癌症蜂毒的细胞靶点及分子活性机制研究进展

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2022-02-15 DOI:10.1080/15569543.2021.2024576

Ayşegül Varol, Serap Sezen, Dilhan Evcimen, Atefeh Zarepour, Gönül Ulus, A. Zarrabi, Gamal Badr, S. Daştan, Asya Gülistan Orbayoğlu, Z. Selamoğlu, M. Varol

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引用次数: 3

摘要

蜂毒疗法被认为是治疗许多疾病的传统方法，如关节炎、疼痛和风湿病。蜂毒在治疗乳腺癌、肺癌、卵巢癌、胃癌、肾癌、前列腺癌、宫颈癌、结肠癌和食管癌、骨肉瘤、白血病、黑色素瘤和肝细胞癌等多种癌症方面也有很大的潜力。因此，我们不仅关注蜂毒及其成分的分子活性机制和细胞靶点，还关注现代解决方案，如尖端纳米技术的进步，以克服现有的瓶颈，以及蜂毒在临床环境中抗癌应用的最新进展。

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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

Abstract Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ovary, stomach, kidney, prostate, cervical, colon and esophageal cancers, osteosarcoma, leukemia, melanoma and hepatocellular carcinoma. We therefore focused not only on the molecular activity mechanisms and cellular targets of bee venom and its components, but also on modern solutions as cutting-edge nanotechnological advances to overcome existing bottlenecks, and the latest advances in the anticancer application of bee venom in clinical settings.

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.