Individualized therapy guided by single-cell sequencing in anti-GABA_AR encephalitis.

IF 5.8 1区医学 Q1 PSYCHIATRY

Translational Psychiatry Pub Date : 2025-03-08 DOI:10.1038/s41398-025-03300-y

Yaqing Shu, Yu Huang, Qihui Li, Huilu Li, Zhibin Li, Jinlong Ye, Jianning Chen, Jianfang Li, Ling Fang, Jing Li, Yi Lu, Libao Liu, Yongjian Luo, Zhanhang Wang, Zhengqi Lu, Zhongxi Huang, Fuhua Peng, Wei Qiu

引用次数: 0

Abstract

We presented a patient with refractory anti-GABA_A-R encephalitis, and constructed libraries for single-cell sequencing from the patient's peripheral blood mononuclear cells (PBMCs), cerebrospinal fluid cells, as well as four healthy volunteer's PBMCs. A distinct group of monoclonal CD8⁺ T cells and an abnormal JAK-STAT signaling pathway was implicated in the disease. The cross-reactive protein LIM-domain-only protein 5 (LMO5) identified in the patient's thymoma, prompted the activation of the specific CD8⁺ T cells. Furthermore, in vitro analysis revealed the involvement of the JAK-STAT pathway in LMO5-induced CD8⁺T cell activation, a process effectively suppressed by tofacitinib, which improved the patient's clinical outcome.

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来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.

Individualized therapy guided by single-cell sequencing in anti-GABAAR encephalitis.

Abstract

Individualized therapy guided by single-cell sequencing in anti-GABA_AR encephalitis.