Translational Neuroscience最新文献_第10页

Erratum to "Construction and effect evaluation of different sciatic nerve injury models in rats". “不同大鼠坐骨神经损伤模型的构建及效果评价”的勘误。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0246

Siwei Qu, Ning Ma, Weixin Wang, Sen Chen, Qi Wu, Yangqun Li, Zhe Yang

引用次数: 0

A rare brainstem anaplastic astrocytoma. 罕见的脑干间变性星形细胞瘤。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0233

Rongjiao You, Xiangfa Liu, Songfa Chen, Lixi Tan, Aiqun Liu, Mingfan Hong, Zhongxing Peng

引用次数: 0

Perinatal diet and offspring anxiety: A scoping review. 围产期饮食与后代焦虑:一项范围综述。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0242

Sasha Monteiro, Yousef Sadat Nejad, Monique Aucoin

{"title":"Perinatal diet and offspring anxiety: A scoping review.","authors":"Sasha Monteiro, Yousef Sadat Nejad, Monique Aucoin","doi":"10.1515/tnsci-2022-0242","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0242","url":null,"abstract":"Health behaviors during pregnancy have an impact on the developing offspring. Dietary factors play a role in the development of mental illness: however, less is known about the impact of diet factors during pre-conception, gestation, and lactation on anxiety levels in offspring. This scoping review sought to systematically map the available research involving human and animal subjects to identify nutritional interventions which may have a harmful or protective effect, as well as identify gaps. Studies investigating an association between any perinatal diet pattern or diet constituent and offspring anxiety were included. The number of studies reporting an association with increased or decreased levels of anxiety were counted and presented in figures. A total of 55,914 results were identified as part of a larger scoping review, and 120 articles met the criteria for inclusion. A greater intake of phytochemicals and vitamins were associated with decreased offspring anxiety whereas maternal caloric restriction, protein restriction, reduced omega-3 consumption, and exposure to a high fat diet were associated with higher levels of offspring anxiety. Results were limited by a very large proportion of animal studies. High quality intervention studies involving human subjects are warranted to elucidate the precise dietary factors or constituents that modulate the risk of anxiety in offspring.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson's disease. 农药诱导的帕金森病小鼠模型黑质致密部基因表达的单细胞分析。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0237

Arshad H Khan, Lydia K Lee, Desmond J Smith

引用次数: 0

Propofol ameliorates ischemic brain injury by blocking TLR4 pathway in mice. 异丙酚通过阻断TLR4通路改善小鼠缺血性脑损伤。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0238

Kazuha Mitsui, Masakazu Kotoda, Sohei Hishiyama, Ayasa Takamino, Sho Morikawa, Tadahiko Ishiyama, Takashi Matsukawa

{"title":"Propofol ameliorates ischemic brain injury by blocking TLR4 pathway in mice.","authors":"Kazuha Mitsui, Masakazu Kotoda, Sohei Hishiyama, Ayasa Takamino, Sho Morikawa, Tadahiko Ishiyama, Takashi Matsukawa","doi":"10.1515/tnsci-2022-0238","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0238","url":null,"abstract":"Ischemic brain injury is one of the most serious perioperative complications. However, effective preventative methods have not yet been established. This study aimed to investigate whether propofol has neuroprotective effects against ischemic brain injury, with a specific focus on Toll-like receptor 4 (TLR4). Focal brain ischemia was induced via a combination of left common carotid artery occlusion and distal left middle cerebral artery coagulation in mice. Either propofol (10 mg/kg) or vehicle was intravenously injected 10 min prior to the induction of brain ischemia in wild-type and TLR4 knockout mice. Infarct volume, pro-inflammatory cytokine expression, inflammatory cell infiltration, and neurobehavioral function were assessed. Propofol administration significantly reduced infarct volume in wild-type mice (26.9 ± 2.7 vs 15.7 ± 2.0 mm3 at day 7), but not in TLR4 knockout mice. Compared with the control mice, the propofol-treated wild-type mice exhibited lower levels of IL-6 (0.57 ± 0.23 vs 1.00 ± 0.39 at 24 h), and smaller numbers of TLR4-expressing microglia in the penumbra (11.7 ± 3.1 vs 25.1 ± 4.7 cells/0.1 mm2). In conclusion, propofol administration prior to ischemic brain insult attenuated brain injury by blocking the TLR4-dependent pathway and suppressing pro-inflammatory cytokine production.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40365596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autosomal dominant sleep-related hypermotor epilepsy associated with a novel mutation of KCNT1. 常染色体显性睡眠相关性运动性癫痫与KCNT1新突变相关。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-08-30 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0241

Jinyu Lu, Gaohua Zhao, Dayao Lv, Lanxiao Cao, Guohua Zhao

{"title":"Autosomal dominant sleep-related hypermotor epilepsy associated with a novel mutation of KCNT1.","authors":"Jinyu Lu, Gaohua Zhao, Dayao Lv, Lanxiao Cao, Guohua Zhao","doi":"10.1515/tnsci-2022-0241","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0241","url":null,"abstract":"Autosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by severe sleep-related rigid hypermotor seizures. The pathogenic genes of ADSHE include genes encoding subunits of the neuronal nicotinic acetylcholine receptor, KCNT1, DEPDC5, NPRL2/3, CABP4, and CRH. Individuals with KCNT1-related ADSHE are more likely to develop seizures at a younger age, have cognitive comorbidity, and display psychiatric and behavioral problems. In this study, a 12-year-old Chinese girl was referred for genetic evaluation of grand mal seizures. She had paroxysmal convulsions of the limbs and loss of consciousness just after falling asleep without obvious triggers. A novel heterozygous missense mutation c.2797C > T (p.Arg933Cys) in exon 24 of the KCNT1 was identified in the proband by whole-exome sequencing and Sanger sequencing, and the clinical symptoms were compatible with ADSHE. The proband's father has been showing similar symptoms for more than 20 years and had the same site mutation. Her mother and sister were physically and genetically normal. The study revealed a novel variant in the KCNT1 and expanded the mutation spectrum for this clinical condition. Our results provide further evidence supporting a causative role in KCNT1 variants in ADSHE.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40365597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Patients with post-COVID-19 vaccination facial palsy: To boost or not to boost? covid -19疫苗接种后面瘫患者:加强还是不加强?

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-08-22 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0240

Nicola Cirillo, Massimiliano Orlandi, Giuseppe Colella

引用次数: 3

Machine learning approaches for diagnosing depression using EEG: A review. 脑电诊断抑郁症的机器学习方法综述。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-08-12 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0234

Yuan Liu, Changqin Pu, Shan Xia, Dingyu Deng, Xing Wang, Mengqian Li

引用次数: 2

The effect of stimulation frequency on transcranial evoked potentials. 刺激频率对经颅诱发电位的影响。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0235

Giorgio Leodori, Lorenzo Rocchi, Marco Mancuso, Maria Ilenia De Bartolo, Viola Baione, Matteo Costanzo, Daniele Belvisi, Antonella Conte, Giovanni Defazio, Alfredo Berardelli

{"title":"The effect of stimulation frequency on transcranial evoked potentials.","authors":"Giorgio Leodori, Lorenzo Rocchi, Marco Mancuso, Maria Ilenia De Bartolo, Viola Baione, Matteo Costanzo, Daniele Belvisi, Antonella Conte, Giovanni Defazio, Alfredo Berardelli","doi":"10.1515/tnsci-2022-0235","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0235","url":null,"abstract":"Introduction: Transcranial magnetic stimulation-evoked electroencephalography potentials (TEPs) have been used to study motor cortical excitability in healthy subjects and several neurological conditions. However, optimal recording parameters for TEPs are still debated. Stimulation rates could affect TEP amplitude due to plasticity effects, thus confounding the assessment of cortical excitability. We tested whether short interpulse intervals (IPIs) affect TEP amplitude.Methods: We investigated possible changes in TEP amplitude and global mean field amplitude (GMFA) obtained with stimulation of the primary motor cortex at IPIs of 1.1-1.4 s in a group of healthy subjects.Results: We found no differences in TEP amplitude or GMFA between the first, second and last third of trials.Discussion: Short IPIs do not affect TEP size and can be used without the risk of confounding effects due to short-term plasticity.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40431557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Increased levels of neurofilament light chain in suicide attempters' serum. 自杀未遂者血清中神经丝轻链水平升高。

IF 2.1 4区医学

Translational Neuroscience Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.1515/tnsci-2022-0236

Mahtab Ramezani, Leila Simani, Mahdiye Golestani Fard, Fatemeh Abbaszadeh, Shahin Shadnia

{"title":"Increased levels of neurofilament light chain in suicide attempters' serum.","authors":"Mahtab Ramezani, Leila Simani, Mahdiye Golestani Fard, Fatemeh Abbaszadeh, Shahin Shadnia","doi":"10.1515/tnsci-2022-0236","DOIUrl":"https://doi.org/10.1515/tnsci-2022-0236","url":null,"abstract":"Background: A specific biological vulnerability underlies suicidal behavior. Recent findings have suggested a possible role of inflammation and neuroaxonal injury. However, the relationship between inflammation and clinical symptoms in this disorder is still unclear. The objective of this study is applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL) and comparing the results with the healthy control subjects.Methods: In this cross-sectional study patients with suicide attempts were evaluated. The serum concentration of NfL on admission was measured by enzyme-linked immunosorbent assays.Results: A total of 50 patients with a suicide attempts and 35 healthy controls were included in the study. The levels of NfL in attempted suicide patients were significantly higher in comparison with healthy controls (40.52 ± 33.54 vs 13.73 ± 5.11, P < 0.001). A significant association between serum levels of NfL and risk factors for suicide was not found.Conclusion: These findings indicate that axonal damage may be an underlying neuropathological component of suicide attempt patients, although no correlation was observed with clinical features. This line of work could lead to new horizons in understanding the neurobiology of suicidal attempts and the development of better management strategies for these patients.","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40431558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1