Toxin Reviews最新文献_第9页

Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments 癌症蜂毒的细胞靶点及分子活性机制研究进展

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-02-15 DOI: 10.1080/15569543.2021.2024576

Ayşegül Varol, Serap Sezen, Dilhan Evcimen, Atefeh Zarepour, Gönül Ulus, A. Zarrabi, Gamal Badr, S. Daştan, Asya Gülistan Orbayoğlu, Z. Selamoğlu, M. Varol

引用次数: 3

In vivo evaluation of antivenom activity of Adenocarpus anagyrifolius methanolic extract against Hottentotta gentili scorpion venom 金合欢甲醇提取物抗龙胆蝎毒活性的体内评价

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-02-09 DOI: 10.1080/15569543.2022.2033778

K. Benrazzouk, Mehdi Ait Laaradia, Malika Ait Sidi Brahim, S. Ouhaddou, A. Ouhammou, A. Chait, K. Bekkouche, M. Markouk, M. Larhsini

引用次数: 2

Determination and seasonal analysis of physicochemical characterization and metal(oid)s of landfill leachate in Bushehr port along the Persian Gulf 波斯湾沿岸布什尔港垃圾渗滤液理化特征及金属(类)含量测定及季节分析

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-28 DOI: 10.1080/15569543.2022.2027454

A. Mohammadi, Mohammad Malakootian, S. Dobaradaran, Majid Hashemi, Neemat Jaafarzadeh, Nasrin Parniani

引用次数: 10

The effects of environmental lead on teeth and bone status and the mechanisms of these effects, animal and human evidence, a review 环境铅对牙齿和骨骼状况的影响及其机制，动物和人类证据，综述

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-25 DOI: 10.1080/15569543.2022.2026398

M. Boskabady, V. Ghorani, Sima Beigoli, M. Boskabady

引用次数: 0

Himalayan poisonous plants for traditional healings and protection from viral attack: a comprehensive review 喜马拉雅有毒植物的传统治疗和保护从病毒攻击:全面审查

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-24 DOI: 10.1080/15569543.2021.2023575

Shriya Pathania, D. Pathania, P. Chauhan, Mamta Sharma

{"title":"Himalayan poisonous plants for traditional healings and protection from viral attack: a comprehensive review","authors":"Shriya Pathania, D. Pathania, P. Chauhan, Mamta Sharma","doi":"10.1080/15569543.2021.2023575","DOIUrl":"https://doi.org/10.1080/15569543.2021.2023575","url":null,"abstract":"Abstract The goal of the evaluation of the current review is to offer a report on toxic vegetation with healthful properties and plants that are accustomed to treat infectious agent diseases (antiviral properties). Use of plants is as old as mankind, even then poisonous plants come under the most underrated category of plants all over the world and used less often due to folklores about their adverse effects. Knowledge of poisonous plants is important as some of them are useful to treat remedies. The poisonous feature of plants is due to the production of toxic substance which includes alkaloids, amines, saponins, tannins, etc. To illustrate improved affinity and effectiveness for health endorsement, they should be explored more. Along with the medicinal impact of the plants against various diseases, they are also used to treat viral diseases. Antiviral property is the most common medicinal asset of poisonous floras and used since ancient times. Natural treatment is cheap and claimed to be safe. Long ago, the investigation into antiviral action of assorted capable plants was restricted due to the extremely communicable nature of viruses and deficiency of applicable separation procedures for the documentation of antiviral plants from other plants. As we know that, Viruses nowadays, lead to situations of pandemics all over the world. This bibliographic analysis is therefore compendium of information on plants used for the treatment of viral sicknesses. Graphical abstract","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1374 - 1381"},"PeriodicalIF":3.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48441512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Carcinogenic risk assessment, health endpoint and source identification of heavy metals in Mahshahr, Iran 伊朗Mahshahr重金属致癌风险评估、健康终点和来源鉴定

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-22 DOI: 10.1080/15569543.2021.2023576

Farzaneh Nikfar, S. Sabzalipour, A. Gholami, A. Nazarpour

{"title":"Carcinogenic risk assessment, health endpoint and source identification of heavy metals in Mahshahr, Iran","authors":"Farzaneh Nikfar, S. Sabzalipour, A. Gholami, A. Nazarpour","doi":"10.1080/15569543.2021.2023576","DOIUrl":"https://doi.org/10.1080/15569543.2021.2023576","url":null,"abstract":"Abstract Heavy metals (HM) are one of the main agents that threaten human health. The most important source that release heavy metals (As, Cd, Cu, Cr, Pb, Ni, V, and Zn) in the environment is Petrochemical industries. This study was investigated the carcinogenic risk assessment, health endpoint and source identification of heavy metals. Samples were taken from the different regions: parks, residential, industrial, administrative and central and high traffic areas in Mahshahr, southwest, Iran and investigate the environmental impacts of the studied petrochemical industry. Measurement of heavy metals performed by Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Results of the PCA showed that As had a different source than other heavy metals, which can be owing to numerous human and industrial activities in the region. Based on the results, the Igeo factor was assessed at high levels for Ni, Pb, and Cd metals. Moreover, the results demonstrated high intensities of pollution for Pb, Zn, Cd, and Ni metals under the application of PI and IPI indices, and for Ni, Pb, and Cd metals under the application of the EF index. The index of the risk index (RI) average of the studied metals represented a significant risk for Ni, Cr and As metals on children and adults. In addition, Pb isotopic results showed high levels of 208Pb/206Pb to 207Pb/206Pb, which indicated that the increase of the Pb isotope in the studied region was concerned with petrochemical activities of human origin. In this study, it was found that the soils of the Mahshahr port industrial zone have high anomalies of some metals, especially Ni, Pb, Zn and Cd, which were due to the growth of traffic and economic and industrial activities in the region. However, heavy metals such as As and V exhibited the lowest risk and very low pollution in all indicators.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"132 - 145"},"PeriodicalIF":3.1,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49160842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neuromodulation of neurological disorders in a demyelination model: effect of a potassium channel inhibitor from Androctonus scorpion venom 脱髓鞘模型中神经系统疾病的神经调节:来自蝎蝎毒液的钾通道抑制剂的作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-20 DOI: 10.1080/15569543.2021.2022698

Hadjila Moussaoui, A. Ladjel-Mendil, F. Laraba-Djebari

{"title":"Neuromodulation of neurological disorders in a demyelination model: effect of a potassium channel inhibitor from Androctonus scorpion venom","authors":"Hadjila Moussaoui, A. Ladjel-Mendil, F. Laraba-Djebari","doi":"10.1080/15569543.2021.2022698","DOIUrl":"https://doi.org/10.1080/15569543.2021.2022698","url":null,"abstract":"Abstract Scorpion’s toxins have attracted attention as a treatment for diverse neurological diseases related to myelin loss. This study aimed to investigate the effect of kaliotoxin2 (KTX2), a potassium-channel blocker from Androctonus australis hector venom on cuprizone model of demyelination. Results showed that KTX2 modulates the behavioral functions, the demyelination, and reduces the recruitment of microglia, astrocytes, and granulocyte in the brain. KTX2 modulates the inflammatory response by increasing the IL-10 release, attenuating NFκB activation, and decreasing the oxidative stress markers and IL-6 levels. Results highlight the modulating effects of KTX2 on cuprizone model and confirm its therapeutic potential in demyelination diseases. Highlights Kaliotoxin2 (KTX2) prevents the excessive reduction in body weight gain and modulate motor coordination disorder induced by cuprizone. KTX2 from Aah venom protect myelin from the destructive effects of cuprizone. KTX2 inoculation to the CNS reduce microglia, astrocytes and granulocyte infiltration in the brain. KTX2 increases the production of the anti-inflammatory cytokine IL-10 and attenuates the activation of NFκB. KTX2 counterbalances cuprizone-induced brain unbalance of neurochemical redox parameters.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"99 - 114"},"PeriodicalIF":3.1,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46513222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pollution assessment and estimation of the percentages of toxic elements to be removed to make polluted drinking water safe: a case from Nigeria 为使受污染的饮用水安全而需清除的有毒元素百分比的污染评估和估计:来自尼日利亚的一个案例

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-17 DOI: 10.1080/15569543.2021.2025401

J. C. Egbueri, Daniel A. Ayejoto, J. C. Agbasi

引用次数: 20

Acrylamide in foods: from regulation and registered levels to chromatographic analysis, nutritional relevance, exposure, mitigation approaches, and health effects 食品中的丙烯酰胺：从法规和注册水平到色谱分析、营养相关性、暴露、缓解方法和健康影响

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-11 DOI: 10.1080/15569543.2021.2018611

Mónica Quesada-Valverde, Graciela Artavia, F. Granados-Chinchilla, Carolina Cortés-Herrera

{"title":"Acrylamide in foods: from regulation and registered levels to chromatographic analysis, nutritional relevance, exposure, mitigation approaches, and health effects","authors":"Mónica Quesada-Valverde, Graciela Artavia, F. Granados-Chinchilla, Carolina Cortés-Herrera","doi":"10.1080/15569543.2021.2018611","DOIUrl":"https://doi.org/10.1080/15569543.2021.2018611","url":null,"abstract":"Abstract Herein we explore the latest research on a chemical compound resulting from food processing and during the Maillard reaction: Acrylamide (ACR). ACR is formed during high-temperature cooking processes (i.e. >120 °C), such as frying, roasting, and baking. Considering the relevance of ACR in the food industry, first, we briefly explored the nature of ACR and its mechanisms of formation and current available legislative framework (with especial emphasis on baked goods and cereals, potato-based products, and coffee). Special attention was given to which foods are more likely to contain considerable amounts of ACR and the particulars of chromatographic methodologies involved in its testing (including extraction). Additionally, health effects caused by ACR were addressed that include an introduction to eukaryotic and prokaryotic ACR metabolism, biotransformation, and fate. Risk assessment, including a margin of exposure (MOE) and tolerance levels for ACR, was highlighted. Finally, we concluded our review with a section regarding methods and strategies available to reduce ACR in foods; this includes the role of asparagine (Asn), operation units available to industry, and the addition of natural products. ACR is still a relevant compound regarding food safety, and still, research is ongoing to develop methods for accurate surveillance and strategies for quenching its formation at the processing stage.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"41 1","pages":"1343 - 1373"},"PeriodicalIF":3.1,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49388024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Polycyclic aromatic hydrocarbons in soil situated around solid waste dumpsite in Awka, Nigeria 尼日利亚奥卡市固体废物倾倒场周围土壤中的多环芳烃

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-01-06 DOI: 10.1080/15569543.2021.2022700

C. Aralu, P. Okoye, K. Akpomie, H. O. Chukwuemeka-Okorie, H. O. Abugu

{"title":"Polycyclic aromatic hydrocarbons in soil situated around solid waste dumpsite in Awka, Nigeria","authors":"C. Aralu, P. Okoye, K. Akpomie, H. O. Chukwuemeka-Okorie, H. O. Abugu","doi":"10.1080/15569543.2021.2022700","DOIUrl":"https://doi.org/10.1080/15569543.2021.2022700","url":null,"abstract":"Abstract Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in the environment that can threaten the populace living close to contaminated soil. Soil samples were collected from the study and control areas which were analyzed for PAHs using Gas chromatography. The detected PAHs concentrations varied from ND to 6.83 ± 10.58 µg/kg for the study sample and ND − 3.23 ± 4.72 µg/kg for the control sample for the wet season. The study sample dry season concentration values of PAHs ranged from ND to 4.73 ± 5.69 µg/kg and varied from ND to 3.67 ± 5.49 µg/kg for the control sample in the dry season. The study sample ( PAHs) values were significantly higher than the control location in both seasons. The detected 2–3 ringed PAHs values were higher than the 4–6 ringed PAHs for both locations and seasons. The ratios of the molecular groups indicated that the PAHs were delivered to the soil from pyrolytic and petrogenic sources. The values of the cancer risks for adults and children ranged from 1.02 − 5.68 to 2.27 − 4.3 for dermal and ingestion pathways respectively which makes cancer risks unlikely for both age categories in both locations.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"122 - 131"},"PeriodicalIF":3.1,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44204306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7