Translational Neuroscience最新文献

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TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways. TIPE2敲低通过诱导STAT3和NF-κB信号通路的激活,加重异氟醚诱导的小鼠术后认知功能障碍。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0282
Rui Jian, Xin He
{"title":"TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways.","authors":"Rui Jian,&nbsp;Xin He","doi":"10.1515/tnsci-2022-0282","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0282","url":null,"abstract":"<p><strong>Objective: </strong>Anesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed to examine the role of TIPE2 in isoflurane-induced postoperative cognitive decline (POCD).</p><p><strong>Methods: </strong>An AAV empty vector and AAV shTIPE2 vector for the knockdown of TIPE2 were injected into the dorsal hippocampus of mice. Mice were continuously exposed to 1.5% isoflurane followed by abdominal exploration. Behavioral tests including the open field test and fear conditioning test were performed on the third and fourth day post-operation. Apoptosis was detected by terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling staining. The kits were used to detect the activity of antioxidant enzymes. Inflammatory cytokine levels were detected by enzyme-linked immunosorbent assay. Signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB) signaling pathway activities were detected by western blotting.</p><p><strong>Results: </strong>TIPE2 expression increased after isoflurane anesthesia and surgery. TIPE2 deficiency aggravated cognitive impairment in mice and further caused apoptosis and oxidative stress in hippocampal neurons. TIPE2 deficiency induced microglial activation and increased secretion of proinflammatory cytokines. In addition, TIPE2 deficiency promoted STAT3 and NF-κB signaling activation induced by isoflurane anesthesia and after surgery.</p><p><strong>Conclusion: </strong>TIPE2 may play a neuroprotective role in POCD by regulating STAT3 and NF-κB pathways.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220282"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TPVB and general anesthesia affects postoperative functional recovery in elderly patients with thoracoscopic pulmonary resections based on ERAS pathway. TPVB和全麻对老年胸腔镜肺切除术患者ERAS通路术后功能恢复的影响。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0305
Na An, Wenzhe Dong, Guangdong Pang, Yiwei Zhang, Chunling Liu
{"title":"TPVB and general anesthesia affects postoperative functional recovery in elderly patients with thoracoscopic pulmonary resections based on ERAS pathway.","authors":"Na An,&nbsp;Wenzhe Dong,&nbsp;Guangdong Pang,&nbsp;Yiwei Zhang,&nbsp;Chunling Liu","doi":"10.1515/tnsci-2022-0305","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0305","url":null,"abstract":"<p><strong>Objective: </strong>Thoracic surgery is easy to cause various perioperative complications, especially in elderly patients, due to their physical weakness and physiological function degeneration. Postoperative cognitive dysfunction is a common complication in elderly patients undergoing thoracic surgery. This study focuses on exploring the effects of thoracic paravertebral block (TPVB) combined with general anesthesia on postoperative functional recovery in elderly patients undergoing thoracoscopic radical resection for lung cancer based on enhanced recovery after surgery (ERAS) pathway.</p><p><strong>Methods: </strong>A total of 104 patients aged 60 years or older undergoing thoracoscopic radical resection of lung cancer were randomized into the combination group (<i>n</i> = 52) and the control group (<i>n</i> = 52). Patients in the control group were given general anesthesia alone, while patients in the combination group were given TPVB combined with general anesthesia. All patients applied the ERAS model for the perioperative intervention. Hemodynamic indices (heart rate [HR] and mean arterial pressure [MAP]) before anesthesia (T0), 5 min after thoracoscopic trocar placement (T1), at extubation (T2), 30 min after extubation (T3), and 6 h after the surgery (T4), postoperative analgesia, preoperative and postoperative serum pain stress factors (5-hydroxytryptamine [5-HT], prostaglandin E2 [PGE2], cortisol [Cor], substance P [SP], and norepinephrine [NE]), tumor markers (CYFRA21-1, CEA, and CA50), inflammatory factors (IL-6, TNF-α, and c-reactive protein (CRP)), lung function indicators (forced vital capacity [FVC] and forced expiratory volume in the first second [FEV1]), 6 min walking distance (6MWD), clinical recovery indicators, hospitalization status, and postoperative complications in patients between both groups were compared.</p><p><strong>Results: </strong>Compared with the control group, patients in the combination group had lower HR and MAP at T1-T4 time points, less intraoperative doses of remifentanil and propofol, less patient-controlled interscalene analgesia compression number 24 h after the surgery, lower visual analogue scale scores 24 h after the surgery, shorter hospitalization time, postoperative off-bed time, postoperative chest tube removal time, postoperative first feeding time and gastrointestinal function recovery time, reduced postoperative serum levels of 5-HT, PGE2, Cor, SP, NE, CYFRA21-1, CEA, CA50, IL-6, TNF-α, and CRP, decreased complications, and higher FVC, FEV1, and 6MWD.</p><p><strong>Conclusion: </strong>Based on the ERAS pathway, TPVB combined with general anesthesia in thoracoscopic surgery for lung cancer in elderly patients can effectively reduce the patients' hemodynamic fluctuations, alleviate postoperative pain, accelerate the recovery process, and reduce complications.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220305"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Esmolol inhibits cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury. 艾司洛尔抑制脓毒症脑损伤小鼠的认知障碍和神经元炎症。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0297
Yanpeng Li, Junli Ma, Jianjun Diao, Wei Chen, Zhihua Wang
{"title":"Esmolol inhibits cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury.","authors":"Yanpeng Li,&nbsp;Junli Ma,&nbsp;Jianjun Diao,&nbsp;Wei Chen,&nbsp;Zhihua Wang","doi":"10.1515/tnsci-2022-0297","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0297","url":null,"abstract":"<p><p>Sepsis is a potentially fatal organ failure resulting from a dysregulated host response to infection. It can be a substantial financial burden on families and society due to the high cost of medical care. The study aims to investigate the protective roles of Esmolol in mice with sepsis-induced brain injuries against cognitive dysfunction and neuronal inflammation. Male C57BL/6J mice were intraperitoneally injected with LPS (10 mg/kg, L2630, Sigma) to establish a septic encephalopathy model. Esmolol (15 mg/kg/h, HY-B1392, MedChemExpress) was subcutaneously infused using osmotic mini-pumps for 6 h before LPS injection. Morris water maze and novel object recognition tests evaluated LPS-induced cognitive impairment and behavioral phenotypes. Cytokines and protein expression were assessed using ELISA assay and RT-qPCR. Esmolol treatment potentially improved cognitive impairment in septic mice. Esmolol administration markedly diminished the abnormal hippocampal neuronal structure, and the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α was significantly downregulated in the hippocampal tissue. Esmolol treatment significantly reduced apoptotic TUNEL-positive cells and reversed the related gene expression (BAX and BCL-2). The effects of esmolol on the reactive oxidative species and oxidative stress markedly reduce malondialdehyde MDA content and increase superoxide dismutase and catalase in hippocampal tissues. In addition, esmolol significantly reduced the percentage and density of Iba-1 + microglia in septic mice. Our results demonstrated that esmolol potentially improved cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220297"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The correlation between non-arteritic anterior ischemic optic neuropathy and cerebral infarction. 非动脉性前缺血性视神经病变与脑梗死的关系。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0281
Xiaochun Li, Xiaolu Cao, Fenglou Ma, Peipei Jia, Fuyin Wang, Xiaoguang Cao
{"title":"The correlation between non-arteritic anterior ischemic optic neuropathy and cerebral infarction.","authors":"Xiaochun Li,&nbsp;Xiaolu Cao,&nbsp;Fenglou Ma,&nbsp;Peipei Jia,&nbsp;Fuyin Wang,&nbsp;Xiaoguang Cao","doi":"10.1515/tnsci-2022-0281","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0281","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to explore the correlation between non-arteritic anterior ischemic optic neuropathy (NAION) and cerebral infarction (CI). Moreover, the ocular and systemic parameters are also compared between NAION patients with or without CI.</p><p><strong>Methods: </strong>Retrospective analysis is performed for NAION patients and the controls. The controls were collected at the eye outpatient with cranial computed tomography (CT), and data of blood triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B were drawn. The diagnosed NAION patients with cranial CT are included, and data of clinical history and routine clinical examination were drawn from the medical record. Visual acuity, intraocular pressure (IOP), visual field, and visual evoked potential were also drawn.</p><p><strong>Results: </strong>Eighty-two unilateral and 6 bilateral patients, totally 94 eyes for 88 NAION patients and 69 controls are included. NAION and control patients have matched age, gender, and weight. There is no difference in triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B between these two groups. NAION patients (43.18%, 38/88) have a higher ratio of CI than the controls (14.49%, 10/69) (<i>p</i> = 0.000). For NAION, the odds ratio (OR) of CI is 2.691 (<i>p</i> = 0.011). Body mass index, height, and IOP show no significant difference between NAION patients with or without CI. NAION patients with CI have a significant higher ratio of hypertension than those without CI, and the OR of HBP is 2.623 (<i>p</i> = 0.008).</p><p><strong>Conclusions: </strong>The correlation between NAION and CI is possible as NAION patients have a significant higher ratio with CI. In NAION patients, hypertension is a risk factor for those with CI.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220281"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression. CircYIPF6通过靶向miR-760调节PTBP1表达,调控胶质瘤细胞增殖、凋亡和糖酵解。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0271
Dan Lei, Wenyong Xiao, Bo Zhang
{"title":"CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression.","authors":"Dan Lei,&nbsp;Wenyong Xiao,&nbsp;Bo Zhang","doi":"10.1515/tnsci-2022-0271","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0271","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have highlighted that circular RNAs regulate cancer-related genes' expression by functioning as microRNA sponges in cancers. Herein, we investigated the function and molecular mechanism of circYIPF6 in glioma.</p><p><strong>Methods: </strong>5-Ethynyl-2'-deoxyuridine assay, colony formation, and flow cytometry were performed to assess the proliferation and apoptosis of glioma cells. The levels of glycolytic metabolism were evaluated by measuring the glucose uptake and lactate production. The protein levels of Bax, Bcl2, GLUT1, LDHA, and PTBP1 were examined by western blot. The interplay between miR-760 and circYIPF6 or PTBP1 was confirmed by a dual-luciferase reporter. The effect of circYIPF6 silencing on the growth of glioma <i>in vivo</i> was determined by a xenograft experiment.</p><p><strong>Results: </strong>circYIPF6 was significantly upregulated in glioma. Knockdown of circYIPF6 suppressed glioma cell proliferation and glycolysis while promoting cell apoptosis. Mechanistic studies revealed that circYIPF6 targeted miR-760 and could abundantly sponge miR-760 to inhibit the expression of its downstream target gene PTBP1. Functional rescue experiments showed that both miR-760 inhibition and PTBP1 overexpression could attenuate the regulatory effect of circYIPF6 silencing on glioma cells. Furthermore, circYIPF6 knocking down effectively impeded glioma growth <i>in vivo</i>.</p><p><strong>Conclusion: </strong>These findings suggested that circYIPF6 participated in the proliferation, apoptosis, and glycolysis of glioma through the miR-760/PTBP1 axis.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220271"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10017154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of enriched environment on the expression of β-amyloid and transport-related proteins LRP1 and RAGE in chronic sleep-deprived mice. 富集环境对慢性睡眠剥夺小鼠β-淀粉样蛋白及转运相关蛋白LRP1和RAGE表达的影响。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0301
Ren Yuan, Zhang Yisen, Wang Xiu, Tang Wei, Wang Wei
{"title":"Effects of enriched environment on the expression of β-amyloid and transport-related proteins LRP1 and RAGE in chronic sleep-deprived mice.","authors":"Ren Yuan,&nbsp;Zhang Yisen,&nbsp;Wang Xiu,&nbsp;Tang Wei,&nbsp;Wang Wei","doi":"10.1515/tnsci-2022-0301","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0301","url":null,"abstract":"<p><p>Sleep plays an important role in the learning process and memory consolidation, and sleep deprivation (SD) leads to inadequate memory consolidation and plays an important role in brain development and plasticity. SD increases β-amyloid levels while impairing cognitive function. We explored the effect of enriched environment (EE) on β-amyloid and transporter protein LRP1 and receptor for advanced glycosylation end-products (RAGE) expression in chronic sleep deprived mice. We randomly divided mice into four groups (<i>n</i> = 10), the standard environment group (Ctrl group), the sleep deprivation group (SD group), the enriched environment intervention group (EE group), and the sleep deprivation plus environmental enrichment intervention group (SD + EE group). A modified multi-platform SD model was used to sleep deprive the mice for 19 h per day. Five hours of EE intervention was performed daily in the EE group and the SD + EE group, respectively. The behavioral measurements of mice were performed by Y-maze method and new object recognition; the expression levels of Aβ1-42, LRP1, and RAGE in prefrontal cortex and hippocampus of mice were measured by immunofluorescence; the expression levels of LRP1 and RAGE in prefrontal cortex and hippocampus were detected by Western blot. The results showed that EE could effectively ameliorate the effects of SD on cognitive impairment, reduce SD induced Aβ deposition, and decrease the expression of RAGE, while increase the expression of LRP1.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220301"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction of "Eriodictyol corrects functional recovery and myelin loss in SCI rats". “戊周醇纠正脊髓损伤大鼠的功能恢复和髓磷脂丢失”的撤回。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0275
Chenggang Li, Chunfang Wang
{"title":"Retraction of \"Eriodictyol corrects functional recovery and myelin loss in SCI rats\".","authors":"Chenggang Li,&nbsp;Chunfang Wang","doi":"10.1515/tnsci-2022-0275","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0275","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1515/tnsci-2020-0128.].</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220275"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10758734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translation of surface electromyography to clinical and motor rehabilitation applications: The need for new clinical figures. 表面肌电图在临床和运动康复应用中的翻译:对新的临床数字的需求。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0279
Roberto Merletti, Federico Temporiti, Roberto Gatti, Sanjeev Gupta, Giorgio Sandrini, Mariano Serrao
{"title":"Translation of surface electromyography to clinical and motor rehabilitation applications: The need for new clinical figures.","authors":"Roberto Merletti,&nbsp;Federico Temporiti,&nbsp;Roberto Gatti,&nbsp;Sanjeev Gupta,&nbsp;Giorgio Sandrini,&nbsp;Mariano Serrao","doi":"10.1515/tnsci-2022-0279","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0279","url":null,"abstract":"<p><p>Advanced sensors/electrodes and signal processing techniques provide powerful tools to analyze surface electromyographic signals (sEMG) and their features, to decompose sEMG into the constituent motor unit action potential trains, and to identify synergies, neural muscle drive, and EEG-sEMG coherence. However, despite thousands of articles, dozens of textbooks, tutorials, consensus papers, and European and International efforts, the translation of this knowledge into clinical activities and assessment procedures has been very slow, likely because of lack of clinical studies and competent operators in the field. Understanding and using sEMG-based hardware and software tools requires a level of knowledge of signal processing and interpretation concepts that is multidisciplinary and is not provided by most academic curricula in physiotherapy, movement sciences, neurophysiology, rehabilitation, sport, and occupational medicine. The chasm existing between the available knowledge and its clinical applications in this field is discussed as well as the need for new clinical figures. The need for updating the training of physiotherapists, neurophysiology technicians, and clinical technologists is discussed as well as the required competences of trainers and trainees. Indications and examples are suggested and provide a basis for addressing the problem. Two teaching examples are provided in the Supplementary Material.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220279"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway. 京尼平苷通过NF-κB信号通路抗炎保护脑缺血损伤。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0273
Qian Sun, Xiangjian Zhang, Jingyi Fan, Lan Zhang, Hui Ji, Jing Xue, Cong Zhang, Rong Chen, Jing Zhao, Junmin Chen, Xiaoxia Liu, Degang Song
{"title":"Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway.","authors":"Qian Sun,&nbsp;Xiangjian Zhang,&nbsp;Jingyi Fan,&nbsp;Lan Zhang,&nbsp;Hui Ji,&nbsp;Jing Xue,&nbsp;Cong Zhang,&nbsp;Rong Chen,&nbsp;Jing Zhao,&nbsp;Junmin Chen,&nbsp;Xiaoxia Liu,&nbsp;Degang Song","doi":"10.1515/tnsci-2022-0273","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0273","url":null,"abstract":"<p><strong>Context: </strong>Accumulated evidence indicates that geniposide exhibits neuroprotective effects in ischemic stroke. However, the potential targets of geniposide remain unclear.</p><p><strong>Objective: </strong>We explore the potential targets of geniposide in ischemic stroke.</p><p><strong>Materials and methods: </strong>Adult male C57BL/6 mice were subjected to the middle cerebral artery occlusion (MCAO) model. Mice were randomly divided into five groups: Sham, MCAO, and geniposide-treated (i.p. twice daily for 3 days before MCAO) at doses of 25, 75, or 150 mg/kg. We first examined the neuroprotective effects of geniposide. Then, we further explored via biological information analysis and verified the underlying mechanism <i>in vivo</i> and <i>in vitro</i>.</p><p><strong>Results: </strong>In the current study, geniposide had no toxicity at concentrations of up to 150 mg/kg. Compared with the MCAO group, the 150 mg/kg group of geniposide significantly (<i>P</i> < 0.05) improved neurological deficits, brain edema (79.00 ± 0.57% vs 82.28 ± 0.53%), and infarct volume (45.10 ± 0.24% vs 54.73 ± 2.87%) at 24 h after MCAO. Biological information analysis showed that the protective effect was closely related to the inflammatory response. Geniposide suppressed interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) expression in the brain homogenate, as measured by enzyme-linked immunosorbent assay (ELISA). Geniposide upregulated A20 and downregulated TNF receptor-associated factor-6 and nuclear factor kappa-B phosphorylation in the MCAO model and lipopolysaccharide-treated BV2 cells at 100 μM.</p><p><strong>Conclusions: </strong>Geniposide exhibited a neuroprotective effect via attenuating inflammatory response, as indicated by biological information analysis, <i>in vivo</i> and <i>in vitro</i> experiments, which may provide a potential direction for the application of geniposide in the treatment of ischemic stroke.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":"14 1","pages":"20220273"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain functional connectivity and network characteristics changes after vagus nerve stimulation in patients with refractory epilepsy. 难治性癫痫迷走神经刺激后脑功能连通性和网络特征的改变。
IF 2.1 4区 医学
Translational Neuroscience Pub Date : 2023-01-01 DOI: 10.1515/tnsci-2022-0308
Yongqiang Ding, Kunlin Guo, Xinjun Wang, Mingming Chen, Xinxiao Li, Yuehui Wu
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