Translational Neuroscience最新文献

Epigallocatechin gallate mitigates the motor deficits in a rotenone-induced Parkinson's disease rat model via promoting protein kinase D1 and inhibiting neuronal Parthanatos.

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1515/tnsci-2025-0366

Jianjun Wang, Yaqi Tang, Chenwu Guo, Zekun Du, Fen Chen, Shujuan Fang, Yinjuan Tang

{"title":"Epigallocatechin gallate mitigates the motor deficits in a rotenone-induced Parkinson's disease rat model via promoting protein kinase D1 and inhibiting neuronal Parthanatos.","authors":"Jianjun Wang, Yaqi Tang, Chenwu Guo, Zekun Du, Fen Chen, Shujuan Fang, Yinjuan Tang","doi":"10.1515/tnsci-2025-0366","DOIUrl":"https://doi.org/10.1515/tnsci-2025-0366","url":null,"abstract":"Parkinson's disease (PD), a neurodegenerative disorder characterized by degeneration of the dopaminergic (DA) neurons, is still lack of available treatments to completely block neurodegeneration. (-)-Epigallocatechin-3-gallate (EGCG), a predominant active polyphenol generated from green tea, exerts multiple neuroprotective roles in the nervous system. However, the function role of EGCG in PD and the underlying mechanism remains to be investigated. In the current study, we used the rotenone injection to build the PD rat model, followed by the EGCG treatment and determined by the behavior tests, measurements of malondialdehyde, glutathione, and superoxide dismutase levels, and enzyme-linked immunosorbent assay. We revealed that, in PD rats, EGCG upregulates protein kinase D1 (PKD1) and inhibits Parthanatos to ameliorate the impaired motor function, reduce the expression of tyrosine hydroxylase, suppress the oxidative stress, and suppress the inflammation in substantia nigra. These combined results suggest that EGCG can suppress oxidative stress and inflammation to prevent DA neuron degeneration to prevent rotenone-induced motor impairments, laying the foundation for EGCG to be a novel candidate for the treatment of PD.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"16 1","pages":"20250366"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-related behavioural abnormalities in C57BL/6.KOR-Apoe ^shl mice.

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1515/tnsci-2022-0363

Hiroshi Ueno, Yu Takahashi, Sachiko Mori, Eriko Kitano, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

{"title":"Age-related behavioural abnormalities in C57BL/6.KOR-Apoe shl mice.","authors":"Hiroshi Ueno, Yu Takahashi, Sachiko Mori, Eriko Kitano, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara","doi":"10.1515/tnsci-2022-0363","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0363","url":null,"abstract":"Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified. The behavioural abnormalities of ApoE-deficient mice, which are genetically modified mice artificially deficient in ApoE, have been investigated in detail, and it has been reported that they can serve as a model of Alzheimer's disease (AD). To understand whether Apoeshl mice can also serve as a murine model of AD, it is necessary to investigate age-related behavioural abnormalities in Apoeshl mice. In this study, we conducted a series of behavioural experiments on 7- and 11-month-old Apoeshl mice to investigate the behavioural abnormalities associated with ageing in Apoeshl mice. In this study, 7-month-old Apoeshl mice showed decreased body weight and grip strength compared to age-matched wild-type mice. In the open field test, 7-month-old Apoeshl mice showed increased anxiety-like behaviour compared to wild-type mice, whereas 11-month-old Apoeshl mice showed decreased anxiety-like behaviour. Moreover, Apoeshl mice aged 7 and 11 months had increased serum cholesterol levels. These results indicate that the behaviour of Apoeshl mice changes with age. However, 11-month-old Apoeshl mice did not show a decline in cognitive function or memory ability similar to murine models of AD. Our findings indicate that Apoeshl mice can be used to investigate the function of ApoE in the central nervous system.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"16 1","pages":"20220363"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rearing in an envy-like environment increases anxiety-like behaviour in mice.

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2025-02-22 eCollection Date: 2025-01-01 DOI: 10.1515/tnsci-2022-0364

Hiroshi Ueno, Eriko Kitano, Yu Takahashi, Sachiko Mori, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

{"title":"Rearing in an envy-like environment increases anxiety-like behaviour in mice.","authors":"Hiroshi Ueno, Eriko Kitano, Yu Takahashi, Sachiko Mori, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara","doi":"10.1515/tnsci-2022-0364","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0364","url":null,"abstract":"Interest in the societal and psychological harm caused by widespread envy and social comparison is increasing. Envy is associated with anxiety and depression, though the mechanism by which envy affects neuropsychiatric disorders, such as depression, remains unclear. Clarifying the neurobiological basis of envy's effects on behaviour and emotion regulation in experimental mice is essential for developing disease-prevention and treatment strategies. As mice recognize other mice in neighbouring cages, this study investigated whether they recognize neighbouring cages housed in environmentally enriched cages and suffer psychological stress due to envy. After being raised in an envy-like environment for 3 weeks, we revealed changes in the behaviour of the mice through a series of behavioural experiments. Mice raised in an envious environment showed increased body weight and anxiety-like behaviour but decreased social behaviour and serum corticosterone levels compared to control mice. Thus, mice recognize their neighbouring cages and experience psychological stress due to envy. This study revealed a part of the scientific basis for why envy increased anxiety. Using this novel experimental breeding environment, it may be possible to create an experimental animal model of anxiety disorders.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"16 1","pages":"20220364"},"PeriodicalIF":1.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of gradual diameter thrombectomy stent in vitro.

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.1515/tnsci-2022-0351

Caifeng Shen, Zhenjian Ma, Hong Li, Ming Wei

{"title":"Analysis of gradual diameter thrombectomy stent in vitro.","authors":"Caifeng Shen, Zhenjian Ma, Hong Li, Ming Wei","doi":"10.1515/tnsci-2022-0351","DOIUrl":"10.1515/tnsci-2022-0351","url":null,"abstract":"Objective: To analyze the effect of gradient thrombectomy stent in vitro.Methods: The cerebrovascular fluid circulation model was made and fixed on the test table. About 0.9% sodium chloride injection was injected to the vascular model through a miniature water pump to circulate it. Four kinds of thrombus products containing different red blood cell (RBC) volumes of 0, 5, 40, and 80% were placed at the target location as thrombus. Each type of thrombus was removed five times using SOLITAIRE stent and gradient thrombectomy stent. The thrombectomy effects were observed by comparison of the two types of stents.Results: Thrombus containing 80% volume of RBC escaped thrombus fragments during thrombectomy with both stents. Thrombus containing 0% volume of RBC (rich in fibrin) had poor chimerism with stents. In the thrombus containing 0% RBC volume, there was no statistically significant difference between the two stents (p = 1). Thrombus removal was successful in all cases.Conclusion: The gradient thrombectomy stent is as effective as the currently used thrombectomy stent in vitro studies, and there is much room for improvement.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"16 1","pages":"20220351"},"PeriodicalIF":1.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot evaluation of the diagnostic accuracy of ChatGPT-3.5 for multiple sclerosis from case reports. 从病例报告中初步评估ChatGPT-3.5对多发性硬化症的诊断准确性。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-24 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0361

Anika Joseph, Kevin Joseph, Angelyn Joseph

{"title":"A pilot evaluation of the diagnostic accuracy of ChatGPT-3.5 for multiple sclerosis from case reports.","authors":"Anika Joseph, Kevin Joseph, Angelyn Joseph","doi":"10.1515/tnsci-2022-0361","DOIUrl":"10.1515/tnsci-2022-0361","url":null,"abstract":"The limitation of artificial intelligence (AI) large language models to diagnose diseases from the perspective of patient safety remains underexplored and potential challenges, such as diagnostic errors and legal challenges, need to be addressed. To demonstrate the limitations of AI, we used ChatGPT-3.5 developed by OpenAI, as a tool for medical diagnosis using text-based case reports of multiple sclerosis (MS), which was selected as a prototypic disease. We analyzed 98 peer-reviewed case reports selected based on free-full text availability and published within the past decade (2014-2024), excluding any mention of an MS diagnosis to avoid bias. ChatGPT-3.5 was used to interpret clinical presentations and laboratory data from these reports. The model correctly diagnosed MS in 77 cases, achieving an accuracy rate of 78.6%. However, the remaining 21 cases were misdiagnosed, highlighting the model's limitations. Factors contributing to the errors include variability in data presentation and the inherent complexity of MS diagnosis, which requires imaging modalities in addition to clinical presentations and laboratory data. While these findings suggest that AI can support disease diagnosis and healthcare providers in decision-making, inadequate training with large datasets may lead to significant inaccuracies. Integrating AI into clinical practice necessitates rigorous validation and robust regulatory frameworks to ensure responsible use.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"15 1","pages":"20220361"},"PeriodicalIF":1.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Tongxinluo promotes axonal plasticity and functional recovery after stroke". “通心络促进脑卒中后轴突可塑性和功能恢复”的勘误。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0988

Xiaoting Wang, Xiaoqin Huang, Mengqi Yang, Xueying Pan, Meiyi Duan, Hui Cai, Guimiao Jiang, Xianlong Wen, Donghua Zou, Li Chen

引用次数: 0

The hidden link: Investigating functional connectivity of rarely explored sub-regions of thalamus and superior temporal gyrus in Schizophrenia. 隐藏的联系调查精神分裂症患者丘脑和颞上回中极少被探索的亚区域的功能连接。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0356

Adnan Alahmadi, Jamaan Al-Ghamdi, Haythum O Tayeb

{"title":"The hidden link: Investigating functional connectivity of rarely explored sub-regions of thalamus and superior temporal gyrus in Schizophrenia.","authors":"Adnan Alahmadi, Jamaan Al-Ghamdi, Haythum O Tayeb","doi":"10.1515/tnsci-2022-0356","DOIUrl":"10.1515/tnsci-2022-0356","url":null,"abstract":"Functional magnetic resonance imaging (fMRI) stands as a pivotal tool in advancing our comprehension of Schizophrenia, offering insights into functional segregations and integrations. Previous investigations employing either task-based or resting-state fMRI primarily focused on large main regions of interest (ROI), revealing the thalamus and superior temporal gyrus (STG) as prominently affected areas. Recent studies, however, unveiled the cytoarchitectural intricacies within these regions, prompting a more nuanced exploration. In this study, resting-state fMRI was conducted on 72 schizophrenic patients and 74 healthy controls to discern whether distinct thalamic nuclei and STG sub-regions exhibit varied functional integrational connectivity to main networks and to identify the most affected sub-regions in Schizophrenia. Employing seed-based analysis, six sub-ROIs - four in the thalamus and two in the STG - were selected. Our findings unveiled heightened positive functional connectivity in Schizophrenic patients, particularly toward the anterior STG (aSTG) and posterior STG (pSTG). Notably, positive connectivity emerged between the medial division of mediodorsal thalamic nuclei (MDm) and the visual network, while increased functional connectivity linked the ventral lateral nucleus of the thalamus with aSTG. This accentuated functional connectivity potentially influences these sub-regions, contributing to dysfunctions and manifesting symptoms such as language and learning difficulties alongside hallucinations. This study underscores the importance of delineating sub-regional dynamics to enhance our understanding of the nuanced neural alterations in Schizophrenia, paving the way for more targeted interventions and therapeutic approaches.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"15 1","pages":"20220356"},"PeriodicalIF":1.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disgust sensitivity and psychopathic behavior: A narrative review. 厌恶敏感性与精神病行为：一个叙述性回顾。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0358

German Torres, Amina A Sheikh, Beatrice G Carpo, Riya A Sood, Mervat Mourad, Joerg R Leheste

{"title":"Disgust sensitivity and psychopathic behavior: A narrative review.","authors":"German Torres, Amina A Sheikh, Beatrice G Carpo, Riya A Sood, Mervat Mourad, Joerg R Leheste","doi":"10.1515/tnsci-2022-0358","DOIUrl":"10.1515/tnsci-2022-0358","url":null,"abstract":"Humans live under constant threat from pathogenic microorganisms and minimizing such threat has been a major evolutionary selective force in shaping human behavior and health. A particular adaptive mechanism against the harm caused by parasites and their infectiousness is disgust sensitivity, which has evolved to detect and avoid poisonous foods as well as bodily secretions harboring virulent microorganisms. This ubiquitous and reflexive behavior requires the integration of several internal and external sensory signals between the brain, the autonomic nervous system (ANS), and the gastrointestinal tract. Although the emotional expression of disgust is experienced by almost all individuals, the neural mechanisms of sensory signals underlying disgust sensitivity may differ in certain psychiatric conditions. Psychopathy, for instance, is a personality disorder in which disgust sensitivity to contagious bodily secretions is apparently absent or downregulated from its atypical personality temperament. In this review, we provide convergent behavioral, anatomical, and cellular evidence to suggest that a fractured experience of disgust sensitivity might be an additional feature of psychopathic behavior. First, we discuss the neural networks of certain brain regions mediating the emotional states of disgust and then discuss the intersection of the ANS and gastrointestinal tract in the processing of disgust and its relevance to aberrant antisocial behavior. Together, this work highlights the interconnections between the brain and the bilateral body plan as an integrated cell network that is relevant for understanding common principles underlying function and dysfunction of disgust levels in psychiatric domains.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"15 1","pages":"20220358"},"PeriodicalIF":1.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population. 心理健康专业文化量表的内部一致性：罗马尼亚人口的试点研究。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0350

Frédéric Denis, Hélène Kane, Jade Gourret Baumgart, Emmanuel Rusch, Jocelyn Deloyer, Claudio Fuenzalida, Gabriela Kelemen, Mihaela Gavrila-Ardelean, Marek Krzystanek, Donatella Marazziti, Margarita Moraitou, Merja Reunanen, Rexhaj Shyhrete, Wissam El Hage, Johannes Thome, Wim Verwaest, Nathalie Rude, Charline Laruppe, Laurence Fond-Harmant

{"title":"Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population.","authors":"Frédéric Denis, Hélène Kane, Jade Gourret Baumgart, Emmanuel Rusch, Jocelyn Deloyer, Claudio Fuenzalida, Gabriela Kelemen, Mihaela Gavrila-Ardelean, Marek Krzystanek, Donatella Marazziti, Margarita Moraitou, Merja Reunanen, Rexhaj Shyhrete, Wissam El Hage, Johannes Thome, Wim Verwaest, Nathalie Rude, Charline Laruppe, Laurence Fond-Harmant","doi":"10.1515/tnsci-2022-0350","DOIUrl":"10.1515/tnsci-2022-0350","url":null,"abstract":"Background: The objective of this study (registered under number 2020 006) was to assess the internal consistency of the revised Mental Health Professional Culture Inventory (MHPCI) scale, which comprises 15 items, among mental health service workers in Romania. Methods: To examine the psychometric properties of the MHPCI questionnaire within the Romanian population, we employed two main methods: The partial credit model (PCM) and Exploratory factor analysis (EFA). Results: A total of 94 individuals were interviewed, and among them, 71 provided complete responses to the questionnaire. All 15 items demonstrate a strong fit with the PCM, as indicated by mean-square (MSQ) outfit and MSQ infit values falling within the range of 0.5 to 1.5. But items 3 and 11 exhibit MSQ values greater than 1.5, suggesting that it may be challenging to predict individuals' responses to these items. The KMO index stands at 0.7, surpassing the recommended threshold of 0.6, signifying an acceptable level of suitability. Nevertheless, only 59.3% of the total variance is accounted for by the first four factors, and these factors do not align with the dimensions identified in the original article. Conclusion: The internal structure of the Romanian version of the MHPCI demonstrates satisfactory psychometric properties. These properties will need to be further validated through additional studies conducted in diverse socio-cultural contexts.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"15 1","pages":"20220350"},"PeriodicalIF":1.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-based nanoparticles for drug delivery in Parkinson's disease. 脂基纳米颗粒用于帕金森病的药物递送。

IF 1.8 4区医学

Translational Neuroscience Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI: 10.1515/tnsci-2022-0359

Han Cai, Dong Liu, Wei-Wei Xue, Liya Ma, Hai-Tao Xie, Ke Ning

{"title":"Lipid-based nanoparticles for drug delivery in Parkinson's disease.","authors":"Han Cai, Dong Liu, Wei-Wei Xue, Liya Ma, Hai-Tao Xie, Ke Ning","doi":"10.1515/tnsci-2022-0359","DOIUrl":"10.1515/tnsci-2022-0359","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder that predominantly affects dopaminergic neurons in the substantia nigra and ventral tegmental area, resulting in symptoms such as tremors, muscle rigidity, bradykinesia, and potential cognitive and affective disturbances. The effective delivery of pharmacological agents to the central nervous system is hindered by various factors, including the restrictive properties of the blood‒brain barrier and blood‒spinal cord barrier, as well as the physicochemical characteristics of the drugs. Traditional drug delivery methods may not provide the therapeutic concentrations necessary for functional restoration in PD patients. However, lipid-based nanoparticles (NPs) offer new possibilities for enhancing the bioavailability of established treatment regimens and developing innovative therapies that can modify the course of the disease. This review provides a concise overview of recent advances in lipid-based NP strategies aimed at mitigating specific pathological mechanisms relevant to PD progression. This study also explores the potential applications of nanotechnological innovations in the development of advanced treatment modalities for individuals with PD.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"15 1","pages":"20220359"},"PeriodicalIF":1.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0