findings suggest that neuroaxonal and astrocytic stress is a component of adolescent psychopathology, particularly in AN. sNfL appears sensitive to starvation-related neurobiological changes, with levels normalizing alongside weight restoration. GFAP showed similar but less robust trends. Accordingly, the observed biomarker changes reflect more than underweight alone, supporting a potential role in differential diagnosis and treatment monitoring.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine's impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial. 氯胺酮对反刍相关脑动力学的影响：来自随机对照fMRI试验的见解。

IF 7.5 1区医学

Translational Psychiatry Pub Date : 2026-08-18 DOI: 10.1038/s41398-026-04392-w

Marvin S Meiering, David Weigner, Matti Gärtner, Luisa Carstens, Christian Keicher, Gerd Luippold, Andreas Wunder, Anne Weigand, Simone Grimm

{"title":"Ketamine's impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial.","authors":"Marvin S Meiering, David Weigner, Matti Gärtner, Luisa Carstens, Christian Keicher, Gerd Luippold, Andreas Wunder, Anne Weigand, Simone Grimm","doi":"10.1038/s41398-026-04392-w","DOIUrl":"10.1038/s41398-026-04392-w","url":null,"abstract":"Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a randomized, double-blind, placebo-controlled fMRI study, we investigated ketamine's effects on dynamic CAPs associated with rumination and examined whether inhibition of glutamatergic release through lamotrigine attenuates these effects. Seventy-five healthy adults were randomized to placebo-placebo, placebo-ketamine, or lamotrigine-ketamine treatment. Resting-state fMRI was acquired at baseline, during ketamine/placebo infusion, and 24 h post-infusion. Whole-brain CAP analysis identified seven recurring network configurations. Occurrence rates were examined for group differences, while controlling for age, sex, and drug plasma concentrations. Rumination was assessed using a validated self-report questionnaire. A hybrid DMN + FPN CAP showed a positive association with rumination at baseline. Ketamine acutely reduced the occurrence rate of this hybrid CAP compared to placebo, with larger decreases in individuals reporting higher rumination. These effects were transient, returning to baseline after 24 h. Exploratorily, ketamine also reduced engagement of a canonical somatomotor CAP during infusion. Lamotrigine pretreatment nominally attenuated ketamine-induced changes across analyses. Ketamine transiently alters dynamic brain states implicated in rumination and somatosensory processing, and preliminary evidence suggests partial glutamatergic mediation. These findings provide insights into ketamine's mechanism of action.","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"16 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0