Transplantation proceedings最新文献

{"title":"Central Nervous System Infections in Recipients of Solid Organ Transplant","authors":"Oscar Morado-Aramburo,&nbsp;Leeja Joseph,&nbsp;Harmanpreet Kaur,&nbsp;Rodrigo Hasbun","doi":"10.1016/j.transproceed.2024.12.032","DOIUrl":"10.1016/j.transproceed.2024.12.032","url":null,"abstract":"<div><h3>Background</h3><div>Central nervous system (CNS) infections are severe and life-threatening complications that can occur in solid organ transplant (SOT) recipients. We describe the epidemiology, clinical presentation, diagnosis, disease course, and outcome of CNS infections in SOT.</div></div><div><h3>Methods</h3><div>We analyzed data of patients who underwent transplantation from September 2012 to February 2023, diagnosed and treated for CNS infections at our institution in Houston, TX. Data were retrospectively collected from medical charts.</div></div><div><h3>Results</h3><div>Of 1,345 patients who received a SOT, 30 (2.23%) were diagnosed with CNS infection, with a median age of 63 years, 60% were male. Time to CNS infection onset after transplant in 53.3% of the cases was after the first year. There were 15/30 (50%) cases of fungal infection, 8/30(26.7%) of viral infection, 7/30 (23.3%) of bacterial infection. There were no unknown causes. The most common etiologies were <em>Cryptococcus neoformans</em> 14/30(46.6%), and <em>nocardiosis</em> 3/30 (10%). On presentation, 22 (73.4%) patients had normal mental status, but 21 (70%) reported headaches, and 18 (60%) were febrile. Abnormal neuroimaging was found in 5 cases (16.6%) on computed tomography (CT)-scans and 10 cases (33.3%) on magnetic resonance imaging (MRI) scans. An adverse clinical outcome on discharge was noticed in 33%, and 6.7% died. Fever was associated with an increased risk of adverse clinical outcomes (OR 11; <em>P</em> = .018).</div></div><div><h3>Conclusion</h3><div>The incidence of CNS infections in SOT recipients is low but associated with substantial adverse clinical outcomes. The most common causes are fungal, with no unknown etiologies seen in this study.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 410-415"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serosurvey of Visceral Leishmaniasis in Organ Transplant Recipients in the South of Iran","authors":"Amirhossein Haydarian ,&nbsp;Leila Morrabi ,&nbsp;Mojtaba Shafiekhani ,&nbsp;Mostafa Omidian ,&nbsp;Bahador Sarkari","doi":"10.1016/j.transproceed.2024.12.030","DOIUrl":"10.1016/j.transproceed.2024.12.030","url":null,"abstract":"<div><h3>Background</h3><div>Visceral leishmaniasis (VL) can become active and cause specific problems in transplant recipients. The current study was conducted with the aim of serological evaluation of VL in transplant patients in a comprehensive transplantation center in Fars province southern Iran.</div></div><div><h3>Methods</h3><div>The study population included 150 organ transplant recipients. Blood sample was taken from each patient and the sera were evaluated for anti-<em>Leishmania</em> antibodies by an ELISA method. While sampling from patients, the required information was recorded in a questionnaire and finally analyzed by SPSS software.</div></div><div><h3>Results</h3><div>Out of the 150 recruited patients, 96 (64%) were men and 54 (36%) were women. The youngest participant was 18 years old and the oldest was 85, with an average age of 46.24 (±15.13). Among the participants, 79 (52.66%) had undergone kidney transplantation, 69 (46%) liver transplantation, 1 (0.66%) intestinal transplantation, and 1 (0.66%) had undergone SPK (kidney and pancreas) transplantation. The participants were from various provinces of Iran, with the majority (61.33%) residing in Fars province. Anti-<em>Leishmania</em> antibodies were detected in the sera of 4 individuals (2.7%) among the study population. The overall seroprevalence of VL did not have a statistically significant association with variables such as gender, age, type of transplant, transplant rejection, or place of residence (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The results of the current study indicate a noticeable seroprevalence of VL in transplant patients in southern Iran. Given the potential risk of reactivation of VL in transplant patients, the need for greater attention to its prevention, timely diagnosis, and treatment becomes more obvious.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 406-409"},"PeriodicalIF":0.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dealing With Antibiotic Prophylaxis in Lung Transplantation in the Era of Multidrug Resistance: The Milano Algorithm","authors":"Andrea Lombardi ,&nbsp;Davide Mangioni ,&nbsp;Giulia Renisi ,&nbsp;Jacopo Fumagalli ,&nbsp;Letizia Morlacchi ,&nbsp;Lorenzo Rosso ,&nbsp;Alessandro Palleschi ,&nbsp;Valeria Rossetti ,&nbsp;Mauro Panigada ,&nbsp;Chiara Abbruzzese ,&nbsp;Lisa Cariani ,&nbsp;Annapaola Callegaro ,&nbsp;Mario Nosotti ,&nbsp;Francesco Blasi ,&nbsp;Giacomo Grasselli ,&nbsp;Alessandra Bandera","doi":"10.1016/j.transproceed.2024.12.024","DOIUrl":"10.1016/j.transproceed.2024.12.024","url":null,"abstract":"<div><div>Infectious complications significantly impact morbidity and mortality following lung transplantation (LuTx), with over 25% of post-transplant deaths attributed to infections. Antibiotic prophylaxis during the surgical procedure is crucial for reducing early infections, though the current use of wide-spectrum antibiotics, especially in cases of multidrug-resistant organisms (MDROs), is contentious and varies widely across centre. This practice raises concerns about antimicrobial resistance (AMR), particularly in immunosuppressed patients requiring lifelong healthcare access. Syndromic multiplex polymerase chain reaction (mPCR) tests, which detect multiple pathogens simultaneously, have shown promise in quickly identifying pathogens and resistance mechanisms, thus enabling targeted treatments. However, their application in LuTx has been limited.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 339-341"},"PeriodicalIF":0.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Do They Persist? Understanding Living Kidney Donors and Persistence","authors":"Kelly L. Nottingham ,&nbsp;Hallie Klosterman ,&nbsp;Olivia Prevost ,&nbsp;Rebekah Perkins Crawford","doi":"10.1016/j.transproceed.2024.12.025","DOIUrl":"10.1016/j.transproceed.2024.12.025","url":null,"abstract":"<div><div>Many participants persist through the living kidney donation process, although it is challenging, multifaceted, and burdensome, particularly during the predonation evaluation (PDE) phase. This study uses a constructivist grounded theory approach to analyze the experiences of living kidney donors (LKDs) undergoing evaluation who shared their perspectives in blog reflections. One hundred five (105) blog posts met the inclusion criteria. They generated three overarching themes: (1) Facilitators to completing the PDE qualification process, (2) Burdens experienced during the PDE qualification process, and (3) Tools to mitigate burdens or enhance facilitators. Internal facilitators, such as the desire to help and other motivating emotions, emerged as key drivers for LKDs to persist through the donation process. Religious belief or faith, an external facilitator, is also crucial in motivating donors. Conversely, internal burdens, such as doubts, fears, financial concerns, and health risks, posed challenges to the donation process. External burdens also included recipient relationship management, delays and setbacks, poor communication, qualification testing, lack of support, and being denied as a donor. This study's findings shed light on the complex interplay between burdens, facilitators, and tools in shaping the experiences of LKDs during the PDE, which enabled their persistence through the process and highlights a potential persistence spectrum. The insights gained from this research can inform interventions to better support living kidney donors throughout their donation journey, enhancing the overall donor experience and potentially increasing the number of living kidney donations.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 223-229"},"PeriodicalIF":0.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Gram-Ghost Bacilli and Additional Ziehl–Neelsen Stain for the Early Diagnosis of Driveline Infection: A Case Report","authors":"Megumi Kawano ,&nbsp;Shotaro Komeyama ,&nbsp;Tasuku Hada ,&nbsp;Hiroki Mochizuki ,&nbsp;Naoki Tadokoro ,&nbsp;Satoshi Kainuma ,&nbsp;Takuya Watanabe ,&nbsp;Satsuki Fukushima ,&nbsp;Yasumasa Tsukamoto","doi":"10.1016/j.transproceed.2024.10.035","DOIUrl":"10.1016/j.transproceed.2024.10.035","url":null,"abstract":"<div><h3>Background</h3><div>Driveline infections (DLI) caused by nontuberculous mycobacteria (NTM) in patients with implantable left ventricular assist devices (iLVAD) are rare but fatal, requiring early diagnosis and appropriate treatment. Herein, we present a rare case of DLI caused by <em>Mycobacterium chelonae</em>, which was promptly diagnosed using Gram stain and Ziehl–Neelsen stain and followed a favorable clinical course.</div></div><div><h3>Case presentation</h3><div>A 51-year-old man with an iLVAD complicated by DLI was admitted to our center. He had no fever but had a slight ache and rash around the driveline exit site on admission. The wound condition gradually deteriorated with increasing purulent discharge from the driveline exit site and an elevated inflammatory response, despite daily irrigation. Gallium scintigraphy led to the diagnosis of deep DLI, followed by surgical debridement and omental flap transposition with driveline translocation. The Gram stain of the purulent discharge from the surgical site showed unstained bacilli (Gram-neutral, neither positive nor negative) along with leukocyte phagocytosis. Additionally, the Ziehl–Neelsen stain was positive. NTM was suspected after confirming the negative polymerase chain reaction for <em>M. tuberculosis</em>. Antibiotic therapy was switched to a specific regimen for skin and soft tissue infections caused by NTM. After identifying <em>M. chelonae</em>, antibiotic therapy was switched to a more specific regimen (clarithromycin and doxycycline) for <em>M. chelonae</em> according to the susceptibility test results. The patient was discharged after 3 months without infection recurrence.</div></div><div><h3>Conclusions</h3><div>Detecting Gram-ghost bacilli and using an additional Ziehl–Neelsen stain can be beneficial for the early diagnosis of repeated DLI with unknown etiology.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 143-147"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact on Survival of Heart and Heart-Lung Transplantation in Patients With Cyanotic and Noncyanotic Congenital Heart Diseases","authors":"Víctor Donoso-Trenado ,&nbsp;Raquel López-Vilella ,&nbsp;Joaquín Rueda-Soriano ,&nbsp;Francisco Buendía-Fuentes ,&nbsp;Luis Martínez-Dolz ,&nbsp;Luis Almenar-Bonet","doi":"10.1016/j.transproceed.2024.12.005","DOIUrl":"10.1016/j.transproceed.2024.12.005","url":null,"abstract":"<div><h3>Background</h3><div>A high percentage of patients with congenital heart diseases (CHD) reach adulthood and, over time, require heart transplantation (HTx) or combined heart-lung transplantation (HLTx). Among CHD, there are subgroups associated with a higher risk.</div></div><div><h3>Methods</h3><div>Retrospective analysis of HTx and HLTx in CHD patients. They are subdivided based on the etiology of cyanotic or noncyanotic CHD. Baseline characteristics and mortality are comparatively analyzed. No comparative analysis is performed between HTx and HLTx.</div></div><div><h3>Results</h3><div>A total of 1015 HTx were performed, 933 (91,9%) were first-time HTx, and 42 (4.1%) were HLTx. Of the HTx, 18 (1.8%) were in CHD patients. In the HLTx group, 18 (42.8%) had CHD. In the HTx group, cyanotic patients had fewer surgical interventions (57% vs. 18%), compared to noncyanotic patients, where corrective surgeries were more common. Cyanotic patients had a higher mortality rate (57.1% vs. 18.2%), and their median survival was slightly lower (15.9 vs. 16.7 years). In the HLTx group, ninety percent of cyanotic patients had no previous surgeries, compared to 25% in the other group. The mortality rate was higher in cyanotic patients (60% vs. 37.5%), and their median survival was lower (1.7 vs. 9.5 years). Mortality occurred mainly in the first 30 days and was higher in cyanotic patients.</div></div><div><h3>Conclusions</h3><div>In CHD patients following HTx or HLTx, cyanotic conditions are associated with lower survival, with higher mortality occurring during the first 30 days.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 86-89"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page- ORIGINAL CONTRIBUTIONS: CASE REPORTS JANUARY/FEBRUARY 2025","authors":"","doi":"10.1016/S0041-1345(25)00026-0","DOIUrl":"10.1016/S0041-1345(25)00026-0","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Page 93"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft Intolerance Syndrome Complicates Retransplantation","authors":"Manuel Parra Collado ,&nbsp;Paula Gandía Ureña ,&nbsp;Eva Gavela Martínez ,&nbsp;Julia Kanter Berga ,&nbsp;Cristina Castro Alonso ,&nbsp;Emma Calatayud Aristoy ,&nbsp;Aina Quilis Pellicer ,&nbsp;Sandra Beltrán Catalán ,&nbsp;Belén Vizcaíno Castillo ,&nbsp;Asunción Sancho Calabuig","doi":"10.1016/j.transproceed.2024.11.027","DOIUrl":"10.1016/j.transproceed.2024.11.027","url":null,"abstract":"<div><h3>Background</h3><div>Patients with non-functioning renal grafts constitute approximately 4% of patients with incident dialysis. Complete withdrawal of immunosuppression has been associated with a higher risk of HLA sensitization and renal graft intolerance syndrome (GIS).</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study of 63 patients with renal graft failure (from January 2012 to December 2022). Immediate graft losses due to vascular thrombosis or technical complications were excluded. We analyzed demographic and clinical characteristics, as well as the evolution of GIS. A comparative study was performed with patients who did not develop GIS (non-GIS).</div></div><div><h3>Results</h3><div>Twenty-three patients (36.5%) developed GIS. The most common presentation was anemia (73.9%), followed by renal graft pain (65.2%). Seventeen patients (74%) required renal graft embolization. GIS was associated with a higher degree of sensitization. We did not find differences in prior HLA sensitization, causes of graft failure, history of acute rejection, or doses/levels of immunosuppression after graft failure, although rejections were more severe in the GIS group. Patients with GIS had a lower rate of retransplantation after graft failure (4.3% vs 25%, <em>P</em> = .02). Graft failure within the first 2 years after transplantation was the main predictive factor for GIS (hazard ratio = 2.740, 95% confidence interval = 1.06–7.06, <em>P</em> = .03).</div></div><div><h3>Conclusions</h3><div>GIS was more prevalent in patients who experienced graft failure within the first 2 years. Despite increased immunosuppression, a significant percentage required graft embolization. GIS was associated with an increase in HLA sensitization and a lower likelihood of retransplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 30-32"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Recipient: Case Report","authors":"María Araceli Povedano Medina ,&nbsp;Álvaro Arnau Prieto ,&nbsp;Aitor Parra Zurutuza ,&nbsp;Cristina Martínez Amunarriz ,&nbsp;María Jesús Bustinduy Odriozola ,&nbsp;Xabier Camino Ortiz de Barrón ,&nbsp;Esther Pérez Santaolalla ,&nbsp;Olga Maíz Alonso ,&nbsp;Iasone Benavente Claveras ,&nbsp;María Teresa Rodrigo de Tomas","doi":"10.1016/j.transproceed.2024.12.012","DOIUrl":"10.1016/j.transproceed.2024.12.012","url":null,"abstract":"<div><div>Hemophagocytic lymphohistiocytosis is a potentially fatal multisystemic inflammatory syndrome that is better understood in the pediatric population. Consequently, the diagnostic criteria for adults still derives from studies conducted in the pediatric population. Several genetic mutations and secondary causes, including infections, autoimmunity, and malignancy, have been reported as significant actors in this condition, especially in adults. It is of the utmost importance to identify these triggers, as the treatment of this condition is largely dependent on addressing the underlying cause. Those who have undergone transplantation and whose immune response is already compromised are particularly susceptible to this condition. We present the case of a 74-year-old kidney transplant recipient who was admitted due to a persistent fever of unknown origin, pancytopenia, and splenomegaly. The patient was ultimately diagnosed with hemophagocytic lymphohistiocytosis in our hospital secondary to Epstein–Barr virus, aspergillosis, and leishmania infections. Targeted treatments for the aforementioned conditions led to the resolution of the syndrome and the recovery of the patient. Lymphohistiocytosis is a rare, albeit serious, condition that should be considered a differential diagnosis in the early stages of critical illness in transplant recipient patients. Doing so enables target treatments to be administered as soon as possible.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 90-92"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk Cytomegalovirus in Heart Transplant: How Can We Improve?","authors":"Andrea Severo ,&nbsp;Javier González Martín ,&nbsp;Cristina Mateo Gómez ,&nbsp;Josefina Arias Mahiques ,&nbsp;Alexia Denisse Aguzezko ,&nbsp;María Eugenia Tanaro ,&nbsp;Ruth Echeverría ,&nbsp;Javier de Juan Bagudá ,&nbsp;Christian Muñoz Guijosa ,&nbsp;Francisco López Medrano ,&nbsp;Juan Delgado ,&nbsp;María Dolores García-Cosío Carmena","doi":"10.1016/j.transproceed.2024.11.024","DOIUrl":"10.1016/j.transproceed.2024.11.024","url":null,"abstract":"<div><h3>Background</h3><div>Cytomegalovirus (CMV) infection is associated with worse outcomes after heart transplant (HT). CMV mismatch (donor positive, recipient negative serology, D+/R-) increases the risk of infection. Guidelines recommend 3 to 6 months of antiviral prophylaxis in these patients. An increase in primary CMV infections at our center prompted us to analyses this population in search of improvement.</div></div><div><h3>Methods</h3><div>From 185 adult HT receptors in 10 years, we selected those with CMV D+/R-. Patients were followed until October 2023. We evaluated the patterns of transmission of CMV in accordance with current recommendations.</div></div><div><h3>Results</h3><div>We assessed 35 HT recipients with CMV mismatch (median age of 48.8 ± 13.8 years, 71% men). Median follow-up was 5.5 years [1.9-7.4]. Median duration of CMV prophylaxis was 3.7 (±2.1) months post-HT. CMV infection occurred in 74% of patients (96% within the first 6 months after ending prophylaxis) and CMV disease in 26%. Half of them required hospital admission. One third had concomitant infections by other microorganisms. There were no significant differences in the duration of prophylaxis between patients with and without CMV infection. Survival on follow-up was 77%. 2 patients died during CMV infection due to other infection.</div></div><div><h3>Conclusions</h3><div>CMV infection rate in D+/R- HT receptors remains high even after the prophylactic period recommended by current guidelines. A better knowledge of CMV-transmitted infection, coupled with the pursuit of a suitable equilibrium between the prevention of infection and rejection, have the potential to enhance the outcomes of this high-risk population through tailored protocols.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 67-69"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}