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Tackling coinfections. 应对合并感染。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1016/j.tim.2024.10.003
Gordon D Brown, Pablo R Murcia, Andrew P Waters, Jose Penades, Alberto Muñoz
{"title":"Tackling coinfections.","authors":"Gordon D Brown, Pablo R Murcia, Andrew P Waters, Jose Penades, Alberto Muñoz","doi":"10.1016/j.tim.2024.10.003","DOIUrl":"10.1016/j.tim.2024.10.003","url":null,"abstract":"<p><p>Mechanistic understanding of the impact of coinfections is a critical knowledge gap. A workshop on coinfections highlighted key aspects required to advance this field, including identifying the coinfection priorities, creating research platforms for this type of research, promoting cross-expertise collaborations, and securing funding to support cross-kingdom pathogen research.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1148-1149"},"PeriodicalIF":14.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Borrelia (Borreliella) burgdorferi. Borrelia (Borreliella) burgdorferi.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tim.2024.09.002
Martin Strnad, Marie Vancová, Ryan O M Rego
{"title":"Borrelia (Borreliella) burgdorferi.","authors":"Martin Strnad, Marie Vancová, Ryan O M Rego","doi":"10.1016/j.tim.2024.09.002","DOIUrl":"10.1016/j.tim.2024.09.002","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1253-1254"},"PeriodicalIF":14.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From advisors to mentors: fostering supportive mentorship in academia. 从顾问到导师：促进学术界的支持性导师关系。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1016/j.tim.2024.10.004
Hamed Azarbad, Ryszard Laskowski, Heidrun Stoeger, Nico M van Straalen
{"title":"From advisors to mentors: fostering supportive mentorship in academia.","authors":"Hamed Azarbad, Ryszard Laskowski, Heidrun Stoeger, Nico M van Straalen","doi":"10.1016/j.tim.2024.10.004","DOIUrl":"10.1016/j.tim.2024.10.004","url":null,"abstract":"<p><p>A supportive mentorship has long-lasting effects on shaping students' personal and professional development. Here, we outline important aspects of mentoring and indicators of good mentors, focusing on effective mutualistic interaction. We believe that traditional academic advice should be expanded to include supportive group mentoring to foster future top scientific talent.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1145-1147"},"PeriodicalIF":14.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KAP1/TRIM28 - antiviral and proviral protagonist of herpesvirus biology. KAP1/TRIM28--疱疹病毒生物学中的抗病毒和激病毒主角。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-01 Epub Date: 2024-06-12 DOI: 10.1016/j.tim.2024.05.007
Sumita Bhaduri-McIntosh, Beth A Rousseau
{"title":"KAP1/TRIM28 - antiviral and proviral protagonist of herpesvirus biology.","authors":"Sumita Bhaduri-McIntosh, Beth A Rousseau","doi":"10.1016/j.tim.2024.05.007","DOIUrl":"10.1016/j.tim.2024.05.007","url":null,"abstract":"<p><p>Dysregulation of the constitutive heterochromatin machinery (HCM) that silences pericentromeric regions and endogenous retroviral elements in the human genome has consequences for aging and cancer. By recruiting epigenetic regulators, Krüppel-associated box (KRAB)-associated protein 1 (KAP1/TRIM28/TIF1β) is integral to the function of the HCM. Epigenetically silencing DNA genomes of incoming herpesviruses to enforce latency, KAP1 and HCM also serve in an antiviral capacity. In addition to gene silencing, newer reports highlight KAP1's ability to directly activate cellular gene transcription. Here, we discuss the many facets of KAP1, including recent findings that unexpectedly connect KAP1 to the inflammasome, reveal KAP1 cleavage as a novel mode of regulation, and argue for a pro-herpesviral KAP1 function that ensures transition from transcription to replication of the herpesvirus genome.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1179-1189"},"PeriodicalIF":14.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of trophic interactions on carbon accrual in soils. 营养相互作用对土壤碳积累的影响。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-29 DOI: 10.1016/j.tim.2024.10.009
Xiaoyue Wang, Chao Liang, Francisco Dini-Andreote, Shungui Zhou, Yuji Jiang
{"title":"Impacts of trophic interactions on carbon accrual in soils.","authors":"Xiaoyue Wang, Chao Liang, Francisco Dini-Andreote, Shungui Zhou, Yuji Jiang","doi":"10.1016/j.tim.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.tim.2024.10.009","url":null,"abstract":"<p><p>The transformation and stabilization of soil organic carbon (SOC) are important processes of global carbon (C) cycling, with implications for climate change. Much attention has been given to microbial anabolic processes driving SOC accrual. These are referred to as the soil microbial carbon pump (MCP), which emphasizes the contribution of microbial metabolism and necromass to the stable soil C pool. However, we still lack a fundamental understanding of how trophic interactions between soil fauna and microbiota modulate microbial necromass production and, consequently, SOC formation. Here, we provide an ecological perspective on the impacts of trophic interactions on modulating necromass formation and C accrual in soils. We discuss the mechanisms of trophic interactions in the context of food web ecology, with a focus on trophic control of microbial population densities and their influences on soil microbiota assembly. We foresee that integrating trophic interactions into the soil MCP framework can provide a more comprehensive basis for guiding future research efforts to elucidate the mechanisms modulating microbial necromass and SOC formation in terrestrial ecosystems. This perspective offers an ecological foundation for leveraging the use of biological interventions to enhance SOC accrual, providing valuable insights for sustainable C management strategies.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial peptidoglycan recycling. 细菌肽聚糖回收。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-28 DOI: 10.1016/j.tim.2024.11.004
Michael C Gilmore, Felipe Cava
{"title":"Bacterial peptidoglycan recycling.","authors":"Michael C Gilmore, Felipe Cava","doi":"10.1016/j.tim.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.004","url":null,"abstract":"<p><p>During growth and division, the bacterial cell wall is remodeled, resulting in the liberation of peptidoglycan (PG) fragments which are typically reinternalized and recycled. Recycling of PG has been studied in a few model species, but its importance and diversity are not yet well understood. Here, we review how bacteria transport and recycle the components of their PG, highlighting updates and new findings.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic maneuvering: an emerging strategy for mycobacterial intracellular survival. 表观遗传操纵：分枝杆菌胞内生存的新策略。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-28 DOI: 10.1016/j.tim.2024.10.007
Prakruti R Singh, Valakunja Nagaraja
{"title":"Epigenetic maneuvering: an emerging strategy for mycobacterial intracellular survival.","authors":"Prakruti R Singh, Valakunja Nagaraja","doi":"10.1016/j.tim.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.tim.2024.10.007","url":null,"abstract":"<p><p>Mycobacterium tuberculosis (Mtb) has elaborated numerous mechanisms for its pathogenesis. Mtb manipulates host signaling pathways to interfere with the immune response and cell death pathways. By employing virulence factors - of which secretory proteins are emerging as significant components - it ensures successful survival in the host. In this review, we discuss advances made on the largely unexplored secretory modifiers of Mtb that alter the host epigenome to impact host pathways for the pathogen's advantage. We highlight the findings on the Mtb-encoded modification enzymes and their role in maneuvering the host machinery. We also provide pointers to the gaps that still exist in this area and approaches to address these questions for a better appreciation of the uncanny success of Mtb as an intracellular pathogen.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges of female microbial ecologists at different stages of their academic life: a Mexican perspective. 女性微生物生态学家在学术生涯不同阶段的挑战：墨西哥视角。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-27 DOI: 10.1016/j.tim.2024.11.002
Valeria Souza, Nguyen E López-Lozano, Ana E Escalante, Mirna Vazquez-Rosas-Landa, Gabriela Olmedo-Alvarez
{"title":"Challenges of female microbial ecologists at different stages of their academic life: a Mexican perspective.","authors":"Valeria Souza, Nguyen E López-Lozano, Ana E Escalante, Mirna Vazquez-Rosas-Landa, Gabriela Olmedo-Alvarez","doi":"10.1016/j.tim.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.002","url":null,"abstract":"<p><p>Latin American women scientists face a double glass ceiling because of cultural, institutional, and geographic biases, including those from international journal editors. Despite under-representation, they advance in science, technology, engineering, and mathematics (STEM), particularly microbiology. In Mexico, more efforts are needed to create an inclusive community, driving progress enriched by women's perspectives in science.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges. 病毒感染中的短链脂肪酸：潜在机制、机遇和挑战。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-05 DOI: 10.1016/j.tim.2024.10.001
Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun
{"title":"Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges.","authors":"Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun","doi":"10.1016/j.tim.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tim.2024.10.001","url":null,"abstract":"<p><p>Viral infections can cause cellular pathway derangements, cell death, and immunopathological responses, leading to host inflammation. Short-chain fatty acids (SCFAs), produced by the microbiota, have emerged as a potential therapeutic for viral infections due to their ability to modulate these processes. However, SCFAs have been reported to have both beneficial and detrimental effects, necessitating a comprehensive understanding of the underlying mechanisms. This review highlights the complex mechanisms underlying SCFAs' effects on viral infection outcomes. We also emphasize the importance of considering how SCFAs' activities may differ under diverse contexts, including but not limited to target cells with different metabolic wiring, different viral causes of infection, the target organism/cell's nutrient availability and/or energy balance, and hosts with varying microbiome compositions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking microbiome temporal dynamics to host ecology in the wild. 将微生物组的时间动态与野外宿主生态学联系起来。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-05-25 DOI: 10.1016/j.tim.2024.05.001
Kirsty J Marsh, Stuart Bearhop, Xavier A Harrison
{"title":"Linking microbiome temporal dynamics to host ecology in the wild.","authors":"Kirsty J Marsh, Stuart Bearhop, Xavier A Harrison","doi":"10.1016/j.tim.2024.05.001","DOIUrl":"10.1016/j.tim.2024.05.001","url":null,"abstract":"<p><p>Ignoring the dynamic nature of microbial communities risks underestimating the power of microbes to impact the health of their hosts. Microbiomes are thought to be important for host fitness, yet the coarse temporal scale and population-level focus of many studies precludes the ability to investigate the importance of among-individual variation in stability and identify the ecological contexts in which this variation matters. Here we briefly summarise current knowledge of temporal dynamics in wild host-associated microbial communities. We then discuss the implications of among-individual variation in microbiota stability and suggest analytical approaches for understanding these patterns. One major requirement is for future studies to conduct individual-level longitudinal analyses, with some systems already well set up for answering these questions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1060-1071"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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