Transplantation proceedings最新文献

{"title":"Belatacept in Kidney Transplantation: A Single-center Experience","authors":"Maria Fernandez Martin ,&nbsp;Oihane Abaunza de Juan ,&nbsp;Monica Paola Rodriguez Davis ,&nbsp;Nerea Ormaetxe Ruiz de Hilla ,&nbsp;Neike Murua Etxarri ,&nbsp;Raquel Vila I Noguer ,&nbsp;Isabel Benito Castaño ,&nbsp;Eva Maria Alvarez Quintana ,&nbsp;Iñigo Yañez Mendia ,&nbsp;Sofia Zarraga Larrondo","doi":"10.1016/j.transproceed.2024.12.007","DOIUrl":"10.1016/j.transproceed.2024.12.007","url":null,"abstract":"<div><div>Belatacept was introduced as an immunosuppressant for kidney transplantation in 2010, but its use in Spain remains limited. Since its commercialization, 15 kidney transplant recipients have received immunosuppressive treatment with belatacept at the Cruces University Hospital. This observational and retrospective study analyzes the reasons for switching to belatacept, its impact on kidney function, and the drug's safety profile. In all cases, it was used as a maintenance immunosuppressant rather than for induction, and its use was determined by the presence of severe side effects from other immunosuppressants, particularly calcineurin inhibitors. The estimated glomerular filtration rate during the first year increased in patients who had previously experienced nephrotoxicity from calcineurin inhibitors and remained stable in the others, whereas proteinuria improved in patients who had been treated with mammalian target of rapamycin inhibitors. Additionally, no adverse effects clearly related to belatacept were observed. This analysis suggests that belatacept is a safe and well-tolerated drug that does not negatively affect kidney function and may even have a beneficial effect on certain groups of patients. Therefore, it presents a therapeutic alternative to consider in patients with serious contraindications to other treatments.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 7-9"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterococcus avium Infection After Liver Transplantation in Vietnam: A Case Report","authors":"Ngo Dinh Trung ,&nbsp;Nguyen Chi Tam ,&nbsp;Dao Trong Chinh ,&nbsp;Ho Nam ,&nbsp;Nguyen Duc Trung ,&nbsp;Le Thi Phuong Thao ,&nbsp;Patrice N. Marche ,&nbsp;Hoang Xuan Su","doi":"10.1016/j.transproceed.2024.11.020","DOIUrl":"10.1016/j.transproceed.2024.11.020","url":null,"abstract":"<div><h3>Background</h3><div>The infectious complications are the most common and can be life-threatening to liver transplant recipients, in particular, within the first month after transplantation. Early diagnosis of these severe complications and accurate detection of causative etiologies are crucial for the choice of therapeutic strategies and management of liver transplants.</div></div><div><h3>Case report</h3><div>We present a case report of a patient with a history of primary sclerosing cholangitis who underwent a liver transplantation (LT) from a living donor. The postoperative care was complicated with the hepatic artery thrombosis on day 16 and then the presence of sepsis on day 22 and intra-abdominal abscess on day 30, caused by Enterococcus avium (<em>E. avium</em>). The patient was treated with stent placement for hepatic artery thrombosis, percutaneous drainage of the abscess, and used an intensive intravenous antibiotic regimen with a combination of fosfomycin and vancomycin for a duration of 14 days. After the interventional procedure, the clinical examination and laboratory findings became normal and the patient left the hospital on day 46 in good general condition.</div></div><div><h3>Conclusion</h3><div>We diagnosed early and well-recognized complications during the perioperative care to make a prompt therapeutic approach with conservative treatment to rescue the patient without requiring urgent surgery and retransplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 126-129"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 Infection and Liver Transplant: How Are We Now?","authors":"Carlos Gutiérrez García ,&nbsp;Antonio Cuadrado ,&nbsp;José Ignacio Fortea ,&nbsp;Ángela Puente ,&nbsp;Reinhard Wallmann ,&nbsp;Alejandra Comins-Boo ,&nbsp;David San Segundo ,&nbsp;Javier Crespo ,&nbsp;Emilio Fábrega","doi":"10.1016/j.transproceed.2024.12.013","DOIUrl":"10.1016/j.transproceed.2024.12.013","url":null,"abstract":"<div><h3>Background</h3><div>The Omicron variant of SARS-CoV-2 emerged as a new variant of concern, characterized by high transmissibility and lower severity compared with previous variants, and became the majority variant in the sixth wave in Spain. This study aims to assess the impact of SARS-CoV-2 infection on liver transplant recipients (LTRs) during 2023 in the population of Cantabria.</div></div><div><h3>Methods</h3><div>The study included 295 LTRs undergoing follow-up at the Liver Transplant Unit of the Marqués de Valdecilla University Hospital. Data on patient characteristics, comorbidities, and vaccination schedules were collected. Humoral response to mRNA vaccines was evaluated using IgG antibodies against the S protein and an adequate response was defined as antibody titers of &gt;260 BAU/mL 1 month after the third vaccine dose.</div></div><div><h3>Results</h3><div>In Cantabria, 0.75% of the general population and 7.10% of LTRs were infected with SARS-CoV-2. Most LTRs were men with comorbidities, mainly cardiovascular disease and hypertension. Of the LTRs, 95.2% were fully vaccinated and received 3 doses of the Moderna mRNA vaccine, and all had an adequate response after 4 to 5 doses. Most infections in LTRs were asymptomatic or mild, with lower hospitalization rates. No LTRs required intensive care admission or died owing to SARS-CoV-2 infection.</div></div><div><h3>Conclusions</h3><div>LTRs are targets for SARS-CoV-2 vaccination. The Omicron variant has shown greater transmissibility but causes milder disease in vaccinated LTRs. All vaccinated LTRs showed an adequate response after 4 to 5 doses. Therefore, vaccination protects against severe disease and mortality in LTRs, and booster vaccinations with variant-adapted vaccines are recommended.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 33-36"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Telomere Shortening on Post-transplant Outcomes in Interstitial Lung Disease","authors":"Eduardo Catalinas-Muñoz,&nbsp;Miguel Jiménez-Gómez,&nbsp;Julia Díaz-Miravalls,&nbsp;Carlos Andrés Quezada-Loaiza,&nbsp;Virginia Luz Pérez-González,&nbsp;Alicia De-Pablo-Gafas,&nbsp;Rodrigo Alonso-Moralejo","doi":"10.1016/j.transproceed.2024.12.004","DOIUrl":"10.1016/j.transproceed.2024.12.004","url":null,"abstract":"<div><div>Shortened telomere length (STL) is associated with increased rates of interstitial lung diseases, malignancy, hematological disorders, and immunosuppressive treatment toxicities. In this single-center retrospective study, we aim to determine whether patients with interstitial lung diseases who have STL, as determined by quantitative PCR of buccal epithelial cells, exhibit worse post-transplant outcomes compared to recipients with normal telomere length. In our series of 26 patients, STL was associated with a higher incidence of chronic kidney disease following lung transplantation (100% vs 55%, <em>P</em> = .042). However, STL was not associated with an increased incidence of acute cellular rejection, infections, cytomegalovirus viremia, cytopenias, elevated liver enzymes, cancer diagnosis, venous thromboembolism, or mortality. Thus, lung transplant recipients with STL are at an increased risk of developing chronic kidney disease during the post-transplant period compared to those with normal telomere length.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 77-81"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pre-Transplant Renal Anticoagulation and Antiplatelet Therapy on Post-Transplant Outcomes: A Retrospective Single-Center Study","authors":"Cristina Fuentes-Fernández,&nbsp;María Maldonado-Martin,&nbsp;Elena González Garcia,&nbsp;Lina León-Machado,&nbsp;Carlos Jiménez,&nbsp;Maria O. López-Oliva","doi":"10.1016/j.transproceed.2024.12.010","DOIUrl":"10.1016/j.transproceed.2024.12.010","url":null,"abstract":"<div><div>The management of anticoagulation and antiplatelet therapy in stage V chronic kidney disease (CKD) patients undergoing renal transplantation remains controversial. Some centers advocate for the use of reversal agents or procoagulants preoperatively, while others suggest that transplantation can proceed safely without halting these treatments. This study aims to evaluate the incidence of hemorrhagic and thrombotic complications in the first 72 hours post-transplant in patients receiving anticoagulant or antiplatelet therapy compared to a control group without such treatments. We conducted a retrospective cohort study involving 168 kidney transplant patients at our center from June 2018 to February 2022, with a follow-up period of 6 months post-transplant. Among these, 147 patients were included: 8.2% were anticoagulated, 16.3% were on antiplatelet therapy, and 75.5% received neither treatment. Patients on anticoagulants or antiplatelets were generally older, had a higher prevalence of cardiovascular history, and experienced longer dialysis times. Anticoagulated patients exhibited longer cold ischemia times and increased rates of hyperimmunization, alongside prolonged hospital stays. The overall incidence of hemorrhagic complications in the first 3 days post-transplant was low across all groups: 9% in the control group, 8.3% in anticoagulated patients, and 8.4% in antiplatelet-treated patients, with no significant differences. Blood transfusion rates were 75% for anticoagulated patients, 62.5% for antiplatelet patients, and 51.7% for controls (<em>P = .</em>214). Renal function at 6 months was similar across groups (<em>P = .</em>477), though acute rejection rates were higher in anticoagulated patients (16.6% vs. 4.2% vs. 2.7%; <em>P = .</em>067). No significant differences were found in hemorrhagic and thrombotic complications among the groups.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 19-23"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired Diaphragmatic Hernia and Intestinal Obstruction in a Child with Methylmalonic Acidemia Following Pediatric Liver Transplantation","authors":"Huilan Ye ,&nbsp;Xingfei Chen ,&nbsp;Yongmin Lin ,&nbsp;Peidan Hu ,&nbsp;Lihua Wen ,&nbsp;Yiyu Yang ,&nbsp;Nuoheng Liu ,&nbsp;Run Dang","doi":"10.1016/j.transproceed.2025.01.001","DOIUrl":"10.1016/j.transproceed.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>An acquired diaphragmatic hernia (ADH) is an uncommon event following pediatric liver transplantation. Pediatric liver transplantation proves effective in prolonging survival and improving quality of life for children with methylmalonic acidemia. Remarkably, there have been no previous reports documenting the occurrence of post-liver transplant ADH in patients diagnosed with methylmalonic acidemia.</div></div><div><h3>Methods</h3><div>We present a case of a child with methylmalonic acidemia who underwent pediatric liver transplantation at the age of 19 months, followed by choledochoenterostomy due to bile leakage. Three months later, during a subsequent computed tomography (CT) scan, a focal protrusion of the right diaphragmatic muscle was observed. Subsequently, a severe intestinal obstruction emerged a year later, which was diagnosed as an ADH.</div></div><div><h3>Results</h3><div>Following an emergency assessment of the right hemithorax, necrotic bowel resection and repair of the diaphragmatic hernia (DH) were conducted. Consequently, the hernia repair procedure was successful, and the child was discharged on the 18th postoperative day.</div></div><div><h3>Conclusions</h3><div>The clinical presentation and laboratory tests of ADH resembles metabolic decompensation in methylmalonic acidemia, primarily impacting the gastrointestinal and respiratory systems. It can result in severe complications, including intestinal obstruction, and should be considered a potential late complication.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 133-137"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De Novo C3 Glomerulonephritis of Allograft Associated With Factor H Autoantibody in a Patient with Systemic Lupus Erythematosus: A Case Report","authors":"Sumit Sureshkumar Patel,&nbsp;Miroslav Smogorzewski,&nbsp;Thin Thin Maw,&nbsp;Neeraj Sharma","doi":"10.1016/j.transproceed.2024.11.006","DOIUrl":"10.1016/j.transproceed.2024.11.006","url":null,"abstract":"<div><div>C3 Glomerulonephritis (C3GN) is a rare disease with a challenging diagnosis and poor prognosis. It is characterized by dysregulation of alternate complement pathway and diagnosed by biopsy findings of isolated or predominant C3 deposits on immunofluorescence (IF) staining. Dysregulation of alternate complement pathway (ACP) caused by genetic mutations or autoantibodies leads to C3 glomerulopathy (C3G) and complement-mediated thrombotic microangiopathies (c-TMA), later also referred to as atypical hemolytic uremic syndrome (aHUS). Autoantibodies like C3 nephritic factor and Factor H autoantibodies (FHAA) are frequently seen as acquired abnormalities in C3GN. SLE is a multisystem complex disorder distinguished by the presence of autoantibodies to multiple nuclear antigens, including DNA and ribonucleoprotein leading to complement activation, characterized by low level of C3 and C4 and may present with c-TMA. There are not many cases of C3GN with SLE that have been described, and current literature lacks strong evidence-based treatment options of post-transplant C3GN. Here, we describe a case of de novo C3GN of allograft in a patient with SLE.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 116-121"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gun-Sight Technique With Dual Hepatic Vascular Embolization for Sigmoidal Refractory Biliary Stricture After Living-Donor Liver Transplantation: A Case Report","authors":"Yuta Yamada,&nbsp;Kenei Furukawa,&nbsp;Koichiro Haruki,&nbsp;Shinji Onda,&nbsp;Yoshihiro Shirai,&nbsp;Masashi Tsunematsu,&nbsp;Mitsuru Yanagaki,&nbsp;Michinori Matsumoto,&nbsp;Yosuke Igarashi,&nbsp;Toru Ikegami","doi":"10.1016/j.transproceed.2024.10.041","DOIUrl":"10.1016/j.transproceed.2024.10.041","url":null,"abstract":"<div><h3>Background</h3><div>Biliary stricture is a common complication after living-donor liver transplantation (LDLT), but its management is challenging. We herein report a case of successful internal drainage achieved through combination of the gun-sight technique and dual hepatic vascular embolization (DHVE).</div></div><div><h3>Case presentation</h3><div>A 54-year-old woman with primary biliary cholangitis underwent ABO-incompatible LDLT with the right lobe. Duct-to-duct biliary anastomosis was performed, and V5 and V8 of the graft were reconstructed using a vein graft. However, 5 months after surgery, magnetic resonance cholangiopancreatography revealed stricture of the bile duct anastomosis. Endoscopic stenting could not be attempted because of the sigmoidal bending of the bile duct. Instead, percutaneous transhepatic cholangiographic drainage (PTCD) of the anterior and posterior branches was performed. We attempted to remove the PTCD tube by an endofistulization technique. We performed the gun-sight technique, originally employed for transjugular intrahepatic portosystemic shunt procedures, to create a pathway for internal drainage of the posterior segment. The anterior lobe was abandoned by applying DHVE, resulting in no external drainage tubes.</div></div><div><h3>Conclusion</h3><div>Application of the gun-sight technique with DHVE for sigmoidal refractory biliary stricture after LDLT appears to be a feasible treatment.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 130-132"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Allograft Enteropathy Treated with Vedolizumab: A Case Report","authors":"Guido Trentadue ,&nbsp;Gursah Kats-Ugurlu ,&nbsp;Tjasso Blokzijl ,&nbsp;Jan Willem Haveman ,&nbsp;Klaas Nico Faber ,&nbsp;Gerard Dijkstra","doi":"10.1016/j.transproceed.2024.11.021","DOIUrl":"10.1016/j.transproceed.2024.11.021","url":null,"abstract":"<div><h3>Introduction</h3><div>The most common cause of late graft loss in intestinal transplantation is chronic allograft enteropathy (CAE). The diagnosis is often delayed because of late symptoms and signs, and the only available treatment is graft enterectomy. We present the first case of CAE successfully treated with a gut-specific integrin blocker.</div></div><div><h3>Case Report</h3><div>We present a patient who developed CAE 15 years after transplantation and was treated with vedolizumab, a gut-specific integrin blocker that is used for inflammatory bowel disease, thereby avoiding complete graft resection. We show the clinical, endoscopic, radiological, serological, and histopathological course of CAE beginning with discovery of the first signs of disease until 15 months after the start of vedolizumab treatment.</div></div><div><h3>Conclusion</h3><div>To our knowledge, this case represents the first use of vedolizumab in such a circumstance and provides evidence of its usefulness as a rescue therapy for chronic intestinal rejection to, at least, extend graft survival.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 148-155"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbid Obesity and Liver Transplant","authors":"Gerardo Moro ,&nbsp;Arkaitz Perfecto ,&nbsp;Jaime Encinas ,&nbsp;Alberto Ventoso ,&nbsp;Beatriz Villota ,&nbsp;Patricia Ruiz ,&nbsp;Teresa Pascual ,&nbsp;Ibone Palomares ,&nbsp;Mikel Prieto ,&nbsp;Sara Mambrilla ,&nbsp;Ander García ,&nbsp;Mikel Gastaca","doi":"10.1016/j.transproceed.2024.12.003","DOIUrl":"10.1016/j.transproceed.2024.12.003","url":null,"abstract":"<div><h3>Background</h3><div>The progressive increase in the prevalence of morbid obesity (MO) in the general population is a pressing issue. This rise in MO has also been observed in patients with liver disease who are candidates for liver transplantation (LT).</div></div><div><h3>Methods</h3><div>A retrospective study of a single-center series was conducted to analyze the impact of MO on morbidity, mortality, and patient survival after LT.</div></div><div><h3>Results</h3><div>Fifteen patients with a body mass index (BMI) of ≥ 40 kg/m² (mean 40.4 ± 2.99 SD) were transplanted from 2004 to 2023. Thirteen were 13 men (87%) and 2 women (13%), with a mean age of 55 years (±9). The most common indication for LT was liver cirrhosis (93%: 6 alcohol related, 4 hepatitis C virus [HCV] related, and 3 from other causes), and only one case was due to hepatocellular carcinoma in a non-cirrhotic liver (7%). The median stay in the Intensive Care Unit was 5 days (range 2-52), with a median total hospital stay of 15 days (range 10-103). Five patients had a major complication each (≥ IIIa on the Clavien-Dindo scale): liver re-transplantation due to primary graft failure, reoperation due to hemoperitoneum, late superior mesenteric vein (SMV) thrombosis, acute renal failure that required hemodialysis, and surgical wound infection that required drainage. The only patient who required urgent re-transplantation (7%) had an adequate subsequent recovery without other complications. None of the patients underwent obesity surgery pre-, post-, or concurrently with the LT. Patient and graft survival after 5 years was 97%.</div></div><div><h3>Conclusions</h3><div>In our experience, the outcomes of LT in patients with MO were satisfactory in terms of postoperative morbimortality, as well as in patient survival. Therefore, we do not support the notion of considering MO as a contraindication for LT.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 1","pages":"Pages 52-54"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}