肺炎克雷伯菌新出现的抗免疫范式:从隐身到逃避。

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Microbiology Pub Date : 2025-05-01 Epub Date: 2025-01-30 DOI:10.1016/j.tim.2025.01.003
Joana Sá-Pessoa, Ricardo Calderón-González, Alix Lee, José A Bengoechea
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引用次数: 0

摘要

肺炎克雷伯菌(KP)由于分离出多重耐药菌株而对人类健康构成全球性威胁。尽管在了解KP的种群结构、抗生素耐药机制和传播模式方面取得了进展,但KP如何逃避防御,使病原体在免疫系统激活的情况下在组织中繁殖仍然存在空白。KP感染生物学已经形成的概念是,病原体已经进化到屏蔽防御,而不是积极抑制它们。这篇综述描述了KP如何利用与先天免疫系统的共同进化来劫持免疫效应器和受体来消融信号通路并抵消细胞内在免疫的新范式,这表明KP不再仅仅被认为是一种隐形病原体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Klebsiella pneumoniae emerging anti-immunology paradigms: from stealth to evasion.

Klebsiella pneumoniae (KP) is a global threat to human health due to the isolation of multidrug-resistant strains. Despite advancements in understanding KP's population structure, antibiotic resistance mechanisms, and transmission patterns, a gap remains in how KP evades defenses, allowing the pathogen to flourish in tissues despite an activated immune system. KP infection biology has been shaped by the notion that the pathogen has evolved to shield from defenses more than actively suppress them. This review describes new paradigms of how KP exploits the coevolution with the innate immune system to hijack immune effectors and receptors to ablate signaling pathways and to counteract cell-intrinsic immunity, making apparent that KP can no longer be considered only as a stealth pathogen.

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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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