The Eradication of Hepatitis C Virus after Liver Transplantation Improved Liver Function and Maintained the Health-related Quality of Life.

Transplantation proceedings Pub Date : 2025-03-12 DOI:10.1016/j.transproceed.2025.02.040

Atsushi Takai, Yoshihide Ueda, Etsuro Hatano, Hiroshi Seno

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Abstract

Background: The outcomes of hepatitis C virus eradication and health-related quality of life in the patients treated with direct-acting antivirals (DAAs) after liver transplantation were examined.

Methods: Thirty-five patients with HCV infection treated with sofosbuvir/ledipasvir after liver transplantation were enrolled in the study. The achievement rate of sustained viral response (SVR), liver function and health-related quality of life based on Short-Form-36 version 2 were evaluated.

Results: All 35 patients achieved SVR and liver function was improved to a level comparable to that of non-transplanted cases by the DAA treatment. As to health-related quality of life, the scores of general health, vitality and mental health were comparable to Japanese national standard scores among 8 subscales of Short-Form-36 version 2.

Conclusion: HCV eradication after liver transplantation is useful for not only improving liver function but maintaining health-related quality of life.

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Transplantation proceedings

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