The effects of environmental lead on teeth and bone status and the mechanisms of these effects, animal and human evidence, a review

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2022-01-25 DOI:10.1080/15569543.2022.2026398

M. Boskabady, V. Ghorani, Sima Beigoli, M. Boskabady

引用次数: 0

Abstract

Abstract The effects of lead (Pb) exposure, a major human health threat, on the bone, teeth, and the possible underlying mechanisms are reviewed. The effects of environmental lead on the bone, mouth, and teeth such as osteoporosis and dental caries were demonstrated, which are reported to be due to increased production of osteoclast, bone resorption, oxidative stress, changes in the circulating D3 level, disruption of mineralization, delay fracture healing, effect on Ca2+ metabolism, inflammation, and affecting humoral and cell-mediated immunity. Therefore, reducing environmental lead in workplaces to prevent its harmful effects on the bone and teeth is needed.

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环境铅对牙齿和骨骼状况的影响及其机制，动物和人类证据，综述

本文综述了铅（Pb）暴露对骨骼、牙齿的影响，以及可能的潜在机制。铅是人类健康的主要威胁。证明了环境铅对骨骼、口腔和牙齿的影响，如骨质疏松症和龋齿，据报道，这是由于破骨细胞的产生增加、骨吸收、氧化应激、循环D3水平的变化、矿化破坏、骨折愈合延迟、对Ca2+代谢的影响、炎症、，以及影响体液和细胞介导的免疫。因此，需要减少工作场所的环境铅，以防止其对骨骼和牙齿的有害影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.