Transplantation proceedings最新文献

{"title":"A Study to Determine If Donor Kidney Volume Influences Kidney Function After Renal Transplantation","authors":"Abhijit Konnur,&nbsp;Sishir Gang,&nbsp;Umapati Hegde,&nbsp;Hardik Patel,&nbsp;Akashkumar Pandya,&nbsp;Harshil Shukla,&nbsp;Yogesh Rathi,&nbsp;Nitiraj Shete","doi":"10.1016/j.transproceed.2026.05.024","DOIUrl":"10.1016/j.transproceed.2026.05.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplantation is the preferred treatment for end-stage renal disease. Donor kidney volume (DKV) and its adjustment to recipient body surface area (BSA), termed <em>nephron dose</em> (DKV/BSA), may influence graft function based on the nephron dosing hypothesis. This study evaluated the impact of nephron dose on recipient estimated glomerular filtration rate (eGFR) at 1 year.</div></div><div><h3>Materials and Methods</h3><div>A prospective observational study was conducted on 130 living donor kidney transplants at a tertiary care center (August 2022 to July 2023). Donor kidney volume was measured via computed tomography angiography and 3-dimensional volumetric analysis. Nephron dose (mL/m²) was calculated and correlated with recipient eGFR (Chronic Kidney Disease Epidemiology Collaboration 2021) at baseline, 3, 6, and 12 months. A ≥30% eGFR decline from peak was defined as significant deterioration.</div></div><div><h3>Results</h3><div>The mean DKV was 103.2 ± 20.9 mL, with a mean nephron dose of 64.5 ± 14.7 mL/m². A significant positive correlation was observed between nephron dose and eGFR, strongest at baseline (<em>r</em> = 0.436) and persisting at 1 year (<em>r</em> = 0.184). Receiver operating characteristic curve analysis identified a nephron dose cutoff of 61.88 mL/m², predicting &gt;30% eGFR decline with 79.3% sensitivity and 54.1% specificity (area under the curve = 0.634, <em>P</em> = .028).</div></div><div><h3>Conclusion</h3><div>Donor kidney volume relative to recipient size significantly predicts graft function at 1 year. Incorporating nephron dose into preoperative planning may optimize donor-recipient matching and improve long-term outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 994-1000"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neopterin Levels in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: A Potential Biomarker for Acute Graft-Versus-Host Disease?","authors":"Serap Kirkiz Kayalı,&nbsp;Tuba Saadet Deveci,&nbsp;Özlem Gülbahar,&nbsp;Zühre Kaya,&nbsp;İdil Yenicesu,&nbsp;Ülker Koçak","doi":"10.1016/j.transproceed.2026.04.038","DOIUrl":"10.1016/j.transproceed.2026.04.038","url":null,"abstract":"<div><h3>Introduction</h3><div>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematologic disorders. Acute graft-versus-host disease (aGVHD) remains a major cause of nonrelapse mortality. Distinguishing aGVHD from early post-transplant complications is challenging. This study evaluated serum neopterin (Np) as a potential early biomarker in pediatric patients.</div></div><div><h3>Methods</h3><div>Forty-five pediatric allo-HSCT patients with available serum samples were included. Clinical, laboratory, and transplant-related parameters were retrospectively assessed. Patients were categorized by aGVHD status. Blood samples for Np measurement were collected on days 0, 7, and 28 post-transplant and stored at –80°C. Normal Np was defined as &lt;10 nmol/L.</div></div><div><h3>Results</h3><div>Patients (18 female, 27 male; mean age 8.97 ± 4.82 years) underwent HSCT for acute lymphoblastic leukemia (ALL) (n: 12), acute myeloblastic leukemia (AML) (n: 9), thalassemia major (TM) (n: 10), severe aplastic anemia (sAA) (n: 9), hemophagocytic lymphohistiocytosis (HLH) (n: 2), biphenotypic leukemia (BL) (n: 1) and inborn errors of metabolism (IEM) (n: 2). Twenty-three developed aGVHD. No significant differences were observed between patients with and without aGVHD regarding age, sex, diagnosis, ABO incompatibility, HLA matching, stem cell source, infused CD34+ and CD3+ cells, myeloid and platelet engraftment, or Np levels on days 0, 7, and 28. In all patients, levels were higher on day 28 than on day 7.</div></div><div><h3>Conclusions</h3><div>Early detection and treatment of aGVHD after HSCT is crucial for reducing morbidity and mortality. Although no significant correlation between Np and aGVHD was observed, larger studies are warranted.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1195-1200"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Development and Validation of a Risk Prediction Model for Postoperative Pulmonary Infection in Renal Transplant Patients” Transplantation Proceedings, 58(2026), 511−519","authors":"Ning Pan,&nbsp;Ying Guo,&nbsp;Meixia Zhang,&nbsp;Qiao Meng,&nbsp;Yan Li,&nbsp;Xiao Fang,&nbsp;Miao Miao,&nbsp;Qian Wang,&nbsp;Haoyue Lv","doi":"10.1016/j.transproceed.2026.05.010","DOIUrl":"10.1016/j.transproceed.2026.05.010","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1224-1226"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148280748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate Dynamic Changes as a Predictive Tool for Early Primary Graft Dysfunction After Lung Transplantation: A Retrospective Study","authors":"Ting Lin,&nbsp;Sinan Liu,&nbsp;Ying Zhao,&nbsp;Shenghai Tan,&nbsp;Qifei Wu,&nbsp;Shuo Li,&nbsp;Hongyi Wang,&nbsp;Guangjian Zhang","doi":"10.1016/j.transproceed.2026.05.025","DOIUrl":"10.1016/j.transproceed.2026.05.025","url":null,"abstract":"<div><h3>Background</h3><div>Primary graft dysfunction (PGD) is one of the most common and severe complications after lung transplantation. However, beyond the ratio of partial pressure of oxygen to fraction of inspired oxygen, there is a lack of objective clinical or laboratory indicators to guide real-time decision-making during the first 24 hours after surgery.</div></div><div><h3>Methods</h3><div>We retrospectively examined 74 patients who underwent lung transplantation at our center between September 2022 and December 2024. The patients were classified into 2 groups based on the presence or absence of PGD. We analyzed their clinical data and lactate dynamic changes within 24 hours.</div></div><div><h3>Results</h3><div>The PGD group showed significantly higher lactate values at 0 hours (L0, <em>P</em> = .011), 3 hours (L3, <em>P</em> = .001), and 6 hours (L6, <em>P</em> = .001) after intensive care unit admission than the group without PGD. The largest difference occurred at 6 hours. There was no statistically significant difference in lactate levels at 24 hours (L24, <em>P</em> = .139) between the 2 groups. Delta lactate values between 0 and 24 hours (L0-L24) showed no statistically significant difference (<em>P</em> = .096), while the values of L3-L24 and L6-L24 showed statistically significant differences between the 2 groups (<em>P</em> = .015 and <em>P</em> = .002, respectively). Multivariate Cox regression analysis showed that L6-L24 was independently a protective factor for PGD (Wald = 4.227, <em>P</em> = .04).</div></div><div><h3>Conclusions</h3><div>After lung transplantation, a significant increase in 6-hour lactate levels and untimely clearance from 6 to 24 hours are powerful warning signs for the development of PGD.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1156-1163"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Psychosocial Status and Quality of Life of Liver Transplant Recipients","authors":"Cengiz Darilmaz,&nbsp;Ahmet Unal,&nbsp;Sezai Yilmaz","doi":"10.1016/j.transproceed.2026.05.029","DOIUrl":"10.1016/j.transproceed.2026.05.029","url":null,"abstract":"<div><h3>Background</h3><div>To determine the prevalence and types of psychiatric disorders in liver transplant patients, identify sociodemographic and clinical risk factors, and assess their impact on quality of life compared with healthy individuals.</div></div><div><h3>Methods</h3><div>Sixty liver transplant patients (≥1 year post-transplant) and 60 healthy volunteers were included in this cross-sectional study. Psychiatric disorders were assessed using the Structured Clinical Interview for DSM-5 (SCID-5/CV). Quality of life was measured with the Short Form-36 Health Survey (SF-36), depressive symptoms with Hamilton Depression Rating Scale (HAM-D), and anxiety with Beck Anxiety Inventory (BAI). Sociodemographic and clinical data were collected using a structured form. Nonparametric tests were applied.</div></div><div><h3>Results</h3><div>At least 1 psychiatric disorder was present in 36.7% of patients. Anxiety related to another health condition (40.9%) and depression (27.3%) were most common. Psychiatric disorders were significantly associated with female gender and unmarried status, but not with clinical variables such as pre-transplant disease duration, waiting time, or post-transplant hospitalizations. Patients with psychiatric disorders had lower SF-36 scores in all subscales except physical functioning. Even patients without psychiatric disorders showed lower scores than healthy controls in some domains.</div></div><div><h3>Conclusion</h3><div>Psychiatric disorders are common in liver transplant patients and negatively affect emotional, social, and mental aspects of quality of life. Post-transplant follow-up should include psychiatric assessment and psychosocial support, in addition to biomedical care.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1138-1142"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Dose of Pre-Transplant Cyclophosphamide in Bu/Cy Conditioning Regimens Promote the Prognosis of Patients With Younger Donors in Haploidentical Hematopoietic Stem Cell Transplantation for Aplastic Anemia","authors":"Jing Li,&nbsp;Shijia Li,&nbsp;Xiya Wei,&nbsp;Shiyuan Zhou,&nbsp;Wenjuan Zhu,&nbsp;Qian Zhu,&nbsp;Chao Ma,&nbsp;Xiao Ma,&nbsp;Depei Wu,&nbsp;Xiaojin Wu","doi":"10.1016/j.transproceed.2026.05.013","DOIUrl":"10.1016/j.transproceed.2026.05.013","url":null,"abstract":"<div><h3>Objective</h3><div>The establishment of an optimal preparative regimen for haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in patients with aplastic anemia remains a matter of investigation. This study aimed to assess whether reducing the total dose of cyclophosphamide to 160 mg/kg could decrease toxicity while maintaining engraftment and achieving survival rates comparable to or better than those observed with the conventional Bu/Cy regimen using a cyclophosphamide dose of 200 mg/kg for haplo-HSCT.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 157 patients who underwent myeloablative haplo-HSCT with a Bu/Cy-based conditioning regimen for aplastic anemia. Of the 157 patients, the median age of the recipients was 29 years (range: 7-56), and the median age of the donors was 40 years (range: 9-63). The patients were divided into 2 groups based on the dose of cyclophosphamide in the conditioning regimen: the Cy 160mg group (n = 41, 160 mg/kg) and the Cy 200mg group (n = 116, 200 mg/kg). Subsequent analyses were conducted on patients who were separately divided into 2 groups , using the median age of the donors, 40 years ,as the cutoff.</div></div><div><h3>Results</h3><div>In the overall cohort, there were no significant differences in 1-year overall survival (OS) and 1-year failure-free survival (FFS) between patients transplanted from the Cy 160 mg group and the Cy 200mg group (<em>p</em> = .32 and <em>p</em> = .55, respectively), despite the Cy 160mg group exhibited significantly delayed neutrophil engraftment compared to the Cy 200mg group (<em>p</em> = .043). What‘s more, when selecting donors below the age of 40, patients in the Cy 160mg group showed a lower rate of TRM (<em>p</em> = .046) and a higher rate of OS and FFS compared to those in the Cy 200mg group (<em>p</em> = .027 and <em>p</em> = .027, respectively), although when donors were above 40 years of age, the cumulative incidence of graft failure was higher in the Cy 160mg group compared to the Cy 200mg group in these people (<em>p</em> = .012). As for transplant-related complications, such as infections, GVHD and TMA, no significance were found between the Cy 160mg group and Cy 200mg group mainly, furthermore, the Cy 160mg group had a trend to a lower incidence of severe cardiotoxicity, despite the difference was still not statistically significant (0% vs. 6.1%, <em>p</em> = .11).</div></div><div><h3>Conclusion</h3><div>Our results suggest that a reduced dose of cyclophosphamide in the Bu/Cy conditioning regimen should be selected for AA patients to obtain a better prognosis when donors are younger than 40 years.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1185-1194"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI and Early Morphological Fibrosis Biomarkers are Important Predictive Factors for Long-Term Kidney Graft Outcome","authors":"Leelo Järv,&nbsp;Živile Riispere,&nbsp;Anne Kuudeberg,&nbsp;Margus Lember,&nbsp;Mai Ots-Rosenberg","doi":"10.1016/j.transproceed.2026.06.002","DOIUrl":"10.1016/j.transproceed.2026.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Kidney transplant (KT) survival depends on various immunological and non-immunological factors.</div><div>The aim of the study was to evaluate impact of clinical and morphological parameters on long-term kidney graft survival in overweight and normal weight patients.</div></div><div><h3>Materials and Methods</h3><div>A retrospective study included 124 KT patients (pts) whose serial biopsies could be evaluated (KT biopsies at 0 or 3 months, and 1 year), and data on the following clinical parameters were collected: renal function (eGFR), acute rejections (AR), number of anti-hypertensive drugs, donor age and body mass index (BMI). Pts were divided into 2 groups according to BMI (BMI &lt; 25 lt; 25 vs BMI ≥ 25). KT and the patient's long-term (10 years) survival was calculated. Morphological factors included the presence of tubulointerstitial fibrosis (TIF) and glomerulosclerosis (GS) and the results of immunohistochemical (collagen-3, Col 3, TGF-β) studies.</div></div><div><h3>Results</h3><div>The long-term results of KT were influenced by donor age (HR = 0.9, <em>p</em> &lt; .05), 3-mo BMI (HR = 1.69; <em>p</em> &lt; .05), 1-year HT drugs (HR = 3.92, <em>p</em> &lt; .05) and Col 3 (HR = 12.62, <em>p</em> &lt; .05). Pts 10-year survival was influenced by 1-year BMI (HR = 2.53, <em>p</em> &lt; .05), Col 3 accumulation (HR = 91.26, <em>p</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>Our study revealed predictive factors for long-term outcome were donor age, amount of 1-year antihypertensive medications and Col 3 accumulation, also excess bodyweight had a negative impact on the pts and allograft survival. Col 3, especially Δ Col 3, is a promising long-term predictive morphological parameter.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1001-1007"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Colistin Sulfate in Treating Carbapenem-Resistant Gram-Negative Bacterial Infections in Liver Transplant Recipients","authors":"Yun Chen,&nbsp;Zhongbiao Fang,&nbsp;Xiangyan Liu,&nbsp;Yinglu Pan,&nbsp;Wen Zheng,&nbsp;Huijuan Hong,&nbsp;Tingwei Xu,&nbsp;Yanli Wu,&nbsp;Lingling Tang","doi":"10.1016/j.transproceed.2026.06.013","DOIUrl":"10.1016/j.transproceed.2026.06.013","url":null,"abstract":"<div><h3>Objective</h3><div>Carbapenem-resistant Gram-negative bacteria (CR-GNB), including carbapenem-resistant <em>Enterobacterales (</em>CRE), carbapenem-resistant <em>Pseudomonas aeruginosa</em> (CRPA), and carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB), are critical postoperative complications in liver transplant recipients. This study aimed to evaluate the clinical efficacy and safety of intravenous colistin sulfate (CS) in treating CR-GNB infections in liver transplant patients and identify independent predictive factors influencing therapeutic outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 20 liver transplant recipients with CR-GNB infections admitted to the intensive care unit (ICU) was included. Patients received intravenous colistin sulfate and were stratified into an effective treatment group (n = 10) and an ineffective group (n = 10) based on clinical response. Baseline clinical data and laboratory parameters were collected. Chi-square tests and <em>t</em>-tests compared differences between groups. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors of CS efficacy.</div></div><div><h3>Results</h3><div>Significant differences in serum procalcitonin (PCT) and tumor necrosis factor-alpha (TNF-α) levels were observed between the effective and ineffective groups (<em>P</em> &lt; .05). Multivariate analysis identified TNF-α (OR = 1.009, 95% CI: 0.955-1.066; <em>P</em> = .049) and PCT (OR = 0.590, 95% CI: 0.350-0.997; <em>P</em> = .049) as independent predictors of treatment efficacy. ROC curve analysis demonstrated that TNF-α alone predicted efficacy with an area under the curve (AUC) of 0.900 (specificity=100%, sensitivity=70%), while PCT showed an AUC of 0.885 (specificity = 100%, sensitivity = 80%). Combined TNF-α and PCT improved predictive accuracy (AUC = 0.970, specificity = 100%, sensitivity = 90%).</div></div><div><h3>Conclusion</h3><div>TNF-α and PCT serve as reliable biomarkers for optimizing colistin sulfate therapy in liver transplant recipients with CR-GNB infections. Dynamic monitoring of these inflammatory markers during treatment may enhance therapeutic outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1097-1103"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Blood Eosinophilia as a Marker of Acute Cellular Rejection in Liver Transplant Recipients: A Retrospective Analysis","authors":"Adem Şafak,&nbsp;Emre Karakaya,&nbsp;Sedat Yıldırım,&nbsp;İsmail Tırnova,&nbsp;Meriç Yavuz Çolak,&nbsp;Mehmet Haberal","doi":"10.1016/j.transproceed.2026.04.034","DOIUrl":"10.1016/j.transproceed.2026.04.034","url":null,"abstract":"<div><h3>Introduction</h3><div>Although liver biopsy in patients with acute cellular rejection (ACR) is the gold standard for diagnosis, its invasive nature highlights the need for reliable noninvasive biomarkers. With evidence suggesting that peripheral blood eosinophil levels may be associated with rejection, we evaluated the relationship between eosinophil levels and ACR to determine whether eosinophil dynamics reflect rejection severity.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 151 liver transplant recipients who underwent 398 liver biopsies between 2012 and 2022. To analyze eosinophil changes, we collected data on eosinophil counts, eosinophil percentages, liver enzymes, bilirubin, international normalized ratio, and rejection activity index (RAI) scores from biopsy day (day 0) and day 5 after treatment; patients with and without rejection (established histopathologically with RAI) were compared. We analyzed correlations between RAI severity and eosinophil levels.</div></div><div><h3>Results</h3><div>Liver enzyme levels were significantly higher in patients with versus without ACR (<em>P</em> &lt; .05). In the rejection group, eosinophil count and percentage decreased markedly after treatment (<em>P</em> &lt; .001), whereas no significant change was observed in the non-rejection group. Higher RAI scores were associated with increased eosinophil count (<em>P</em> = .029) and percentage (<em>P</em> = .021) on day 0 and a more pronounced decline on day 5 (both <em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>Peripheral blood eosinophil levels were associated with ACR and exhibited characteristic changes that reflected rejection severity and therapeutic response. Eosinophil monitoring may be a useful noninvasive adjunct in the early detection and follow-up of ACR. Larger prospective multicenter studies are needed to validate these findings.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1134-1137"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlating Infrared Surface Thermometry With Core Temperature Assessments in Simulated Cooling and Rewarming of Porcine Kidneys","authors":"Martin Igbokwe,&nbsp;John Wang,&nbsp;Cory Byrne,&nbsp;Khushi A. Vyas,&nbsp;Mahmoud Richard-Mohammed,&nbsp;Abdullah Alfaifi,&nbsp;Alp Sener,&nbsp;Patrick P. Luke","doi":"10.1016/j.transproceed.2026.05.019","DOIUrl":"10.1016/j.transproceed.2026.05.019","url":null,"abstract":"<div><h3>Background</h3><div>In developing strategies to analyze the effects of controlled rewarming of donor kidneys, accurate and reproducible measurements of renal temperatures are required. While invasive probes provide accurate core temperature measurements, they risk tissue damage and may compromise the sterile field. Infrared thermometry (IRT) offers a non-contact alternative, but correlation with renal core temperature remains insufficiently validated in transplant-related scenarios.</div></div><div><h3>Objective</h3><div>To correlate surface IRT temperatures compared with core temperature assessments in porcine models of donor kidney cooling and rewarming.</div></div><div><h3>Methods</h3><div>This study was conducted in a controlled surgical setting. Porcine kidneys were procured for study. Core temperatures were measured with a calibrated thermocouple probe (Physitemp Thermalert TH-8) inserted into the renal pelvis via the ureter. Surface temperature was recorded using a non-contact infrared thermometer (CEM DT-8839) held 10 to 15 cm perpendicular to the renal capsule. Measurements were obtained by both techniques every minute from cold flush with perfusion solution and during rewarming. Agreement between modalities was assessed with Bland–Altman analysis, and correlation was determined using Pearson’s coefficient.</div></div><div><h3>Results</h3><div>Across all phases, IRT measurements demonstrated strong correlation with core temperatures (r &gt; 0.9, <em>p</em> &lt; .001). Bland–Altman plots indicated minimal systematic bias, with narrower limits of agreement during steady-state cooling and wider variability during rewarming. IRT effectively tracked temperature trends, though minor deviations (±0.5–1.0°C) from core readings were observed during dynamic thermal transitions.</div></div><div><h3>Conclusions</h3><div>Surface IRT has strong correlation with core temperature during pig kidney cooling and rewarming. IRT is well suited for trend monitoring and intraoperative workflow guidance during evaluation of controlled rewarming of donor kidneys.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"Pages 1201-1206"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}